Events in December 2024
SunSunday | MonMonday | TueTuesday | WedWednesday | ThuThursday | FriFriday | SatSaturday |
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December 1, 2024
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December 2, 2024(1 event)
– Lab Exam See syllabus for location
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December 3, 2024(1 event)
– Lab Exam See syllabus for location
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December 4, 2024(1 event)
– Lab Exam See syllabus for location
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December 5, 2024(2 events)
– Yaxian Zhou, Pharmaceutical Sciences graduate student (Tang Research Group, will be defending her PhD research thesis: Development and Mechanistic Investigation of Chimeric Molecules for the Degradation of Intra- and Extracellular ProteinsTargeted protein degradation (TPD) has rapidly emerged as a transformative therapeutic modality and a powerful tool for selectively depleting various protein targets. Proteolysis Targeting Chimeras (PROTACs) are the most advanced, with dozens of PROTAC molecules currently in clinical trials. However, traditional PROTAC synthesis methods are stepwise, time-consuming, and unsuitable for high-throughput screening. In this thesis, we introduce Rapid-TAC, a rapid synthesis platform employing a traceless OPA-amine coupling reaction to enables high-throughput synthesis of PROTACs for direct screening without requiring additional purification steps. Using Rapid-TAC platform, we successfully identified PROTACs targeting the androgen receptor (AR) and bromodomain-containing protein 4 (BRD4), demonstrating the feasibility and efficiency of this platform. Complementing PROTACs, Lysosome Targeting Chimeras (LYTACs) expand TPD to include extracellular secreted and membrane-bound proteins. The first LYTACs, which recruit cation independent mannose-6-phosphate receptors (CIM6PR), can induce protein degradation across various tissues due to M6PR’s ubiquitous expression. However, this widespread expression raises concerns about on-target/off-tissue toxicity. Additionally, the complex synthesis and high multivalency required for CIM6PR ligands have hindered their broader application. To address these limitations, we developed structurally well-defined M6Pn-peptide ligands with a simplified synthesis process, demonstrated its ability to mediate internalization of soluble proteins and degradation of membrane proteins. To minimize on-target/off-tissue toxicity, we developed triantennary N-acetylgalactosamine (tri-GalNAc)-attached conjugates that interact with asialoglycoprotein receptor (ASGPR) for selective degradation of target proteins in liver cells. To broaden the scope of TPD for cancer-related targets, we developed two novel platforms: integrin-targeting chimeras (ITACs) and Folate Receptor Targeting Chimeras (FRTACs). These platforms leverage cancer-overexpressing receptors, integrin and folate receptor (FR), respectively, to specifically induce protein degradation in cancer cells. Notably, FRTACs targeting PD-L1 exhibit significant anti-tumor effects by promoting the infiltration of cytotoxic T cells into tumors. Lastly, we explored the potential of developing catalytic degraders using transferrin and its receptor (TfR). This innovative approach demonstrated the feasibility of recycling degraders to enhance 777 Highland Ave
Madison, WI 53705
United States
– Lab Exam See syllabus for location
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December 6, 2024(2 events)
– Lab Exam See syllabus for location
– This event starts at 5 PM on November 18 and ends at 11:55 PM on December 6th, Online
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December 7, 2024
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December 8, 2024
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December 9, 2024
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December 10, 2024(1 event)
– Exam 777 Highland Ave
Madison, WI 53705
United States
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December 11, 2024(1 event)
– Exam 777 Highland Ave
Madison, WI 53705
United States
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December 12, 2024
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December 13, 2024(4 events)
