Louis W. Busse Lecture Series

Past Busse Lectures

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Feb 16, 2024: Kam W. Leong, PhD

Kam W. Leong, PhD
Professor, Dept. of Biomedical Engineering
Columbia University

  • Targeting Nucleic Acids to Combat Inflammation: A New Therapeutic Strategy

April 28, 2023: Samir Mitragotri, PhD

Samir Mitragotri, PhD
Professor and Chair, Dept. of Biomedical Engineering
Harvard University

  • A Hitchhiker’s and Backpacker’s Perspective on Drug Delivery

April 8, 2022: Aliasger K. Salem, PhD, FAAPS, FAIMBE

Aliasger K. Salem, PhD, FAAPS, FAIMBE
Professor, Dept. of Pharmaceutical Sciences
University of Iowa College of Pharmacy

  • Biodegradable Particles for Vaccine Delivery

April 8-9, 2021: James R. Baker, Jr., MD

James R. Baker, Jr., MD
Professor Emeritus
Dept. of Internal Medicine and Dept. of Biomedical Engineering
University of Michigan

  • Polymer Targeted Therapeutics: Learning from Our Failures
  • Manipulating the Immune System for Therapeutic Benefit

March 28-29, 2019: Dale Wurster, PhD

Dale Wurster, PhD
Professor, Department of Pharmaceutical Sciences and Experimental
University of Iowa College of Pharmacy

  • Determination of Adsorption Site Specificity – Activated Carbon as a Model
  • Compression Calorimetry

May 4, 2018: Dr. Simon J.L. Billinge

Dr. Simon J.L. Billinge
Professor of Materials Science and of Applied Mathematics
Columbia University
Physicist, Brookhaven National Laboratory

  • Amorphous or nanocrystalline? Advances in total scattering pair distribution function methods for characterizing amorphous and nanocrystalline pharmaceuticals
  • Finding atoms at the nanoscale for more controlled drug delivery

Sept 14-15, 2017: Dr. Allen S. Hoffman

Dr. Allen S. Hoffman
Professor Emeritus
Department of Bioengineering
University of Washington, Seattle

  • Update on PEG and PEGylation
  • History of Biomaterials & Medical Devices

Apr 8, 2016: Dr. Mauro Ferrari, PhD

Dr. Mauro Ferrari, PhD
President and CEO, Houston Methodist Research Institute
Director, Institute for Academic Medicine, Houston Methodist Hospital System
Senior Associate Dean & Professor of Medicine, Weill Cornell Medical College

  • Nanomedicine 101 & 102
  • Transport Oncophysics

Apr 30 – May 1, 2015: Dr. Kazunori Kataoka

Dr. Kazunori Kataoka
Professor of Biomaterials, Graduate School of Engineering
University of Tokyo

  • Nanotechnology to Develop “the Magic Bullet” for Targeted Cancer Therapy
  • Targeted Chemo- and Molecular-Therapy by self-Asssembled Supramolecular Smart (SSS) Nanosystems from Funcitonalized Block Copolymers

Dec 12-13, 2013: Dr. Leslie Z. Benet

Dr. Leslie Z. Benet
Professor, Department of Bioengineering & Therapeutic Sciences
Schools of Pharmacy & Medicine – UC-San Francisco

  • Transporters, Enzymes and Transporter-Enzyme Interplay in Predicting Drug Absorption and Disposition
  • A Unifying PK/PD Relationship to Predict Drug Dosing REgimens for NMEs, Validate clinical Biomarkers as Qualified Surrogates and Serve as a Quality PK/PD Model Metric

May 9-10, 2013: Dr. Gordon L. Amidon

Dr. Gordon L. Amidon
Charles R. Walgreen, Jr., Professor of Pharmacy
Professor of Pharmaceutical Sciences
College of Pharmacy, University of Michigan

  • A Century of Conflation, Confusion and Global Warming: Biopharmaceutical Product Standards
  • Improving the Oral Absorption of BCS Class III and IV Drugs

Dec 1-2, 2011: Dr. Donald A. Tomalia

Dr. Donald A. Tomalia
CEO and Founder NanoSynthons, LLC
National Dendrimer & Nanotechnology Center, Mount Pleasant, Michigan

  • Dendrimer-based Drug Delivery, Imaging and nanopharmaceuticals
  • Dentron/Dendrimers: Windo to a New Systematic Framework for Unifying Neuroscience

Oct 7-8, 2010: Dr. James M. Anderson

Dr. James M. Anderson
Department of Pathology
Case Western Reserve University

  • Inflammatory Cell Interactions and the Foreign Body Reaction with Surface-Modified Biomaterials
  • Biomaterial Biocompatibility and Biological Design Criteria: Issues and Perspectives

Oct 22-23, 2009: Dr. Valentino J. Stella

Dr. Valentino J. Stella
Distinguished Professor of Pharmaceutical Chemistry
University of Kansas

  • A Case for Prodrugs
  • Drug Release of a Poorly Water Soluble Drug from Microporous Pump Tablets and Pellets with (SBE)TM-β-CD as Both a Soubizer and Osmoagent?

