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University of Wisconsin-Madison

Pharm Sci Seminar – Changquan Calvin Sun, PhD

November

9,

2018

Crystal and Particle Engineering to Enable Successful Tablet Manufacturing

Changquan Calvin Sun, PhD
Dept. of Pharmaceutics
University of Minnesota

Host: Lian Yu

 

Abstract:

The development of a quality pharmaceutical tablet product is a complex process, involving informed decisions on the type and amount of excipients and several process parameters.  Owning to the level of complexity, tablet development has been empirical.  Generally, a significant amount of active pharmaceutical ingredient (API) and a long time is required before a scalable formulation is identified.  Unfortunately, problems during manufacturing still occur frequently for such empirically developed tablet formulations.  In contrast, formulation development guided by Materials Science Tetrahedron (MST) is efficient.  Robust tablet formulation and manufacturing process can be developed quickly and using a small amount of API.  The MST guided approach starts from identifying problems that affect tablet quality.  Structural origin of each problem is then understood and appropriate engineering strategies are developed to modify structure.  This leads to efficient development of high performance tablets.  Assisted by predictive characterization tools, such as shear cell tester and compaction simulator, scalable tablet formulation can be developed using a small amount of API.  This talk will discuss useful particle and engineering strategies, such as salt formation, nanocoating, and spherical crystallization.  Three case studies will be discussed to demonstrate the benefits of integrated crystal and particle engineering in the expedited development of robust tablet formulations.    

Date
Friday, November 9, 2018
Time
8:50 AM – 9:50 AM
Location

Signe Skott Cooper Hall 1227

Madison, WI 53705

This event is brought to you by: Pharmaceutical Sciences Division