University of Wisconsin-Madison

CLOSE

ENHANCED BY  

World-class leader in pharmacy education, research, and service in the pharmaceutical, social, and clinical sciences.

Publications

Yu Lab

Yu Lab

Peer-Reviewed Publications
  1. Wu, H.; Yao, X.; Hao, H.; Yu, Lian. Surface Enhancement of Crystal Nucleation in Amorphous Acetaminophen. Crystal Growth and Design, in press.
  2. Li, Y.; Yu, J.; Tan, X.; Yu, Lian. Influence of moisture and surfactants on surface dynamics of amorphous drugs: A concentration-temperature superposition principle. Mol. Pharm., in press.
  3. Xin Yao, Qitong Liu, Bu Wang, Ilia Guzei, Michael M Aristov, Chenyang Shi, Geoff G. Z. Zhang, Lian Yu. Anisotropic Molecular Organization at a Liquid/Vapor Interface Promotes Crystal Nucleation with Polymorph Selection. Am. Chem. Soc. 2022, 144, 26, 11638–11645. https://doi.org/10.1021/jacs.2c02623
  4. Hernández Espinell, José; Toro, Veronica; Yao, Xin; Yu, Lian; López-Mejías, Vilmalí; Stelzer, Torsten. Solvent-mediated Polymorphic Transformations in Molten Polymers: The Account of Acetaminophen. Pharm. 2022, in press.
  5. Yao, X.; Benson, E. G.; Stelzer, T.; Zhang, G. G. Z.; Yu, Lian. Effect of Surfactants on Crystal Nucleation and Growth of Amorphous Nifedipine. Pharm. 2022, in press. Special Mol. Pharm and Crystal Growth Des. Issue “Crystallizing the Role of Solid-State Form in Drug Delivery”. https://doi.org/10.1021/acs.molpharmaceut.2c00156
  6. Yu, J.; Yao, X.; Que, C.; Huang, L.; Hui, H.-W.; Gong, Y.; Yu, Lian. Kinetics of Surface Enrichment of a Polymer in a Glass-Forming Molecular Liquid. Mol. Pharm., in press.
  7. Gui, Y.; Huang, C.; Shi, C.; Stelzer, T.; Zhang, G. G. Z.; Yu, Lian. Polymorphic Selectivity in Crystal Nucleation. Chem. Phys. 2022, 156, 144504. DOI: 10.1063/5.0086308
  8. Ajay Annamareddy; Manel Molina-Ruiz; Donez Horton-Bailey; Frances Hellman; Yuhui Li; Lian Yu; Dane Morgan. Compositional Trends in Surface Enhanced Diffusion in Lead Silicate Glasses. Computational Materials Science 2022, 206, 111304. https://doi.org/10.1016/j.commatsci.2022.111304
  9. Li, Y.; Bishop, C.; Ediger, M. D.; Yu, Lian. Surface diffusion of a glassy discotic organic semiconductor and the surface mobility gradient of molecular glasses. Chem. Phys. 2022, 156, 094710. https://doi.org/10.1063/5.0079890
  10. Yu, Junguang; Chen, Zhenxuan; Teerakapibal, Rattavut; Benmore, Chris; Richert, Ranko; Yu, Lian. Structure of Glasses Created by Multiple Kinetic Arrests. Chem. Phys. 2022, 156, 084504. DOI: 10.1063/5.0080846
  11. Yu, J.; Li, Y.; Yao, X.; Que, C.; Huang, L.; Hui, H.-W.; Gong, Y.; Qian, F.; Yu, Lian. Surface Enrichment of Surfactants in Amorphous Drugs: An X-Ray Photoelectron Spectroscopy Study. Pharmaceutics 2022, 19, 654−660. https://doi.org/10.1021/acs.molpharmaceut.1c00786
  12. Li, Y.; Annamareddy, A.; Morgan, D.; Cao, C.; Perepezko, J.; Ediger, M.D.; Voyles, P.; Yu, L. Surface diffusion is controlled by bulk fragility across all glass types. Rev. Lett. 2022, 128, 075501. DOI: 10.1103/PhysRevLett.128.075501.
  13. Gui, Y.; Jin, Y.; Ruan, S.; Sun, G.; López-Mejías, V.; Yu, Lian. Crystal energy landscape of nifedipine by experiment and computer prediction. Growth Des. 2022, 22, 1365−1370. https://doi.org/10.1021/acs.cgd.1c01317
  14. Zhenxuan Chen, Chengbin Huang, Xin Yao, Chris J. Benmore, Lian Yu. Structure of supercooled glycerol, xylitol, and D-sorbitol by synchrotron X-ray scattering and relation to dynamic fragility. Chem. Phys. 2021, 155, 244508.  https://doi.org/10.1063/5.0073986
  15. Xin Yao, Amy Neusaenger, Lian Yu. Perspective: Amorphous Drug-Polymer Salts. Pharmaceutics 2021, 13 (8), 1271.  https://doi.org/10.3390/pharmaceutics13081271.
  16. Xin Yao, Soojin Kim, Yue Gui, Zhenxuan Chen, Junguang Yu, Lian Yu. Amorphous drug-polymer salt with high stability under tropical conditions and fast dissolution: The case of lumefantrine-PAA. J. Pharm. Sci. 2021, 110, 3670−3677.  https://doi.org/10.1016/j.xphs.2021.07.018.
  17. Zhenxuan Chen, Yue Gui, Kai Cui, J. R. Schmidt, and Lian Yu. Prolific Polymorph Generator ROY in Its Liquid and Glass: Two Conformational Populations Mirroring the Crystalline-State Distribution. J. Phys. Chem. B 2021, 125, 10304−10311.  https://doi.org/10.1021/acs.jpcb.1c05834
  18. Chen, Zhenxuan; Bishop, Camille; Thoms, Erik; Bock, Harald; Ediger, Mark; Richert, Ranko; Yu, Lian.  Controlling columnar order in a discotic liquid-crystal by kinetic arrest of disc tumbling. Chem. Mater. 2021, 33, 12, 4757–4764. https://doi.org/10.1021/acs.chemmater.1c01331
  19. Ajay Annamareddy, Yuhui Li, Lian Yu,  Paul M. Voyles, and  Dane Morgan. Factors correlating to enhanced surface diffusion in metallic glasses. J. Chem. Phys. 2021, 154, 104502 (2021); https://doi.org/10.1063/5.0039078
  20. Yue Gui, Xin Yao, Ilia A. Guzei, Michael M. Aristov, Junguang Yu, and Lian Yu. A Mechanism for Reversible Solid-State Transitions Involving Nitro Torsion. Chem. Mater. 2020, 32, 18, 7754–7765.
