The Binding Avidity of a Nanoparticle-Based Multivalent Targeted Drug Delivery Platform

Summary

Dendrimer-based anticancer nanotherapeutics containing ∼5 folate molecules have shown in vitro and in vivo efficacy in cancer cell targeting. Multivalent interactions have been inferred from observed targeting efficacy, but have not been experimentally proven. This study provides quantitative and systematic evidence for multivalent interactions between these nanodevices and folate-binding protein (FBP). A series of the nanodevices were synthesized by conjugation with different amounts of folate. Dissociation constants (K_D) between the nanodevices and FBP measured by SPR are dramatically enhanced through multivalency (∼2,500- to 170,000-fold). Qualitative evidence is also provided for a multivalent targeting effect to KB cells using flow cytometry. These data support the hypothesis that multivalent enhancement of K_D, not an enhanced rate of endocytosis, is the key factor resulting in the improved biological targeting by these drug delivery platforms.

Cited by

This article is cited by 180 publications

Kohon, A. I., Man, K., Mathis, K., Webb, J., Yang, Y., & Meckes, B. (2023). Nanoparticle targeting of mechanically modulated glycocalyx. bioRxiv : the preprint server for biology, 2023.02.27.529887. https://doi.org/10.1101/2023.02.27.529887
Zhang, S., Ouyang, T., & Reinhard, B. M. (2022). Multivalent Ligand-Nanoparticle Conjugates Amplify Reactive Oxygen Species Second Messenger Generation and Enhance Epidermal Growth Factor Receptor Phosphorylation. Bioconjugate chemistry, 33(9), 1716–1728. https://doi.org/10.1021/acs.bioconjchem.2c00335
Yang, T., Zhai, J., Hu, D., Yang, R., Wang, G., Li, Y., & Liang, G. (2022). “Targeting Design” of Nanoparticles in Tumor Therapy. Pharmaceutics, 14(9), 1919. https://doi.org/10.3390/pharmaceutics14091919
Perli, G., Bertuzzi, D. L., Souto, D., Ramos, M. D., Braga, C. B., Aguiar, S. B., & Ornelas, C. (2022). Synthesis and Characterization of Dendronized Gold Nanoparticles Bearing Charged Peripheral Groups with Antimicrobial Potential. Nanomaterials (Basel, Switzerland), 12(15), 2610. https://doi.org/10.3390/nano12152610
Sun, Y., Yan, L., Sun, J., Xiao, M., Lai, W., Song, G., Li, L., Fan, C., & Pei, H. (2022). Nanoscale organization of two-dimensional multimeric pMHC reagents with DNA origami for CD8+ T cell detection. Nature communications, 13(1), 3916. https://doi.org/10.1038/s41467-022-31684-8
Wang, Z., Yang, X., Lee, N. Z., & Cao, X. (2022). Multivalent Aptamer Approach: Designs, Strategies, and Applications. Micromachines, 13(3), 436. https://doi.org/10.3390/mi13030436
Rawding, P. A., Bu, J., Wang, J., Kim, D. W., Drelich, A. J., Kim, Y., & Hong, S. (2022). Dendrimers for cancer immunotherapy: Avidity-based drug delivery vehicles for effective anti-tumor immune response. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 14(2), e1752. https://doi.org/10.1002/wnan.1752
Jeong, W. J., Bu, J., Jafari, R., Rehak, P., Kubiatowicz, L. J., Drelich, A. J., Owen, R. H., Nair, A., Rawding, P. A., Poellmann, M. J., Hopkins, C. M., Král, P., & Hong, S. (2022). Hierarchically Multivalent Peptide-Nanoparticle Architectures: A Systematic Approach to Engineer Surface Adhesion. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 9(4), e2103098. https://doi.org/10.1002/advs.202103098
Rotter, L. K., Berisha, N., Hsu, H. T., Burns, K. H., Andreou, C., & Kircher, M. F. (2022). Visualizing surface marker expression and intratumoral heterogeneity with SERRS-NPs imaging. Nanotheranostics, 6(3), 256–269. https://doi.org/10.7150/ntno.67362
Bakshi, A. K., Haider, T., Tiwari, R., & Soni, V. (2022). Critical parameters for design and development of multivalent nanoconstructs: recent trends. Drug delivery and translational research, 1–24. Advance online publication. https://doi.org/10.1007/s13346-021-01103-4
Bae, J. H., Kim, H. S., Kim, G., Song, J. J., & Kim, H. S. (2021). Dendrimer-Like Supramolecular Assembly of Proteins with a Tunable Size and Valency Through Stepwise Iterative Growth. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(24), e2102991. https://doi.org/10.1002/advs.202102991
Makhani, E. Y., Zhang, A., & Haun, J. B. (2021). Quantifying and controlling bond multivalency for advanced nanoparticle targeting to cells. Nano convergence, 8(1), 38. https://doi.org/10.1186/s40580-021-00288-1
Nappi, F., Iervolino, A., Avtaar Singh, S. S., & Chello, M. (2021). MicroRNAs in Valvular Heart Diseases: Biological Regulators, Prognostic Markers and Therapeutical Targets. International journal of molecular sciences, 22(22), 12132. https://doi.org/10.3390/ijms222212132
Stawicki, C. M., Rinker, T. E., Burns, M., Tonapi, S. S., Galimidi, R. P., Anumala, D., Robinson, J. K., Klein, J. S., & Mallick, P. (2021). Modular fluorescent nanoparticle DNA probes for detection of peptides and proteins. Scientific reports, 11(1), 19921. https://doi.org/10.1038/s41598-021-99084-4
Nagy, K. S., Toth, K., Pallinger, E., Takacs, A., Kohidai, L., Jedlovszky-Hajdu, A., Mathe, D., Kovacs, N., Veres, D. S., Szigeti, K., Molnar, K., Krisch, E., & Puskas, J. E. (2021). Folate-Targeted Monodisperse PEG-Based Conjugates Made by Chemo-Enzymatic Methods for Cancer Diagnosis and Treatment. International journal of molecular sciences, 22(19), 10347. https://doi.org/10.3390/ijms221910347
Ruiz-López, E., & Schuhmacher, A. J. (2021). Transportation of Single-Domain Antibodies through the Blood-Brain Barrier. Biomolecules, 11(8), 1131. https://doi.org/10.3390/biom11081131
Teunissen, A., Burnett, M. E., Prévot, G., Klein, E. D., Bivona, D., & Mulder, W. (2021). Embracing nanomaterials’ interactions with the innate immune system. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 13(6), e1719. https://doi.org/10.1002/wnan.1719
Abbas, M., Ovais, M., & Chen, C. (2020). Phage capsid nanoparticles as multivalent inhibitors of viral infections. Science bulletin, 65(24), 2050–2052. https://doi.org/10.1016/j.scib.2020.09.019
Alshehri, S., Imam, S. S., Rizwanullah, M., Akhter, S., Mahdi, W., Kazi, M., & Ahmad, J. (2020). Progress of Cancer Nanotechnology as Diagnostics, Therapeutics, and Theranostics Nanomedicine: Preclinical Promise and Translational Challenges. Pharmaceutics, 13(1), 24. https://doi.org/10.3390/pharmaceutics13010024