– Final Exam 2002 and 2006 Rennebohm Hall
777 Highland Ave.
Madison, WI 53705
United States
– Final Exam 2002 and 2006 Rennebohm Hall
777 Highland Ave.
Madison, WI 53705
United States
– Final Exam 2002 and 2006 Rennebohm Hall
777 Highland Ave.
Madison, WI 53705
United States
– Final Exam 2002 and 2006 Rennebohm Hall
777 Highland Ave.
Madison, WI 53705
United States
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December 14, 2024
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December 15, 2024
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December 16, 2024(3 events)
– Final Exam 2002 and 2006 Rennebohm Hall
777 Highland Ave.
Madison, WI 53705
United States
– Final Exam 2002 and 2006 Rennebohm Hall
777 Highland Ave.
Madison, WI 53705
United States
– Final Exam 2002 and 2006 Rennebohm Hall
777 Highland Ave.
Madison, WI 53705
United States
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December 17, 2024(6 events)
– Ryan D. Ward, Genetics graduate student (Peters Research Group), will be defending his PhD research thesis: Genetic Determinants of Antibiotic Resistance and Susceptibility in Gram-negative Pathogens777 Highland Ave
Madison, WI 53705
United States
– Final Exam 2002 and 2006 Rennebohm Hall
777 Highland Ave.
Madison, WI 53705
United States
– Final Exam 2002 and 2006 Rennebohm Hall
777 Highland Ave.
Madison, WI 53705
United States
– Final Exam 750 Highland Ave
Madison, WI 53705
United States
– Virtual Event
– Info session link: https://unc.zoom.us/j/95113453209?pwd=owlqKTYsSMLyYVUZWVffyi605bdbAB.1
The University of North Carolina at Chapel Hill Eshelman School of Pharmacy’s Community-Based Residency Program includes a variety of innovative sites across the state of North Carolina in independent, chain, supermarket, college health, ambulatory care, outpatient health-system, and specialty pharmacy settings. Each site is centered around a community pharmacy that focuses on providing medication management, health and wellness services, immunizations, disease state management, and care transition services. We are recruiting for 11 sites (2 of which are looking for their very first resident) for the 2025-2026 year!
To learn more about the Community-Based Pharmacy Residency Program: https://pharmacy.unc.edu/education/residencies/pgy1-community-based-pharmacy-residency/
The University of North Carolina at Chapel Hill Eschelman School of Pharmacy is thrilled to announce the recruitment of its first Community-Based Veterinary Pharmacy Resident. This groundbreaking program, the first in the nation, was created in collaboration with Vet Meds to address a critical gap in veterinary pharmacotherapy. The program is centered around key elements including specialized training in veterinary pharmacotherapy, integration of community-based pharmacy practices, support for rural healthcare needs, and fostering collaboration with veterinary care teams to enhance overall care. To learn more about the Community-Based Veterinary Pharmacy Residency Program: https://pharmacy.unc.edu/education/residencies/community-based-veterinary-pharmacy-residency/
The University of North Carolina at Chapel Hill Eschelman School of Pharmacy also offers a Community-Based Psychiatry Fellowship. This one-year program provides an exceptional opportunity for passionate pharmacists to advance their careers in mental health and community-based pharmacy. To learn more about the Community-Based Psychiatry Fellowship: https://pharmacy.unc.edu/education/fellowships/community-based-psychiatry/ Virtual Event
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December 18, 2024(2 events)
– Final Exam 2002 and 2006 Rennebohm Hall
777 Highland Ave.
Madison, WI 53705
United States
– Final Exam 2002 and 2006 Rennebohm Hall
777 Highland Ave.
Madison, WI 53705
United States
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December 19, 2024(2 events)
– FInal Exam 2002 and 2006 Rennebohm Hall
777 Highland Ave.
Madison, WI 53705
United States
– Final Exam 2002 and 2006 Rennebohm Hall
777 Highland Ave.
Madison, WI 53705
United States
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December 20, 2024(1 event)
December 20, 2024 Block 5 Runs from November 4 to December 20, 2024. Online
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December 21, 2024
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December 22, 2024
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December 23, 2024
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December 24, 2024
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December 25, 2024
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December 26, 2024
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December 27, 2024
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December 28, 2024
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December 29, 2024
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December 30, 2024
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December 31, 2024
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January 1, 2025
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January 2, 2025
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January 3, 2025(1 event)
This events starts on 11/18/24 at 8 AM and ends on 1/3/25 at 12 Noon. Online
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January 4, 2025
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