Publications

75. “Addressing the Challenge of Carbohydrate Site Selectivity by Synergistic Catalysis.”
  Blaszczyk, S. A. and Tang W.* Chem  2017, 3, 722–723. link.

74. “Isoquinoline-1-carboxylate as a Traceless Leaving Group for Chelation-Assisted Glycosylation under Mild Neutral Conditions.”
Wang, H.-Y.; Simmons, C. J.; Blaszczyk, S. A.; Balzer, P. G.; Luo, R.; Duan, X.; and Tang W.* Angew. Chem. Int. Ed.  2017, in press. link.

Thumbnail image of graphical abstract

73. “Harnessing the Reactivity of Iridium Hydrides by Air: Iridium- Catalyzed Oxidation of Aldehydes to Acids in Water.”
Yang, Z.; Luo, R.; Zhu, Z.; Yang, X.; and Tang W.* Organometallics. 2017, in press, 7490-7504. link.

Abstract Image

72. “Transition metal mediated carbonylative benzannulations.”
Song, W.; Blaszczyk, S. A.; Liu, J.; Wang, S.;* and Tang W.* Org. Biomol. Chem. 2017, 15, 7490-7504. link.

71. “Iridium-catalyzed highly efficient chemoselective reduction of aldehydes in water using formic acid as the hydrogen source.”
Yang, Z.;  Zhu, Z.; Luo, R.; Qiu, X.; Liu, J.-L.; Yang, J.-K.; and Tang W.* Green Chem. 2017, 19, 3296-3301. link.

Graphical abstract: Iridium-catalyzed highly efficient chemoselective reduction of aldehydes in water using formic acid as the hydrogen source

70. “De novo Synthesis of Mono- and Oligosaccharides via Dihydropyran Intermediates.”
Song, W.; Wang, S.* and Tang, W.* Chem. Asian J.  2017, 12, 1027-1042. link.

69. “Catalytic Site-Selective Acylation of Carbohydrates Directed by Cation–n Interaction.”
Xiao, G.; Cintron-Rosado, G. A.; Glazier, D. A.; Xi, B.-m.; Liu, C.; Liu, P.* and Tang, W.* J. Am. Chem. Soc. 2017, 139, 4346-4349. link.

Abstract Image

68. “Neuroendocrine Tumor-Targeted Upconversion Nanoparticle-Based Micelles for Simultaneous NIR-Controlled Combination Chemotherapy and Photodynamic Therapy, and Fluorescence Imaging.”
Chen, G.; Jaskula-Sztul, R.; Esquibel, C. R.; Lou, I.; Zheng, Q.; Dammalapati, A.; Harrison, A.; Eliceiri, K. W.; Tang, W.; Chen, H.;* Gong, S.* Adv. Funct. Mater. 2017, 27, 1604671. link.

67. “Chiral Catalyst-Directed Dynamic Kinetic Diastereoselective Acylation of Anomeric Hydroxyl Groups and a Controlled Reduction of the Glycosyl Ester Products.”
Wang, H.-Y.; Simmons, C. J.; Zhang, Y.; Smits, A. M.; Balzer, P. G.; Wang, S.;* and Tang, W.* Org. Lett. 2017, 19, 508-511. link.

Abstract Image

66. “Synthesis of Highly Substituted Benzofuran-containing Natural Products via Rh-catalyzed Carbonylative Benzannulation.”
Liu, J.-t.; Simmons, C. J.; Xie, H.; Yang, F.; Zhao, X-l.;* Tang, Y.;* and Tang, W.* Adv. Syn. Catal. 2017, 359, 693-697. link. Highlight in Synfacts, 2017, 13(05): 0478 (DOI: 10.1055/s-0036-1590363).

Link to full-size graphical abstract

65. “Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma.”
Hideshima, T.; Qi, J.; Paranal, R. M.; Tang, W.;  Greenberg, E.; West, N.; Colling, M. E.; Estiu, G.; Mazitschek, R.; Perry, J. A.; Ohguchi, H.; Cottini, F.; Mimura, N.; Görgün, G.; Tai, Y.-T.;  Richardson, P. G.; Carrasco, R. D.; Wiest, O.; Schreiber, S. L.; Anderson, K. C.;* Bradner, J. E.* Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 13162-13167. link.

64. “Author Profile ” Tang, W. Angew. Chem. Int. Ed. 2016, 55, 12412. . link.

