School of Pharmacy UNIVERSITY OF WISCONSIN - MADISON Research Organic Synthesis: We are interested in developing novel reactions for the synthesis of carbo- and heterocycles that are present in diverse bioactive polycyclic natural products and pharmaceutical agents. Currently, we are interesting in advancing glycoscience by streamlining the synthesis of carbohydrates through the development of novel technologies. We are also developing new methods for the synthesis of various heterocycles. Medicinal Chemistry: We are interested in optimizing the pharmacological properties of small molecules such as potency, selectivity, stability, and solubility for treating various human diseases. Currently, we are interested in developing small molecules that can selectively remove disease-causing proteins. These small molecules can be used as probes to knock out proteins and therapeutics to treat human diseases. Assay Development: We develop a variety of different cell-based and biochemical assays to evaluate the pharmacological properties of small molecules such as potency, selectivity, stability, and solubility. Chemical Biology: We are interested in dissecting the complex biological pathways by novel small molecule probes. We are currently developing small molecules that can selectively modulate protein stability and epigenetic markers. For example, we have developed small molecules that can selectively downregulate PCSK9 proteins, which may have the potential for treating hyperlipidemia. We have also developed small molecules that can selectively degrade estrogen receptors, which may have the potential for treating certain types of breast cancers.