Events in November 2024
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October 27, 2024
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October 28, 2024(3 events)
– Exam 777 Highland Ave
Madison, WI 53705
United States
– Lab Exam See syllabus for location
– This event runs from 4:30 on 10/28/24 to 12 Noon on 10/29/24.
Online
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October 29, 2024(4 events)
– The Office of Global Health and the Office of Diversity, Equity, and Inclusion presents the panel discussion: Bridging Gaps: Disability Awareness and Patient-Centered Care in Pharmacy Tuesday, October 29th at noon Room 2006 Event Description: This event aims to equip pharmacists and aspiring pharmacists with the knowledge to better assist patients with disabilities, promote healthcare accessibility, and reduce healthcare disparities. Following a movie preview on your own (the movie will be announced soon), join our panelists for a discussion on how to best interact with and provide healthcare to people living with disabilities. Panelists:
777 Highland Ave
Madison, WI 53705
United States
– This event runs from 4:30 on 10/28/24 to 12 Noon on 10/29/24. Online
– Lab Exam See syllabus for location
– This event runs from 4:30 PM 10/29/24 to 12 Noon on 10/30/24. Online
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October 30, 2024(3 events)
– This event runs from 4:30 PM 10/29/24 to 12 Noon on 10/30/24. Online
– Lab Exam See syllabus for location
– This event runs from 4:30 PM 10/30/24 to 12 Noon on 10/31/24. Online
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October 31, 2024(2 events)
– This event runs from 4:30 PM 10/30/24 to 12 Noon on 10/31/24. Online
– Lab Exam See syllabus for location
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November 1, 2024(2 events)
November 1, 2024 Block 4 runs from September 23 to November 1, 2024 . Online
– Pharmaceutical Sciences Seminar Series(Drug DISCOVERY Specific Seminar)
Development of Pan-Viral Nucleoside InhibitorsThe severity and rapid spread of the coronavirus pandemic served to drive home that we were completely unprepared to fight such an outbreak. As a result, it became clear that there was a critical need for small molecule, orally bioavailable, broad-spectrum drugs that could be stockpiled and readily distributed when the next outbreak occurs. In that regard, for many years nucleos(t)ides have maintained a prominent role as one of the cornerstones of antiviral and anticancer therapeutics, and numerous scaffolds in nucleos(t)ide and nucleic acid drug design have been pursued. One such approach involves adding flexibility to the sugar moieties of nucleos(t)ides, for example, in the highly successful anti-HIV/HBV drug Tenofovir developed by Antonín Holý. In contrast, introduction of flexibility to the nucleobase scaffold has only more recently gained significance with the invention of our fleximers. This modification has led to a significant improvements in antiviral activity, and in some cases endowing the nucleoside with potent broad-spectrum activity across several viral families, when the parent rigid nucleoside was inactive. Another advantage observed is the ability to avoid resistance mechanisms related to point mutations by engaging secondary amino acid residues not previously involved in the mechanism of action. A second series of nucleosides being pursued in our group, involves insertion of a heterocyclic spacer ring in between the two moieties of the bicyclic purine ring system, forming an expanded tricyclic nucleoside with increased aromaticity. This modification has also led to potent antiviral activity, again targeting several different pathogens of pandemic concern. A brief history of their design, synthesis, and recent antiviral findings for these innovative nucleos(t)ide scaffolds will be discussed. Hosted by Jennifer Golden 777 Highland Ave
Madison, WI 53705
United States
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November 2, 2024
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November 3, 2024
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November 4, 2024(2 events)
November 4, 2024 Block 5 runs from November 4 to December 20, 2024. Online
– This event runs from 4:30 PM 11/4/24 to 12 Noon on 11/5/24. Online
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November 5, 2024(2 events)