  21. Yue Gui, Erin C. McCann, Xin Yao, Yuhui Li, Karen J. Jones, and Lian Yu. Amorphous Drug–Polymer Salt with High Stability under Tropical Conditions and Fast Dissolution: The Case of Clofazimine and Poly(acrylic acid). Mol. Pharmaceutics 2021, 18, 1364–1372.  https://doi.org/10.1021/acs.molpharmaceut.0c01180
  22. Barták, J.; Málek, J.; Bagchi, K.; Ediger, M. D.; Li, Y.; Yu, L. Surface mobility in amorphous selenium and comparison with organic molecular glasses. J. Chem. Phys. 2021, 154, 074703 (2021). https://doi.org/10.1063/5.0041273
  23. Changlin Yao, Ilia A Guzei, Yingdi Jin, Lian Yu. Polymorphism of Piroxicam: New Polymorphs by Melt Crystallization and Crystal Structure Prediction. Cryst. Growth Des. 2020, 20, 12, 7874–7881. DOI: 10.1021/acs.cgd.0c01165.
  24. Xiao Ou, Xizhen Li, Haowei Rong, Lian Yu, and Ming Lu. A general method for cultivating single crystals from melt microdroplets. Chem. Commun. 2020, 56, 9950-9953. https://doi.org/10.1039/d0cc03157g.
  25. Yue Gui, Xin Yao, Ilia A. Guzei, Michael M. Aristov, Junguang Yu, and Lian Yu*. A Mechanism for Reversible Solid-State Transitions Involving Nitro Torsion. Chem. Mater. 2020, 32, 18, 7754–7765.
  26. Xizhen Li, Xiao Ou, Haowei Rong, Siyong Huang, Jonas Nyman, Lian Yu, Ming Lu. The Twelfth Solved Structure of ROY: Single Crystals of Y04 Grown from Melt Microdroplets. Cryst. Growth Des. 2020, 20, 11, 7093–7097. https://doi.org/10.1021/acs.cgd.0c01017.
  27. Lu, X.; Li, M.; Huang, C.; Lowinger, M. B.; Xu, Wei; Yu, Lian; Byrn, Stephen R.; Templeton, A. C.; Su, Yongchao. Atomic-level Drug Substance and Polymer Interaction in Posaconazole Amorphous Solid Dispersion from 19F Magic Angle Spinning NMR. Pharm. 2020, 17, 2585–2598. doi.org/10.1021/acs.jpcb.0c02131. Cover art.
  28. Bagchi, Kushal; Deng, Chuting; Bishop, Camille; Li, Yuhui; Jackson, Nicholas; Yu, Lian; Toney, Michael; de Pablo, Juan; Ediger, Mark. Over what length scale does an inorganic substrate perturb the structure of a glassy organic semiconductor? ACS Appl. Mater. Interfaces 2020, 12, 26717–26726.
  29. Cao, Chengrong; Yu, Lian; Perepezko, John. Surface dynamics measurement on a gold based metallic glass. Phys. Lett. 2020, 116, 231601. doi.org/10.1063/5.0007838
  30. Xizhen Li, Xiao Ou, Bingquan Wang, Haowei Rong, Bing Wang, Chao Chang, Baimei Shi, Lian Yu & Ming Lu. Rich polymorphism in nicotinamide revealed by melt crystallization and crystal structure prediction. Communications Chemistry 2020, 3(1):152. DOI: 10.1038/s42004-020-00401-1.
  31. Xizhen Li, Xiao Ou, Bingquan Wang, Lian Yu, Ming Lu. Nicotinamide: Seven New Polymorphic Structures Revealed by Melt Crystallization and Crystal Structure Prediction. ChemRxiv 2020. DOI: 10.26434/chemrxiv.12387452.
  32. Li, Yuhui; Zhang, Wei; Bishop, Camille; Huang, Chengbin; Ediger, M. D.; Yu, Lian. Surface diffusion in glasses of rod-like molecules posaconazole and itraconazole: Effect of interfacial molecular alignment and bulk penetration. Soft Matter 2020, 16, 5062-5070.
  33. Bishop, C.; Yu, L.; Ediger, M. D. Fytas, G. Extreme Elasticity Anisotropy in Molecular Glasses. Advanced Functional Materials 2020, 30, 2001481. Cover art.
  34. Lu, Xingyu; Huang, Chengbin; Li, Mingyue; Skomski, Daniel; Xu, Wei; Yu, Lian; Byrn, Stephen; Templeton, Allen; Su, Yongchao. Molecular Mechanism of Crystalline-to-Amorphous Conversion of Pharmaceutical Solids from 19F Magic Angle Spinning NMR. Phys. Chem. B 2020, 124, 5271–5283. DOI: 10.1021/acs.jpcb.0c02131. Cover art.
  35. Bishop, C.; Li, Y.; Toney, M. F.; Yu, L.; Ediger, M. D. Molecular orientation for vapor-deposited organic glasses follows rate-temperature superposition: The case of posaconazole. Phys. Chem. B 2020, 124, 2505-2513.
  36. Chen, Z.; Yu, J.; Teerakapibal, R.; Meerpoel, L.; Richert, R.; Yu, Lian. Organic glasses with tunable liquid-crystalline order through kinetic arrest of end-over-end rotation: The case of saperconazole. Soft Matter 2020, 16, 2025 – 2030. DOI: 10.1039/c9sm02180a
  37. Yao, X.; Huang, C.; Benson, E. G.; Shi, C.; Zhang, G. G. Z.; Yu, Lian. Effect of polymer solute on crystal nucleation in glass-forming molecular liquids: Equal suppression of nucleation and growth. Growth Des. 2020, 20, 237−244. DOI: 10.1021/acs.cgd.9b01095
  38. Bishop, C.; Delongchamp; Toney, M. F.; Yu, Lian; Ediger, M. D. Vapor deposition of a nonmesogen prepares highly structured organic glasses. 2019, 116, 21421–21426. www.pnas.org/cgi/doi/10.1073/pnas.1908445116
  39. Bishop, C.; Gujral, A.; Toney, M. F.; Yu, Lian; Ediger, M. D. Vapor-Deposited Glass Structure Determined by Deposition Rate−Substrate Temperature Superposition Principle. Phys. Chem. Lett. 2019, ASAP. https://doi.org/10.1021/acs.jpclett.9b01377
  40. Zeng, A.; Yao, X.; Gui, Y.; Li, Y.; Jones, K. J.; Yu, Lian. Inhibiting Surface Crystallization and Improving Dissolution of Amorphous Loratadine by Dextran Sulfate Nano-coating. Pharm. Sci. 2019, online. DOI: https://doi.org/10.1016/j.xphs.2019.02.018
  41. Gui, Y.; Chen, Y.; Yu, L. Improving Stability and Dissolution of Amorphous Clofazimine by Nano-Coating. Res. 2019, 36:67. https://doi.org/10.1007/s11095-019-2584-9. Journal Cover.
