Past Rennebohm Lectures

The Rennebohm Lectures at the School of Pharmacy, University of Wisconsin-Madison, are supported by a generous grant from the Oscar Rennebohm Foundation. Those who have participated in the past programs and their topics include:

2013-14 Theo Raynor, PhD, BPharm, FRPharmS University of Leeds

  • From Zero to Hero – Europe’s 30 Year Journey in Consumer Medicines
  • ‘To be or Not to Be Taken?’ – Are the Consequences of Patient Empowerment All Good?
2011-12 Mario Capecchi, PhD University of Utah

  • The Making of a Scientist – An Unlikely Journey
  • Gene Targeting Into the 21st Century: Mouse Models of Human Disease from Cancer to Neuropsychiatric Disorders
2010-11 Bonnie L. Bassler, PhD Princeton University

  • Tiny Conspiracies: Cell-to-Cell Communication in Bacteria
  • Manipulating Quorum-Sensing to Control Bacterial Pathogenicity
2010-11 Jeffrey M. Drazen, MD Editor-in-Chief, New England Journal of Medicine

  • Leukotrienes in Asthma: From Bench to Bedside to Bench to Bedside
  • The Cholesterol Lowering Story: Is It Always Good?
2009-10 William E. Evans, PharmD Director and Chief Executive Office of St. Jude Children’s Research Hospital

  • A 30-year Evolution, from Pharmacokinetics to Pharmacogenomics: Where to Next?
  • Pharmacogenomics of Acute Lymphoblastic Leukemia: from Discovery to Clinical Practice
2008-09 Ahvie Herskowitz, MD Co-Founder, CEO and Chief Medical Officer of the Institute for OneWorld Health

  • Bridging Health Inequity – Social Return on Investment
  • Advancing Global Health: OneWorld Health’s Vision – Challenges and Opportunities
2007-08 Invited: Judah Folkman, MD Andrus Professor of Pediatric Surgery & Cell Biology
Harvard Medical School Director, Vascular Biology Program, Children’s Hospital Boston

  • Angiogenesis: An Organizing Principle for Drug Discovery?
  • Clinical Aplications of Anti-Angiogenic Therapy
2005-06 Molecular Therapy in the 21st Century – A Symposium Honoring 50 Years of the Rennebohm Lectures
Septetmber 21, 2005

Prof. Helen M. Blau
Stanford University
Cell Fusion and Nuclear Reprogramming

Prof. R. Alta Charo
University of Wisconsin
The Politics of Progress

Dr. Saeng H. Cheng
Genzyme Corporation
Prospects for Gene Therapy of Lysosomal Storage Disorders

Prof. Sheng Ding
Scripps Research Institute
Chemical and Functional Genomic Approaches toward Regenerative Medicine

Prof. Vicki L. Ellingrod
University of Iowa
Pharmacogenetics of Schizophrenia Treatment

Prof. Jeffrey A. Johnson
University of Wisconsin
The Nrf2-ARE Pathway: A Potential New Therapeutic Approach for Treating Neurodegenerative Diseases

Prof. Julie A. Johnson
University of Florida
Beta Blocker Pharmacogenetics

Prof. Mark Kay
Stanford University
Gene Therapy for Hemophilia and RNAi based Therapies for Human Viral Hepatitis

Prof. Daren Knoell
Ohio State University
The A to Z’s of Cell Survival in the Lung

Prof. Jill M. Kolesar
University of Wisconsin
Pharmacogenetics of Lung Cancer

Prof. Robert MacDonald
Northwestern University
Lipiplexes and Non-Lamellar Lipid Phases
Insights into Optimizing Lipofection

Dr. Ronald D.G. McKay
National Institute of Neurological Disorders and Stroke
The Molecular Biology and Medical Potential of CNS Stem Cells

Prof. Ida “Ki” Moore
University of Arizona
Childhood Leukemia: Contributions and Challenges of CNS Treatment

Prof. Clive N. Svendsen
University of Wisconsin
Neural Stem Cells for Parkinsons’ and ALS

Prof. James A. Thomson
University of Wisconsin
Human Embryonic Stem Cells

Prof. Richard M. Weinshilboum
Mayo Clinic College of Medicine
Pharmacogenomics: Inheritance and Drug Response

Prof. Jon A. Wolff
University of Wisconsin
The development of Non-Viral Vectors

2003-04 Dr. David Mangelsdorf, PhD
Howard Hughes Medical Institute

  • The Role of Nuclear Receptors as Sensors of Dietary Lipids
  • Oxysterols as Modulators of Nuclear Receptor Signaling
2002-03 Dr. Jane Henney
Senior Scholar in Residence, Association of Academic Health Centers
Former Commissioner, U.S. Food and Drug Administration

  • Developing Medical Products in the Future
  • Challenges for the Research Enterprise
2001-02 Prof. Peter Schultz Scripps Research Institute and Novartis Research Foundation

