October 17, 2021 Cite this Abstract Docetaxel (DTX) is among the most frequently prescribed chemotherapy drugs and has recently been shown to extend survival in advanced prostate cancer patients. However, the poor water solubility of …
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Multimodal imaging demonstrates enhanced tumor exposure of PEGylated FUD peptide in breast cancer
October 1, 2022 Cite this Abstract In breast cancer, the extracellular matrix (ECM) undergoes remodeling and changes the tumor microenvironment to support tumor progression and metastasis. Fibronectin (FN) assembly is an important step in the regulation of the tumor …
Production of paclitaxel-loaded PEG-b-PLA micelles using PEG for drug loading and freeze-drying
October 1, 2022 Cite this Abstract A new approach named PEG-assist is introduced for the production of drug-loaded polymeric micelles. The method is based on the use of PEG as the non-selective solvent for PEG-b-PLA in the fabrication …
Acyl and Oligo(Lactic Acid) Prodrugs for PEG-b-PLA and PEG-b-PCL Nano-Assemblies for Injection
February 10, 2021 Cite this Abstract Poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-b-PLA) and poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-b-PCL) form nano-assemblies, including micelles and nanoparticles, that increase the water solubility of anticancer drugs for injection. PEG-b-PLA and PEG-b-PCL are less …
Probing the Subcutaneous Absorption of a PEGylated FUD Peptide Nanomedicine via In Vivo Fluorescence Imaging
July 8, 2019 Cite this Abstract The Functional Upstream Domain (FUD) peptide is a potent inhibitor of fibronectin assembly and a therapeutic candidate for disorders linked with hyperdeposition of fibronectin-modulated ECM proteins. Most recently, experiments …
Poly(ethylene glycol)-block-poly(d,l-lactic acid) Micelles Containing Oligo(lactic acid) 8-paclitaxel Prodrug: In Vivo Conversion and Antitumor Efficacy
March 28, 2019 Cite this Abstract Poly(ethylene glycol)-block-poly(d,l-lactic acid) (PEG-b-PLA) micelles affect drug solubilization, and a paclitaxel (PTX) loaded-PEG-b-PLA micelle (PTX-PM) is approved for cancer treatment due to injection safety and dose escalation (Genexol-PM®) compared …
Oligo(Lactic Acid)8-Rapamycin Prodrug-Loaded Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Micelles for Injection
Pharmaceutical Research
Stereocomplex Prodrugs of Oligo(lactic acid)n-Gemcitabine in Poly(ethylene glycol)-block-poly(d,l-lactic acid) Micelles for Improved Physical Stability and Enhanced Antitumor Efficacy
ACS Nano
Characterization of the PEGylated Functional Upstream Domain Peptide (PEG-FUD): A Potent Fibronectin Assembly Inhibitor with Potential as an Anti-fibrotic Therapeutic
Pharmaceutical Research