  42. Li, Yuhui; Yu, J.; Hu, S.; Chen, Z.; Sacchetti, M.; Sun, C. C.; Yu, Lian. Polymer nanocoating of amorphous drugs for improving stability, dissolution, powder flow, and tabletability: The case of chitosan-coated indomethacin. Pharm. 2019, 16, 1305−1311. DOI: 10.1021/acs.molpharmaceut.8b01237
  43. Ediger, M. D.; de Pablo, J. J.; Yu, Lian. Anisotropic vapor-deposited glasses: Hybrid organic solids. Chem. Res. 2019, 52, 407-414. DOI: 10.1021/acs.accounts.8b00513
  44. Bagchi, K.; Jackson, N. E.; Gujral, A.; Huang,; Toney, M. F.; Yu, Lian; de Pablo, J. J.; Ediger, M. D. Origin of Anisotropic Molecular Packing in Vapor-Deposited Alq3 Glasses. J. Phys. Chem. Lett. 2019, 10, 164–170. DOI: 10.1021/acs.jpclett.8b03582
  45. Zhong, Z.; Xiaotong Yang, X.; Wang, B.-H.; Yao, Y.-F.; Guo, B.; Yu, Lian; Huang, Y.; Xu, J. Solvent-Polymer Guest Exchange in Carbamazepine Inclusion Complex: Structure, Kinetics and Implication for Guest Selection. CrystEngComm 2019, 21, 2164. DOI: 10.1039/C8CE01766B
  46. Chen, Yinshan; Chen, Zhenxuan.; Tylinski, Michael.; Ediger, M. D.; Yu, Lian. Effect of molecular size and hydrogen bonding on three surface-facilitated processes in molecular glasses: Surface diffusion, surface crystal growth, and formation of stable glasses by vapor deposition. Chem. Phys. 2019, 150, 024502. doi: 10.1063/1.5079441. Editor’s Pick
  47. Amidon, G. E.; Anderson, B. D.; Balthasar, J. P.; Christel Bergstrom, C.; S.-M. Gerald Kasting, G.; Kesisoglou, F.; Khinast, J.; Mager, D.; Roberts, C. J.; Yu, Lian Fifty-eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-based Modeling. Pharm. Sci. 2019, 108, 2-7.
    https://doi.org/10.1016/j.xphs.2018.11.002
  48. Su, Yuan; Yu, Lian; Cai, Ting. Enhanced Crystal Nucleation in Glass-Forming Liquids by Tensile Fracture in the Glassy State. Crystal Growth and Design 2019, 19(1), 40–44. DOI: 10.1021/acs.cgd.8b01427
  49. Nyman, J.; Yu, Lian; Reutzel-Edens, S. M. Accuracy and reproducibility in crystal structure prediction: The curious case of ROY. CrystEngComm 2019, 21, 2080–2088. DOI: 10.1039/C8CE01902A
  50. Huang, C.; Chen, Z.; Gui, Y.; Shi, C.; Zhang, G. G. Z.; Yu, Lian. Crystal nucleation rates in glass-forming molecular liquids: D-sorbitol, D-arabitol, D-xylitol, and glycerol. Chem. Phys. 2018, 149, 054503. https://doi.org/10.1063/1.5042112. Editor’s Pick.
  51. Stan F.S.P. Looijmans, S. F. S. P.; Dario Cavallo, D.; Yu, Lian; Peters, G. W. M. Cross-nucleation between polymorphs: Quantitative modeling of kinetics and morphology. Crystal Growth and Design 2018, 18, 3921−3926. DOI: 10.1021/acs.cgd.8b00254
  52. Teerakapibal, R.; Huang, C.; Gujral, A.; Ediger, M. D.; Yu, L. Organic glasses with tunable liquid-crystalline order. Rev. Lett. 2018, 120, 055502.
    DOI: 10.1103/PhysRevLett.120.055502.
  53. Su, Yuan; Xu, Jia; Shi, Qin; Yu, Lian; Cai, Ting. Polymorphism of Griseofulvin: Concomitant Crystallization from the Melt and Single Crystal Structure of a Metastable Polymorph with Anomalously Large Thermal Expansion. Commun. 2018, 54, 358-361. DOI: 10.1039/c7cc07744k
  54. Zhen, C.; Yang, K.; Huang, C.; Zhu, A.; Yu, L.; Qian, F. Surface enrichment and depletion of the active ingredient in spray dried amorphous solid dispersions. Res. 2018, 35(2), 38. doi: 10.1007/s11095-018-2345-1.
  55. Gujral, A.; Yu, L.; Ediger, M. D. Anisotropic organic glasses. Current Opinion in Solid State & Materials Science 2018, 22, 49-57. https://doi.org/10.1016/j.cossms.2017.11.001.
  56. Zhu, M.; Yu, L. Isomerization energies of azopyridines. Therm. Anal. Calorimetry 2017, 132, 463-469. https://doi.org/10.1007/s10973-017-6913-0.
  57. Teerakapibal, R.; Gui, Y.; Yu, L. Gelatin Nano-coating for Inhibiting Surface Crystallization of Amorphous Drugs. Res. 2017, 35, 23. https://doi.org/10.1007/s11095-017-2315-z.
  58. Roque Flores, Roxana L.; Ilia A. Guzei, Ilia, A.; do Rosario Matos, Jivaldo; Yu, Lian. Polymorphs of the Antiviral Drug Ganciclovir polymorph I. Acta Crystallographica Section C 2017, C73, 1-5.
  59. Huang, C.; Ruan, S.; Cai, T.; Yu, L. Fast Surface Diffusion and Crystallization of Amorphous Griseofulvin. Phys. Chem. B 2017, 121, 9463–9468. DOI: 10.1021/acs.jpcb.7b07319
  60. Chen, Yinshan; Zhu, Men; Laventure, Audrey; Lebel, Olivier; Ediger, Mark; Yu, Lian. Influence of Hydrogen Bonding on the Surface Diffusion of Molecular Glasses: Comparison of Three Triazines. Phys. Chem. B 2017, 121, 7221–7227. DOI: 10.1021/acs.jpcb.7b05333
  61. Zhu, M.; Yu, L. Polyamorphism of D-manntitol. Chem. Phys. 2017, 146, 244503. doi: http://dx.doi.org/10.1063/1.4989961.