  • New Opportunities at the Interface of Chemistry and Biology
1999-2000 Dr. Albert Eschenmoser Swiss Federal Institute of Technology

  • Chemical Etiology of Nucleic Acide Structure
  • Chemistry of Pentopyranosyl-(2’→4″)-oligonuceotide Systems
1997-98 Prof. Barry M. Trost Stanford University

  • On Artificial Enzymes: Crafting Chiral Space for Molecular Recognition in a Catalystic Synthetic Reaction
1996-97 Prof. Christopher T. Walsh Harvard Medical School

  • The Molecular Mechisms of Bacterial Resistance to the Vancomycin Group of Glycopeptide Antibiotics
  • Post-Translational Modifications that Prime the Biosynthesis of Polyketide and Polypeptide Antibiotics
1995-96

Prof. Richard C. Mulligan
Massachusetts Institute of Technology
The Basic Science of Gene Therapy

Prof. Gary Nabel
University of Michigan
Gene Therapy Strategies for Human Cancer

Prof. James Wilson
University of Pennsylvania
Gene Therapy: Challenges and Directions

Prof. Jon A. Wolff
University of Wisconsin
New Approaches to Non-Viral Gene Therapy

Prof. Robert Debs
Californnia Pacific Medical Center
Cationic Liposome-Mediated Gene Transfer in vivo and in vitro

Prof. Dorothy Nelkin
New York University
Gene Therapy and the Public Response

1994-95 Prof. Henry R. Bourne University of California – San Francisco

  • Diseases Tell Us How Trimeric G-Proteins Work
  • Trimeric G-Proteins: Associations with Proteins and Lipid Membranes
1992-93 Prof. Carl Djerassi Stanford University

  • The Pill at Forty-one: What Now?
Prof. Stephen J. Bencovic Pennsylvania State University

  • How Reverse Transcriptase Transcribes
  • Catalytic Antibodies
1991-92 Prof. Jeremy R. Knowles Harvard University

  • An Enzymatic Pericyclic Reaction: The Pursuit of Mechanism
  • Enzyme Catalysis: What do We Understand?
1990-91 Prof. Phillip A. Sharp Massachusetts Institute of Technology

  • Mechanisms of Transcription and REgulation of Eukaryotes
  • Protein-RNA Recognition in Regulation of Gene Expression
1989-90 Dr. Richard A. Lerner Research Institutes of the Scripps Clinic

  • Catalytic Antibidies – I
  • Catalytic Antibodies – II
1987-88 Dr. Ira Pastan National Cancer Institute

  • Oncotoxins: Genetically Engineered Toxins for Cancer Treatment
  • The Role of the Human Multidrug Resistance Gene in Chemotherapy
1986-87 Prof. Leroy E. Hood California Institute of Technology

  • Immunity and the Immunoglobulin Gene Super Family
  • Biotechnology and Medicine of the Future
1985-86 Dr. Max F. Perutz MRC Laboratory of Molecular Biology

  • Protein Crystallography and New Drug Design
  • The Impact of Science on Society: Would We Be Better Off Without Research?
1984-85 Dr. Ronald Breslow Columbia University

  • Approaches to Artificial Enzymes
  • Imitating the Selectivity of Biochemical Reactions
1983-84 Dr. Leslie L. Iverson Merck Sharp & Dohme Ltd.

  • Neurobiology and Neuropharmacology of Alzheimer’s Disease
  • Substance P and Other Brain Peptides: Basis of a New Psychopharmacology?
1982-83 Dr. Elwood V. Jensen Ludwig Institute for Cancer Research, Zurich, Switzerland

  • Estrogen Receptor Interaction in Target Cells
  • Hormone Dependency of Breast Cancer
1981-82 Dr. Alan R. Battersby Cambridge University

  • Biosynthesis of the Pigments of Life: Heme
  • Biosynthesis of the Pigments of Life: Vitamin B12
1980-81 Dr. K. Nakanishi Columbia University

  • Recent Studies on Visual Pigments and Bacteriorhodopsin
  • Additivity Relation in the Exciton Chirality Method: Application in Structure Determination of Oligosaccharides and Other Cases
1979-80 Dr. James Black The Wellcome Foundation, Beckenham, England

  • Prospecting for New Drugs
  • Pharmacological Analysis of the Neurochemical Control of Gastric Secretion
1978-79 Dr. John R. Vane The Wellcome Foundation, Beckenham, England

  • Prostacyclin, Platelets and Vascular Disease
1977-78 Prof. Andrew Schally Tulane University

  • Hypothalamic Regulation of the Pituitary Gland with Major Emphasis on Its Implications for the Control of the Productive Processes
  • Present Status of Hypothalamic Regulatory Hormones Especially Somatostatin: Basic and Clinical Studies
1976-77 Prof. Solomon H. Snyder Johns Hopkins University

