Pharm Sci Seminar – Brian Shoichet, PhD
Molecular docking screens large compound libraries for molecules that complement a binding site, but do not resemble known ligands
Stay up-to-date with the latest events, including faculty presentations, career events for students and alumni, and so much more.
Molecular docking screens large compound libraries for molecules that complement a binding site, but do not resemble known ligands
Methyl-lysine (Kme) recognition domains play a central role in chromatin regulation during cellular differentiation, development, and gene transcription with more than 200 known Kme “reader” domains
This seminar will share our work on the development & clinical translation of nanotherapeutics in cancer chemoradiotherapy treatment, on recent work on applying nanotechnology to improve cancer immunotherapy, and the application of tissue engineering for cancer model development
Traditional cytotoxic chemotherapy’s safety and efficacy are limited by the tendency of these drugs to widely distribute throughout the body. Our work utilizes the hijacked “plumbing” of tumors to concentrate anti-cytotoxins in the cancer
The promise of high throughput automated synthesis to produce diverse compound libraries for drug discovery has been severely restricted by the range of chemical methods amenable to automation. The result is that libraries across the world look very similar and generally lack complexity
The contribution of antigen-presenting cell (APC) types in generating CD8+ T cell responses in the central nervous system (CNS) is not fully defined, limiting the development of vaccines and understanding of immune-mediated neuropathology. Here, we generate a transgenic mouse
This lecture will describe recent mechanistic studies on futalosine-dependent menaquinone biosynthesis and the development of new radical trapping strategies.
The development of a quality pharmaceutical tablet product is a complex process, involving informed decisions on the type and amount of excipients and several process parameters. Owning to the level of complexity, tablet development has been empirical.
Dr. Howard Jacob, a leader in the genetics and genomics fields, will speak about the growing role of genome sequencing in medication management and the pivotal role that pharmacists play in pharmacogenomics and precision medicine in his talk "Better Care, Better Management of Medications and Better Health through Genome Sequencing".
Presentation Title: Solid-State Pharmaceutical Sciences: Past, Present and Future. Understanding both the solid-state chemistry and material properties of a drug molecule is essential to the development of a medicine. However, solid-state pharmaceutical science as a discipline was largely unrecognized in some sectors even two or three decades ago.