The Medicinal Chemistry Center operates under a hybrid collaborative/fee-for-service model.
Collaborative
For projects involving development of novel small molecules, the Medicinal Chemistry Center will work with the collaborator to meet their project aims. Projects of this nature include:
- Development of small molecule probes (attachment of fluorophore, biotin, clickable tether, etc.)
- Hit-to-lead optimization campaigns from validated screening hits
- Rational drug design program
- SAR analysis
Details on the collaboration including potential cost-sharing plans can be discussed at or after the initial meeting.
We recently received a UW2020 award to establish a targeted protein degradation platform to accelerate translational research at UW–Madison. Please contact the MCC Director for more details.
Fee-for-service
For projects generally short in scope with well defined chemistries, the Medicinal Chemistry Center will work with clients in a fee-for-service model to meet their project aims, including:
- Synthesis of known bioactive small molecules from the literature (not commercially available)
- Scale-up synthesis of bioactive small molecules to support animal studies (up to multi-gram scale)
- Sample analysis (ie. NMR, MS, IR, m.p., optical rotation, HPLC purity)
Project involvement may include:
- Limited Pro-bono consulting
- Fee-based laboratory services
- Consultant/Contractor for grant-based activities
- “Core Laboratory” for grant-based programs
Workflow may include:
- Client inquiry
- Review of screen and other relevant project data
- Preparation of a formal or informal project proposal
- Agreement of project scope
- Project commencement
- Project completion
Grant supported projects should provide the following information:
- PI Name and Title
- Affiliation
- ERA Commons Name
- Project Title
- Project Funding Source
- Intended Project Outcome