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Oligo(Lactic Acid)8-Docetaxel Prodrug-Loaded PEG-b-PLA Micelles for Prostate Cancer

Posted on May 27, 2025

October 17, 2021 Cite this Abstract Docetaxel (DTX) is among the most frequently prescribed chemotherapy drugs and has recently been shown to extend survival in advanced prostate cancer patients. However, the poor water solubility of …

Posted in Uncategorized

Multimodal imaging demonstrates enhanced tumor exposure of PEGylated FUD peptide in breast cancer

Posted on May 27, 2025

October 1, 2022 Cite this Abstract In breast cancer, the extracellular matrix (ECM) undergoes remodeling and changes the tumor microenvironment to support tumor progression and metastasis. Fibronectin (FN) assembly is an important step in the regulation of the tumor …

Posted in Uncategorized

Production of paclitaxel-loaded PEG-b-PLA micelles using PEG for drug loading and freeze-drying

Posted on May 27, 2025

October 1, 2022 Cite this Abstract A new approach named PEG-assist is introduced for the production of drug-loaded polymeric micelles. The method is based on the use of PEG as the non-selective solvent for PEG-b-PLA in the fabrication …

Posted in Uncategorized

Acyl and Oligo(Lactic Acid) Prodrugs for PEG-b-PLA and PEG-b-PCL Nano-Assemblies for Injection

Posted on February 10, 2021

February 10, 2021 Cite this Abstract Poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-b-PLA) and poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-b-PCL) form nano-assemblies, including micelles and nanoparticles, that increase the water solubility of anticancer drugs for injection. PEG-b-PLA and PEG-b-PCL are less …

Posted in Uncategorized

Probing the Subcutaneous Absorption of a PEGylated FUD Peptide Nanomedicine via In Vivo Fluorescence Imaging

Posted on July 8, 2019

July 8, 2019 Cite this Abstract The Functional Upstream Domain (FUD) peptide is a potent inhibitor of fibronectin assembly and a therapeutic candidate for disorders linked with hyperdeposition of fibronectin-modulated ECM proteins. Most recently, experiments …

Posted in Uncategorized

Poly(ethylene glycol)-block-poly(d,l-lactic acid) Micelles Containing Oligo(lactic acid) 8-paclitaxel Prodrug: In Vivo Conversion and Antitumor Efficacy

Posted on March 28, 2019

March 28, 2019 Cite this Abstract Poly(ethylene glycol)-block-poly(d,l-lactic acid) (PEG-b-PLA) micelles affect drug solubilization, and a paclitaxel (PTX) loaded-PEG-b-PLA micelle (PTX-PM) is approved for cancer treatment due to injection safety and dose escalation (Genexol-PM®) compared …

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Oligo(Lactic Acid)8-Rapamycin Prodrug-Loaded Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Micelles for Injection

Posted on March 19, 2019

Pharmaceutical Research

Posted in Uncategorized

Stereocomplex Prodrugs of Oligo(lactic acid)n-Gemcitabine in Poly(ethylene glycol)-block-poly(d,l-lactic acid) Micelles for Improved Physical Stability and Enhanced Antitumor Efficacy

Posted on June 29, 2018

ACS Nano

Posted in Uncategorized

Characterization of the PEGylated Functional Upstream Domain Peptide (PEG-FUD): A Potent Fibronectin Assembly Inhibitor with Potential as an Anti-fibrotic Therapeutic

Posted on April 24, 2018

Pharmaceutical Research

Posted in Uncategorized

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