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University of Wisconsin-Madison

Drug ACTION Specific Seminar – Leonard MacGillivray, PhD




Pharmaceutical Sciences Seminar Series

Pharmaceutical Cocrystals as a Pathway to New Medicines and Prostate Health

(Drug ACTION Specific Seminar)

  • Leonard MacGillivray, PhD
  • University of Iowa

Pharmaceutical cocrystals provide a versatile platform toward the innovate design of solid forms of medicine. Existing drug molecules can be developed into multicomponent solids using principles of supramolecular chemistry and crystal engineering.  Robust structural units in the form of supramolecular synthons provide means to preselect molecular components that interact to form cocrystals via noncovalent bonds (e.g., hydrogen bonds). In this presentation, we will describe our efforts to employ principles of supramolecular chemistry to form pharmaceutical cocrystals. We will address masked synthons, synthon hierarchies, and polymorphism in cocrystals of a variety of active pharmaceutical ingredients (e.g., Fluorouracil). A focus will be the design and development of cocrystals for prostate health, as well as cocrystals that undergo covalent-bond-forming reactions.

Hosted by Will Ricke

Friday, November 3, 2023
3:30 PM – 4:30 PM

2006 Rennebohm Hall

Madison, WI 53705

This event is brought to you by: Pharmaceutical Sciences Division