  62. Shi, C.; Teerakapibal, R.; Yu, Lian; Zhang, G. Pair distribution functions of amorphous organic thin films from synchrotron X-ray scattering in transmission mode. IUCrJ 2017, 4, 555–559. https://doi.org/10.1107/S2052252517009344.
  63. Cavallo, D.; Francesca Galli, F.; Yu, L.; Alfonso, G. C. Cross-nucleation between concomitantly crystallizing a- and g-phases in polypivalolactone: secondary nucleation of one polymorph on another. Crystal Growth & Design 2017, 17, 2639–2645.
  64. Gómez, J.; Gujral, A.; Huang, C.; Bishop, C.; Yu, L.; Ediger, M. D. Nematic-like stable glasses without equilibrium liquid crystal phases. Chem. Phys. 2017, 146, 54503.
  65. Gujral, A.; Gómez, J.; Jiang, J.; Huang, C.; O’Hara, K. A.; Toney, M. F.; Chabinyc, M. L.; Yu, L.; Ediger, M. D. Highly organized smectic-like packing in vapor-deposited glasses of a liquid crystal. Mater. 2017, 29, 849–858. DOI: 10.1021/acs.chemmater.6b04877
  66. Huang, C.; Powell, C. T.; Sun, Y.; Cai, T.; Yu, L. Effect of Low-Concentration Polymers on Crystal Growth in Molecular Glasses: A Controlling Role for Polymer Segmental Mobility Relative to Host Dynamics. Phys. Chem. B 2017, 121, 1963−1971. DOI: 10.1021/acs.jpcb.6b11816
  67. Ruan, S.; Musumeci, D.; Zhang, W.; Gujral, A.; Ediger, M. D.; Yu, L. Surface Transport Mechanisms in Molecular Glasses Probed by the Exposure of Nano-particles. Chem. Phys. 2017, 146, 203324. doi: http://dx.doi.org/10.1063/1.4978667
  68. Chen, Y.; Powell, C. T.; Yu, L. Tensile Fracture of Molecular Glasses Studied by Differential Scanning Calorimetry: Reduction of Heat Capacity by Lateral Constraint. Phys. Chem. B. 2017, 121, 444−449.
  69. Chen, Y.; Zhang, W.; Yu, L. Hydrogen Bonding Slows Down Surface Diffusion of Molecular Glasses. Phys. Chem. B 2016, 120 (32), 8007–8015.
  70. Ruan, S.; Zhang, W.; Sun, Y.; Ediger, M. D.; Yu, L. Surface Diffusion and Surface Crystal Growth of tris-Naphthyl Benzene Glasses. Chem. Phys. 2016, 145, 064503.
  71. Zhang, W.; Teerakapibal, R.; Yu, L. Surface Mobility of Amorphous o-Terphenyl: A Strong Inhibitory Effect of Low-Concentration Polystyrene. Phys. Chem. B 2016, 120, 6842–6847.
  72. Musumeci, D.; Hasebe, M.; Yu, L. Crystallization of Organic Glasses: How Does Liquid Flow Damage Surface Crystal Growth? Crystal Growth and Design 2016, 16, 2931−2936.
  73. Gomez, J.; Jiang, J.; Gujral, A.; Huang, C.; Yu, L.; Ediger, M. D. Vapor deposition of a smectic liquid crystal: Homogeneous, highly anisotropic glasses with tunable molecular orientation. Soft Matter 2016, 12, 2942-2947.
  74. Yu, L. Surface Mobility of Molecular Glasses and Its Importance in Physical Stability. Drug Delivery Rev. 2016, 100, 3–9. DOI: 10.1016/j.addr.2016.01.005
  75. Zhang, W.; Yu, L. Surface diffusion of polymer glasses. Macromolecules 2016¸ 49, 731–735. DOI: 10.1021/acs.macromol.5b02294
  76. Powell, C. T.; Chen, Y.; Yu, L. Fracture of molecular glasses under tension and increasing their fracture resistance with polymer additives. Non-Crystalline Solids 2015, 429, 122–128.
  77. Powell, C. T.; Xi, H.; Sun, Y.; Gunn, E.; Chen, Y.; Ediger, M. D.; Yu, L. Fast Crystal Growth in o-Terphenyl Glasses: A Possible Role for Fracture and Surface Mobility. Phys. Chem. B 2015, 119, 10124−10130. DOI: 10.1021/acs.jpcb.5b05389
  78. Zhu, M.; Wang, J.; Perepezko, J. H.; Yu, L. Possible existence of two amorphous phases of D-mannitol related by a first-order transition. Chem. Phys. 2015, 142, 244504-1 to 244504-7. doi: http://dx.doi.org/10.1063/1.4922543
  79. Zhang, W.; Brian, C. W.; Yu, L. Fast Surface Diffusion of Amorphous o-Terphenyl and its Competition with Viscous Flow in Surface Evolution. Phys. Chem. B. 2015, 119, 5071–5078.
  80. Hasebe, M.; Musumeci, D.; Yu, L. Fast Surface Crystallization of Molecular Glasses: Creation of Depletion Zones by Surface Diffusion and Crystallization Flux. Phys. Chem. B. 2015, 119, 3304-3311.
  81. Zhang, S.W.; Yu, L.; Huang, J.; Hussain, M. A.; Derdour, L.; Qian, F.; de Villiers, M. M. A Method to Evaluate the Effect of Contact with Excipients on the Surface Crystallization of Amorphous Drugs. AAPS PharmSciTech 2014, 15, 1516-1526.
  82. Lin, Po-Han; Lyubimov, Ivan; Yu, Lian; Ediger, M. D.; de Pablo, Juan J. Molecular modeling of vapor-deposited polymer glasses. Chem. Phys. 2014, 140, 204504/1-204504/9.
  83. Hasebe, M.; Musumeci, D.; Powell, C. T.; Cai, T.; Gunn, E. M.; Yu, L. Fast surface crystal growth on organic glasses and its termination by the onset of fluidity. Phys. Chem. B. 2014, 118, 7638−7646.
  84. Musumeci, D.; Powell, C. T.; Ediger, M. D.; Yu, L. Termination of Solid-State Crystal Growth in Molecular Glasses by Fluidity. Phys. Chem. Lett. 2014, 5, 1705−1710. DOI: 10.1021/jz5006169
  85. Powell, C. T.; Paeng, K.; Chen, Z.; Richert, R.; Yu, L.; Ediger, M. D. Fast crystal growth from organic glasses: Comparison of o-terphenyl with its structural analogs. Phys. Chem. B. 2014, 118 (28), 8203–8209.
