Cell polarity is essential for the development and homeostasis of animal tissues. The

Reproduction in all systems is heavily influenced by nutrition and the metabolic state

Building Structural Complexity via Tandem Catalytic Transformations: Total

Dr. Nikoleta G. Tsvetanova Department of Psychiatry University of California, San Francisco Functional Diversification of Signaling by GPCR Localization G protein-coupled receptors (GPCRs) are critical cell signaling molecules that also comprise the largest class of therapeutic drug targets.  GPCRs are well known to signal upon ligand binding via cyclic AMP (cAMP) production at the plasma […]

We have characterized functional components of the blood-brain barrier (BBB) and blood-tumor barrier (BTB) in highly permeable and poorly permeable experimental brain metastases from breast cancer.

Dr. Vicki Plaks Assistant Adjunct Professor Department of Orofacial Sciences & Anatomy University of California-San Francisco Enhancing Immunotherapy by Targeting the Cancer Stem Cell Niche Immunotherapy is the new promise in effectively combating cancer.  It has proven to be effective in solid tumors of an inflamed phenotype but still faces challenges in tumors that are […]

Immunotherapy is the new promise in effectively combating cancer. It has proven to

Occluding Junctions are Master Regulators of Communication Between Stem Cells and Their Niche

Discovery and Development of SJ733, a Novel Antimalarial Drug

Monoclonal antibodies (mAbs) are an important class of therapeutic proteins widely used for the