Skip to main content
University of Wisconsin-Madison

Drug DISCOVERY Specific Seminar – Peng Wu, PhD




Pharmaceutical Sciences Seminar Series

Glycan-centric approaches for cancer immunotherapy

(Drug DISCOVERY Specific Seminar)

  • Peng Wu, PhD
  • Scripps Research Institute

The development of immune checkpoint inhibitors based on anti-CTLA-4, anti-PD-1/PD-L1 has revolutionized cancer treatment. However, more than 50% of cancer patients fail to respond to anti-CTLA-4, anti-PD-1/PD-L1.

In this talk, I will discuss our recent progress in developing glycan-centric approaches for cancer immunotherapy, including FucoID, a proximity-based technique for identifying antigen-specific T cells, and bispecific T cell-engager-sialidase conjugates. I will also discuss how these new approaches can be combined with FDA-approved checkpoint blockade to achieve improved therapeutic efficacy in murine tumor models.

Hosted by Weiping Tang

Friday, March 15, 2024
3:30 PM – 4:30 PM

2006 Rennebohm Hall

Madison, WI 53705

This event is brought to you by: Pharmaceutical Sciences Division