Rennebohm Lecture Series

David Kingsley, PhD
Professor of Developmental Biology
HHMI and Stanford University

• Fishing for the Secrets of Vertebrate Evolution
• Applying Evolutionary Principles to Common Traits and Diseases in Humans

H. Robert Horvitz, PhD
David H. Koch Professor of Biology, MIT
Nobel Prize Laureate in Physiology or Medicine, 2002

• Genetic Control of Programmed Cell Death in Animal Development and Human Disease
• Genes, Neurons, Circuits and Behavior: Aspects of C. elegans Nervous System Development and Function

Theo Raynor, PhD, BPharm, FRPharmS
University of Leeds

• From Zero to Hero – Europe’s 30 Year Journey in Consumer Medicines
• ‘To be or Not to Be Taken?’ – Are the Consequences of Patient Empowerment All Good?

Mario Capecchi, PhD
University of Utah

• The Making of a Scientist – An Unlikely Journey
• Gene Targeting Into the 21st Century: Mouse Models of Human Disease from Cancer to Neuropsychiatric Disorders

Bonnie L. Bassler, PhD
Princeton University

• Tiny Conspiracies: Cell-to-Cell Communication in Bacteria
• Manipulating Quorum-Sensing to Control Bacterial Pathogenicity

Jeffrey M. Drazen, MD
Editor-in-Chief, New England Journal of Medicine

• Leukotrienes in Asthma: From Bench to Bedside to Bench to Bedside
• The Cholesterol Lowering Story: Is It Always Good?

William E. Evans, PharmD
Director and Chief Executive Office
St. Jude Children’s Research Hospital

• A 30-year Evolution, from Pharmacokinetics to Pharmacogenomics: Where to Next?
• Pharmacogenomics of Acute Lymphoblastic Leukemia: from Discovery to Clinical Practice

Ahvie Herskowitz, MD
Co-Founder, CEO and Chief Medical Officer
Institute for OneWorld Health

• Bridging Health Inequity – Social Return on Investment
• Advancing Global Health: OneWorld Health’s Vision – Challenges and Opportunities

Judah Folkman, MD
Andrus Professor of Pediatric Surgery & Cell Biology
Harvard Medical School Director
Vascular Biology Program, Children’s Hospital Boston

• Angiogenesis: An Organizing Principle for Drug Discovery?
• Clinical Aplications of Anti-Angiogenic Therapy

Molecular Therapy in the 21st Century – A Symposium Honoring 50 Years of the Rennebohm Lectures
September 21, 2005

Dr. David Mangelsdorf, PhD
Howard Hughes Medical Institute

• The Role of Nuclear Receptors as Sensors of Dietary Lipids
• Oxysterols as Modulators of Nuclear Receptor Signaling

Dr. Jane Henney
Senior Scholar in Residence, Association of Academic Health Centers
Former Commissioner, U.S. Food and Drug Administration

• Developing Medical Products in the Future
• Challenges for the Research Enterprise

Prof. Peter Schultz
Scripps Research Institute and Novartis Research Foundation

• New Opportunities at the Interface of Chemistry and Biology

Dr. Albert Eschenmoser
Swiss Federal Institute of Technology

• Chemical Etiology of Nucleic Acide Structure
• Chemistry of Pentopyranosyl-(2’→4″)-oligonuceotide Systems

Prof. Barry M. Trost
Stanford University

• On Artificial Enzymes: Crafting Chiral Space for Molecular Recognition in a Catalystic Synthetic Reaction

Prof. Christopher T. Walsh
Harvard Medical School

• The Molecular Mechanisms of Bacterial Resistance to the Vancomycin Group of Glycopeptide Antibiotics
• Post-Translational Modifications that Prime the Biosynthesis of Polyketide and Polypeptide Antibiotics

Prof. Henry R. Bourne
University of California – San Francisco

• Diseases Tell Us How Trimeric G-Proteins Work
• Trimeric G-Proteins: Associations with Proteins and Lipid Membranes

Prof. Carl Djerassi
Stanford University

• The Pill at Forty-one: What Now?

Prof. Stephen J. Bencovic
Pennsylvania State University

• How Reverse Transcriptase Transcribes
• Catalytic Antibodies

Prof. Jeremy R. Knowles
Harvard University

• An Enzymatic Pericyclic Reaction: The Pursuit of Mechanism
• Enzyme Catalysis: What do We Understand?

Prof. Phillip A. Sharp
Massachusetts Institute of Technology

• Mechanisms of Transcription and REgulation of Eukaryotes
• Protein-RNA Recognition in Regulation of Gene Expression

Dr. Richard A. Lerner
Research Institutes of the Scripps Clinic

• Catalytic Antibidies – I
• Catalytic Antibodies – II

Dr. Ira Pastan
National Cancer Institute

• Oncotoxins: Genetically Engineered Toxins for Cancer Treatment
• The Role of the Human Multidrug Resistance Gene in Chemotherapy

Prof. Leroy E. Hood
California Institute of Technology

• Immunity and the Immunoglobulin Gene Super Family
• Biotechnology and Medicine of the Future

Dr. Max F. Perutz
MRC Laboratory of Molecular Biology

• Protein Crystallography and New Drug Design
• The Impact of Science on Society: Would We Be Better Off Without Research?

Dr. Ronald Breslow
Columbia University

• Approaches to Artificial Enzymes
• Imitating the Selectivity of Biochemical Reactions

Dr. Leslie L. Iverson,
Merck Sharp & Dohme Ltd.

• Neurobiology and Neuropharmacology of Alzheimer’s Disease
• Substance P and Other Brain Peptides: Basis of a New Psychopharmacology?

