School of Pharmacy UNIVERSITY OF WISCONSIN - MADISON Past Rennebohm Lectures The Rennebohm Lectures at the School of Pharmacy, University of Wisconsin-Madison, are supported by a generous grant from the Oscar Rennebohm Foundation. Those who have participated in the past programs and their topics include: 2013-14 Theo Raynor, PhD, BPharm, FRPharmS University of Leeds From Zero to Hero – Europe’s 30 Year Journey in Consumer Medicines ‘To be or Not to Be Taken?’ – Are the Consequences of Patient Empowerment All Good? 2011-12 Mario Capecchi, PhD University of Utah The Making of a Scientist – An Unlikely Journey Gene Targeting Into the 21st Century: Mouse Models of Human Disease from Cancer to Neuropsychiatric Disorders 2010-11 Bonnie L. Bassler, PhD Princeton University Tiny Conspiracies: Cell-to-Cell Communication in Bacteria Manipulating Quorum-Sensing to Control Bacterial Pathogenicity 2010-11 Jeffrey M. Drazen, MD Editor-in-Chief, New England Journal of Medicine Leukotrienes in Asthma: From Bench to Bedside to Bench to Bedside The Cholesterol Lowering Story: Is It Always Good? 2009-10 William E. Evans, PharmD Director and Chief Executive Office of St. Jude Children’s Research Hospital A 30-year Evolution, from Pharmacokinetics to Pharmacogenomics: Where to Next? Pharmacogenomics of Acute Lymphoblastic Leukemia: from Discovery to Clinical Practice 2008-09 Ahvie Herskowitz, MD Co-Founder, CEO and Chief Medical Officer of the Institute for OneWorld Health Bridging Health Inequity – Social Return on Investment Advancing Global Health: OneWorld Health’s Vision – Challenges and Opportunities 2007-08 Invited: Judah Folkman, MD Andrus Professor of Pediatric Surgery & Cell Biology Harvard Medical School Director, Vascular Biology Program, Children’s Hospital Boston Angiogenesis: An Organizing Principle for Drug Discovery? Clinical Aplications of Anti-Angiogenic Therapy 2005-06 Molecular Therapy in the 21st Century – A Symposium Honoring 50 Years of the Rennebohm Lectures Septetmber 21, 2005 Prof. Helen M. Blau Stanford University Cell Fusion and Nuclear Reprogramming Prof. R. Alta Charo University of Wisconsin The Politics of Progress Dr. Saeng H. Cheng Genzyme Corporation Prospects for Gene Therapy of Lysosomal Storage Disorders Prof. Sheng Ding Scripps Research Institute Chemical and Functional Genomic Approaches toward Regenerative Medicine Prof. Vicki L. Ellingrod University of Iowa Pharmacogenetics of Schizophrenia Treatment Prof. Jeffrey A. Johnson University of Wisconsin The Nrf2-ARE Pathway: A Potential New Therapeutic Approach for Treating Neurodegenerative Diseases Prof. Julie A. Johnson University of Florida Beta Blocker Pharmacogenetics Prof. Mark Kay Stanford University Gene Therapy for Hemophilia and RNAi based Therapies for Human Viral Hepatitis Prof. Daren Knoell Ohio State University The A to Z’s of Cell Survival in the Lung Prof. Jill M. Kolesar University of Wisconsin Pharmacogenetics of Lung Cancer Prof. Robert MacDonald Northwestern University Lipiplexes and Non-Lamellar Lipid Phases Insights into Optimizing Lipofection Dr. Ronald D.G. McKay National Institute of Neurological Disorders and Stroke The Molecular Biology and Medical Potential of CNS Stem Cells Prof. Ida “Ki” Moore University of Arizona Childhood Leukemia: Contributions and Challenges of CNS Treatment Prof. Clive N. Svendsen University of Wisconsin Neural Stem Cells for Parkinsons’ and ALS Prof. James A. Thomson University of Wisconsin Human Embryonic Stem Cells Prof. Richard M. Weinshilboum Mayo Clinic College of Medicine Pharmacogenomics: Inheritance and Drug Response Prof. Jon A. Wolff University of Wisconsin The development of Non-Viral Vectors 2003-04 Dr. David Mangelsdorf, PhD Howard Hughes Medical Institute The Role of Nuclear Receptors as Sensors of Dietary Lipids Oxysterols as Modulators of Nuclear Receptor Signaling 2002-03 Dr. Jane Henney Senior Scholar in Residence, Association of Academic Health Centers Former Commissioner, U.S. Food and Drug Administration Developing Medical Products in the Future Challenges for the