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University of Wisconsin-Madison

Pharm Sci Seminar – Aaron J. Johnson, PhD

October

26,

2018

The Impact of Cell-Specific Deletion of MHC I in Generating CD8 T Cell Responses in the Central Nervous System

Aaron J. Johnson, PhD
Departments of Immunology, Neurology and Molecular Medicine
Mayo Clinic, Rochester, MN

Host: Michael Taylor

The contribution of antigen-presenting cell (APC) types in generating CD8+ T cell responses in the central nervous system (CNS) is not fully defined, limiting the development of vaccines and understanding of immune-mediated neuropathology. Here, we generate a transgenic mouse that enables cell-specific deletion of the H-2Kb MHC class I molecule. By deleting H-2Kb on dendritic cells and macrophages, we compare the effect of each APC in three distinct models of neuroinflammation: picornavirus infection, experimental cerebral malaria, and a syngeneic glioma. Dendritic cells and macrophages both activate CD8+ T cell responses in response to these CNS immunological challenges. However, the extent to which each of these APCs contributes to CD8+ T cell priming varies. These findings reveal distinct functions for dendritic cells and macrophages in generating CD8+ T cell responses to neurological disease.

Date
Friday, October 26, 2018
Time
12:00 PM – 12:50 PM
Location

2339 Rennebohm Hall

Madison, WI 53705

This event is brought to you by: Pharmaceutical Sciences Division