Feiner, R. C., Kemker, I., Krutzke, L., Allmendinger, E., Mandell, D. J., Sewald, N., Kochanek, S., & Müller, K. M. (2020). EGFR-Binding Peptides: From Computational Design towards Tumor-Targeting of Adeno-Associated Virus Capsids. International journal of molecular sciences, 21(24), 9535. https://doi.org/10.3390/ijms21249535
Sun, M., , Miyazawa, K., , Pendekanti, T., , Razmi, A., , Firlar, E., , Yang, S., , Shokuhfar, T., , Li, O., , Li, W., , & Sen Gupta, A., (2020). Combination targeting of ‘platelets + fibrin’ enhances clot anchorage efficiency of nanoparticles for vascular drug delivery. Nanoscale, 12(41), 21255–21270. https://doi.org/10.1039/d0nr03633a
Luo, D., Johnson, A., Wang, X., Li, H., Erokwu, B. O., Springer, S., Lou, J., Ramamurthy, G., Flask, C. A., Burda, C., Meade, T. J., & Basilion, J. P. (2020). Targeted Radiosensitizers for MR-Guided Radiation Therapy of Prostate Cancer. Nano letters, 20(10), 7159–7167. https://doi.org/10.1021/acs.nanolett.0c02487
Chaturvedi, S., Verma, A., & Saharan, V. A. (2020). Lipid Drug Carriers for Cancer Therapeutics: An Insight into Lymphatic Targeting, P-gp, CYP3A4 Modulation and Bioavailability Enhancement. Advanced pharmaceutical bulletin, 10(4), 524–541. https://doi.org/10.34172/apb.2020.064
Wen, Y., Bai, H., Zhu, J., Song, X., Tang, G., & Li, J. (2020). A supramolecular platform for controlling and optimizing molecular architectures of siRNA targeted delivery vehicles. Science advances, 6(31), eabc2148. https://doi.org/10.1126/sciadv.abc2148
Maslanka Figueroa, S., Fleischmann, D., Beck, S., Tauber, P., Witzgall, R., Schweda, F., & Goepferich, A. (2020). Nanoparticles Mimicking Viral Cell Recognition Strategies Are Superior Transporters into Mesangial Cells. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 7(11), 1903204. https://doi.org/10.1002/advs.201903204
Qiao, J., Tian, F., Deng, Y., Shang, Y., Chen, S., Chang, E., & Yao, J. (2020). Bio-orthogonal click-targeting nanocomposites for chemo-photothermal synergistic therapy in breast cancer. Theranostics, 10(12), 5305–5321. https://doi.org/10.7150/thno.42445
Zhou, X. L., Yang, Y., Wang, S., & Liu, X. W. (2020). Surface Plasmon Resonance Microscopy: From Single-Molecule Sensing to Single-Cell Imaging. Angewandte Chemie (International ed. in English), 59(5), 1776–1785. https://doi.org/10.1002/anie.201908806
Farokhirad, S., Bradley, R. P., & Radhakrishnan, R. (2019). Thermodynamic analysis of multivalent binding of functionalized nanoparticles to membrane surface reveals the importance of membrane entropy and nanoparticle entropy in adhesion of flexible nanoparticles. Soft matter, 15(45), 9271–9286. https://doi.org/10.1039/c9sm01653h
Myung, J. H., Cha, A., Tam, K. A., Poellmann, M., Borgeat, A., Sharifi, R., Molokie, R. E., Votta-Velis, G., & Hong, S. (2019). Dendrimer-Based Platform for Effective Capture of Tumor Cells after TGFβ1-Induced Epithelial-Mesenchymal Transition. Analytical chemistry, 91(13), 8374–8382. https://doi.org/10.1021/acs.analchem.9b01181
Mourtas, S., Christodoulou, P., Klepetsanis, P., Gatos, D., Barlos, K., & Antimisiaris, S. G. (2019). Preparation of Benzothiazolyl-Decorated Nanoliposomes. Molecules (Basel, Switzerland), 24(8), 1540. https://doi.org/10.3390/molecules24081540
Csizmar, C. M., Petersburg, J. R., Perry, T. J., Rozumalski, L., Hackel, B. J., & Wagner, C. R. (2019). Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density. Journal of the American Chemical Society, 141(1), 251–261. https://doi.org/10.1021/jacs.8b09198
Jeong, W. J., Bu, J., Kubiatowicz, L. J., Chen, S. S., Kim, Y., & Hong, S. (2018). Peptide-nanoparticle conjugates: a next generation of diagnostic and therapeutic platforms?. Nano convergence, 5(1), 38. https://doi.org/10.1186/s40580-018-0170-1
Vieira Gonzaga, R., da Silva Santos, S., da Silva, J. V., Campos Prieto, D., Feliciano Savino, D., Giarolla, J., & Igne Ferreira, E. (2018). Targeting Groups Employed in Selective Dendrons and Dendrimers. Pharmaceutics, 10(4), 219. https://doi.org/10.3390/pharmaceutics10040219
Zhang, Q., & Reinhard, B. M. (2018). Ligand Density and Nanoparticle Clustering Cooperate in the Multivalent Amplification of Epidermal Growth Factor Receptor Activation. ACS nano, 12(10), 10473–10485. https://doi.org/10.1021/acsnano.8b06141
Zhang, M., Zhu, J., Zheng, Y., Guo, R., Wang, S., Mignani, S., Caminade, A. M., Majoral, J. P., & Shi, X. (2018). Doxorubicin-Conjugated PAMAM Dendrimers for pH-Responsive Drug Release and Folic Acid-Targeted Cancer Therapy. Pharmaceutics, 10(3), 162. https://doi.org/10.3390/pharmaceutics10030162
Li, Y., Wang, Y., Huang, G., & Gao, J. (2018). Cooperativity Principles in Self-Assembled Nanomedicine. Chemical reviews, 118(11), 5359–5391. https://doi.org/10.1021/acs.chemrev.8b00195
Wonder, E., Simón-Gracia, L., Scodeller, P., Majzoub, R. N., Kotamraju, V. R., Ewert, K. K., Teesalu, T., & Safinya, C. R. (2018). Competition of charge-mediated and specific binding by peptide-tagged cationic liposome-DNA nanoparticles in vitro and in vivo. Biomaterials, 166, 52–63. https://doi.org/10.1016/j.biomaterials.2018.02.052
Li, W., Sun, D., Li, N., Shen, Y., Hu, Y., & Tan, J. (2018). Therapy of cervical cancer using 131I-labeled nanoparticles. The Journal of international medical research, 46(6), 2359–2370. https://doi.org/10.1177/0300060518761787
Mangadlao, J. D., Wang, X., McCleese, C., Escamilla, M., Ramamurthy, G., Wang, Z., Govande, M., Basilion, J. P., & Burda, C. (2018). Prostate-Specific Membrane Antigen Targeted Gold Nanoparticles for Theranostics of Prostate Cancer. ACS nano, 12(4), 3714–3725. https://doi.org/10.1021/acsnano.8b00940
Ma, W., Fu, F., Zhu, J., Huang, R., Zhu, Y., Liu, Z., Wang, J., Conti, P. S., Shi, X., & Chen, K. (2018). 64Cu-Labeled multifunctional dendrimers for targeted tumor PET imaging. Nanoscale, 10(13), 6113–6124. https://doi.org/10.1039/C7NR09269E
Lu, Y. J., Lin, P. Y., Huang, P. H., Kuo, C. Y., Shalumon, K. T., Chen, M. Y., & Chen, J. P. (2018). Magnetic Graphene Oxide for Dual Targeted Delivery of Doxorubicin and Photothermal Therapy. Nanomaterials (Basel, Switzerland), 8(4), 193. https://doi.org/10.3390/nano8040193
Hsu, H. J., Palka-Hamblin, H., Bhide, G. P., Myung, J. H., Cheong, M., Colley, K. J., & Hong, S. (2018). Noncatalytic Endosialidase Enables Surface Capture of Small-Cell Lung Cancer Cells Utilizing Strong Dendrimer-Mediated Enzyme-Glycoprotein Interactions. Analytical chemistry, 90(6), 3670–3675. https://doi.org/10.1021/acs.analchem.8b00427
