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Join us for the second lecture of the 2019 Busse Lecture Series on March 29 at 3:30pm in Rennebohm Hall, room 2006. Professor Dale Wurster from the University of Iowa College of Pharmacy and Department of Pharmaceutical Sciences and Experimental Therapeutics will present his research about activated carbon adsorption site specificity. Reception immediately following the lecture in the Rennebohm Hall Atrium.
A unique compression calorimeter built in these laboratories allows the work of compression, work of decompression, heat of compression, and heat of decompression to be determined from a single compression-decompression cycle. The calculation of the net change in internal energy for the complete compression-decompression cycle can be calculated from the aforementioned heat and work terms. The net change in internal energy has been found to be more predictive of successful compact formation than either the net change in work or the net change in heat. The net change in internal energy can be correlated with the Hiestand Bonding Index, and, for soluble excipients, has the same value as appropriate experiments employing isoperibol solution calorimetry. Thus, the experimental results are also predictive of molecular-scale physical phenomena occurring in the interiors of the compacted particles.
Host: Mel de Villiers