  86. Zhang, S.; Kendrick, ; Leusen, F. J. J.; Yu, L. Co-crystallization with Nicotinamide in Two Conformations Lowers Energy but Expands Volume. J. Pharm. Sci. 2014, 103 (9), 2896–2903. Special issue in honor of George Zografi.
  87. Brian, C. W.; Zhu, L.; Yu, L. Effect of Bulk Aging on Surface Diffusion of Organic Glasses. Chem. Phys. 2014, 140, 054509. https://doi.org/10.1063/1.4863556.
  88. Zhang, S.; Harasimowicz, M. T.; Yu, L. Co-Crystals of Nicotinamide and R-Mandelic Acid in Many Ratios with Anomalous Formation Properties. Am. Chem. Soc. 2013, 135, 18981−18989.
  89. Powell, C. T.; Cai, T.; Hasebe, M.; Gunn, E. M.; Gao, P.; Zhang, G.; Gong, Y.; Yu, L. Low-Concentration Polymers Inhibit and Accelerate Crystal Growth in Organic Glasses in Correlation with Segmental Mobility. Phys. Chem. B 2013, 117, 10334−10341.
  90. Brian, C. W.; Yu, L. Surface Self-Diffusion of Organic Glasses. Phys. Chem. A. 2013, 117, 13303−13309.
  91. Paeng, K.; Powell, C. T.; Yu, L.; Ediger, M. D. Fast crystal growth induces mobility and tension in supercooled o-terphenyl. Phys. Chem. Lett. 2012, 3, 2562−2567.
  92. Adrjanowicz, K.; Kaminski, K.; Paluch, M.; Ngai, K. L.; Yu, L. Study of dynamics and crystallization kinetics of 5-methyl-2- (2-nitrophenyl)amino-3-thiophenecarbonitrile at ambient and elevated pressure. Chem. Phys. 2012, 136(23), 234509.
  93. Zhang, S.; de Villiers, M. M.; Yu, L.; Krzyzaniak, J. F. Formation Enthalpies and Polymorphs of Nicotinamide – R-Mandelic Acid Co-crystals. Crystal Growth and Design 2012, 12, 4090−4097.
  94. Ediger, M. D.; Yu, L. From Gas to Nanoglobular Glass. Nature Materials 2012, 11, 267-268. Invited News and Views
  95. Sun, Y.; Zhu, L.; Wu, T.; Cai, T.; Gunn, E. M.; Yu, L. Stability of Amorphous Pharmaceutical Solids: Crystal Growth Mechanisms and Effect of Polymer Additives. AAPS Journal. 2012, 14, 380-388. Invited review.
  96. Dawson, K.; Kopff, L. A.; Zhu, L.; McMahon, R. J.; Yu, L.; Richert, R.; Ediger, M. D. Molecular packing in highly stable glasses of vapor-deposited tris-naphthylbenzene isomers. Chem. Phys. 2012, 136, 094505-1 to 094505-11. Chosen as a Research Highlight featured on the journal website home page.
  97. Gunn, E.; Guzei, I. A.; Yu, L. Polymorphism of Nifedipine: Structure and Reversible Transformation of b Crystal Growth and Design 2012, 12, 2037–2043.
  98. Dawson, Kevin J.; Zhu, Lei; Kopff, Laura A.; McMahon, Robert J.; Yu, Lian; Ediger, Mark D. Highly Stable Vapor-deposited Glasses of Four Tris-naphthylbenzene Isomers. Journal of Physical Chemistry Letters 2011, 2, 2683–2687.
  99. Shtukenberg, Alexander; Freundenthal, John; Gunn, Erica; Yu, Lian; Kahr, Bart Glass-Crystal Growth Mode for Testosterone Propionate. Crystal Growth & Design 2011, 11(10), 4458-4462.
  100. Gunn, E.; Guzei, I. A.; Yu, L. Does Crystal Density Control Fast Surface Crystal Growth in Glasses? A Study with Polymorphs. Crystal Growth & Design 2011, 11(9), 3979-3984.
  101. Zhu, L.; Brian, C.; Swallen, S. F.; Straus, P. T.; Ediger, M. D.; Yu, L. Surface Self Diffusion of an Organic Glass. Rev. Lett. 2011, 106, 256103-1 to 256103-4. DOI: 10.1103/PhysRevLett.106.256103
  102. Cai, T.; Zhu, L.; Yu, L. Crystallization of Organic Glasses: Effects of Polymer Additives on Bulk and Surface Crystal Growth in Amorphous Nifedipine. Res. 2011, 28, 2458–2466.
  103. Sun, Y.; Zhu, L.; Kearns, K. L.; Ediger, M. D.; Yu, L. Glasses Crystallize Rapidly at Surfaces by Growing Crystals Upward. Natl. Acad. Sci. U. S. A. 2011, 108(15), 5990-5995. DOI: 10.1073/pnas.1017995108
  104. Malshe, R.; Ediger, M. D.; Yu, L.; de Pablo, J. J. Evolution of glassy gratings with variable aspect ratios under surface diffusion. Chem. Phys. 2011, 134(19), 194704/1-194704/8.
  105. Zhu, L.; Cai, T.; Huang, J.; Stringfellow, T. C.; Wall, M.; Yu, L. Water Self Diffusion in Glassy and Liquid Maltose Measured by Raman Microscopy and NMR. Phys. Chem. B 2011, 115(19), 5849-5855.
  106. Dawson, K. J.; Zhu, L.; Yu, L.; Ediger, M. D Anisotropic structure and transformation kinetics of vapor-deposited indomethacin glasses. Phys. Chem. B. 2011, 115, 455-463.
  107. Yu, L. Polymorphism in Molecular Solids: An Extraordinary System of Red, Orange, and Yellow Crystals. Chem. Res. 2010, 43, 1257-1266. DOI: 10.1021/ar100040r. Cover article.
  108. Zhu, L.; Yu, L. Generality of Forming Stable Organic Glasses by Vapor Deposition. Phys. Lett. 2010, 499, 62–65.
  109. Sun, Y.; Tao, J.; Zhang, G. G. Z.; Yu, L. Solubilities of Crystalline Drugs in Polymers: Improved Analytical Method and Comparison of Solubilities of Indomethacin and Nifedipine in PVP, PVP/VA, and PVAc. Pharm. Sci. 2010, 99, 4023-4031. DOI: 10.1002/jps.222
  110. Strydom, S.; Liebenberg, W.; Yu, L.; de Villiers, M. The effect of temperature and moisture on the amorphous-to-crystalline transformation of stavudine. J. Pharmaceutics 2009, 379, 72-81.