63. “Total Synthesis of Diptoindonesin G and Its Analogues as Selective Modulators of Estrogen Receptors.”
Liu, J.-t.; Do, T. J.; Simmons, C. J.; Lynch, J. C.; Gu, W.; Ma, Z.-X.; Xu, W.; and Tang, W.* Org. Biomol. Chem. 2016, 14,  8927-8930. link.

Graphical abstract: Total synthesis of diptoindonesin G and its analogues as selective modulators of estrogen receptors

62. “Rhodium(I)-Catalyzed Benzannulation of Heteroaryl Propargylic Esters: Synthesis of Indoles and Related Heterocycles.”
Li, X.; Xie, H.; Fu, X.; Liu, J.-t.; Wang, H.-y.; Xi, B.-m.;* Liu, P.;* Xu, X.;* and Tang, W.* Chem. Eur. J. 2016, 22, 10410-10414. link.

Link to full-size graphical abstract

61.  “Rhodium-catalyzed [5+2] Cycloaddition of 3-Acyloxy-1,4-enyne and Alkene or Allene.”
Song, W.; Lynch, J. C.; Shu, X.-z.; and Tang, W.* Adv. Syn. Catal. 2016, 358, 2007-2011. link.

Link to full-size graphical abstract

  1. “Rhodium-Catalyzed [5+2] Cycloaddition of Inverted 3-Acyloxy-1,4-enyne and Alkyne: Experimental and Theoretical Studies.”
    Li, X.; Song, W.; Zhao, X.-l.; Ke, X.; Xu, X.;* Liu, P.; Houk, K. N. and Tang, W.* Chem. Eur. J. 2016, 22, 7079-7083. link.
    chem201601195-toc-0001-m
  2. “Design and Synthesis of a New Generation of Substituted Purine Hydroxamate Analogs as Histone Deacetylase Inhibitors.”
    Liu, R.; Wang, J.; Tang, W.; Fang, H.* Bioorg. Med. Chem. 2016, 24, 1446-1454. link.
  3. “Synthesis of Carbazoles and Carbazole-Containing Heterocycles via Rhodium-Catalyzed Tandem Carbonylative Benzannulations.”
    Song, W.; Li, X.; Yang, K.; Zhao, X.-l.; Glazier, D. A.; Xi, B.-m.;* Tang, W.* J. Org. Chem. 2016, 81, 2930–2942. link.
    jo-2016-00212g_0019
  4. “Mechanism and reactivity of rhodium-catalyzed intermolecular [5+1] cycloaddition of 3-acyloxy-1,4-enyne (ACE) and CO: A computational study.”
    Ke, X.-N.; Schienebeck, C. M.; Zhou, C.-C.; Xu, X.-F.;* Tang, W.* Chin. Chem. Lett. 2015, 26, 730-734. link.
  5. “Chiral Catalyst-Directed Dynamic Kinetic Diastereoselective Acylation of Lactols for De Novo Synthesis of Carbohydrate.”
    Wang, H.-Y.; Yang, K.; Yin, D.; Liu, C.; Glazier, D. A.; Tang, W.* Org. Lett. 2015, 17, 5272-5275. link.
    c
  6. “Divergent De Novo Synthesis of All Eight Stereoisomers of 2,3,6-Trideoxyhexopyranosides and Their Oligomers.”
    Song, W.; Zhao, Y.;* Lynch, J. C.; Kim, H.; Tang, W.* Chem Commun. 2015, 51, 17475-17478. link.
  7. “Rhodium-Catalyzed Stereoselective Intramolecular [5 + 2] Cycloaddition of 3-Acyloxy 1,4-Enyne and Alkene.”
    Shu, X.-Z.; Schienebeck, C. M.; Li, X.; Zhou, X.; Song, W.; Chen, L.; Guzei, I. A.; Tang, W.* Org. Lett. 2015, 17, 5128-5131. link.
  8. “Divergent Reactivity of Rhodium(I) Carbenes Derived from Indole Annulations.”
    Li, X.; Li, H.; Song, W.; Tseng, P.-S.; Liu, L.-Y.*; Guzei, I. A.; Tang, W.* Angew. Chem. Int. Ed. 2015, 54, 12905-12908. link.
  9. “Design, synthesis and preliminary bioactivity evaluations of substituted quinoline hydroxamic acid derivatives as novel histone deacetylase (HDAC) inhibitors.”
    Wang, L.; Hou, X.; Fu, H.; Pan, X.; Xu, W.; Tang, W.; Fang, H.* Bioorg. Med. Chem. 2015, 23, 4364-4374. link.
  10. “Iridium-Catalyzed Dynamic Kinetic Isomerization: Expedient Synthesis of Carbohydrates from Achmatowicz Rearrangement Products.”
    Wang, H.-Y.; Yang, K.; Bennett S. R.; Guo, S.-R.;* Tang, W.* Angew. Chem. Int. Ed. 2015, 54, 8756–8759. link.
  11. “Novel Analogs Targeting Histone Deacetylase Suppress Aggressive Thyroid Cancer Cell Growth and Induce Re-differentiation.”
