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University of Wisconsin-Madison

2023 Busse Lecture – Samir Mitragotri, PhD




All-Division Colloquium

2023 Louis Busse Lecture

  • Samir Mitragotri, PhD
  • Hiller Professor of Bioengineering
    Hansjorg Wyss Professor of Biologically Inspired Engineering Area Chair, Bioengineering
    Harvard University

A Hitchhiker’s and Backpacker’s Perspective on Drug Delivery

Effective delivery of drugs is a major problem in today’s therapeutics. At a fundamental level, the challenge of drug delivery reflects the fact that the drug distribution in the body is limited by body’s natural metabolic processes and transport barriers. These biological barriers, while serving an important purpose of regulating body’s metabolic functions, limit the drug dose that ultimately reaches the target site. Accordingly, many drugs fail to reach their full therapeutic potential. Our research aims to understand body’s key biological barriers and develop novel means to negotiate these barriers to deliver drugs. We have developed means to use body’s own circulatory cells including red blood cells, macrophages, monocytes, neutrophils, NK cells and T cells to overcome body’s barriers and deliver drugs to target tissues for the treatment of cancer, autoimmune disorders and trauma. I will present an overview of these strategies and their effectiveness in drug delivery. 

Hosted by Seungpyo Hong

Samir Mitragotri, PhD, Harvard University. 2023 Busse LecturerSamir Mitragotri is the Hiller Professor of Bioengineering and Wyss Professor of Biologically Inspired Engineering at Harvard University. His research is focused on drug delivery systems. He is an elected member of the National Academy of Engineering, National Academy of Medicine and National Academy of Inventors. He is also an elected fellow of AAAS, CRS, BMES, AIMBE, and AAPS. He is an author of over 400 publications, an inventor on over 225 patent/patent applications, and a Clarivate Highly Cited Researcher. He received his BS in Chemical Engineering from the Institute of Chemical Technology, India and a PhD in Chemical Engineering from the Massachusetts  Institute of Technology.

The Busse Lecture Series is intended to bring speakers to the School of Pharmacy who have a fundamental research interest combined with a strong knowledge of the industrial pharmaceutical research environment.

Friday, April 28, 2023
3:30 PM – 4:30 PM

2006 Rennebohm Hall

Madison, WI 53705

This event is brought to you by: Pharmaceutical Sciences Division