The research of Professor Lingjun Li and Dr. Chenxi Jia in the Pharmaceutical Sciences Division is featured on the cover of Analytical Chemistry. The February 2014 article highlights the novel strategy developed by Li and her colleagues to address the misidentification of peptides and proteins during the mass spectrometry-based gas-phase fragmentation analysis. Graduate students Chris Lietz and Zhidan Liang from the Li laboratory and Dr. Zhe Wu from Professor Qiang Cui’s laboratory in the Department of Chemistry, are co-authors on the paper.

The cover artwork, created by Sally Griffith-Oh, senior information processing consultant, UW-Madison School of Pharmacy, and entitled “Gas-Phase Ion Isomer Analysis Reveals the Mechanism of Peptide Sequence Scrambling” illustrates that the peptide fragment isomers are separated by ion mobility spectrometry, and are also subjected to electron transfer dissociation producing characteristic fragments for identity assignments.

Analytical Chemistry is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of analytical chemistry, and is the most cited journal in this field.