Yue Gui

Ph.D. candidate in Pharmaceutical Sciences, UW-Madison

M.S. in Chemical Biology, Peking University, China, 2016

B.S. in Pharmacy, Peking University, China, 2014

B.S. in Economics (dual degree), Peking University, China, 2014

Amorphous formulations are explored as a general solution to low solubility and bioavailability of drug candidates, while crystallization of amorphous drugs eliminates all these advantages. My research interest is to understand the fundamental mechanism of crystallization and to further improve the physical stability of amorphous drugs against crystallization. On the one hand, I pay special attention to the crystal nucleation, the essential step in crystallization, of different polymorphs from the same liquid. The goal is to predict the physical stability of amorphous liquids and the outcome polymorph of crystallization. On the other hand, with the understanding of crystallization, we develop convenient and inexpensive polymer nano-coating techniques to prepare amorphous particles with enhanced physical stability and improved dissolution (PharmRes 2019). We expect the technique to improve global health, especially help people in third world countries.