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University of Wisconsin-Madison

Fruit research linked to cancer chemoprevention

Jeremy Johnson, assistant scientist in the Pharmacy Practice Division, received funding from the National Cancer Institute to study xanothes in the mangosteen fruit and the anti-cancer properties on prostate cancer chemoprevention.

The R03 project titled “Mangostin: A Dietary-Based Xanthone For Prostate Cancer Chemoprevention,” will investigate alpha-mangostin in the Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model.

Chemoprevention is the use of natural or synthetic agents that can prevent, delay, or bock the carcinogenic process. The most abundant source of xanthones in nature is from the mangosteen fruit (Garcinia mangostana) with well over 50 different xanthones isolated to date.

Johnson is also a UW Clinical and Translational Science Award KL2 Scholar. The program provides promising young clinical and translational researchers the necessary training and protected time to develop an independent research program.