    Jang, S.; Yu, X. M.; Odorico, S.; Clark, M.; Jaskula-Sztul, R.; Schienebeck, C. M.; Kupcho, K. R.; Harrison, A. D.; Winston-McPherson, G. N.; Tang, W.; Chen, H.* Cancer Gene Ther. 2015, 22, 410. link.
  12. “Synthesis of Substituted Tropones by Sequential Rh-Catalyzed [5+2] Cycloaddition and Elimination.”
    Song, W.; Xi, B.-m.;* Yang, K.; Tang, W.* Tetrahedron 2015, 71, 5979-5984. (Invited contribution for Prof. Barry Trost’s Tetrahedron Award.). link.
  13. “Rhodium-Catalyzed Intermolecular [5+1] and [5+2] Cycloadditions Using 1,4-Enynes with an Electron-Donating Ester on the 3-Position.”
    Schienebeck, C. M.; Song, W.; Smits, A. M.; Tang, W.* Synthesis 2015, 47, 1076-1084. (invited feature article). link.
  14. “Tumor Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction.”
    Jaskula-Sztul, R.; Eide, J.; Tesfazghi, S.; Dammalapati, A.; Harrison, A. D.; Yu, X.-M.; Scheinebeck, C.; Winston-McPherson, G.; Kupcho, K. R.; Robers, M. B.; Hundal, A. K.; Tang, W.;* Chen, H.* Mol. Cancer Therap. 2015, 14, 499. link.
  15. “Gold versus Rhodium: Divergent Reactivity Enabled by the Catalyst.”
    Winston-McPherson, G. N.; Tang, W.* ChemCatChem 2015, 7, 574-576. link.
  16. “Design, synthesis, and preliminary bioactivity studies of substituted purine hydroxamic acid derivatives as novel histone deacetylase (HDAC) inhibitors.”
    Wang, J.; Sun, F.; Han, L.; Hou, X.; Pan, X.; Liu, R.; Tang, W.; Fang, H.* MedChemComm. 2014, 5, 1887-1891. link.
    Graphical abstract: Design, synthesis, and preliminary bioactivity studies of substituted purine hydroxamic acid derivatives as novel histone deacetylase (HDAC) inhibitors
  17. “Improved antiproliferative activity of 1,3,4-thiadiazole-containing histone deacetylase (HDAC) inhibitors by introduction of the heteroaromatic surface recognition motif.”
    Guan, P.; Wang, L.; Hou, X.; Wan, Y.; Xu, W.; Tang, W.; Fang, H.* Bioorg. Med. Chem. 2014, 22, 5766-5775. link.
  18. “Copper-catalyzed tandem annulation/arylation for the synthesis of diindolylmethanes from propargylic alcohols.”
    Li, H.; Li, X.; Wang, H.-Y.; Winston-McPherson, G. N.; Geng, H.-M. J.; Guzei, I. A.; Tang, W.* Chem. Commun. 2014, 50, 12293-12296. link.
    Graphical abstract: Copper-catalyzed tandem annulation/arylation for the synthesis of diindolylmethanes from propargylic alcohols
  19. “Synthesis of naturally occurring tropones and tropolones.”
    Liu, N.; Song, W.; Schienebeck, C. M.; Zhang, M.* Tang, W.* Tetrahedron. 2014, 70, 9281-9305. (Invited review) link.
    thumbnail image of tropone and tropolones
  20. “Synthesis and Biological Evaluation of 2,3’-Diindolylmethanes as Agonists of Aryl Hydrocarbon Receptor.”
    Winston-McPherson, G. N.; Shu, D.; Tang, W.* Bioorg. Med. Chem. Lett. 2014, 24, 4023-4025. link.
  21. “Cinchona Alkaloids as Organocatalysts in Enantioselective Halofunctionalization of Alkenes and Alkynes.”
    Zheng, S.; Schienebeck, C. M.; Zhang, W.; Wang, H.-Y.; Tang, W.* Asian J. Org. Chem. 2014, 3, 366-376. (Invited review) link.
    thumbnail image
  22. “Intermolecular bromoesterification of conjugated enynes: an efficient synthesis of bromoallenes.”
    Wang, H.-Y.; Zhang, W.; Schienebeck, C. M.; Bennett, S. R.; Tang, W.* Org. Chem. Front. 2014, 1, 386-390. (Invited contribution) link.
    thumbnail preview of pub 39
  23. “3-Acyloxy-1,4-enyne: a New Five-Carbon Synthon for Rhodium-Catalyzed [5 + 2] Cycloadditions.”