  111. Sun, Y.; Xi, H.; Ediger, M. D.; Richert, R.; Yu, L. Diffusion-Controlled and “Diffusionless” Crystal Growth near the Glass Transition Temperature: Relation between Liquid Dynamics and Growth Kinetics of Seven ROY Polymorphs. Chem. Phys. 2009, 131, 074506/1-074506/9.
  112. Strydom, S.; Zhu, L.; Yu, L.; de Villiers, M. Ultra-Thin Coatings for Stabilizing Amorphous Drugs against Surface-Enhanced Crystallization. Scientia 2009, September Issue.
  113. Zhao, J.; Ediger, M. D.; Sun, Ye; Yu, L. Two DSC Glass Transitions in Miscible Blends of Polyisoprene/Poly(4-tert-butylstyrene). Macromolecules 2009, 42, 6777-6783.
  114. Dawson, K. J; Kearns, K. L; Yu, L.; Steffen, W.; Ediger, M. D. Physical vapor deposition as a route to hidden amorphous states. Nat. Acad. Sci. 2009, 106, 15165-15170.
  115. Kearns, K. L.; Sun, Y.; Swallen, S. F.; Yu, L.; Ediger, M. D. Calorimetric evidence of two distinct molecular packings in stable glasses of indomethacin. Phys. Chem. B 2009, 113, 1579-1586.
  116. Xi, H.; Sun, Y.; Yu, L. Diffusion-controlled and Diffusionless Crystal Growth in Liquid o-Terphenyl near Its Glass Transition Temperature. Chem. Phys. 2009, 130, 094508/1 – 094508/9.
  117. Tao, J.; Sun, Y.; Zhang, G. G. D.; Yu, L. Solubility of Small-Molecule Crystals in Polymers: D-Mannitol in PVP, Indomethacin in PVP/VA, and Nifedipine in PVP/VA. Res. 2009, 26, 855 – 864. No. 1 most viewed paper of Pharm. Res. online (7874 times by 28 March 2012; http://www.pharmagateway.net/MostViewedArticles.aspx?JournalID=11095).
  118. Zhu, L.; Wong, L.; Yu, L. Surface-Enhanced Crystallization of Amorphous Nifedipine. Scientia 2008, September Issue.
  119. Huang, J.; Stringfellow, T. C.; Yu, L. Glycine Exists Mainly as Monomers, Not Dimers, in Supersaturated Aqueous Solutions: Implications for Understanding Its Crystallization and Polymorphism. Am. Chem. Soc. 2008, 130, 13973-13980. DOI: 10.1021/ja804836d
  120. Zhu, L.; Wong, L.; Yu, L. Surface-Enhanced Crystallization of Amorphous Nifedipine. Molecular Pharmaceutics 2008, 5, 921-926.
  121. Kearns, K. L.; Swallen, S. F.; Ediger, M. D.; Wu, T.; Sun, Y.; Yu, L. Hiking down the Energy Landscape: Progress toward the Kauzmann Temperature via Vapor Deposition. Phys. Chem. B 2008, 112, 4934-4942.
  122. Sun, Y.; Xi, H.; Chen, S.; Ediger, M. D.; Yu, L. Crystallization near Glass Transition: Transition from Diffusion-Controlled to Diffusionless Crystal Growth Studied with Seven Polymorphs. Phys. Chem. B 2008, 112, 5594-5601.
  123. Sun, Y.; Xi, H.; Ediger, M. D.; Yu, L. Diffusionless Crystal Growth from Glass Has Precursor in Equilibrium Liquid. Phys. Chem. B 2008, 112, 661-664.
  124. Ediger, M.; Harrowell, P.; Yu, L. Crystal Growth Kinetics Depend on Liquid Fragility. Chem. Phys. 2008, 128, 034709/1-034709/6.
  125. Yu, L. Survival of the fittest polymorph: how fast nucleater can lose to fast grower. CrystEngComm, 2007, 9, 847 – 851. Invited Highlight.
  126. Tao, J.; Yu, L. Cross-Nucleation between D-Mannitol Polymorphs in Seeded Crystallization. Growth & Design 2007, 7, 2410-2414.
  127. Kearns, K. L.; Swallen, S. F.; Ediger, M. D.; Wu, T.; Yu, L. Influence of Substrate Temperature on the Stability of Glasses Prepared by Vapor Deposition. Chem. Phys. 2007, 127, 154702.
  128. Ishida, H.; Wu, T.; Yu, L. Sudden Acceleration of Crystal Growth of Nifedipine near Tg without and with Polyvinylpyrrolidone. Pharm. Sci. 2007, 96, 1131-8.
  129. Wu, T.; Sun, Y.; Li, N.; de Villiers, M.; Yu, L. Inhibiting Surface Crystallization of Amorphous Indomethacin by Nanocoating. Langmuir 2007, 23, 5148-5153. DOI: 10.1021/la070050i
  130. Milton, N.; Gopalrathnam, G.; Craig, G. D.; Mishra, D. S.; Roy, M. L.; Yu, L. Vial breakage during freeze-drying: crystallization of sodium chloride in sodium chloride-sucrose frozen aqueous solutions. Pharm. Sci. 2007, 96, 1848-1853.
  131. Kanatzidis, Mercouri G.; Poeppelmeier, Kenneth R.; Bobev, Svilen; Guloy, Arnold M.; Hwu, Shiou-Jyh; Lachgar, Abdou; Latturner, Susan E.; Schaak, Raymond E.; Seo, Dong-Kyun; Sevov, Slavi C.; Stein, Andreas; Dabrowski, Bogdan; Greedan, John E.; Greenblatt, Martha; Grey, Clare P.; Jacobson, Allan J.; Keszler, Douglas A.; Li, Jing; Subramanian, Mas A.; Xia, Younan; Cagin, Tahir; Haeussermann, Ulrich; Hughbanks, Timothy; Mahanti, S. D.; Morgan, Dane; Seo, Dong-Kyun; Spaldin, Nicola A.; Buhro, William E.; Giammar, Daniel E.; Hollingsworth, Jennifer A.; Johnson, David C.; Nozik, Arthur J.; Peng, Xiaogang; Bedard, Robert L.; Brese, Nathaniel E.; Cao, Guang; Dhingra, Sandeep S.; Kagan, Cherie R.; Mitzi, David B.; Geselbracht, Margret J.; Lisensky, George C.; Lufaso, Michael W.; Maggard, Paul A.; Michael, O’Keeffe; Wilkinson, Angus P.; zur Loye, Hans-Conrad; Egami, Takeshi; Greedan, John E.; Hodges, Jason P.; Martin, James D.; Parise, John B.; Toby, Brian H.; Vanderah, Terrell A.; Burns, Peter C.; Chan, Julia Y.; Meyer, Anne E.; Murray, Christopher B.; Ramirez, Arthur P.; Ward, Michael D.; Yu, Lian; Alario-Franco, Miguel A.; Battle, Peter D.; Bein, Thomas; Cahill, Christopher L.; Halasyamani, P. Shiv; Maignan, Antoine; Seshadri, Ram. Report from the third workshop on future directions of solid-state chemistry: The status of solid-state chemistry and its impact in the physical sciences. Progress in Solid State Chemistry 2007, 36(1-2), 1-133.