Myung, J. H., Park, S. J., Wang, A. Z., & Hong, S. (2018). Integration of biomimicry and nanotechnology for significantly improved detection of circulating tumor cells (CTCs). Advanced drug delivery reviews, 125, 36–47. https://doi.org/10.1016/j.addr.2017.12.005
Jun, S. W., Kwon, J., Chun, S. K., Lee, H. A., Lee, J., Hwang, D. Y., Dong, C. Y., & Kim, C. S. (2018). Modality switching between therapy and imaging based on the excitation wavelength dependence of dual-function agents in folic acid-conjugated graphene oxides. Biomedical optics express, 9(2), 705–716. https://doi.org/10.1364/BOE.9.000705
Le Kim, T. H., Jun, H., Kim, J. H., Park, K., Kim, J. S., & Nam, Y. S. (2017). Lipiodol nanoemulsions stabilized with polyglycerol-polycaprolactone block copolymers for theranostic applications. Biomaterials research, 21, 21. https://doi.org/10.1186/s40824-017-0108-4
Ren, Y., Sagers, J. E., Landegger, L. D., Bhatia, S. N., & Stankovic, K. M. (2017). Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas. Scientific reports, 7(1), 12922. https://doi.org/10.1038/s41598-017-13032-9
Jones, S. K., Sarkar, A., Feldmann, D. P., Hoffmann, P., & Merkel, O. M. (2017). Revisiting the value of competition assays in folate receptor-mediated drug delivery. Biomaterials, 138, 35–45. https://doi.org/10.1016/j.biomaterials.2017.05.034
Kalia, P., Jain, A., Radha Krishnan, R., Demuth, D. R., & Steinbach-Rankins, J. M. (2017). Peptide-modified nanoparticles inhibit formation of Porphyromonas gingivalis biofilms with Streptococcus gordonii. International journal of nanomedicine, 12, 4553–4562. https://doi.org/10.2147/IJN.S139178
Feng, G., Liu, J., Liu, R., Mao, D., Tomczak, N., & Liu, B. (2017). Ultrasmall Conjugated Polymer Nanoparticles with High Specificity for Targeted Cancer Cell Imaging. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 4(9), 1600407. https://doi.org/10.1002/advs.201600407
Park, S. M., Aalipour, A., Vermesh, O., Yu, J. H., & Gambhir, S. S. (2017). Towards clinically translatable in vivo nanodiagnostics. Nature reviews. Materials, 2(5), 17014. https://doi.org/10.1038/natrevmats.2017.14
Huang, Z., Song, Y., Pang, Z., Zhang, B., Yang, H., Shi, H., Chen, J., Gong, H., Qian, J., & Ge, J. (2017). Targeted delivery of thymosin beta 4 to the injured myocardium using CREKA-conjugated nanoparticles. International journal of nanomedicine, 12, 3023–3036. https://doi.org/10.2147/IJN.S131949
Chi, Y. H., Hsiao, J. K., Lin, M. H., Chang, C., Lan, C. H., & Wu, H. C. (2017). Lung Cancer-Targeting Peptides with Multi-subtype Indication for Combinational Drug Delivery and Molecular Imaging. Theranostics, 7(6), 1612–1632. https://doi.org/10.7150/thno.17573
Wang, M., Ravindranath, S. R., Rahim, M. K., Botvinick, E. L., & Haun, J. B. (2016). Evolution of Multivalent Nanoparticle Adhesion via Specific Molecular Interactions. Langmuir : the ACS journal of surfaces and colloids, 32(49), 13124–13136. https://doi.org/10.1021/acs.langmuir.6b03014
Soni, K. S., Desale, S. S., & Bronich, T. K. (2016). Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation. Journal of controlled release : official journal of the Controlled Release Society, 240, 109–126. https://doi.org/10.1016/j.jconrel.2015.11.009
Levine, R. M., Dinh, C. V., Harris, M. A., & Kokkoli, E. (2016). Targeting HPV-infected cervical cancer cells with PEGylated liposomes encapsulating siRNA and the role of siRNA complexation with polyethylenimine. Bioengineering & translational medicine, 1(2), 168–180. https://doi.org/10.1002/btm2.10022
Jiang, X., Bugno, J., Hu, C., Yang, Y., Herold, T., Qi, J., Chen, P., Gurbuxani, S., Arnovitz, S., Strong, J., Ferchen, K., Ulrich, B., Weng, H., Wang, Y., Huang, H., Li, S., Neilly, M. B., Larson, R. A., Le Beau, M. M., Bohlander, S. K., … Chen, J. (2016). Eradication of Acute Myeloid Leukemia with FLT3 Ligand-Targeted miR-150 Nanoparticles. Cancer research, 76(15), 4470–4480. https://doi.org/10.1158/0008-5472.CAN-15-2949
Pearson, R. M., Sen, S., Hsu, H. J., Pasko, M., Gaske, M., Král, P., & Hong, S. (2016). Tuning the Selectivity of Dendron Micelles Through Variations of the Poly(ethylene glycol) Corona. ACS nano, 10(7), 6905–6914. https://doi.org/10.1021/acsnano.6b02708
Lee, J. R., Bechstein, D. J., Ooi, C. C., Patel, A., Gaster, R. S., Ng, E., Gonzalez, L. C., & Wang, S. X. (2016). Magneto-nanosensor platform for probing low-affinity protein-protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction. Nature communications, 7, 12220. https://doi.org/10.1038/ncomms12220
da Silva Santos, S., Igne Ferreira, E., & Giarolla, J. (2016). Dendrimer Prodrugs. Molecules (Basel, Switzerland), 21(6), 686. https://doi.org/10.3390/molecules21060686
Jenkins, R., Bandera, Y. P., Daniele, M. A., Ledford, L. L., Tietje, A., Kelso, A. A., Sehorn, M. G., Wei, Y., Chakrabarti, M., Ray, S. K., & Foulger, S. H. (2016). Sequestering survivin to functionalized nanoparticles: a strategy to enhance apoptosis in cancer cells. Biomaterials science, 4(4), 614–626. https://doi.org/10.1039/c5bm00580a
Myung, J. H., Tam, K. A., Park, S. J., Cha, A., & Hong, S. (2016). Recent advances in nanotechnology-based detection and separation of circulating tumor cells. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 8(2), 223–239. https://doi.org/10.1002/wnan.1360
Yoo, B., Kavishwar, A., Ross, A., Pantazopoulos, P., Moore, A., & Medarova, Z. (2016). In Vivo Detection of miRNA Expression in Tumors Using an Activatable Nanosensor. Molecular imaging and biology, 18(1), 70–78. https://doi.org/10.1007/s11307-015-0863-3
Desale, S. S., Soni, K. S., Romanova, S., Cohen, S. M., & Bronich, T. K. (2015). Targeted delivery of platinum-taxane combination therapy in ovarian cancer. Journal of controlled release : official journal of the Controlled Release Society, 220(Pt B), 651–659. https://doi.org/10.1016/j.jconrel.2015.09.007
Myung, J. H., & Hong, S. (2015). Microfluidic devices to enrich and isolate circulating tumor cells. Lab on a chip, 15(24), 4500–4511. https://doi.org/10.1039/c5lc00947b
Schneider, C. S., Bhargav, A. G., Perez, J. G., Wadajkar, A. S., Winkles, J. A., Woodworth, G. F., & Kim, A. J. (2015). Surface plasmon resonance as a high throughput method to evaluate specific and non-specific binding of nanotherapeutics. Journal of controlled release : official journal of the Controlled Release Society, 219, 331–344. https://doi.org/10.1016/j.jconrel.2015.09.048
