The contribution of antigen-presenting cell (APC) types in generating CD8+ T cell responses in the central nervous system (CNS) is not fully defined, limiting the development of vaccines and understanding of immune-mediated neuropathology. Here, we generate a transgenic mouse

This lecture will describe recent mechanistic studies on futalosine-dependent menaquinone biosynthesis and the development of new radical trapping strategies.

The development of a quality pharmaceutical tablet product is a complex process, involving informed decisions on the type and amount of excipients and several process parameters. Owning to the level of complexity, tablet development has been empirical.

Presentation Title: Solid-State Pharmaceutical Sciences: Past, Present and Future. Understanding both the solid-state chemistry and material properties of a drug molecule is essential to the development of a medicine. However, solid-state pharmaceutical science as a discipline was largely unrecognized in some sectors even two or three decades ago.

The effective treatment of antibiotic-resistant bacterial infections is an unmet clinical need that is of increasing urgency. The deployment of nanoparticles, specifically targeted to the diseased tissues and carrying payloads designed to either enhance existing therapeutic regimens or to reprogram the immune system response will be described.

Small molecule drugs mostly have molecular weight of less than 500, but they exert large structural diversity as they bind to various drug targets. Drug metabolism by Phase-I and Phase-II enzymes further increases such structural diversity.

Employing a structure/function approach to the understanding of the molecular topology of growth hormone (GH), we discovered that glycine (Gly) 119 of bovine GH and Gly 120 of human GH were important amino acids required for GH activity.