Pharm Sci Seminar – Jason Tennessen, PhD
The metabolism of proliferating cancer cells not only generates energy, but also synthesizes the biomolecules required for growth.
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The metabolism of proliferating cancer cells not only generates energy, but also synthesizes the biomolecules required for growth.
Nature performs challenging synthetic transformations using powerful enzymes. These enzymes are frequently found in the biosynthetic pathways of natural products
It is now possible to estimate the natural product biosynthetic potential of organisms before attempting to isolate compounds by analysis of their biosynthetic gene clusters.
In order to identify and assess sequence markers that support structure and specificity, we have undertaken the study of two enzyme superfamilies, comprising phosphotransferases and phosphoglycosyltransferases, the haloalkanoate dehalogenase superfamily (HADSF) and the phosphoglycosyl transferase superfamily (PGT)
The recent clinical success of IL-17A neutralizing biologics in psoriasis has underlined its importance as a target for drug discovery
Abstract coming soon
Antibiotic resistance is a serious public health crisis. Antibacterial regulatory guidelines have been recently updated to allow for more streamlined development of narrow-spectrum, precision therapies to treat highly problematic, multidrug-resistant bacterial infections
DNA Topoisomerase IIα (TOP2α; 170 kDa) is a prominent target for anticancer drugs whose clinical efficacy is often compromised due to acquired chemoresistance.
We use the Drosophila prothoracic gland (PG) as a model to study tissues with high and dynamic demands in iron and heme.
In the solid state, small molecules such as active pharmaceutical ingredient (API) molecules tend to pack in well defined arrangements leading to different crystalline polymorphs