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WARF Therapeutics Distinguished Lecture in Drug Discovery: Gunda Georg, PhD

2006 Rennebohm Hall 777 Highland Ave, Madison

"The Male Pill: Are We there Yet?"
To provide couples with additional safe and reversible options for contraception, the development of non-hormonal contraceptives for both men and women is highly desirable to assist with family planning and reducing unintended pregnancies. In collaboration with the Wolgemuth group at Columbia University we have discovered the non-hormonal male contraceptive agent YCT529 that is targeting retinoic acid receptor alpha, a validated male contraceptive target. Together with our industrial partner Your Choice Therapeutics (YCT) we are developing YCT529 for first-in-human clinical trials. The presentation will discuss the discovery and development of YCT529 including the preclinical efficacy in mouse and non-human primates.