    Schienebeck, C. M.; Li, X.; Shu, X.-Z.; Tang, W.* Pure Appl. Chem. 2014, 86, 409-417. (Invited review) link.
  24. “Design, Synthesis and Preliminary Bioactivity Studies of 1,2-Dihydrobenzo[d]isothiazol-3-one-1,1-dioxide Hydroxamic Acid Derivatives as Novel Histone Deacetylase Inhibitors.”
    Han, L.; Wang, L.; Hou, X.; Fu, H.; Song, W.; Tang, W.; Fang, H.* Bioorg. Med. Chem. 2014, 22, 1529-2538. link.
    thumbnail: representative example of HDACi with linear chain
  25. “Tethered Spectroscopic Probes Estimate Dynamic Distances with Subnanometer Resolution in Voltage-Dependent Potassium Channels.”
    Jarecki, B. W.; Zheng, S.; Zhang, L.; Li, X.; Zhou, X.; Cui, Q.; Tang, W.; Chanda, B.* Biophysical J. 2013, 105, 2724-2732. link.
    Highlight in Nature Chemical Biology link.
  26. “Rhodium-Catalyzed Tandem Annulation and (5+1) Cycloaddition: 3-Hydroxy-1,4-enyne as the 5-Carbon Component.”
    Li, X.; Song, W.; Tang, W.* J. Am. Chem. Soc. 2013, 135, 16797-16800. link.
    tang-pub35
  27. “Transfer of Chirality in the Rhodium-Catalyzed Intramolecular [5+2] Cycloaddition of 3-Acyloxy-1,4-Enynes (ACEs) and Alkynes: Synthesis of Enantioenriched Bicyclo[5.3.0]decatrienes.”
    Shu, X.-Z.; Schienebeck, C. M.; Song, W.; Guzei, I. A.; Tang, W.* Angew. Chem. Int. Ed. 2013, 52, 13601-13605. link.
    Highlight in Synfacts, 2014, volume 10, issue 3, 0295 (doi:10.1055/s-0033-1340687)
    tang-pub34
  28. “Stereoselective Halocyclization of Alkenes with N-Acyl Hemiaminal Nucleophiles.”
    Liu, N.; Wang, H.-Y.; Zhang, W.; Jia, Z.-H.; Guzei, I. A.; Xu, H.-D.;* Tang, W.* Chirality 2013, 25, 805-809. link.
    (Invited contribution.)
  29. “Stereoselective Total Synthesis of Hainanolidol and Harringtonolide via Oxidopyrylium-Based [5+2] Cycloaddition.”
    Zhang, M.; Liu, N.; Tang, W.* J. Am. Chem. Soc. 2013, 135, 12434-12438. link.
    thumbnail for publication32
  30. “Platinum-Catalyzed Tandem Indole Annulation/Arylation for the Synthesis of Diindolylmethanes and Indolo[3,2-b]carbazoles.”
    Shu, D.; Winston-McPherson, G. N.; Song, W.; Tang, W.* Org. Lett. 2013, 15, 4162-4165. link.
    tang-pub31
  31. “Rh-Catalyzed (5+2) Cycloadditions of 3-Acyloxy-1,4-enynes and Alkynes: Computational Study of Mechanism, Reactivity, and Regioselectivity.”
    Xu, X.;* Liu, P.; Shu, X.-Z.; Tang, W.*; Houk, K. N.* J. Am. Chem. Soc. 2013, 135, 9271-9274. link.
    tang-pub30
  32. “Generation of Rhodium(I) Carbenes from Ynamides and Their Reactions with Alkynes and Alkenes.”
    Liu, R.; Winston-McPherson, G. N.; Yang, Z.-Y.; Zhou, X.; Song, W.; Guzei, I. A.; Xu, X.;* Tang, W.* J. Am. Chem. Soc. 2013, 135, 8201–8204. link.
    tang-pub29
  33. “Stereoselective Addition of Halogen to Conjugated Enynes and Its Application in the Total Synthesis of (-)-Kumausallene.”
    Werness, J. B.; Zhang, W.; Tang, W.* in Strategies and Tactics in Organic Synthesis
    Ed., Harmata, M., Elsevier Science, Pergamon Press: Oxford, UK 2013, Vol. 9, Chapter 10, pp 275-291.
  34. “Enantioselective intermolecular bromoesterification of allylic sulfonamides”
    Zhang, W.; Liu, N.; Schienebeck, C. M.; Zhou, X.; Izhar, I. I.; Guzei, I. A.; Tang, W.* Chem. Sci. 2013, 4, 2652-2656. link.
    thumbnail image of publication 27
  35. “Ring Expansion of Alkynyl Cyclopropanes to Highly Substituted Cyclobutenes via a N-Sulfonyl-1,2,3-Triazole Intermediate”
    Liu, R.; Zhang, M.; Winston-McPherson, G.; Tang, W.* Chem. Commun. 2013, 49, 4376-4378. link.
    (This article is part of the ChemComm ‘Emerging Investigators 2013’ themed issue.)
