Research Interests: Marine natural products chemistry; antibiotic drug discovery; structure determination of novel natural products using NMR and mass spectrometry; and metabolomics studies of marine invertebrate associated microorganisms.
Research Interests: Developing a molecular level mechanistic understanding of the delivery and stability of drugs by physical chemical characterization of guest-host interactions using computational chemistry and NMR as well as studies in pharmacokinetics and pharmacodynamics.
Research Interests: Understanding the transcriptional networks that control keratinocyte proliferation/differentiation and epidermal barrier functions during development and under pathological conditions. Developing novel therapeutic strategies for the treatment of inflammatory skin diseases and skin cancer.
Research Interests: Developing novel nanometer and micrometer sized drug delivery systems. Application of layer-by-layer selfassembly, dendrimers, halloysite and calixarenes in drug delivery and drug solubilization.
Research Interests: Synthetic methodology, medicinal chemistry and drug discovery. Optimization of structure-activity and structure-property relationships. Exploratory pharmacological mining of novel chemical scaffolds. Emphasis on development of anticancer and anti-infective agents.
Research Interests: Developing novel and practical synthetic methods for drug discovery; total syntheses of complex natural products with biological relevance; syntheses of de novo protease inhibitors for drug designs and asymmetric catalysis.
Research Interests: Study the mechanism and function of protein post-translational modifications using a variety of interdisciplinary approaches, such as chemical biology, enzymology, biochemistry, mass spectrometry, X-ray crystallography, cell biology, and genetics.
Research Interests: Transcriptional control of neuroprotective genes and prevention of neurodegeneration in Parkinson's, Alzheimer's, Huntington's and neuromuscular disease. A focus on dysfunctional proteostasis in disease progression and viral-mediated delivery of protective genes to the brain.
Research Interests: The role of uncultured symbionts in natural product biosynthesis within marine invertebrates; marine natural product chemistry; drug discovery; next-generation sequencing; metagenomics; bioinformatics; biosynthesis.
Research Interests: Analytical neurochemistry; neuropeptides; proteomics and peptidomics; glycomics and glycoproteomics; biomarker discovery in neurodegenerative diseases; quantitative system biology; metabolomics; microseparations; imaging mass spectrometry and its application to drug delivery and biodistribution; biological mass spectrometry.
Research Interests: Molecular basis of prostate development; prostate cancer progression; benign prostatic hyperplasia; roles of cell-cell signaling pathways and the use of mouse genetics to discover novel pathways that underlie prostatic diseases.
Medicinal and carbohydrate chemistry; assay development. Developing small molecules that selectively modulate the stability of disease-causing proteins. Designing and synthesizing small molecule ligands for carbohydrate binding proteins. Developing various cell-based and biochemical assays to evaluate pharmacological properties of novel small molecules and to study their mechanism of action.
Weibo Cai , Affiliate Professor, School of Pharmacy; Professor of Radiology, School of Medicine and Public Health (Drug Delivery)
Research Interests: Biomedical nanotechnology; molecular imaging (mostly positron emission tomography and multimodal); image-guided drug delivery; theranostics; translational research; tumor targeting; cancer diagnosis/therapy; imaging of cardiovascular diseases and diabetes.
Adnan Elfarra , Affiliate Professor, School of Pharmacy; Professor of Toxicology, Dept Comparative Biosciences, Vet Med School (Drug Action)
Research Interests: Bioactivation and detoxification of drugs, industrial chemicals, and environmental toxicants; biochemical basis for target organ selectivity; and biomarkers of toxicant exposure.
William Ricke , Affiliate Professor, School of Pharmacy; UW-Medical Foundation Professor of Urologic Research (Drug Action)
Research Interests: Understanding the molecular mechanisms involved with hormone therapy in the prevention and treatment of urologic cancers and benign diseases. Focus areas include: translational research, steroids and small molecules, stromal-epithelial interactions, endocrine disrupting chemicals, mouse models of disease progression.
Lauren Trepanier , Affiliate Professor, School of Pharmacy; Professor and Assistant Dean for Clinical and Translational Research, School of Veterinary Medicine (Drug Action)
Research Interests: Pharmacogenetics of xenobiotic toxicity, including both therapeutic drugs and environmental carcinogens. Risk factors for idiosyncratic and dose-dependent drug toxicity. Genetic variability in phase II detoxification pathways (especially GSTs and cytochrome b5 reductase) and cancer risk in both humans and dogs.
Chad Vezina , Affiliate Professor, School of Pharmacy; Professor of Toxicology, Comparative Biosciences, Vet Med (Drug Action)
Research Interests: Molecular basis of prostate and urinary tract development, physiology, and toxicology.
Jamey Weichert , Affiliate Professor, School of Pharmacy; Professor, Department of Radiology (Drug Delivery) (Drug Discovery)
Research Interests: Design and development of tumor targeted molecular agents for imaging, radiotherapy, and immunotherapy oncology applications.
Research Interests: Synaptic plasticity in substance use and major depressive disorders; Development of antibodies against cannabinoids, opioids, sedative-hypnotics, and classical psychedelics; Immunologic biomarkers of drug use; Implementation of novel psychiatric treatments, including vaccine-based approaches and medication-assisted psychotherapy