We have worked with numerous UW-Madison laboratories across a broad range of projects requiring lead and probe discovery, hit-to-lead optimization, rational drug design, and scale-up synthesis to fuel animal studies.
The Med Chem Center chemistry lab has an Anton Paar Monowave 300 with a 24 position autosampler for microwave facilitated synthesis, Agilent HPLC system set up for both analysis and purification and a Teledyne Isco CombiFlash unit for rapid purification of reactions. MCC chemists also have access to the School of Pharmacy Analytical Instrumentation Center (AIC). The AIC is equipped with Varian Unity-Inova 400 MHz and 500 MHz NMR spectrometers and a number of Mass Spectrometers, such as Agilent 1100 HPLC-MSD VL Quadrupole MS, an Agilent 1100 HPLC-MSD SL Ion Trap MS for MS-MS and an IonSpec ProMALDI FT MS.
In addition, the MCC collaborates with other laboratories in the School of Pharmacy and across campus as needed to access state of the art capabilities for advanced analyses: UW Network of Expertise.
Additional services are available via collaboration with other UW centers of expertise including the Small Molecule Screening Facility, Zeeh Pharmaceutical Experiment Station, Pharmaceutical Sciences Division faculty expertise in drug discovery, drug action and drug delivery and the School of Pharmacy’s Analytical Instrumentation Center.