Reuter, K. G., Perry, J. L., Kim, D., Luft, J. C., Liu, R., & DeSimone, J. M. (2015). Targeted PRINT Hydrogels: The Role of Nanoparticle Size and Ligand Density on Cell Association, Biodistribution, and Tumor Accumulation. Nano letters, 15(10), 6371–6378. https://doi.org/10.1021/acs.nanolett.5b01362
Myung, J. H., Roengvoraphoj, M., Tam, K. A., Ma, T., Memoli, V. A., Dmitrovsky, E., Freemantle, S. J., & Hong, S. (2015). Effective capture of circulating tumor cells from a transgenic mouse lung cancer model using dendrimer surfaces immobilized with anti-EGFR. Analytical chemistry, 87(19), 10096–10102. https://doi.org/10.1021/acs.analchem.5b02766
Leroueil, P. R., DiMaggio, S., Leistra, A. N., Blanchette, C. D., Orme, C., Sinniah, K., Orr, B. G., & Banaszak Holl, M. M. (2015). Characterization of Folic Acid and Poly(amidoamine) Dendrimer Interactions with Folate Binding Protein: A Force-Pulling Study. The journal of physical chemistry. B, 119(35), 11506–11512. https://doi.org/10.1021/acs.jpcb.5b05391
Yin, L., Yang, Y., Wang, S., Wang, W., Zhang, S., & Tao, N. (2015). Measuring Binding Kinetics of Antibody-Conjugated Gold Nanoparticles with Intact Cells. Small (Weinheim an der Bergstrasse, Germany), 11(31), 3782–3788. https://doi.org/10.1002/smll.201500112
Bahrami, B., Mohammadnia-Afrouzi, M., Bakhshaei, P., Yazdani, Y., Ghalamfarsa, G., Yousefi, M., Sadreddini, S., Jadidi-Niaragh, F., & Hojjat-Farsangi, M. (2015). Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(8), 5727–5742. https://doi.org/10.1007/s13277-015-3706-6
Chacko, A. M., Han, J., Greineder, C. F., Zern, B. J., Mikitsh, J. L., Nayak, M., Menon, D., Johnston, I. H., Poncz, M., Eckmann, D. M., Davies, P. F., & Muzykantov, V. R. (2015). Collaborative Enhancement of Endothelial Targeting of Nanocarriers by Modulating Platelet-Endothelial Cell Adhesion Molecule-1/CD31 Epitope Engagement. ACS nano, 9(7), 6785–6793. https://doi.org/10.1021/nn505672x
Bugno, J., Hsu, H. J., & Hong, S. (2015). Recent advances in targeted drug delivery approaches using dendritic polymers. Biomaterials science, 3(7), 1025–1034. https://doi.org/10.1039/c4bm00351a
Chu, D. S., Bocek, M. J., Shi, J., Ta, A., Ngambenjawong, C., Rostomily, R. C., & Pun, S. H. (2015). Multivalent display of pendant pro-apoptotic peptides increases cytotoxic activity. Journal of controlled release : official journal of the Controlled Release Society, 205, 155–161. https://doi.org/10.1016/j.jconrel.2015.01.013
Lane, L. A., Qian, X., Smith, A. M., & Nie, S. (2015). Physical chemistry of nanomedicine: understanding the complex behaviors of nanoparticles in vivo. Annual review of physical chemistry, 66, 521–547. https://doi.org/10.1146/annurev-physchem-040513-103718
Xie, J., Wang, J., Chen, H., Shen, W., Sinko, P. J., Dong, H., Zhao, R., Lu, Y., Zhu, Y., & Jia, L. (2015). Multivalent conjugation of antibody to dendrimers for the enhanced capture and regulation on colon cancer cells. Scientific reports, 5, 9445. https://doi.org/10.1038/srep09445
Xie, J., Dong, H., Chen, H., Zhao, R., Sinko, P. J., Shen, W., Wang, J., Lu, Y., Yang, X., Xie, F., & Jia, L. (2015). Exploring cancer metastasis prevention strategy: interrupting adhesion of cancer cells to vascular endothelia of potential metastatic tissues by antibody-coated nanomaterial. Journal of nanobiotechnology, 13, 9. https://doi.org/10.1186/s12951-015-0072-x
Shan, D., Li, J., Cai, P., Prasad, P., Liu, F., Rauth, A. M., & Wu, X. Y. (2015). RGD-conjugated solid lipid nanoparticles inhibit adhesion and invasion of αvβ3 integrin-overexpressing breast cancer cells. Drug delivery and translational research, 5(1), 15–26. https://doi.org/10.1007/s13346-014-0210-2
Deng, K., Hou, Z., Li, X., Li, C., Zhang, Y., Deng, X., Cheng, Z., & Lin, J. (2015). Aptamer-mediated up-conversion core/MOF shell nanocomposites for targeted drug delivery and cell imaging. Scientific reports, 5, 7851. https://doi.org/10.1038/srep07851
Li, Z., & Gorfe, A. A. (2015). Receptor-mediated membrane adhesion of lipid-polymer hybrid (LPH) nanoparticles studied by dissipative particle dynamics simulations. Nanoscale, 7(2), 814–824. https://doi.org/10.1039/c4nr04834b
Zhou, C., Chen, T., Wu, C., Zhu, G., Qiu, L., Cui, C., Hou, W., & Tan, W. (2015). Aptamer CaCO3 nanostructures: a facile, pH-responsive, specific platform for targeted anticancer theranostics. Chemistry, an Asian journal, 10(1), 166–171. https://doi.org/10.1002/asia.201403115
Nandwana, V., De, M., Chu, S., Jaiswal, M., Rotz, M., Meade, T. J., & Dravid, V. P. (2015). Theranostic Magnetic Nanostructures (MNS) for Cancer. Cancer treatment and research, 166, 51–83. https://doi.org/10.1007/978-3-319-16555-4_3
Bugno, J., Hsu, H. J., & Hong, S. (2015). Tweaking dendrimers and dendritic nanoparticles for controlled nano-bio interactions: potential nanocarriers for improved cancer targeting. Journal of drug targeting, 23(7-8), 642–650. https://doi.org/10.3109/1061186X.2015.1052077
Hsu, H. J., Sen, S., Pearson, R. M., Uddin, S., Král, P., & Hong, S. (2014). Poly(ethylene glycol) Corona Chain Length Controls End-Group-Dependent Cell Interactions of Dendron Micelles. Macromolecules, 47(19), 6911–6918. https://doi.org/10.1021/ma501258c
Sunoqrot, S., Bugno, J., Lantvit, D., Burdette, J. E., & Hong, S. (2014). Prolonged blood circulation and enhanced tumor accumulation of folate-targeted dendrimer-polymer hybrid nanoparticles. Journal of controlled release : official journal of the Controlled Release Society, 191, 115–122. https://doi.org/10.1016/j.jconrel.2014.05.006
Mulyasasmita, W., Cai, L., Dewi, R. E., Jha, A., Ullmann, S. D., Luong, R. H., Huang, N. F., & Heilshorn, S. C. (2014). Avidity-controlled hydrogels for injectable co-delivery of induced pluripotent stem cell-derived endothelial cells and growth factors. Journal of controlled release : official journal of the Controlled Release Society, 191, 71–81. https://doi.org/10.1016/j.jconrel.2014.05.015
van Dongen, M. A., Dougherty, C. A., & Banaszak Holl, M. M. (2014). Multivalent polymers for drug delivery and imaging: the challenges of conjugation. Biomacromolecules, 15(9), 3215–3234. https://doi.org/10.1021/bm500921q
Anikeeva, N., Sykulev, Y., Delikatny, E. J., & Popov, A. V. (2014). Core-based lipid nanoparticles as a nanoplatform for delivery of near-infrared fluorescent imaging agents. American journal of nuclear medicine and molecular imaging, 4(6), 507–524.
