Medicinal Chemistry Center

MCC scientist Zhi-Xiong Ma inspects a vial in the chemical hood.

Located at the University of Wisconsin – Madison School of Pharmacy, the Medicinal Chemistry Center (MCC) is a center of expertise focused on providing collaborative drug discovery services to chemists, biologists, and the biomedical community across all therapeutic areas. Our mission is to drive translational drug discovery and development through the design and synthesis of novel small molecule based therapeutics.

Services provided by the Medicinal Chemistry Center cover a range of drug discovery activities with flexibility to respond to each client’s specific project needs (please contact us to discuss). Our collaborative drug discovery services include:

  • Providing expert opinion to medical researchers seeking medicinal chemistry guidance
  • Synthesis of small molecules that have been identified as bioactive
  • Development of lead and probe molecules for target identification
  • Hit-to-lead optimization to improve drug-like properties
  • Construction of libraries of small molecules, synthetic and naturally occurring, unique to UW-Madison
  • Large-scale preparative synthesis to support animal model studies
  • Chemoinformatic analysis and rational drug design
  • Support for individual and center-based research grants

Though collaborative in nature, MCC services are not free, and an estimate of project costs will be provided prior to project initiation. The MCC works primarily with investigators from UW-Madison; however, we also extend our services to external universities as well as private sector pharmaceutical and biotech industries.

Postdoc Opening

The UW Madison Medicinal Chemistry Center is seeking a highly motivated postdoctoral researcher skilled in synthetic organic chemistry or medicinal chemistry to carry out synthesis of novel small molecule chemical libraries to supplement a UW high-throughput screening collection. The contract term will be 1 year.

Postdoctoral applicants should send their resume and research summary to and also provide an estimate of availability.