  132. Swallen, S.; Kearns, K.; Mapes, M.; McMahon, R.; Kim, S.; Ediger, M.; Yu, L.; Wu, T.; Satija, S. Organic Glasses with Exceptional Thermodynamic and Kinetic Stability. Science 2007, 315, 353 – 356. DOI: http://dx.doi.org/1126/1135795
  133. Huang, J.; Chen, S.; Guzei, I. A.; Yu, L. Discovery of a Solid Solution of Enantiomers in a Racemate-Forming System by Seeding. Am. Chem. Soc. 2006, 128, 11985-11992.
  134. Wu, T.; Yu, L. Origin of Enhanced Crystal Growth Kinetics near Tg Probed with Indomethacin Polymorphs. Phys. Chem. B 2006, 110, 15694-15699.
  135. Wu, T.; Yu, L. Surface Crystallization of Indomethacin below Tg. Res. 2006, 23, 2350-2355.
  136. Tao, J.; Yu, L. Kinetics of Cross-Nucleation between Polymorphs. Phys. Chem. B 2006, 110, 7098-7101.
  137. Huang, J.; Yu, L. Effect of Molecular Chirality on Racemate Stability: a-Amino Acids with Non-polar R Groups. Am. Chem. Soc. 2006, 128, 1873-1878
  138. Chen, S.; Xi, H.; Yu, L. Cross Nucleation between ROY Polymorphs. Am. Chem. Soc. 2005, 127, 17439-17444. DOI: 10.1021/ja056072d
  139. Martin, O. M.; Yu, L.; Mecozzi, S. Solution self-assembly and solid state properties of fluorinated amphiphilic calix[4]arenas. Commun. 2005, 39, 4964 – 4966
  140. Yu, L.; Huang, J.; Jones, K. J. Measuring Free-Energy Difference between Crystal Polymorphs through Eutectic Melting. Phys. Chem. B 2005, 109, 19915-19922.
  141. Chen, S.; Guzei, I. A.; Yu, L. New Polymorphs of ROY and New Record for Coexisting Polymorphs of Solved Structures. Am. Chem. Soc. 2005, 127, 9881-9885.
  142. Milton, N.; Pyne, A.; Mishra, D.; Yu, L. The Exploration and Use of Thermal Analytical Technologies During Formulation and Process Development of Freeze-Dried Products. Pharm. Rev., 2003, 6, 46-51.
  143. Yu, L. Nucleation of One Polymorph by Another. Am. Chem. Soc. 2003, 125, 6380-6381. Featured in Chem. & Eng. News, 2003, 81(May 19), 36 and Science News 2004, 166, 113-128.
  144. Yu, L. Growth Rings of D-Sorbitol Spherulites: Connection to Concomitant Polymorphs and Growth Kinetics. Growth & Design 2003, 3, 967-971.
  145. Telang, C.; Suryanaryana, R.; Yu, L. Crystallization of D-mannitol in binary mixtures with NaCl: phase diagram and polymorphism. Res. 2003, 20, 1939-1945.
  146. Telang, C.; Yu, L.; Suryanaryana, R. Effective Inhibition of Mannitol Crystallization in Frozen Solutions by Sodium Chloride. Res. 2003, 20, 660-667.
  147. Yu, L.; Ng, K. Glycine Crystallization during Spray Drying: The Effect of pH on Polymorphic and Salt Forms. Pharm. Sci. 2002, 91, 2367-2375.
  148. Yu, L. Color Changes Caused by Conformational Polymorphism:  Optical-Crystallography, Single-Crystal Spectroscopy, and Computational Chemistry. Phys. Chem. A 2002, 106, 544-550.
  149. Mitchell, C. A.; Yu, L.; Ward, M. D. Selective Nucleation and Discovery of Organic Polymorphs through Epitaxy with Single Crystal Substrates. Am. Chem. Soc. 2001, 123, 10830-10839.
  150. Yu, L. Amorphous Pharmaceuticals – Preparation, Characterization and Stabilization. Drug Delivery Rev. 2001 48, 27-42.
  151. Yu, L.; Stephenson, G. A.; Mitchell, C. A.; Bunnell, C. A.; Snorek, S. V.; Bowyer, J. J.; Borchardt, T. B.; Stowell, J. G.; Byrn, S. R. Thermochemistry and Conformational Polymorphism of a Hexamorphic Crystal System. Am. Chem. Soc. 2000, 122, 585-591. Featured in Science News 2004, 166, 113-128 and Polymorphism in Molecular Crystals (a textbook by Joel Bernstein; Oxford Univ. Press, 2002).
  152. Reutzel, S. M.; Russell, V.; Yu, L. Molecular Basis for the Stability Relationships between Homochiral and Racemic Crystals of Tazofelone: A Spectroscopic, Crystallographic, and Thermodynamic Investigation, Chem. Soc. Perkin Trans 2 2000, 913-924.
  153. Yu, L.; Reutzel-Edens, S. M.; Mitchell, C. M. Crystallization and Polymorphism of Conformationally Flexible Molecules, Process R&D 2000, 4, 396-402.
  154. Yu, L.; Milton, N.; Groleau, E.; Mishra, D.; Vansickle, R. Existence of a Mannitol Hydrate During Freeze-Drying and Practical Implications. Pharm. Sci. 1999, 88, 196-198.
  155. Yu, L.; Reutzel, S. M.; Stephenson, G. A. Physical Characterization of Polymorphic Drugs: an Integrated Characterization Strategy. Sci. Tech. Today 1998, 1, 118-127.
  156. Yu, L.; Mishra, D.; Rigsbee, D. Determination of the Glass Properties of Mannitol Using Sorbitol as an Impurity. Pharm. Sci. 1998, 87, 774-777.
  157. Yu, L. Relative Stability of Polymorphs: Constructing Quantitative Stability-Temperature Diagram from Melting, Eutectic Melting and Other Thermodynamic Data. Res. 1997, 14, 185S.
  158. Yu, L.; Mishra, D.; Rigsbee, D.; Vansickle, R.; Groleau, E.; Milton, N. Solid-State Studies of Mannitol and Mannitol-Sorbitol Mixtures. Res. 1997, 14, 445S.