Haji-Valizadeh, H., Modery-Pawlowski, C. L., & Sen Gupta, A. (2014). A factor VIII-derived peptide enables von Willebrand factor (VWF)-binding of artificial platelet nanoconstructs without interfering with VWF-adhesion of natural platelets. Nanoscale, 6(9), 4765–4773. https://doi.org/10.1039/c3nr06400j
van Dongen, M. A., Silpe, J. E., Dougherty, C. A., Kanduluru, A. K., Choi, S. K., Orr, B. G., Low, P. S., & Banaszak Holl, M. M. (2014). Avidity mechanism of dendrimer-folic acid conjugates. Molecular pharmaceutics, 11(5), 1696–1706. https://doi.org/10.1021/mp5000967
Toy, R., Peiris, P. M., Ghaghada, K. B., & Karathanasis, E. (2014). Shaping cancer nanomedicine: the effect of particle shape on the in vivo journey of nanoparticles. Nanomedicine (London, England), 9(1), 121–134. https://doi.org/10.2217/nnm.13.191
Chu, D. S., Schellinger, J. G., Bocek, M. J., Johnson, R. N., & Pun, S. H. (2013). Optimization of Tet1 ligand density in HPMA-co-oligolysine copolymers for targeted neuronal gene delivery. Biomaterials, 34(37), 9632–9637. https://doi.org/10.1016/j.biomaterials.2013.08.045
Hauert, S., Berman, S., Nagpal, R., & Bhatia, S. N. (2013). A computational framework for identifying design guidelines to increase the penetration of targeted nanoparticles into tumors. Nano today, 8(6), 566–576. https://doi.org/10.1016/j.nantod.2013.11.001
Gao, X., Qian, J., Zheng, S., Xiong, Y., Man, J., Cao, B., Wang, L., Ju, S., & Li, C. (2013). Up-regulating blood brain barrier permeability of nanoparticles via multivalent effect. Pharmaceutical research, 30(10), 2538–2548. https://doi.org/10.1007/s11095-013-1004-9
Silpe, J. E., Sumit, M., Thomas, T. P., Huang, B., Kotlyar, A., van Dongen, M. A., Banaszak Holl, M. M., Orr, B. G., & Choi, S. K. (2013). Avidity modulation of folate-targeted multivalent dendrimers for evaluating biophysical models of cancer targeting nanoparticles. ACS chemical biology, 8(9), 2063–2071. https://doi.org/10.1021/cb400258d
Sheng, W., Chen, T., Tan, W., & Fan, Z. H. (2013). Multivalent DNA nanospheres for enhanced capture of cancer cells in microfluidic devices. ACS nano, 7(8), 7067–7076. https://doi.org/10.1021/nn4023747
Lee, S., Yang, Y., Fishman, D., Banaszak Holl, M. M., & Hong, S. (2013). Epithelial-mesenchymal transition enhances nanoscale actin filament dynamics of ovarian cancer cells. The journal of physical chemistry. B, 117(31), 9233–9240. https://doi.org/10.1021/jp4055186
van Dongen, M. A., Desai, A., Orr, B. G., Baker, J. R., Jr, & Holl, M. M. (2013). Quantitative analysis of generation and branch defects in G5 poly(amidoamine) dendrimer. Polymer, 54(16), 4126–4133. https://doi.org/10.1016/j.polymer.2013.05.062
Tsekouras, K., Goncharenko, I., Colvin, M. E., Huang, K. C., & Gopinathan, A. (2013). Design of High-Specificity Nanocarriers by Exploiting Non-Equilibrium Effects in Cancer Cell Targeting. PloS one, 8(6), e65623. https://doi.org/10.1371/journal.pone.0065623
Sunoqrot, S., Liu, Y., Kim, D. H., & Hong, S. (2013). In vitro evaluation of dendrimer-polymer hybrid nanoparticles on their controlled cellular targeting kinetics. Molecular pharmaceutics, 10(6), 2157–2166. https://doi.org/10.1021/mp300560n
Ayyaswamy, P. S., Muzykantov, V., Eckmann, D. M., & Radhakrishnan, R. (2013). Nanocarrier Hydrodynamics and Binding in Targeted Drug Delivery: Challenges in Numerical Modeling and Experimental Validation. Journal of nanotechnology in engineering and medicine, 4(1), 101011–1010115. https://doi.org/10.1115/1.4024004
Pearson, R. M., Patra, N., Hsu, H. J., Uddin, S., Král, P., & Hong, S. (2013). Positively Charged Dendron Micelles Display Negligible Cellular Interactions. ACS macro letters, 2(1), 77–81. https://doi.org/10.1021/mz300533w
Huang, W. Y., Davies, G. L., & Davis, J. J. (2013). High signal contrast gating with biomodified Gd doped mesoporous nanoparticles. Chemical communications (Cambridge, England), 49(1), 60–62. https://doi.org/10.1039/c2cc37545a
Xu, S., Olenyuk, B. Z., Okamoto, C. T., & Hamm-Alvarez, S. F. (2013). Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances. Advanced drug delivery reviews, 65(1), 121–138. https://doi.org/10.1016/j.addr.2012.09.041
Ward, B. B., Huang, B., Desai, A., Cheng, X. M., Vartanian, M., Zong, H., Shi, X., Thomas, T. P., Kotlyar, A. E., Van Der Spek, A., Leroueil, P. R., & Baker, J. R., Jr (2013). Sustained analgesia achieved through esterase-activated morphine prodrugs complexed with PAMAM dendrimer. Pharmaceutical research, 30(1), 247–256. https://doi.org/10.1007/s11095-012-0869-3
Thomas, T. P., Joice, M., Sumit, M., Silpe, J. E., Kotlyar, A., Bharathi, S., Kukowska-Latallo, J., Baker, J. R., & Choi, S. K. (2013). Design and in vitro validation of multivalent dendrimer methotrexates as a folate-targeting anticancer therapeutic. Current pharmaceutical design, 19(37), 6594–6605. https://doi.org/10.2174/1381612811319370004
Xu, L., Josan, J. S., Vagner, J., Caplan, M. R., Hruby, V. J., Mash, E. A., Lynch, R. M., Morse, D. L., & Gillies, R. J. (2012). Heterobivalent ligands target cell-surface receptor combinations in vivo. Proceedings of the National Academy of Sciences of the United States of America, 109(52), 21295–21300. https://doi.org/10.1073/pnas.1211762109
Canovi, M., Lucchetti, J., Stravalaci, M., Re, F., Moscatelli, D., Bigini, P., Salmona, M., & Gobbi, M. (2012). Applications of surface plasmon resonance (SPR) for the characterization of nanoparticles developed for biomedical purposes. Sensors (Basel, Switzerland), 12(12), 16420–16432. https://doi.org/10.3390/s121216420
Cheng, Z., Al Zaki, A., Hui, J. Z., Muzykantov, V. R., & Tsourkas, A. (2012). Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities. Science (New York, N.Y.), 338(6109), 903–910. https://doi.org/10.1126/science.1226338
Ren, Y., Hauert, S., Lo, J. H., & Bhatia, S. N. (2012). Identification and characterization of receptor-specific peptides for siRNA delivery. ACS nano, 6(10), 8620–8631. https://doi.org/10.1021/nn301975s
Thomas, T. P., Huang, B., Choi, S. K., Silpe, J. E., Kotlyar, A., Desai, A. M., Zong, H., Gam, J., Joice, M., & Baker, J. R., Jr (2012). Polyvalent dendrimer-methotrexate as a folate receptor-targeted cancer therapeutic. Molecular pharmaceutics, 9(9), 2669–2676. https://doi.org/10.1021/mp3002232