Nov 13-14, 2008: Dr. Kinam Park

Dr. Kinam Park
Showalter Distinguished Professor of Pharmaceutics
Purdue University

  • Drug Delivery Systems: Macro Issues of Nano/Micro Formulations
  • Drug-eluding Stents: What Now?

Nov 8-9, 2007: Dr. Ronald T. Borchardt

Dr. Ronald T. Borchardt
Solon E. Summerfield Distinguished Professor of Pharmaceutical Chemistry
The University of Kansas

  • Drug Design with Biopharmaceutics in Mind: A Paradigm Shift in Drug Discovery
  • The Challenges of Designing Cyclic Prodrugs of Opioid Peptides that Permeate the Intestinal Mucosa and the Blood-Brain Barrier

Nov 30-Dec 1, 2006: Dr. Allan S. Myerson

Dr. Allan S. Myerson
Philip Danforth Amour Professor of Engineering
Provost & Senior Vice President, Illinois Institute of Technology

  • Crystallization Process Development in the Pharmaceutical Industry
  • Nucleation Mechanism and Its Role in the Polymorphic Outcome of Solution Crystallization

May 18-19, 2006: Dr. Jindrich “Henry” Kopecek

Dr. Jindrich “Henry” Kopecek
Distinguished Professor of Bioengineering
Distinguished Professor of Pharmaceutics & Pharmaceutical Chemistry, Department of Bioengineering
University of Utah

  • Water-soluble Polymers for Cancer Therapy: Concept, Clinical Applications, and Future Directions
  • Self-assembly of Graft and Block Copolymers into Stimuli-sensitive Hydrogels

Apr 7-8, 2005: Dr. Stephen R. Byrn

Dr. Stephen R. Byrn
Charles B. Jordan Professor of Medicinal Chemistry
Purdue University

  • Solid State Pharmaceutical Chemistry
  • The Regulated Pharmaceutical Industry in 2010

Apr 8-9, 2004: Dr. Arthur J. Coury

Dr. Arthur J. Coury
Vice President of Biomaterials Research
Genzyme Corp

  • Sustained Drug Delivery: Advanced Systems, Growing Therapeutic Applications
  • A Biomaterials Career Regrospective: 1976-2004

Oct 17-18, 2002: Prof. C. Russell Middaugh

Prof. C. Russell Middaugh
Aya & Takeru Higuchi Distinguished Professor of Pharmaceutical Chemistry
Department of Pharmaceutical Chemistry
University of Kansas

  • Stabilizing Vaccines for the Developing World
  • The Polyanion World Hypothesis

Oct 10-11, 2001: Dr. Arthur R. Mlodozeniec

Dr. Arthur R. Mlodozeniec
Principal Scientist, TechniPharm Consulting Group
Menlo Park, CA

  • The Formulation and Pharmaceutical Develpoment of Haloperoxidase Enzymes as Hybrid Products for Microbicidal Activity – Physical and Analytical Chemistry and Pharmaceutics
  • Microbicidal Activity and Topical Drug Delivery for Vaginal Microbicides and Surgical & Combat Wounds – Pharmaceutical Control and Stability

Sept 23, 24, 1999: Dr. James L. Wright

Dr. James L. Wright
Vice President of Pharmaceutical Development
Alkermes Inc., Cambridge, MA

  • Using Injectable Drug Delivery Systems to Iimprove the Treatment of Patients
  • The Effect of Protein Particle Size on Drug Delivery

May 6-7, 1998: Dr. Sung Wan Kim

Dr. Sung Wan Kim
Professor of Pharmaceutics
Director of the Center for Chemical Delivery Systems
University of Utah

  • Novel Polymers for the Delivery of Macromolecular Drugs and Cells
  • New Polymeric Gene Carriers

Feb 5-7. 1997: Dr. Douwe D. Breimer

Dr. Douwe D. Breimer
Professor of Pharmacology & Therapeutics, Leiden University, Netherlands
Director of Research, The Leiden/Amsterdam Center for Drug Research

  • Drug Transport across the Blood-Brain Barrier
  • Pharmacodynamics of Rate and Time Control in Drug Delivery

Feb 7-8, 1996: Dr. Joseph D. Andrade, Jr.

