Research

We are interested in developing novel small molecules for treating human diseases and facilitating the study of cell biology. Students and postdocs will generally receive training in one or two of the following three areas.

Organic Synthesis:
We are interested in developing novel reactions for the synthesis of carbo- and heterocycles that are present in diverse bioactive polycyclic natural products and pharmaceutical agents. Currently, we are working on developing new methods for the synthesis of various heterocycles. We are also trying to advance glycoscience by streamlining the synthesis of oligosaccharides through the development of novel technologies.

Medicinal Chemistry:
We are interested in optimizing the pharmacological properties of small molecules such as potency, selectivity, stability, and solubility for treating various human diseases. By collaborating with biologists in pharmaceutical companies and UW-Madison, we are currently developing novel compounds for the treatment of hyperlipidemia, diabetes, autoimmune diseases, cancers, and infectious diseases.

Chemical Biology:
We are interested in dissecting the complex biological pathways by novel small molecule probes. We are currently developing small molecules that can selectively modulate protein stability and epigenetic markers. For example, we have developed small molecules that can selectively degrade PCSK9 proteins, which may have the potential for treating hyperlipidemia. We have also developed small molecules that can selectively degrade estrogen receptor-alpha, which may have the potential for treating certain types of breast cancers.