Stravalaci, M., Bastone, A., Beeg, M., Cagnotto, A., Colombo, L., Di Fede, G., Tagliavini, F., Cantù, L., Del Favero, E., Mazzanti, M., Chiesa, R., Salmona, M., Diomede, L., & Gobbi, M. (2012). Specific recognition of biologically active amyloid-β oligomers by a new surface plasmon resonance-based immunoassay and an in vivo assay in Caenorhabditis elegans. The Journal of biological chemistry, 287(33), 27796–27805. https://doi.org/10.1074/jbc.M111.334979
Gu, L., Ruff, L. E., Qin, Z., Corr, M., Hedrick, S. M., & Sailor, M. J. (2012). Multivalent porous silicon nanoparticles enhance the immune activation potency of agonistic CD40 antibody. Advanced materials (Deerfield Beach, Fla.), 24(29), 3981–3987. https://doi.org/10.1002/adma.201200776
Yang, Y., Sunoqrot, S., Stowell, C., Ji, J., Lee, C. W., Kim, J. W., Khan, S. A., & Hong, S. (2012). Effect of size, surface charge, and hydrophobicity of poly(amidoamine) dendrimers on their skin penetration. Biomacromolecules, 13(7), 2154–2162. https://doi.org/10.1021/bm300545b
Mullen, D. G., Desai, A., van Dongen, M. A., Barash, M., Baker, J. R., Jr, & Banaszak Holl, M. M. (2012). Best practices for purification and characterization of PAMAM dendrimer. Macromolecules, 45(12), 5316–5320. https://doi.org/10.1021/ma300485p
Hassouneh, W., Fischer, K., MacEwan, S. R., Branscheid, R., Fu, C. L., Liu, R., Schmidt, M., & Chilkoti, A. (2012). Unexpected multivalent display of proteins by temperature triggered self-assembly of elastin-like polypeptide block copolymers. Biomacromolecules, 13(5), 1598–1605. https://doi.org/10.1021/bm300321n
Sunoqrot, S., Bae, J. W., Pearson, R. M., Shyu, K., Liu, Y., Kim, D. H., & Hong, S. (2012). Temporal control over cellular targeting through hybridization of folate-targeted dendrimers and PEG-PLA nanoparticles. Biomacromolecules, 13(4), 1223–1230. https://doi.org/10.1021/bm300316n
Choi, S. K., Thomas, T. P., Li, M. H., Desai, A., Kotlyar, A., & Baker, J. R., Jr (2012). Photochemical release of methotrexate from folate receptor-targeting PAMAM dendrimer nanoconjugate. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 11(4), 653–660. https://doi.org/10.1039/c2pp05355a
Huang, Y. Y., Sharma, S. K., Dai, T., Chung, H., Yaroslavsky, A., Garcia-Diaz, M., Chang, J., Chiang, L. Y., & Hamblin, M. R. (2012). Can nanotechnology potentiate photodynamic therapy?. Nanotechnology reviews, 1(2), 111–146. https://doi.org/10.1515/ntrev-2011-0005
Witte, A. B., Timmer, C. M., Gam, J. J., Choi, S. K., Banaszak Holl, M. M., Orr, B. G., Baker, J. R., & Sinniah, K. (2012). Biophysical characterization of a riboflavin-conjugated dendrimer platform for targeted drug delivery. Biomacromolecules, 13(2), 507–516. https://doi.org/10.1021/bm201566g
Choi, S. K., Verma, M., Silpe, J., Moody, R. E., Tang, K., Hanson, J. J., & Baker, J. R., Jr (2012). A photochemical approach for controlled drug release in targeted drug delivery. Bioorganic & medicinal chemistry, 20(3), 1281–1290. https://doi.org/10.1016/j.bmc.2011.12.020
Agasti, S. S., Liong, M., Tassa, C., Chung, H. J., Shaw, S. Y., Lee, H., & Weissleder, R. (2012). Supramolecular host-guest interaction for labeling and detection of cellular biomarkers. Angewandte Chemie (International ed. in English), 51(2), 450–454. https://doi.org/10.1002/anie.201105670
Li, M. H., Choi, S. K., Thomas, T. P., Desai, A., Lee, K. H., Kotlyar, A., Banaszak Holl, M. M., & Baker, J. R., Jr (2012). Dendrimer-based multivalent methotrexates as dual acting nanoconjugates for cancer cell targeting. European journal of medicinal chemistry, 47(1), 560–572. https://doi.org/10.1016/j.ejmech.2011.11.027
Muzykantov, V. R., Radhakrishnan, R., & Eckmann, D. M. (2012). Dynamic factors controlling targeting nanocarriers to vascular endothelium. Current drug metabolism, 13(1), 70–81. https://doi.org/10.2174/138920012798356916
Myung, J. H., Gajjar, K. A., Saric, J., Eddington, D. T., & Hong, S. (2011). Dendrimer-mediated multivalent binding for the enhanced capture of tumor cells. Angewandte Chemie (International ed. in English), 50(49), 11769–11772. https://doi.org/10.1002/anie.201105508
Waite, C. L., & Roth, C. M. (2011). Binding and transport of PAMAM-RGD in a tumor spheroid model: the effect of RGD targeting ligand density. Biotechnology and bioengineering, 108(12), 2999–3008. https://doi.org/10.1002/bit.23255
Ullal, A. V., Reiner, T., Yang, K. S., Gorbatov, R., Min, C., Issadore, D., Lee, H., & Weissleder, R. (2011). Nanoparticle-mediated measurement of target-drug binding in cancer cells. ACS nano, 5(11), 9216–9224. https://doi.org/10.1021/nn203450p
Mullen, D. G., & Banaszak Holl, M. M. (2011). Heterogeneous ligand-nanoparticle distributions: a major obstacle to scientific understanding and commercial translation. Accounts of chemical research, 44(11), 1135–1145. https://doi.org/10.1021/ar1001389
Chen, T., Shukoor, M. I., Wang, R., Zhao, Z., Yuan, Q., Bamrungsap, S., Xiong, X., & Tan, W. (2011). Smart multifunctional nanostructure for targeted cancer chemotherapy and magnetic resonance imaging. ACS nano, 5(10), 7866–7873. https://doi.org/10.1021/nn202073m
Bae, J. W., Pearson, R. M., Patra, N., Sunoqrot, S., Vuković, L., Král, P., & Hong, S. (2011). Dendron-mediated self-assembly of highly PEGylated block copolymers: a modular nanocarrier platform. Chemical communications (Cambridge, England), 47(37), 10302–10304. https://doi.org/10.1039/c1cc14331j
Cheng, C. J., & Saltzman, W. M. (2011). Enhanced siRNA delivery into cells by exploiting the synergy between targeting ligands and cell-penetrating peptides. Biomaterials, 32(26), 6194–6203. https://doi.org/10.1016/j.biomaterials.2011.04.053
Singh, A. N., Liu, W., Hao, G., Kumar, A., Gupta, A., Öz, O. K., Hsieh, J. T., & Sun, X. (2011). Multivalent bifunctional chelator scaffolds for gallium-68 based positron emission tomography imaging probe design: signal amplification via multivalency. Bioconjugate chemistry, 22(8), 1650–1662. https://doi.org/10.1021/bc200227d
Swaminathan, T. N., Liu, J., Balakrishnan, U., Ayyaswamy, P. S., Radhakrishnan, R., & Eckmann, D. M. (2011). Dynamic factors controlling carrier anchoring on vascular cells. IUBMB life, 63(8), 640–647. https://doi.org/10.1002/iub.475
Ashley, C. E., Carnes, E. C., Phillips, G. K., Durfee, P. N., Buley, M. D., Lino, C. A., Padilla, D. P., Phillips, B., Carter, M. B., Willman, C. L., Brinker, C. J., Caldeira, J., Chackerian, B., Wharton, W., & Peabody, D. S. (2011). Cell-specific delivery of diverse cargos by bacteriophage MS2 virus-like particles. ACS nano, 5(7), 5729–5745. https://doi.org/10.1021/nn201397z