Dr. Joseph D. Andrade, Jr.
Professor
Department of Bioengineering, Materials Science, & Engineering and Department of Pharmaceutics
College of Pharmacy, University of Utah

  • Direct Reading Biosensors: Analytical Chemistry without Instruments
  • Scientists and the Public Understanding of Science

May 3-4, 1994: Dr. William J. Curatolo

Dr. William J. Curatolo
Manager, Oral Druge Delivery and Controlled Release Groups
Pfizer Central Research Division

  • Intestinal Permeability Enhancement for Poorly Permeable Drugs: Efficacy and Toxicity
  • Oral Bioavailability Improvement Strategies for Tripeptide Renin Inhibitors

Apr 19, 1993: Dr. Lewis J. Leeson

Dr. Lewis J. Leeson
Distinguished Research Fellow
CIBA-GEIGY Pharmaceuticals

  • Generic Substitution in New Jersey – A New Jersey Drug Utilization Rreview Council Report
  • A Bit of Physical Pharmacy Nostalgia – The Ionization of Tetracyclines

Oct 23-24, 1991: Dr. Elizabeth B. Vadas

Dr. Elizabeth B. Vadas
Director, Pharmaceutical Research & Development
Merck-Frosst Center for Therapeutic Research

  • The Development of a New Therapeutic Entity: The Search for New Therapies in Respiratory Disease
  • Formulation Development and Bioanalytical Evaluation of MK-886, an Orally Active Leukotriene Biosynthesis Inhibitor

Apr 15-16, 1991: Dr. Robert Langer

Dr. Robert Langer
Kenneth J. Germeshausen Professor of Chemical and Biochemical Engineering
Massachusetts Institute of Technology

  • Immobilized Enzyme Bioreactors for Removal of Heparin, Bilirubin, and cholesterol
  • Novel Polymeric Delivery Systems for Drugs and Mammalian Cells

Nov 28-29, 1989: Dr. Felix Franks

Dr. Felix Franks
Director of the Biopreservation Division
Pafra Ltd.

  • Cold Resistance in Living Organisms: What Can We Learn from Nature?
  • The In Vitro Stabilization of Proteins: Science, Engineering, Legislation and Economics

Apr 5-6, 1988: Dr. Russell O. Potts

Dr. Russell O. Potts
Manager of the Dermally Applied Drugs (DAD) Group
Pfizer Central Research

  • Statum Corneum Lipids and Skinn Barrier Function: In Vitro and In Vivo Effects
  • Can Epidermal Metabolism Affect Topical Drug Delivery?

Apr 28-29, 1987: Dr. Richard E. Jones

Dr. Richard E. Jones
Director of Pharmaceutical Research and Development
Genentech, Inc.

  • Design and Development of Protein Pharmaceuticals
  • Preformulation Characterization of Recombinant Tissue-Type Plasminogen Activator (rt-PA)

Apr 22-23, 1986: Dr. Francis C. Szoka, Jr.

Dr. Francis C. Szoka, Jr.
Associate Professor of Pharmacy and Pharmaceutical Chemistry
School of Pharmacy, UC-San Francisco

  • The Role of Bilayer Contact in Membrane Destabilization: Applications to Drug Delivery from pH Sensitive Liposomes
  • The Magic Bullet Revisted – Targeting of Drugs Using Drug Carriers

Apr 22-23, 1985: Dr. Takeru Higuchi

Dr. Takeru Higuchi
University Regents Professor
School of Pharmacy, University of Kansas

  • Drug Absorption Across the Skin
  • Solubility of Organic Compounds

May 3-4, 1984: Dr. William R. Good

Dr. William R. Good
Director, Basic Pharmaceutics Research, Pharmaceuticals Division
CIBA-GEIGY Corporation

  • Pharmaceutics – An Interdisciplinary Discipline
  • Transdermal Drug Delivery – Opportunities in Endocrinology

Feb 21-22, 1983: Dr. Michael J. Pikal

Dr. Michael J. Pikal
Research Scientist, Lilly Research Laboratories
Division of Eli Lilly and Company

  • Industrial Pharmaceutical Research: Scientific Solutions to Practical Problems
  • Heat and Mass Transfer in the Freeze Drying of Pharmaceuticals

Nov 12-13, 1981: Dr. Felix Theeuwes

Dr. Felix Theeuwes
Vice President, Product Research and Development
Alza Corporation

  • The Development of Osmotic Pumps
  • Osmotic Pumps as Rate Specified Dosage Forms

Nov 3-5, 1980: Dr. K. C. Kwan

Dr. K. C. Kwan
Senior Director, Merck Dohme Research Laboratories

  • Physiological Disposition of Sulindac
  • Drug Interaction as a Pharmacokinetic Tool
  • Methods and Assumptions in Bioavailability Evaluation

Oct 1-3, 1979: Dr. Everett N. Hiestand

Dr. Everett N. Hiestand
Senior Scientist
The Upjohn Company

  • Material Properties That Influence Tableting
  • Time Dependent Properties in Tableting
  • Applications of Powder Flow and Compaction Theory to Tablet Machines