Research Interests: Marine natural products chemistry; antibiotic drug discovery; structure determination of novel natural products using NMR and mass spectrometry; and metabolomics studies of marine invertebrate associated microorganisms.
Research Interests: Developing a molecular level mechanistic understanding of the delivery and stability of drugs by physical chemical characterization of guest-host interactions using computational chemistry and NMR as well as studies in pharmacokinetics and pharmacodynamics.
Research Interests: Understanding the transcriptional networks that control keratinocyte proliferation/differentiation and epidermal barrier functions during development and under pathological conditions. Developing novel therapeutic strategies for the treatment of inflammatory skin diseases and skin cancer.
Research Interests: Developing novel nanometer and micrometer sized drug delivery systems. Application of layer-by-layer selfassembly, dendrimers, halloysite and calixarenes in drug delivery and drug solubilization.
Research Interests: Synthetic methodology, medicinal chemistry and drug discovery. Optimization of structure-activity and structure-property relationships. Exploratory pharmacological mining of novel chemical scaffolds. Emphasis on development of anticancer and anti-infective agents.
Research Interests: Developing novel and practical synthetic methods for drug discovery; total syntheses of complex natural products with biological relevance; syntheses of de novo protease inhibitors for drug designs and asymmetric catalysis.
Research Interests: Study the mechanism and function of protein post-translational modifications using a variety of interdisciplinary approaches, such as chemical biology, enzymology, biochemistry, mass spectrometry, X-ray crystallography, cell biology, and genetics.
Research Interests: Transcriptional control of neuroprotective genes and prevention of neurodegeneration in Parkinson's, Alzheimer's, Huntington's and neuromuscular disease. A focus on dysfunctional proteostasis in disease progression and viral-mediated delivery of protective genes to the brain.
Research Interests: The role of uncultured symbionts in natural product biosynthesis within marine invertebrates; marine natural product chemistry; drug discovery; next-generation sequencing; metagenomics; bioinformatics; biosynthesis.
Research Interests: Analytical neurochemistry; neuropeptides; proteomics and peptidomics; glycomics and glycoproteomics; biomarker discovery in neurodegenerative diseases; quantitative system biology; metabolomics; microseparations; imaging mass spectrometry and its application to drug delivery and biodistribution; biological mass spectrometry.
Research Interests: Molecular basis of prostate development; prostate cancer progression; benign prostatic hyperplasia; roles of cell-cell signaling pathways and the use of mouse genetics to discover novel pathways that underlie prostatic diseases.
Medicinal and carbohydrate chemistry; assay development. Developing small molecules that selectively modulate the stability of disease-causing proteins. Designing and synthesizing small molecule ligands for carbohydrate binding proteins. Developing various cell-based and biochemical assays to evaluate pharmacological properties of novel small molecules and to study their mechanism of action.
Weibo Cai, Affiliate Professor, School of Pharmacy; Professor of Radiology, School of Medicine and Public Health (Drug Delivery)
Research Interests: Biomedical nanotechnology; molecular imaging (mostly positron emission tomography and multimodal); image-guided drug delivery; theranostics; translational research; tumor targeting; cancer diagnosis/therapy; imaging of cardiovascular diseases and diabetes.
Adnan Elfarra, Affiliate Professor, School of Pharmacy; Professor of Toxicology, Dept Comparative Biosciences, Vet Med School (Drug Action)
Research Interests: Bioactivation and detoxification of drugs, industrial chemicals, and environmental toxicants; biochemical basis for target organ selectivity; and biomarkers of toxicant exposure.
William Ricke, Affiliate Professor, School of Pharmacy; UW-Medical Foundation Professor of Urologic Research (Drug Action)
Research Interests: Understanding the molecular mechanisms involved with hormone therapy in the prevention and treatment of urologic cancers and benign diseases. Focus areas include: translational research, steroids and small molecules, stromal-epithelial interactions, endocrine disrupting chemicals, mouse models of disease progression.
Lauren Trepanier, Affiliate Professor, School of Pharmacy; Professor and Assistant Dean for Clinical and Translational Research, School of Veterinary Medicine (Drug Action)
Research Interests: Pharmacogenetics of xenobiotic toxicity, including both therapeutic drugs and environmental carcinogens. Risk factors for idiosyncratic and dose-dependent drug toxicity. Genetic variability in phase II detoxification pathways (especially GSTs and cytochrome b5 reductase) and cancer risk in both humans and dogs.
Chad Vezina, Affiliate Professor, School of Pharmacy; Professor of Toxicology, Comparative Biosciences, Vet Med (Drug Action)
Research Interests: Molecular basis of prostate and urinary tract development, physiology, and toxicology.
Jamey Weichert, Affiliate Professor, School of Pharmacy; Professor, Department of Radiology (Drug Delivery)(Drug Discovery)
Research Interests: Design and development of tumor targeted molecular agents for imaging, radiotherapy, and immunotherapy oncology applications.
Research Interests: Synaptic plasticity in substance use and major depressive disorders; Development of antibodies against cannabinoids, opioids, sedative-hypnotics, and classical psychedelics; Immunologic biomarkers of drug use; Implementation of novel psychiatric treatments, including vaccine-based approaches and medication-assisted psychotherapy