Liu, J., Agrawal, N. J., Calderon, A., Ayyaswamy, P. S., Eckmann, D. M., & Radhakrishnan, R. (2011). Multivalent binding of nanocarrier to endothelial cells under shear flow. Biophysical journal, 101(2), 319–326. https://doi.org/10.1016/j.bpj.2011.05.063
Martinez-Veracoechea, F. J., & Frenkel, D. (2011). Designing super selectivity in multivalent nano-particle binding. Proceedings of the National Academy of Sciences of the United States of America, 108(27), 10963–10968. https://doi.org/10.1073/pnas.1105351108
Chittasupho, C., Siahaan, T. J., Vines, C. M., & Berkland, C. (2011). Autoimmune therapies targeting costimulation and emerging trends in multivalent therapeutics. Therapeutic delivery, 2(7), 873–889. https://doi.org/10.4155/tde.11.60
Zhang, X., Liu, H., Miao, Z., Kimura, R., Fan, F., & Cheng, Z. (2011). Macrocyclic chelator assembled RGD multimers for tumor targeting. Bioorganic & medicinal chemistry letters, 21(11), 3423–3426. https://doi.org/10.1016/j.bmcl.2011.03.110
Zhang, R., Lu, W., Wen, X., Huang, M., Zhou, M., Liang, D., & Li, C. (2011). Annexin A5-conjugated polymeric micelles for dual SPECT and optical detection of apoptosis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 52(6), 958–964. https://doi.org/10.2967/jnumed.110.083220
Plantinga, A., Witte, A., Li, M. H., Harmon, A., Choi, S. K., Banaszak Holl, M. M., Orr, B. G., Baker, J. R., Jr, & Sinniah, K. (2011). Bioanalytical Screening of Riboflavin Antagonists for Targeted Drug Delivery – A Thermodynamic and Kinetic Study. ACS medicinal chemistry letters, 2(5), 363–367. https://doi.org/10.1021/ml100296z
Mullen, D. G., McNerny, D. Q., Desai, A., Cheng, X. M., Dimaggio, S. C., Kotlyar, A., Zhong, Y., Qin, S., Kelly, C. V., Thomas, T. P., Majoros, I., Orr, B. G., Baker, J. R., & Banaszak Holl, M. M. (2011). Design, synthesis, and biological functionality of a dendrimer-based modular drug delivery platform. Bioconjugate chemistry, 22(4), 679–689. https://doi.org/10.1021/bc100360v
Zhang, Y., Thomas, T. P., Lee, K. H., Li, M., Zong, H., Desai, A. M., Kotlyar, A., Huang, B., Holl, M. M., & Baker, J. R., Jr (2011). Polyvalent saccharide-functionalized generation 3 poly(amidoamine) dendrimer-methotrexate conjugate as a potential anticancer agent. Bioorganic & medicinal chemistry, 19(8), 2557–2564. https://doi.org/10.1016/j.bmc.2011.03.019
Bae, K. H., Chung, H. J., & Park, T. G. (2011). Nanomaterials for cancer therapy and imaging. Molecules and cells, 31(4), 295–302. https://doi.org/10.1007/s10059-011-0051-5
Chittasupho, C., Shannon, L., Siahaan, T. J., Vines, C. M., & Berkland, C. (2011). Nanoparticles targeting dendritic cell surface molecules effectively block T cell conjugation and shift response. ACS nano, 5(3), 1693–1702. https://doi.org/10.1021/nn102159g
Myung, J. H., Gajjar, K. A., Pearson, R. M., Launiere, C. A., Eddington, D. T., & Hong, S. (2011). Direct measurements on CD24-mediated rolling of human breast cancer MCF-7 cells on E-selectin. Analytical chemistry, 83(3), 1078–1083. https://doi.org/10.1021/ac102901e
Ledin, P. A., Friscourt, F., Guo, J., & Boons, G. J. (2011). Convergent assembly and surface modification of multifunctional dendrimers by three consecutive click reactions. Chemistry (Weinheim an der Bergstrasse, Germany), 17(3), 839–846. https://doi.org/10.1002/chem.201002052
Zhang, M., Guo, R., Wang, Y., Cao, X., Shen, M., & Shi, X. (2011). Multifunctional dendrimer/combretastatin A4 inclusion complexes enable in vitro targeted cancer therapy. International journal of nanomedicine, 6, 2337–2349. https://doi.org/10.2147/IJN.S24705
Mansoori, G. A., Brandenburg, K. S., & Shakeri-Zadeh, A. (2010). A comparative study of two folate-conjugated gold nanoparticles for cancer nanotechnology applications. Cancers, 2(4), 1911–1928. https://doi.org/10.3390/cancers2041911
Iqbal, U., Albaghdadi, H., Luo, Y., Arbabi, M., Desvaux, C., Veres, T., Stanimirovic, D., & Abulrob, A. (2010). Molecular imaging of glioblastoma multiforme using anti-insulin-like growth factor-binding protein-7 single-domain antibodies. British journal of cancer, 103(10), 1606–1616. https://doi.org/10.1038/sj.bjc.6605937
Park, S., Kang, S., Veach, A. J., Vedvyas, Y., Zarnegar, R., Kim, J. Y., & Jin, M. M. (2010). Self-assembled nanoplatform for targeted delivery of chemotherapy agents via affinity-regulated molecular interactions. Biomaterials, 31(30), 7766–7775. https://doi.org/10.1016/j.biomaterials.2010.06.038
Poon, Z., Chen, S., Engler, A. C., Lee, H. I., Atas, E., von Maltzahn, G., Bhatia, S. N., & Hammond, P. T. (2010). Ligand-clustered “patchy” nanoparticles for modulated cellular uptake and in vivo tumor targeting. Angewandte Chemie (International ed. in English), 49(40), 7266–7270. https://doi.org/10.1002/anie.201003445
Mullen, D. G., Borgmeier, E. L., Desai, A. M., van Dongen, M. A., Barash, M., Cheng, X. M., Baker, J. R., Jr, & Banaszak Holl, M. M. (2010). Isolation and characterization of dendrimers with precise numbers of functional groups. Chemistry (Weinheim an der Bergstrasse, Germany), 16(35), 10675–10678. https://doi.org/10.1002/chem.201001175
Mullen, D. G., Borgmeier, E. L., Fang, M., McNerny, D. Q., Desai, A., Baker, J. R., Jr, Orr, B. G., & Holl, M. M. (2010). Effect of Mass Transport in the Synthesis of Partially Acetylated Dendrimer: Implications for Functional Ligand-Nanoparticle Distributions. Macromolecules, 43(16), 6577–6587. https://doi.org/10.1021/ma100663c
Krovi, S. A., Smith, D., & Nguyen, S. T. (2010). “Clickable” polymer nanoparticles: a modular scaffold for surface functionalization. Chemical communications (Cambridge, England), 46(29), 5277–5279. https://doi.org/10.1039/c0cc00232a
Liu, Z., & Peng, R. (2010). Inorganic nanomaterials for tumor angiogenesis imaging. European journal of nuclear medicine and molecular imaging, 37 Suppl 1, S147–S163. https://doi.org/10.1007/s00259-010-1452-y
Wang, S., & Dormidontova, E. E. (2010). Nanoparticle design optimization for enhanced targeting: Monte Carlo simulations. Biomacromolecules, 11(7), 1785–1795. https://doi.org/10.1021/bm100248e
Hild, W., Pollinger, K., Caporale, A., Cabrele, C., Keller, M., Pluym, N., Buschauer, A., Rachel, R., Tessmar, J., Breunig, M., & Goepferich, A. (2010). G protein-coupled receptors function as logic gates for nanoparticle binding and cell uptake. Proceedings of the National Academy of Sciences of the United States of America, 107(23), 10667–10672. https://doi.org/10.1073/pnas.0912782107
