School of Pharmacy UNIVERSITY OF WISCONSIN - MADISON Program Faculty & Research Pharmacology & Toxicology Faculty Arash Bashirullah, PhD, Associate Professor Regulation of tissue growth and destruction during post-embryonic development. Ron Burnette, PhD, Professor Developing a molecular level mechanistic understanding of the delivery and stability of drugs by physical chemical characterization of guest-host interactions using computational chemistry and NMR as well as studies in pharmacokinetics and pharmacodynamics. Margaret Clagett-Dame, PhD, Professor Therapeutic applications of vitamin A and vitamin D analogs; retinoids in embryonic and nervous system development. Lara Collier, PhD, Associate Professor Genetic and pharmacologic approaches to study cancer initiation, progression, and treatment. Warren Heideman, PhD, Professor Understanding the molecular mechanisms that regulate the cellular transition from quiescence to growth; identifying critical mechanisms regulating vertebrate development that are disrupted by environmental contaminants; evaluating the impact of nanomaterials on early development; creating strategies for the fermentative production of biofuels. Jeffrey A. Johnson, PhD, Professor Faculty Director of the Pharmacology-Toxicology Program Signal transduction, transcriptional control of neuroprotective genes and neurotoxicity in Parkinson’s, Alzheimer’s, Huntington’s and Neuromuscular disease. Paul C. Marker, PhD, Professor Molecular basis of prostate development; prostate cancer progression; benign prostatic hyperplasia; roles of cell-cell signaling pathways and the use of mouse genetics to discover novel pathways that underlie prostatic diseases. Steven G. Oakes, PhD, Clinical Assistant Professor Affiliate Faculty Ralph Albrecht, PhD, Professor Use of inductively heated, antibody-targeted, core-shell nanoparticles for selective removal of targeted cells in vitro and in vivo. Developmenet of high resolution nanoparticle labeling systems for correlative microscopy. Adnan Elfarra, PhD, Professor Bioactivation and detoxification of drugs, industrial chemicals, and environmental toxicants; biochemical basis for target organ selectivity; and biomarkers of toxicant exposure. Colin Jefcoate, PhD, Professor Physiological Mechanisms Associated with P450 Cytochromes Lauren Trepanier, PhD, DVM, Professor Pharmacogenetics of xenobiotic toxicity, including both therapeutic drugs and environmental carcinogens. Mechanisms of familial and acquired risk for sulfamethoxazole drug hypersensitivity (“sulfa allergy”). Examining the links between genetic variability in phase II detoxification pathways (GSTs and b5 reductase) and cancer risk in both humans and dogs. Chad Vezina, Associate Professor Molecular basis of prostate and urinary tract development, physiology, and toxicology.