Mechanistic Studies on the Futalosine-Dependent Menaquinone Biosynthetic Pathway
Tadhg Begley, PhD
Department of Chemistry
Texas A & M University
Host: Jiaoyang Jiang
Abstract:
The futalosine-dependent menaquinone biosynthesis discovered by Tohru Dairi in 2008 is shown below.1 MqnE and MqnC are both radical SAM enzymes. My lecture will describe recent mechanistic studies on these two enzymes and the development of new radical trapping strategies.2-4
References
(1) Hiratsuka, T.; Furihata, K.; Ishikawa, J.; Yamashita, H.; Itoh, N.; Seto, H.; Dairi, T. Science 2008, 321, 1670-1673.
(2)Cooper, L. E.; Fedoseyenko, D.; Abdelwahed, S. H.; Kim, S.-H.; Dairi, T.; Begley, T. P. Biochemistry 2013, 52, 4592-4594.
(3)Joshi, S.; Mahanta, N.; Fedoseyenko, D.; Williams, H.; Begley, T. P. J. Am. Chem. Soc. 2017, 139, 10952-10955.
(4)Mahanta, N.; Fedoseyenko, D.; Dairi, T.; Begley, T. P. J. Am. Chem. Soc. 2013, 135, 15318-15321.