McNerny, D. Q., Leroueil, P. R., & Baker, J. R. (2010). Understanding specific and nonspecific toxicities: a requirement for the development of dendrimer-based pharmaceuticals. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 2(3), 249–259. https://doi.org/10.1002/wnan.79
Ruoslahti, E., Bhatia, S. N., & Sailor, M. J. (2010). Targeting of drugs and nanoparticles to tumors. The Journal of cell biology, 188(6), 759–768. https://doi.org/10.1083/jcb.200910104
Gunaseelan, S., Gunaseelan, K., Deshmukh, M., Zhang, X., & Sinko, P. J. (2010). Surface modifications of nanocarriers for effective intracellular delivery of anti-HIV drugs. Advanced drug delivery reviews, 62(4-5), 518–531. https://doi.org/10.1016/j.addr.2009.11.021
Zhang, Y., Thomas, T. P., Desai, A., Zong, H., Leroueil, P. R., Majoros, I. J., & Baker, J. R., Jr (2010). Targeted dendrimeric anticancer prodrug: a methotrexate-folic acid-poly(amidoamine) conjugate and a novel, rapid, “one pot” synthetic approach. Bioconjugate chemistry, 21(3), 489–495. https://doi.org/10.1021/bc9003958
Veiseh, O., Gunn, J. W., & Zhang, M. (2010). Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Advanced drug delivery reviews, 62(3), 284–304. https://doi.org/10.1016/j.addr.2009.11.002
Mullen, D. G., Fang, M., Desai, A., Baker, J. R., Orr, B. G., & Banaszak Holl, M. M. (2010). A quantitative assessment of nanoparticle-ligand distributions: implications for targeted drug and imaging delivery in dendrimer conjugates. ACS nano, 4(2), 657–670. https://doi.org/10.1021/nn900999c
Chittasupho, C., Manikwar, P., Krise, J. P., Siahaan, T. J., & Berkland, C. (2010). cIBR effectively targets nanoparticles to LFA-1 on acute lymphoblastic T cells. Molecular pharmaceutics, 7(1), 146–155. https://doi.org/10.1021/mp900185u
Tassa, C., Duffner, J. L., Lewis, T. A., Weissleder, R., Schreiber, S. L., Koehler, A. N., & Shaw, S. Y. (2010). Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles. Bioconjugate chemistry, 21(1), 14–19. https://doi.org/10.1021/bc900438a
Djohari, H., & Dormidontova, E. E. (2009). Kinetics of nanoparticle targeting by dissipative particle dynamics simulations. Biomacromolecules, 10(11), 3089–3097. https://doi.org/10.1021/bm900785c
Shi, X., Wang, S. H., Lee, I., Shen, M., & Baker, J. R., Jr (2009). Comparison of the internalization of targeted dendrimers and dendrimer-entrapped gold nanoparticles into cancer cells. Biopolymers, 91(11), 936–942. https://doi.org/10.1002/bip.21279
Waite, C. L., & Roth, C. M. (2009). PAMAM-RGD conjugates enhance siRNA delivery through a multicellular spheroid model of malignant glioma. Bioconjugate chemistry, 20(10), 1908–1916. https://doi.org/10.1021/bc900228m
McNerny, D. Q., Kukowska-Latallo, J. F., Mullen, D. G., Wallace, J. M., Desai, A. M., Shukla, R., Huang, B., Banaszak Holl, M. M., & Baker, J. R., Jr (2009). RGD dendron bodies; synthetic avidity agents with defined and potentially interchangeable effector sites that can substitute for antibodies. Bioconjugate chemistry, 20(10), 1853–1859. https://doi.org/10.1021/bc900217h
Karathanasis, E., Geigerman, C. M., Parkos, C. A., Chan, L., Bellamkonda, R. V., & Jaye, D. L. (2009). Selective targeting of nanocarriers to neutrophils and monocytes. Annals of biomedical engineering, 37(10), 1984–1992. https://doi.org/10.1007/s10439-009-9702-5
Lee, S. M., Chen, H., O’Halloran, T. V., & Nguyen, S. T. (2009). “Clickable” polymer-caged nanobins as a modular drug delivery platform. Journal of the American Chemical Society, 131(26), 9311–9320. https://doi.org/10.1021/ja9017336
Shi, X., Wang, S. H., Van Antwerp, M. E., Chen, X., & Baker, J. R., Jr (2009). Targeting and detecting cancer cells using spontaneously formed multifunctional dendrimer-stabilized gold nanoparticles. The Analyst, 134(7), 1373–1379. https://doi.org/10.1039/b902199j
Majoros, I. J., Williams, C. R., Becker, A. C., & Baker, J. R., Jr (2009). Surface interaction and behavior of poly(amidoamine) dendrimers: deformability and lipid bilayer disruption. Journal of computational and theoretical nanoscience, 6(7), 1430–1436. https://doi.org/10.1166/jctn.2009.1189
Wu, W., Hsiao, S. C., Carrico, Z. M., & Francis, M. B. (2009). Genome-free viral capsids as multivalent carriers for taxol delivery. Angewandte Chemie (International ed. in English), 48(50), 9493–9497. https://doi.org/10.1002/anie.200902426
Johnson, R. N., Kopecková, P., & Kopecek, J. (2009). Synthesis and evaluation of multivalent branched HPMA copolymer-Fab’ conjugates targeted to the B-cell antigen CD20. Bioconjugate chemistry, 20(1), 129–137. https://doi.org/10.1021/bc800351m
Hagy, M. C., Wang, S., & Dormidontova, E. E. (2008). Optimization of functionalized polymer layers for specific targeting of mobile receptors on cell surfaces. Langmuir : the ACS journal of surfaces and colloids, 24(22), 13037–13047. https://doi.org/10.1021/la801935h
Kelly, C. V., Leroueil, P. R., Orr, B. G., Banaszak Holl, M. M., & Andricioaei, I. (2008). Poly(amidoamine) dendrimers on lipid bilayers II: Effects of bilayer phase and dendrimer termination. The journal of physical chemistry. B, 112(31), 9346–9353. https://doi.org/10.1021/jp8013783
Park, J. H., von Maltzahn, G., Zhang, L., Schwartz, M. P., Ruoslahti, E., Bhatia, S. N., & Sailor, M. J. (2008). Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging. Advanced materials (Deerfield Beach, Fla.), 20(9), 1630–1635. https://doi.org/10.1002/adma.200800004
Heath, J. R., & Davis, M. E. (2008). Nanotechnology and cancer. Annual review of medicine, 59, 251–265. https://doi.org/10.1146/annurev.med.59.061506.185523
Zhang, K., Rossin, R., Hagooly, A., Chen, Z., Welch, M. J., & Wooley, K. L. (2008). Folate-mediated Cell Uptake of Shell-crosslinked Spheres and Cylinders. Journal of polymer science. Part A, Polymer chemistry, 46(22), 7578–7583. https://doi.org/10.1002/pola.23020
Destito, G., Yeh, R., Rae, C. S., Finn, M. G., & Manchester, M. (2007). Folic acid-mediated targeting of cowpea mosaic virus particles to tumor cells. Chemistry & biology, 14(10), 1152–1162. https://doi.org/10.1016/j.chembiol.2007.08.015

Read the full article at: https://www.cell.com/cell-chemical-biology/fulltext/S1074-5521(06)00471-6