  • The Opiate Receptor and Its Neurotransmitter Peptides
  • Schizophrenia, Antipsychotic Drugs and the Dopamine Receptor
1975-76 Prof. Barnard R. Belleau McGill University

  • Medicinal Chemistry of the Opiate Receptor: Recent Advances
  • Medicinal Chemistry of Neurotransmitter Receptors: Translation of Recognition Effects by Active Sites: Model Studies
1974-75 Prof. Vladimir Prelog Swiss Federal Institute, Zurich, Switzerland

  • Chirality, the Geometrical Basis of Stereochemistry
  • Boromycin, Structure and Properties
  • Chiral Concave Molecules
1973-74 Prof. Hans Selye University of Montreal

  • Stress Without Distress
  • Creativity in Research
1972-73 Dr. Julius Axelrod National Institutes of Health

  • Regulation of the Adrenergic Neurotransmitter
  • The Use of Drugs in Biomedical Research
1971-72 Prof. Walter J. Kauzmann Princeton University

  • Chemical and Biological Effects of Pressure:
    I. Fundamental Principles
    II. Some Applications
1970-71 Prof. James F. Danielli State University of New York at Buffalo

  • Theory and Hypotheses in Development of Concept of the Plasma Membrane
  • Artificial Synthesis of Living Cells
1969-70 Prof. Daniel E. Koshland University of California

  • A Molecular Model for Enzyme Regulation
  • Peptide-Peptide Interactions
1968-69 Prof. Henry Eyring University of Utah

  • Structure of Water and Ionic Solution
  • Optical Rotatory Dispersion and Circular Dichroism
  • Transport Through Membranes
1967-68 Prof. Jerrold Meinwald Cornell University

  • Chemistry of Insect Attractants and Repellents
1966-67

Prof. E. P. Abraham
University of Oxford
Penicillins and Cephalosporins: Their Chemistry in Relation to Biological Activity

Dr. Karl Heusler
Woodward Research Institute, Basle, Switzerland
Advances in Total Synthesis of Lactam Antibiotics

Prof. Klaus Hofmann
University of Pittsburgh
The Partial Synthesis of Active Enzymes

1965-56 Prof. Myron L. Bender Northwestern University

  • Organic Models of Enzymatic Catalysis
  • Mechanisms of Chymotrypsin Catalysis
1964-65 Dr. Karl J. Brunings Geigy Chemical Corp

  • Medicinal Research: A Field of Common Interest for the Universities, Industry, and Government
  • Drugs Affecting Endogenous Amines
  • Anti-Inflammatory Agents
1963-64 Prof. I. M. Kolthoff University of Minnesota

  • The Development of Analytical Chemistry
  • Induced Reactions
Prof. Karol Mysels University of Southern California

  • The Evolution and Properties of Thick Soap Films
  • Equilibrium Soap Films and Intermolecular Forces
Prof. W. B. Whalley University of London

  • The Constitution of Some Non-Alkaloidal Constituents of Ergot
  • The Sclerotiorin Group of Pigments: Their Chemistry and Biosynthesis
1962-63

Dr. Max Tishler
Merck Sharp and Dohme Research Laboratories
Perspectives in Pharmaceutical Chemistry

Prof. Odin W. Anderson
University of Chicago
The Health Service Establishment Today

1961-62 Prof. Alfred Burger University of Virginia

  • Medicinal Chemistry: Its Problems and Hopes
  • Nonhydrazine Inhibitors of Monoamine Oxidase
1960-61 Dr. Robert P. Fischelis American Pharmaceutical Association

  • Pharmacy and Medical Care
  • Pharmacy and the Pharmaceutical Industry
  • Pharmacy and the Public
1959-60 Prof. Ewart A. Swinyard University of Utah

  • Drugs: From Animals to Man
  • Experimental Seizures and Research
1958-59 Dr. Emil Schlitter CIBA Pharmaceutical Products, Inc.

  • The Drug Industry and Its Research Problems
  • The Importance of Research in the Drug Industry
  • Projects for the Drug Industry
1957-58 Dr. Thomas J. Carney Eli Lilly and Company

  • Major Problems in medicinal Chemical Research
  • Natural Products in Medicinal Chemistry
Prof. A. H. Beckett Chelsea College of Science and Technology

  • Synthetic Analgesics: Stereochemical Considerations
  • Attempts to design Drugs Posessing (a) Analgesic Activity and (b) Antibacterial Activity
1956-57 Dr. Sidney Siggia General Aniline and Film Corp.

  • Modern Analytical Chemistry
  • Organic Functional Group Analysis by Chemical Means
1955-56 Prof. Lyman C. Craig Rockefeller Institute

  • Application of Extraction to Studies of Naturally Occurring Substances
  • Chemical Structure of Some Naturally Occurring Polypeptides