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University of Wisconsin-Madison

Pharm Sci Seminar – Tadhg Begley, PhD

November

2,

2018

Mechanistic Studies on the Futalosine-Dependent Menaquinone Biosynthetic Pathway

Tadhg Begley, PhD
Department of Chemistry
Texas A & M University

Host: Jiaoyang Jiang

Abstract:

The futalosine-dependent menaquinone biosynthesis discovered by Tohru Dairi in 2008 is shown below.1 MqnE and MqnC are both radical SAM enzymes. My lecture will describe recent mechanistic studies on these two enzymes and the development of new radical trapping strategies.2-4

Diagram showing futalosine-dependent menaquinone biosynthesis

References

(1) Hiratsuka, T.; Furihata, K.; Ishikawa, J.; Yamashita, H.; Itoh, N.; Seto, H.; Dairi, T.  Science  2008, 321, 1670-1673.
(2)Cooper, L. E.; Fedoseyenko, D.; Abdelwahed, S. H.; Kim, S.-H.; Dairi, T.; Begley, T. P.  Biochemistry 2013, 52, 4592-4594.  
(3)Joshi, S.; Mahanta, N.; Fedoseyenko, D.; Williams, H.; Begley, T. P.  J. Am. Chem. Soc. 2017, 139, 10952-10955.
(4)Mahanta, N.; Fedoseyenko, D.; Dairi, T.; Begley, T. P.  J. Am. Chem. Soc. 2013, 135, 15318-15321.

Date
Friday, November 2, 2018
Time
3:30 PM – 4:30 PM
Location

2006 Rennebohm Hall

Madison, WI 53705

This event is brought to you by: Pharmaceutical Sciences Division