    thumbnail of publication 26
  36. “Effect of Ester on Rhodium-Catalyzed Intermolecular [5 + 2] Cycloaddition of 3-Acyloxy-1,4-enynes and Alkynes”
    Schienebeck, C. M.; Robichaux, P. J.; Li, X.; Chen, L.; Tang, W.* Chem. Commun. 2013, 49, 2616-2618. link.
    thumbnail for publication 25
  37. “Rhodium- and Platinum-catalyzed [4+3] Cycloaddition with Concomitant Indole Annulation: Synthesis of Cyclohepta[b]indoles”
    Shu, D.; Song, W.; Li, X.; Tang, W.* Angew. Chem. Int. Ed. 2013, 52, 3237-3240. link.
    tang-pub24
  38. “Rhodium-Catalyzed Chemo-and Regioselective Cross-Dimerization of Two Terminal Alkynes”
    Xu, H.-D.*; Zhang, R.-W.; Li, X., Huang, S., Tang, W.; Hu, W.-H. Org. Lett. 2013, 15, 840-843. link.
    thumbnail for publication 23
  39. “Rhodium-catalyzed acyloxy migration of propargylic esters in cycloadditions, inspiration from the recent “gold rush”
    Shu, X.-Z.; Shu, D.; Schienebeck, C. M.; Tang, W.* Chem. Soc. Rev. 2012, 41, 7698-7711. link.
    thumbnail for publication 22
  40. “Rhodium-Catalyzed Carbonylation of Cyclopropyl Substituted Propargyl Esters: A Tandem 1,3-Acyloxy Migration [5 + 1] Cycloaddition”
    Shu, D.; Li, X.; Zhang, M.; Robichaux, P. J.; Guzei, I. A.; Tang, W.* J. Org. Chem. 2012, 77, 6463-6472. link.
    thumbnail for publication 21
  41. .”Synthesis of Functionalized Cyclohexenone Core of Welwitindolinones via Rhodium-Catalyzed [5 + 1] Cycloaddition”
    Zhang, M.; Tang, W.* Org. Lett. 2012, 14, 3756-3759. link.
    thumbnail for publication 20
  42. “Stereoselective Preparation of Cyclobutanes with Four Different Substituents: Total Synthesis and Structural Revision of Pipercyclobutanamide A and Piperchabamide G.”
    Liu, R.; Zhang, M.; Wyche, T. P.; Winston-McPherson, G. N.; Bugni, T. S.; Tang, W.* Angew. Chem. Int. Ed. 2012, 51, 7503-7506. link.
    Highlight in Nature Chemical Biology link.
    thumbnail for publication 19
  43. “Catalytic Enantioselective Halolactonization of Enynes and Alkenes”
    Zhang, W.; Liu, N.; Schienebeck, C. M.; Decloux, K.; Zheng, S. Werness, J. B.; Tang, W.* Chem.-Euro. J. 2012, 18, 7296-7305. link.
    Highlight in Synfacts, 2012, issue 7, 0790 (doi:10.1055/s-0031-1289837).
    thumbnail for publication 18
  44. “Rhodium-catalyzed Intra- and Intermolecular [5+2] Cycloaddi-tion of 3-Acyloxy-1,4-enyne and Alkyne with Concomitant 1,2-Acyloxy Migration”
    Shu, X.-z; Li, X.; Shu, D.; Huang, S.; Schienebeck, C. M.; Zhou, X.; Robichaux, P. J.; Tang, W.* J. Am. Chem. Soc. 2012, 134, 5211-5221. link.
    thumbnail for publication 17
  45. “Rhodium-Catalyzed Carbonylation of 3-Acyloxy-1,4-enynes for the Synthesis of Cyclopentenones”
    Li, X.; Huang, S.; Schienebeck, C. M.; Shu, D.; Tang, W.* Org. Lett. 2012, 14, 1584-1587. link.
    thumbnail for publication 16
  46. “Rhodium-catalyzed 1,3-Acyloxy Migration and Subsequent Intramolecular [4+2] Cycloaddition of Vinylallene and Unactivated Alkyne”
    Huang, S.; Li, X.; Lin, C. L.; Guzei, I. A.; Tang, W.* Chem. Commun. 2012, 48, 2204-2206. link.
    thumbnail for publication 15
  47. “Effect of Halogenation Reagents on Halocyclization and Overman Rearrangement of Allylic Trichloroacetimidates”
    Liu, N.; Schienebeck, C. M.; Collier, M. D.; Tang, W.* Tetrahedron Lett. 2011, 52 , 6217-6219. link.
    thumbnail for publication 14
  48. “Rhodium-catalyzed Ring Expansion of Cyclopropanes to Seven-membered Rings by 1,5-C-C Bond Migration”