Dr. Elwood V. Jensen
Ludwig Institute for Cancer Research
Zurich, Switzerland

• Estrogen Receptor Interaction in Target Cells
• Hormone Dependency of Breast Cancer

Dr. Alan R. Battersby
Cambridge University

• Biosynthesis of the Pigments of Life: Heme
• Biosynthesis of the Pigments of Life: Vitamin B12

Dr. K. Nakanishi
Columbia University

• Recent Studies on Visual Pigments and Bacteriorhodopsin
• Additivity Relation in the Exciton Chirality Method: Application in Structure Determination of Oligosaccharides and Other Cases

Dr. James Black
The Wellcome Foundation
Beckenham, England

• Prospecting for New Drugs
• Pharmacological Analysis of the Neurochemical Control of Gastric Secretion

Dr. John R. Vane
The Wellcome Foundation
Beckenham, England

• Prostacyclin, Platelets and Vascular Disease

Prof. Andrew Schally
Tulane University

• Hypothalamic Regulation of the Pituitary Gland with Major Emphasis on Its Implications for the Control of the Productive Processes
• Present Status of Hypothalamic Regulatory Hormones Especially Somatostatin: Basic and Clinical Studies

Prof. Solomon H. Snyder
Johns Hopkins University

• The Opiate Receptor and Its Neurotransmitter Peptides
• Schizophrenia, Antipsychotic Drugs and the Dopamine Receptor

Prof. Barnard R. Belleau,
McGill University

• Medicinal Chemistry of the Opiate Receptor: Recent Advances
• Medicinal Chemistry of Neurotransmitter Receptors: Translation of Recognition Effects by Active Sites: Model Studies

Prof. Vladimir Prelog
Swiss Federal Institute
Zurich, Switzerland

• Chirality, the Geometrical Basis of Stereochemistry
• Boromycin, Structure and Properties
• Chiral Concave Molecules

Prof. Hans Selye
University of Montreal

• Stress Without Distress
• Creativity in Research

Dr. Julius Axelrod
National Institutes of Health

• Regulation of the Adrenergic Neurotransmitter
• The Use of Drugs in Biomedical Research

Prof. Walter J. Kauzmann
Princeton University

• Chemical and Biological Effects of Pressure
  I. Fundamental Principles
  II. Some Applications

Prof. James F. Danielli
State University of New York at Buffalo

• Theory and Hypotheses in Development of Concept of the Plasma Membrane
• Artificial Synthesis of Living Cells

Prof. Daniel E. Koshland
University of California

• A Molecular Model for Enzyme Regulation
• Peptide-Peptide Interactions

Prof. Henry Eyring
University of Utah

• Structure of Water and Ionic Solution
• Optical Rotatory Dispersion and Circular Dichroism
• Transport Through Membranes

Prof. Jerrold Meinwald
Cornell University

• Chemistry of Insect Attractants and Repellents

Prof. E. P. Abraham
University of Oxford
Penicillins and Cephalosporins: Their Chemistry in Relation to Biological Activity

Dr. Karl Heusler
Woodward Research Institute, Basle, Switzerland
Advances in Total Synthesis of Lactam Antibiotics

Prof. Klaus Hofmann
University of Pittsburgh
The Partial Synthesis of Active Enzymes

Prof. Myron L. Bender
Northwestern University

• Organic Models of Enzymatic Catalysis
• Mechanisms of Chymotrypsin Catalysis

Dr. Karl J. Brunings
Geigy Chemical Corp

• Medicinal Research: A Field of Common Interest for the Universities, Industry, and Government
• Drugs Affecting Endogenous Amines
• Anti-Inflammatory Agents

Prof. I. M. Kolthoff
University of Minnesota

• The Development of Analytical Chemistry
• Induced Reactions

Prof. Karol Mysels
University of Southern California

• The Evolution and Properties of Thick Soap Films
• Equilibrium Soap Films and Intermolecular Forces

Prof. W. B. Whalley
University of London

• The Constitution of Some Non-Alkaloidal Constituents of Ergot
• The Sclerotiorin Group of Pigments: Their Chemistry and Biosynthesis

Dr. Max Tishler
Merck Sharp and Dohme Research Laboratories
Perspectives in Pharmaceutical Chemistry

Prof. Odin W. Anderson
University of Chicago
The Health Service Establishment Today

Prof. Alfred Burger
University of Virginia

• Medicinal Chemistry: Its Problems and Hopes
• Nonhydrazine Inhibitors of Monoamine Oxidase

Dr. Robert P. Fischelis
American Pharmaceutical Association

• Pharmacy and Medical Care
• Pharmacy and the Pharmaceutical Industry
• Pharmacy and the Public

Prof. Ewart A. Swinyard
University of Utah

• Drugs: From Animals to Man
• Experimental Seizures and Research

Dr. Emil Schlitter
CIBA Pharmaceutical Products, Inc.

• The Drug Industry and Its Research Problems
• The Importance of Research in the Drug Industry
• Projects for the Drug Industry

Dr. Thomas J. Carney
Eli Lilly and Company

• Major Problems in medicinal Chemical Research
• Natural Products in Medicinal Chemistry

Prof. A. H. Beckett
Chelsea College of Science and Technology

• Synthetic Analgesics: Stereochemical Considerations
• Attempts to design Drugs Posessing (a) Analgesic Activity and (b) Antibacterial Activity

Dr. Sidney Siggia
General Aniline and Film Corp.

• Modern Analytical Chemistry
• Organic Functional Group Analysis by Chemical Means

Prof. Lyman C. Craig
Rockefeller Institute

• Application of Extraction to Studies of Naturally Occurring Substances
• Chemical Structure of Some Naturally Occurring Polypeptides