  159. Stephenson, G. A.; Borchardt, T. B.; Byrn, S. R.; Bowyer, J. J.; Snorek, S. V.; Bunnell, C. A.; Yu, L. Conformational and Color Polymorphism of LY290437. Pharm. Sci. 1995, 84, 1385.
  160. Yu, L. Inferring Thermodynamic Stability Relationship of Polymorphs from Melting Data. Pharm. Sci. 1995, 84, 966.
  161. Schwier, J.; Cooke, G.; Hartauer, K.; Yu, L. Rayon: A Source of Furfural-A Reactive Aldehyde Capable of Insolublizing Gelatin Capsules. Tech. 1993, May, 78.
  162. Yu, L.; Cullin, D.; Williamson, J.; Miller, T. High Resolution Laser Spectroscopy of Asymmetrically Deuterated Cyclopentadienyl Radicals: A Study of Vibronic Degeneracy Resolution and Jahn-Teller Distortion. Chem. Phys. 1993, 98, 2682.
  163. Yu, L.; Williamson, J.; Foster, S.; Miller, T. High Resolution Laser Spectroscopy of Free Radical- Inert Gas Complexes. Chem. Phys. 1992, 97, 5273.
  164. Cullin, D.; Yu, L.; Williamson, J.; Miller, T. High-Resolution Spectroscopy of Jet-Cooled Substituted Cyclopentadienyl Radicals. Phys. Chem 1992, 96, 89.
  165. Yu, L.; Cullin, D.; Williamson, J.; Miller, T. Rotationally Resolved Laser Spectroscopy of Methylcyclopentadienyl Radical and Deuterated Analog. Chem. Phys. 1991, 95, 804.
  166. Chang, B.; Yu, L.; Cullin, D.; Rehfess, B.; Williamson, J.; Miller, T.; Fawzy, W.; Zheng, S.; Sei, P.; Heaven, M. Rotational, Fine and Hyperfine Structure in the High Resolution Electronic Spectrum of ArOH and ArOD. Chem. Phys 1991, 95, 7086.
  167. Yu, L.; Foster, S.; Williamson, J.; Miller, T. High Resolution Electronic Spectroscopy of Jet-Cooled Hexa- and 1,3,5-trifluorobenzene Cations. Chem. Phys. 1990, 92, 5794.
  168. Liu, X.; Yu, L.; Miller, T. Jahn-Teller Induced Corrections to Rotational and Fine-Structure Parameters in Doubly Degenerate Electronic States. Mol. Spectros. 1990, 140, 112.
  169. Cullin, D.; Yu, L.; Williamson, J.; Platz, M.; Miller, T. Reinvestigation of the Electronic Spectrum of Phenyl Nitrene Radical. Phys. Chem. 1990, 94, 3387.
  170. Liu, X.; Foster, S.; Williamson, J.; Yu, L.; Miller, T. Spin-Rotation Interaction in Methoxy Radical. Phys. 1990, 69, 357.
  171. Yu, L.; Williamson, J.; Miller, T. Rotationally Resolved Electronic Spectrum of Jet-Cooled Deuterated Cyclopentadienyl Radical. Phys. Lett. 1989, 162, 431.
  172. Yu, L.; Foster, S.; Williamson, J.; Heaven, M.; Miller, T. Rotationally Resolved Electronic Spectrum of Jet-Cooled Cyclopentadienyl Radical. J Phys. Chem. 1988, 92, 4263.
  173. Liu, X.; Damo, C. P.; Lin, T. Y. D.; Foster, S. C.; Misra, P.; Yu, L.; Miller, T. A. Free jet-cooled laser-induced fluorescence spectrum of methoxy radical. 2.  Phys. Chem. 1989, 93, 2266-75.
  174. Liu, L.; Damo, C.; Lin, D.; Foster, S.; Misra, P.; Yu, L.; Miller, T. Free-Jet Cooled Laser-Induced Fluorescence Spectrum of Methoxy Radical. Phys. Chem. 1986, 93, 6766.
  175. Ni, C.; Yu, L.; Liu, R. Activity coefficient of benzene and n-hexane in methanol salt solutions at 298 K. Acta Physico-Chimica Sinica 1987, 3 (3), 326-329.
Book Chapters and Monographs
  1. Yu, L. High-resolution laser spectroscopy of cyclopentadienyl radical and its derivatives in a supersonic free jet expansion.  (1991). CAN 116:94462 AN 1992:94462.  D. Thesis.
  2. Yu, L. Characterization and Properties of Amorphous Materials. In “Pharmaceutical Materials Science” edited by Jian-Xin Li and Ping I. Lee, John Wiley & Sons (2015).
  3. Yu, L.; Reutzel-Edens, S. M. Crystallization Basic Principles.  Encyclopedia of Food Sciences and Nutrition.  Academic Press: London (2002).
  4. Zhang, S.; Yu, L. Anomalous formation properties of nicotinamide co-crystals. In Advances in Organic Crystal Chemistry: Comprehensive Review 2015, pp 337-353, edited by Mikiji Miyata and Rui Tamura. Springer (2015).
Patents
  1. Yu, Lian; De Villiers, Melgardt M.; Wu, Tian. Inhibiting surface enhanced crystallization of amorphous pharmaceuticals with ultrathin coatings.  S. Pat. Appl. Publ. (2008), 17pp.  CODEN: USXXCO US  2008233157  A1  20080925  CAN 149:386401  AN 2008:1155830. Granted Feb. 9, 2016 (US Patent 9,254,266 B2).
  2. Ediger, Mark D.; Swallen, Stephen; Kearns, Ken; Yu, Lian; Wu, Tian. Unusually stable glasses and methods for forming same.  S. Pat. Appl. Publ.  (2008), 24pp.  CODEN: USXXCO  US  2008213365  A1  20080904  CAN 149:316008  AN 2008:1070389.  Granted 11 Dec. 2012 (US Patent 8,329,218 B2).  Licensed by Intel, Dec. 2012.
  3. Zhang, Geoff G. Z.; Yu, Lian; Tao, Jing; Sun, Ye; Maegerlein, Markus. Method for evaluating the solubility of a crystalline substance in a polymer.    PCT Int. Appl.  (2009), 29 pp. CODEN: PIXXD2  WO  2009135799  A2  20091112  CAN 151:536889  AN 2009:1394498.
  4. Tao, J.; Sun, Y.; Yu, L.; Zhang, G. G. D.; Maegerlein, M. Provisional US patent application 61/297,424 (Jan. 10, 2010) on Analytical Method for Measuring Solubilities of Crystalline Drugs in Polymers.
  5. N-(2-Arylethyl)Benzylamines as Antagonists of the 5-Ht6 Receptor (P12511A) (2001).