– Exam 2002 and 2006 Rennebohm Hall
777 Highland Ave.
Madison, WI 53705
United States
– This event runs from 4:30 PM 11/4/24 to 12 Noon on 11/5/24. Online
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November 6, 2024(1 event)
– This event runs from 4:30 PM on November 6 to 12 Noon on November 7th. Online
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November 7, 2024(2 events)
– This event runs from 4:30 PM on November 6 to 12 Noon on November 7th. Online
– This event runs from 4:30 PM on November 7 to 12 Noon on November 8th. Online
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November 8, 2024(2 events)
– This event runs from 4:30 PM on November 7 to 12 Noon on November 8th. Online
– Pharmaceutical Sciences Seminar Series(Drug ACTION Specific Seminar)
Non-canonical Paneth cell functions regulate intestinal inflammatory responsePaneth cells are the primary source of C-type lysozyme, a β-1,4-N-acetylmuramoylhydrolase that enzymatically processes bacterial cell walls. Aberrant lysozyme production are hallmarks of inflammatory bowel disease (IBD) pathology. I will show experiments that demonstrate the impact of lack or ectopic lysozyme production on colonic inflammation. I will also show data about how Lyz1-deficiency modulates the gut bacterial composition and intestinal immune responses to bacterial molecular patterns. I will present biochemical and immunology evidence to suggest that Paneth cell lysozyme balances intestinal anti- and pro-inflammatory responses. In addition, I will shed light on our recent finding that a direct engagement of intestinal lysozyme with enteric pathogens such as Salmonella promotes the release of bacterial virulence factors that are barrier-impairing and pro-inflammatory. In the end I’ll discuss our ongoing work investigating the Paneth cell subsets that may be important for host responses to infection and inflammation. Hosted by Ting Fu 777 Highland Ave
Madison, WI 53705
United States
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November 9, 2024
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November 10, 2024
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November 11, 2024
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November 12, 2024(1 event)
– Exam 777 Highland Ave
Madison, WI 53705
United States
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November 13, 2024(1 event)
– Exam 2002 and 2006 Rennebohm Hall
777 Highland Ave.
Madison, WI 53705
United States
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November 14, 2024
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November 15, 2024(1 event)
– 2024 WARF Therapeutics Distinguished Lecture in Drug Discovery
New Approaches to Tuberculosis TherapeuticsTuberculosis (TB) continues to be a major worldwide health problem, despite the existence of numerous drugs for its treatment. This is in part due to the long therapeutics times required to administer cocktails of front-line therapeutics and in part due to the emergence of even more challenging long-term strains. For these reasons, new therapeutic agents for the treatment of TB continue to be sought. In collaborative work with the laboratory of Carl Nathan (Weill–Cornell Medicine) and others, we have sought to find new chemotypes as potential anti-TB agents and to identify new biochemical targets for drug treatment. In this talk, I will describe our efforts in this area, beginning with early approaches to explore beta-lactam antibiotics as possible TB agents. More recent efforts have been focused on finding inhibitors of phosphopantetheinyl transferase (PptT). PptT carries out central biochemistry that is essential for mycobacterial survival; for this reason, it has been a long sought-target for antibacterial agent development. This story begins with our team’s discovery of the first effective small-molecule inhibitors of PptT, efforts to use bioisostere design to create a new series, and more recent chemotypes of PptT. Hosted by Jennifer Golden
Jeffrey Aubé, PhD Jeffrey Aubé attended the University of Miami, where he did undergraduate research with Professor Robert Gawley. He received his Ph.D. in chemistry in 1984 from Duke University, working with Professor Steven Baldwin, and was an NIH postdoctoral fellow at Yale University with Professor Samuel Danishefsky. From 1986 until 2015,he held a faculty position in the Department of Medicinal Chemistry at the University of Kansas. In 2015, he moved to the University of North Carolina, where he is an Eshelman Distinguished Professor in the Division of Chemical Biology and Medicinal Chemistry and holds a joint appointment in the Department of Chemistry. 777 Highland Ave
Madison, WI 53705
United States
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November 16, 2024
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November 17, 2024
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November 18, 2024(2 events)
– Exam 777 Highland Ave
Madison, WI 53705
United States
– This event starts at 5 PM on November 18 and ends on December 6th at 11:55 PM Online
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November 19, 2024
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November 20, 2024
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November 21, 2024
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November 22, 2024(1 event)
– Exam 777 Highland Ave
Madison, WI 53705
United States
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November 23, 2024
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November 24, 2024
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November 25, 2024
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November 26, 2024
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November 27, 2024
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November 28, 2024
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November 29, 2024
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November 30, 2024
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