    Li, X.; Zhang, M.; Shu, D.; Robichaux, P. J.; Huang, S.; Tang, W.* Angew. Chem. Int. Ed. 2011, 50, 10421-10424. link
    thumbnail for publication 13
  49. “Interception of a Rautenstrauch Intermediate by Alkynes for [5+2] Cycloaddition: Rhodium-Catalyzed Cycloisomerization of 3-Acyloxy-4-ene-1,9-diynes to Bicyclo[5.3.0]decatrienes”
    Shu, X.-z.; Huang, S.; Shu, D.; Guzei, I. A.; Tang, W.* Angew. Chem. Int. Ed. 2011, 50, 8153-8156. link. Highlighted as “hot paper”
    thumbnail for publication 12
  50. “Stereoselective Total Synthesis of (-)-Kumausallene”
    Werness, J. B.; Tang, W.* Org. Lett. 2011, 13, 3664-3666. link.
    Highlight in Synfacts, 2011, issue 10, 1042 (doi:10.1055/s-0030-1261141).
    thumbnail for publication 11
  51. “Intramolecular 1,4-Addition of Nitrogen Nucleophile and Bromine Electrophile to Conjugated 1,3-Enyne”
    Liu, N.; Werness, J. B.; Guzei, I. A. Tang, W.* Tetrahedron 2011, 67, 4385-4390. link
    (Invited contribution for F. Dean Toste’s’ Tetrahedron Young Investigator Award.)
    thumbnail for publication 10
  52. “Synthesis of Highly Functionalized Cyclohexenone Rings: Rhodium-Catalyzed 1,3-Acyloxy Migration and Subsequent [5+1] Cycloaddition”
    Shu, D.; Li, X.; Zhang, M.; Robichaux, P. J.; Tang, W.* Angew. Chem. Int. Ed. 2011, 50, 1346-1349. link.
    thumbnail for publication 9
  53. “Synthesis of bromoallenyl pyrrolidines via 1,4-addition to 1,3-enynes”
    Werness, J. B.; Tang, W.* Sci. China Chem. 2011, 54, 56-60. link.
    (Invited contribution for the 6th Sino-US Chemistry Professor Conference at Hangzhou, China.)
    thumbnail for publication 8
  54. “Enantioselective Bromolactonization of Conjugated (Z)-Enynes”
    Zhang, W.; Zheng, S.; Liu, N.; Werness, J. B.; Guzei, I. A.; Tang, W.* J. Am. Chem. Soc. 2010, 132, 3664-3665. link.
    Highlight in Angew. Chem. Int. Ed. link.
    thumbnail for publication 7
  55. “Thermodynamic Control of the Electrocyclic Ring Opening of Cyclobutenes: C=X Substituents at C-3 Mask the Kinetic Torquoselectivity”
    Um, J. M.; Xu, H.-D.; Houk, K. N.*; Tang, W.* J. Am. Chem. Soc. 2009, 131, 6664-6665. link.
    thumbnail for publication 6
  56. “DABCO-Catalyzed 1,4-Bromolactonization of Conjugated Enynes: Highly Stereoselective Formation of a StereogenicCenter and an Axially Chiral Allene”
    Zhang, W.; Xu, H.-D.; Xu, H.; Tang, W.* J. Am. Chem. Soc. 2009, 131, 3832-3833. link.
    Highlight in Synfacts, 2009, issue 6, 0604 (doi:10.1055/s-0029-1216700).
    thumbnail for publication 5
  57. “Intramolecular Hydroamination of Conjugated Enynes”
    Zhang, W.; Werness, J. B.; Tang, W.* Tetrahedron 2009, 65, 3090-3095. link.
    (Invited contribution for Justin DuBois’ Tetrahedron Young Investigator Award.)
    thumbnail for publication 4
  58. “N,N’-(11S,12S)-(9,10-dihydro-9,10-ethanoanthracene-11,12-diyl)bis[2-(diphenylphosphino)-Benzamide”
    Tang, W. The Encyclopedia of Reagents for Organic Synthesis [EROS], (Ed. P. L. Fuchs, John Wiley and Sons) 2008.
  59. “Synthesis of Cyclobutenes by Highly Selective Transition-Metal-Catalyzed Ring Expansion of Cyclopropanes”
    Xu, H.-D.; Zhang, W.; Shu, D.; Werness, J. B.; Tang, W.* Angew. Chem. Int. Ed. 2008, 47, 8933-8936. link .
    Highlight in Synfacts, 2009, issue 1, 0063 (doi:10.1055/s-0028-1087400).
    thumbnail for publication 2
  60. “Base-Catalyzed Intramolecular Hydroamination of Conjugated Enynes”
    Zhang, W.; Werness, J. B.; Tang, W.* Org. Lett. 2008, 10, 2023-2026. link
    thumbnail for publication 1

