Publications

Work at UW-Madison
 

23. Joiner CM, Li H, Jiang J*, Walker S*. Structural characterization of the O-GlcNAc cycling enzymes: insights into substrate recognition and catalytic mechanisms. Current Opinion in Structural Biology (2019) Jan 29. [Epub ahead of print]

O-GlcNAc cycling enzymes

 

22. Hu CW, Worth M, Li H, Jiang J*. Chemical and biochemical strategies to explore the substrate recognition of O-GlcNAc-cycling enzymes. Chembiochem (2018) Sep 10.  [Epub ahead of print] 

O-GlcNAc cycling

 

21. Hu CW#, Worth M#, Fan D#, Li B#, Li H#, Lu L, Zhong X, Lin Z, Wei L, Ge Y, Li L, Jiang J*Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferaseNature Chemical Biology (2017) 13, 1267-73. (#equal contribution)

Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase

 

20. Liu F, Ma F, Wang Y, Hao L, Zeng H, Jia C, Wang Y, Liu P, Ong IM, Li B, Chen G, Jiang J, Gong S, Li L, Xu W. PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesisNature Cell Biology (2017) 19, 1358-70.

 

19. Li B#, Li H#, Hu CW, Jiang J*. Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase. Nature Communications (2017) 8:666. doi: 10.1038/s41467-017-00865-1. (#equal contribution)

O-GlcNAcase

NSMB journal cover

18. Li B, Li H, Lu L, Jiang J*. Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode. Nature Structural & Molecular Biology (2017), 24, 362-369.  [News and Views, Nat Struct Mol Biol. 2017, 24, 433.]

 ACSCB journal cover

17. Worth M#, Li H#, Jiang J*. Deciphering the functions of protein O-GlcNAcylation with chemistry. ACS Chemical Biology (2017), 12, 326-335. (#equal contribution)

 

16. Lu L, Fan D, Hu CW, Worth M, Ma ZX, Jiang J*. Distributive O-GlcNAcylation on the highly repetitive C-terminal domain of RNA polymerase II. Biochemistry (2016), 55, 1149-1158.

jiang-graphical-abstract

Previous Work

15. Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, Duveau DY, Tan ZW, Thomas CJ, Walker S. A small molecule that inhibits OGT activity in cells. ACS Chemical Biology (2015), 10, 1392-1397.

14-science-cover

14. Lazarus MB*, Jiang J*, Kapuria V, Bhuiyan T, Janetzko J, Zandberg WF, Vocadlo DJ, Herr W, Walker S. HCF-1 is cleaved in the active site of O-GlcNAc transferase. (*equal contribution) Science (2013), 342, 1235-1239.

 13-ncb-2012-p966 13. Lazarus, MB*; Jiang, J*; Gloster, TM; Zandberg, WF; Vocadlo, DJ; Walker, S. Structural snapshots of the reaction coordinate for O-GlcNAc transferase. (*equal contribution) Nature Chemical Biology (2012), 8, 966-968.
 12-ncb-2012-p72 12. Jiang, J*; Lazarus, MB*; Pasquina, L; Sliz, P; Walker, S. A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase. (*equal contribution) Nature Chemical Biology (2012), 8, 72–77.
 11-nature-2011 11. Lazarus, MB; Nam, Y; Jiang, J; Sliz, P; Walker, S. Structure of human O-GlcNAc transferase and its complex with a peptide substrate. Nature (2011), 469, 564-567.
Unknown 10. Jiang, J; Tetzlaff, CN; Takamatsu, S; Iwatsuki, M; Komatsu, M; Ikeda, H; Cane, DE. Genome mining in Streptomyces avermitilis. A biochemical Baeyer-Villiger reaction and discovery of a new branch of the pentalenolactone family tree. Biochemistry (2009), 48, 6431-6440.
 Unknown 9. Giglio, S; Jiang, J; Saint, CP; Cane, DE; Monis, PT. Isolation and characterization of the gene associated with geosmin production in cyanobacteria. Environmental Science & Technology (2008), 42, 8027-8032.
 8-jacs-2008-428 8. Jiang, J; Cane, DE. Geosmin biosynthesis. Mechanism of the fragmentation-rearrangement in the conversion of germacradienol to geosmin. Journal of the American Chemical Society (2008), 130, 428-429.
 8-jacs-2008-428 7. Nawrath, T; Dickschat, JS; Muller, R; Jiang, J; Cane, DE; Schulz, S. Identification of (8S,9S,10S)-8,10-dimethyl-1-octalin, a key intermediate in the biosynthesis of geosmin in bacteria. Journal of the American Chemical Society (2008), 130, 430-431.
 6-abb-2008 6. Vedula, SL; Jiang, J; Zakharian, T; Cane, DE; Christianson, DW. Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233-Mg2+B motif. Archives of Biochemistry and Biophysics (2008), 469, 184-194.
 5-ncb-2007 5. Jiang, J; He, X; Cane, DE. Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme. Nature Chemical Biology (2007), 3, 711-715.
 8-jacs-2008-428 4. Jiang, J; He, X; Cane, DE. Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin. Journal of the American Chemical Society (2006), 128, 8128-8129.
 3-loc-2005 3. Zhou, C; Jiang, J; Zhou, Y; Xie, Z; Miao, Q; Wang, Z. Chemoselective carbonyl benzylation mediated by Zn/CdCl2/InCl3 in tap water. Letters in Organic Chemistry (2005), 2, 61-64.
 2-tetra-2005  
2. Zha, Z; Qiao, S; Jiang, J; Wang, Y; Miao, Q; Wang, Z. Barbier-type reaction mediated with tin nano-particles in water. Tetrahedron (2005), 61, 2521-2527.
 1-tl-2004 1. Zhou, C; Zhou, Y; Jiang, J; Xie, Z; Wang, Z; Zhang, J; Wu, J; Yin, H. Organometallic reactions in aqueous media: the allylations of carbonyl compounds mediated in Zn/CdSO4 and Zn/SnCl2 bimetal systems. Tetrahedron Letters (2004), 45, 5537-5540.