Angela Gelli, PhD Professor and Hartwell Investigator Departments of Pharmacology and Medicine College of Biological Sciences University of California, Davis   Targeting Virulence to Promote Development of Evolution-Proof Anti-Invective Drugs […]

Amorphous solid dispersions (ASDs) have been widely used for delivering poorly water soluble pharmaceuticals in recent years

Neuromodulators are signaling molecules that can rapidly broadcast messages to large populations of neurons and exert profound effects on behavior.

Despite the enormous health, social, and economic burdens that psychiatric illnesses have placed on the United States, the rate of entry into clinical trials for central nervous system (CNS) therapeutics is decreasing, as are the rates of success for those CNS compounds that do make it into human trials.

Cyclin D-CDK4/6 are components of the core cell cycle machinery that drives cell proliferation.

Chronic myeloid leukemia, CML, is driven by ABL1 and the introduction of highly effective kinase inhibitors, such as imatinib, has resulted in a 5-year survival rate for CML to approach 90%.

The metabolism of proliferating cancer cells not only generates energy, but also synthesizes the biomolecules required for growth.

Nature performs challenging synthetic transformations using powerful enzymes. These enzymes are frequently found in the biosynthetic pathways of natural products

It is now possible to estimate the natural product biosynthetic potential of organisms before attempting to isolate compounds by analysis of their biosynthetic gene clusters.

In order to identify and assess sequence markers that support structure and specificity, we have undertaken the study of two enzyme superfamilies, comprising phosphotransferases and phosphoglycosyltransferases, the haloalkanoate dehalogenase superfamily (HADSF) and the phosphoglycosyl transferase superfamily (PGT)