Research Enterprise 2001-02 Prof. Peter Schultz Scripps Research Institute and Novartis Research Foundation New Opportunities at the Interface of Chemistry and Biology 1999-2000 Dr. Albert Eschenmoser Swiss Federal Institute of Technology Chemical Etiology of Nucleic Acide Structure Chemistry of Pentopyranosyl-(2’→4″)-oligonuceotide Systems 1997-98 Prof. Barry M. Trost Stanford University On Artificial Enzymes: Crafting Chiral Space for Molecular Recognition in a Catalystic Synthetic Reaction 1996-97 Prof. Christopher T. Walsh Harvard Medical School The Molecular Mechisms of Bacterial Resistance to the Vancomycin Group of Glycopeptide Antibiotics Post-Translational Modifications that Prime the Biosynthesis of Polyketide and Polypeptide Antibiotics 1995-96 Prof. Richard C. Mulligan Massachusetts Institute of Technology The Basic Science of Gene Therapy Prof. Gary Nabel University of Michigan Gene Therapy Strategies for Human Cancer Prof. James Wilson University of Pennsylvania Gene Therapy: Challenges and Directions Prof. Jon A. Wolff University of Wisconsin New Approaches to Non-Viral Gene Therapy Prof. Robert Debs Californnia Pacific Medical Center Cationic Liposome-Mediated Gene Transfer in vivo and in vitro Prof. Dorothy Nelkin New York University Gene Therapy and the Public Response 1994-95 Prof. Henry R. Bourne University of California – San Francisco Diseases Tell Us How Trimeric G-Proteins Work Trimeric G-Proteins: Associations with Proteins and Lipid Membranes 1992-93 Prof. Carl Djerassi Stanford University The Pill at Forty-one: What Now? Prof. Stephen J. Bencovic Pennsylvania State University How Reverse Transcriptase Transcribes Catalytic Antibodies 1991-92 Prof. Jeremy R. Knowles Harvard University An Enzymatic Pericyclic Reaction: The Pursuit of Mechanism Enzyme Catalysis: What do We Understand? 1990-91 Prof. Phillip A. Sharp Massachusetts Institute of Technology Mechanisms of Transcription and REgulation of Eukaryotes Protein-RNA Recognition in Regulation of Gene Expression 1989-90 Dr. Richard A. Lerner Research Institutes of the Scripps Clinic Catalytic Antibidies – I Catalytic Antibodies – II 1987-88 Dr. Ira Pastan National Cancer Institute Oncotoxins: Genetically Engineered Toxins for Cancer Treatment The Role of the Human Multidrug Resistance Gene in Chemotherapy 1986-87 Prof. Leroy E. Hood California Institute of Technology Immunity and the Immunoglobulin Gene Super Family Biotechnology and Medicine of the Future 1985-86 Dr. Max F. Perutz MRC Laboratory of Molecular Biology Protein Crystallography and New Drug Design The Impact of Science on Society: Would We Be Better Off Without Research? 1984-85 Dr. Ronald Breslow Columbia University Approaches to Artificial Enzymes Imitating the Selectivity of Biochemical Reactions 1983-84 Dr. Leslie L. Iverson Merck Sharp & Dohme Ltd. Neurobiology and Neuropharmacology of Alzheimer’s Disease Substance P and Other Brain Peptides: Basis of a New Psychopharmacology? 1982-83 Dr. Elwood V. Jensen Ludwig Institute for Cancer Research, Zurich, Switzerland Estrogen Receptor Interaction in Target Cells Hormone Dependency of Breast Cancer 1981-82 Dr. Alan R. Battersby Cambridge University Biosynthesis of the Pigments of Life: Heme Biosynthesis of the Pigments of Life: Vitamin B12 1980-81 Dr. K. Nakanishi Columbia University Recent Studies on Visual Pigments and Bacteriorhodopsin Additivity Relation in the Exciton Chirality Method: Application in Structure Determination of Oligosaccharides and Other Cases 1979-80 Dr. James Black The Wellcome Foundation, Beckenham, England Prospecting for New Drugs Pharmacological Analysis of the Neurochemical Control of Gastric Secretion 1978-79 Dr. John R. Vane The Wellcome Foundation, Beckenham, England Prostacyclin, Platelets and Vascular Disease 1977-78 Prof. Andrew Schally Tulane University Hypothalamic Regulation of the Pituitary Gland with Major Emphasis on Its Implications for the Control of the Productive Processes Present Status of Hypothalamic Regulatory Hormones Especially Somatostatin: Basic and Clinical Studies 