Located at the University of Wisconsin – Madison School of Pharmacy, the Medicinal Chemistry Center (MCC) is a center of expertise focused on providing collaborative drug discovery services to the biomedical community across all therapeutic areas. Our mission is to drive translational drug discovery and development through the design and synthesis of novel small molecule based therapeutics. Services provided by the Medicinal Chemistry Center cover a range of drug discovery activities with flexibility to respond to each collaborator’s specific project needs (please contact us to discuss). Our collaborative drug discovery services include:

• Providing expert opinion to biomedical researchers seeking medicinal chemistry guidance
• Synthesis of small molecules that have been identified as bioactive
• Development of lead and probe molecules for target identification
• Hit-to-lead optimization to improve drug-like properties
• Construction of libraries of small molecules, synthetic and naturally occurring, unique to UW-Madison
• Large-scale preparative synthesis to support animal model studies
• Chemoinformatic analysis and rational drug design
• Support for individual and center-based research grants

MCC works primarily with investigators from UW-Madison; however, we also extend our services to external universities as well as private sector pharmaceutical and biotech industries.

We recently received a UW2020 award to establish a targeted protein degradation platform to accelerate translational research at UW–Madison. Please contact the MCC Director for more details.