Graduate and Post-Doctoral Work

“Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity”
Fass, D. M.; Reis, S. A.; Ghosh, B.; M. Hennig, K. M.; Joseph, N. F.; Zhao, W.-N.; Nieland, T. J. F.; Guan, J.-S.; Kuhnle, C. E. G.; Tang, W.; Barker, D. D.; Mazitschek, R.; Schreiber, Sl. L.; Tsai, L.-H.; Haggarty, S. J.* Neuropharmacology, 2013, 64, 81. link.

“Discovery of histone deacetylase 8 selective inhibitors”
Tang, W.*; Luo, T.; Greenberg, E. F.; Bradner, J. E.; Schreiber, S. L.* Bioorg. Med. Chem. Lett. 2011, 21, 2601-2605. link.

“Small Molecules Efficiently Direct Differentiation of Mouse Embryonic Stem Cells into Definitive Endoderm”
Borowiak, M.; Maehr, R.; Chen, S.; Chen, A. E.; Tang, W.; Lamenzo, J. O.; Schreiber, S. L.; Melton, D. A.* Cell Stem Cell, 2009, 4, 348-358. link

“Identification and Characterization of Small Molecule Inhibitors of a Class I Histone Deacetylase from Plasmodium falciparum”
Patel, V.; Mazitschek, R.; Coleman, B.; Nguyen, C.; Urgaonkar, S.; Cortese, J.; Barker, R. H.; Greenberg, E.; Tang, W.; Bradner, J. E.; Schreiber, S. L.; Duraisingh, M. T.; Wirth, D. F.; Clardy, J.* J. Med. Chem. 2009, 52, 2185–2187. link

“Fluorous-Based Small-Molecule Microarrays for the Discovery of Histone Deacetylase Inhibitors”
Vegas, A. J.; Bradner, J. E.; Tang, W.; McPherson, O. M.; Greenberg, E. F.; Koehler, A. N. and Schreiber, S. L.* Angew. Chem. Int. Ed. 2007, 46, 7960-7964. link

Fu, Q. S.; Boonchayaanant, B.; Tang, W.; Trost, B. M.; Criddle, C. S.* Biodegradation 2009, 20, 109-116.
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