1976-77 Prof. Solomon H. Snyder Johns Hopkins University The Opiate Receptor and Its Neurotransmitter Peptides Schizophrenia, Antipsychotic Drugs and the Dopamine Receptor 1975-76 Prof. Barnard R. Belleau McGill University Medicinal Chemistry of the Opiate Receptor: Recent Advances Medicinal Chemistry of Neurotransmitter Receptors: Translation of Recognition Effects by Active Sites: Model Studies 1974-75 Prof. Vladimir Prelog Swiss Federal Institute, Zurich, Switzerland Chirality, the Geometrical Basis of Stereochemistry Boromycin, Structure and Properties Chiral Concave Molecules 1973-74 Prof. Hans Selye University of Montreal Stress Without Distress Creativity in Research 1972-73 Dr. Julius Axelrod National Institutes of Health Regulation of the Adrenergic Neurotransmitter The Use of Drugs in Biomedical Research 1971-72 Prof. Walter J. Kauzmann Princeton University Chemical and Biological Effects of Pressure: I. Fundamental Principles II. Some Applications 1970-71 Prof. James F. Danielli State University of New York at Buffalo Theory and Hypotheses in Development of Concept of the Plasma Membrane Artificial Synthesis of Living Cells 1969-70 Prof. Daniel E. Koshland University of California A Molecular Model for Enzyme Regulation Peptide-Peptide Interactions 1968-69 Prof. Henry Eyring University of Utah Structure of Water and Ionic Solution Optical Rotatory Dispersion and Circular Dichroism Transport Through Membranes 1967-68 Prof. Jerrold Meinwald Cornell University Chemistry of Insect Attractants and Repellents 1966-67 Prof. E. P. Abraham University of Oxford Penicillins and Cephalosporins: Their Chemistry in Relation to Biological Activity Dr. Karl Heusler Woodward Research Institute, Basle, Switzerland Advances in Total Synthesis of Lactam Antibiotics Prof. Klaus Hofmann University of Pittsburgh The Partial Synthesis of Active Enzymes 1965-56 Prof. Myron L. Bender Northwestern University Organic Models of Enzymatic Catalysis Mechanisms of Chymotrypsin Catalysis 1964-65 Dr. Karl J. Brunings Geigy Chemical Corp Medicinal Research: A Field of Common Interest for the Universities, Industry, and Government Drugs Affecting Endogenous Amines Anti-Inflammatory Agents 1963-64 Prof. I. M. Kolthoff University of Minnesota The Development of Analytical Chemistry Induced Reactions Prof. Karol Mysels University of Southern California The Evolution and Properties of Thick Soap Films Equilibrium Soap Films and Intermolecular Forces Prof. W. B. Whalley University of London The Constitution of Some Non-Alkaloidal Constituents of Ergot The Sclerotiorin Group of Pigments: Their Chemistry and Biosynthesis 1962-63 Dr. Max Tishler Merck Sharp and Dohme Research Laboratories Perspectives in Pharmaceutical Chemistry Prof. Odin W. Anderson University of Chicago The Health Service Establishment Today 1961-62 Prof. Alfred Burger University of Virginia Medicinal Chemistry: Its Problems and Hopes Nonhydrazine Inhibitors of Monoamine Oxidase 1960-61 Dr. Robert P. Fischelis American Pharmaceutical Association Pharmacy and Medical Care Pharmacy and the Pharmaceutical Industry Pharmacy and the Public 1959-60 Prof. Ewart A. Swinyard University of Utah Drugs: From Animals to Man Experimental Seizures and Research 1958-59 Dr. Emil Schlitter CIBA Pharmaceutical Products, Inc. The Drug Industry and Its Research Problems The Importance of Research in the Drug Industry Projects for the Drug Industry 1957-58 Dr. Thomas J. Carney Eli Lilly and Company Major Problems in medicinal Chemical Research Natural Products in Medicinal Chemistry Prof. A. H. Beckett Chelsea College of Science and Technology Synthetic Analgesics: Stereochemical Considerations Attempts to design Drugs Posessing (a) Analgesic Activity and (b) Antibacterial Activity 1956-57 Dr. Sidney Siggia General Aniline and Film Corp. Modern Analytical Chemistry Organic Functional Group Analysis by Chemical Means 1955-56 Prof. Lyman C. Craig Rockefeller Institute Application of Extraction to Studies of Naturally Occurring Substances Chemical Structure of Some Naturally Occurring Polypeptides