RORs are ligand-regulated nuclear receptors that can function as transcription factors in regulating inflammation, lipid metabolism, and cellular differentiation of several non-epithelial tissues. Despite of the high expression of RORα in skin epithelium, its functions in this tissue remain unclear.

Innovation, Precision Medicine, and Future Challenges in Clinical Development Advancements in basic biology, genetics, analytic and information technologies are revolutionizing drug discovery and development, and the manner in which we conduct clinical research trials. The drive for precision/individualized medicine requires that with the innovative, potent agents entering clinical research, we focus our efforts to ensure […]

Research in the Barrios lab focuses on developing chemical tools that can be applied to further our understanding of important biological processes.

Neuroplasticity and axonal regeneration in the adult central nervous system are limited by both extrinsic components of the neuronal microenvironment and injury-induced and developmentally-related deficiencies in intrinsic neuronal biochemistry. To overcome these barriers and achieve functional recovery

The structural interactions of drug and polymer molecules in orally administered amorphous pharmaceuticals can strongly influence both the stability and solubility of the resulting medicine.

A pressing question in origins-of-life research is how polypeptides arose from amino