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In order to identify and assess sequence markers that support structure and specificity, we have undertaken the study of two enzyme superfamilies, comprising phosphotransferases and phosphoglycosyltransferases, the haloalkanoate dehalogenase superfamily (HADSF) and the phosphoglycosyl transferase superfamily (PGT)
The recent clinical success of IL-17A neutralizing biologics in psoriasis has underlined its importance as a target for drug discovery
Abstract coming soon
Antibiotic resistance is a serious public health crisis. Antibacterial regulatory guidelines have been recently updated to allow for more streamlined development of narrow-spectrum, precision therapies to treat highly problematic, multidrug-resistant bacterial infections
DNA Topoisomerase IIα (TOP2α; 170 kDa) is a prominent target for anticancer drugs whose clinical efficacy is often compromised due to acquired chemoresistance.
We use the Drosophila prothoracic gland (PG) as a model to study tissues with high and dynamic demands in iron and heme.
In the solid state, small molecules such as active pharmaceutical ingredient (API) molecules tend to pack in well defined arrangements leading to different crystalline polymorphs
ncreasingly we seek smarter ways to deliver therapies in a targeted way. Nanoscience can play an important role in this endeavor
Bile acids (BA) are biological surfactants synthesized in the liver and secreted to the duodenum via the gall bladder to help digest dietary fats.
Molecular docking screens large compound libraries for molecules that complement a binding site, but do not resemble known ligands