This completed research project examined the acute effects of Δ⁹-tetrahydrocannabinol (Δ⁹-THC), Δ⁸-tetrahydrocannabinol (Δ⁸-THC), and placebo on cognitive performance, psychomotor function, and simulated driving behavior in healthy adult participants. The study was designed to generate high-quality experimental data to inform ongoing scientific, forensic, and public health discussions surrounding cannabis impairment and roadway safety.
As the availability and use of cannabis products continue to expand—particularly products containing Δ⁸-THC—there remains a critical need for controlled human data to support evidence-based interpretation of impairment, toxicology findings, and regulatory decision-making.
Funding Partner
Research Objectives
This project sought to:
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Characterize and compare the acute effects of Δ⁹-THC and Δ⁸-THC on cognitive and psychomotor performance
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Quantify cannabinoid pharmacokinetics across multiple biological matrices
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Evaluate relationships between measured drug concentrations and indicators of functional impairment
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Generate high-quality data to inform forensic, clinical, and public health interpretation of cannabinoid exposure
Significance and Impact
Findings from this study contribute to a growing evidence base needed to:
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Interpret toxicological results in impaired driving and forensic investigations
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Understand similarities and differences between Δ⁹-THC and Δ⁸-THC exposure
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Inform policy discussions regarding cannabis-derived products and public safety
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Support development of scientifically grounded impairment assessment frameworks
The work also provides foundational data for ongoing and future studies examining cannabis pharmacology, impairment thresholds, and analytical method development.
Status and Dissemination
Data collection for this project has been completed. Analyses are ongoing, and findings will be disseminated through peer-reviewed publications and scientific presentations.
Clinical trial registration
NCT06236815 – High Confusion: Cannabis and Driving