Bile acids (BA) are biological surfactants synthesized in the liver and secreted to the duodenum via the gall bladder to help digest dietary fats.

Molecular docking screens large compound libraries for molecules that complement a binding site, but do not resemble known ligands

Methyl-lysine (Kme) recognition domains play a central role in chromatin regulation during cellular differentiation, development, and gene transcription with more than 200 known Kme “reader” domains

This seminar will share our work on the development & clinical translation of nanotherapeutics in cancer chemoradiotherapy treatment, on recent work on applying nanotechnology to improve cancer immunotherapy, and the application of tissue engineering for cancer model development

Traditional cytotoxic chemotherapy’s safety and efficacy are limited by the tendency of these drugs to widely distribute throughout the body. Our work utilizes the hijacked “plumbing” of tumors to concentrate anti-cytotoxins in the cancer

The promise of high throughput automated synthesis to produce diverse compound libraries for drug discovery has been severely restricted by the range of chemical methods amenable to automation. The result is that libraries across the world look very similar and generally lack complexity

The contribution of antigen-presenting cell (APC) types in generating CD8+ T cell responses in the central nervous system (CNS) is not fully defined, limiting the development of vaccines and understanding of immune-mediated neuropathology. Here, we generate a transgenic mouse

This lecture will describe recent mechanistic studies on futalosine-dependent menaquinone biosynthesis and the development of new radical trapping strategies.