Featured Publications
All Publications
- Georgieva, J. V., Katt, M., Ye, Z., Umlauf, B. J., Wenthur, C. J., & Shusta, E. V. (2022). The 46.1 Antibody Mediates Neurotensin Uptake into the CNS and the Effects Depend on the Route of Intravenous Administration. Pharmaceutics, 14(8), 1706. https://doi.org/10.3390/pharmaceutics14081706
- Worob, A., & Wenthur, C. J. (2022). Development of Cross-Reactive Antibodies for the Identification and Treatment of Synthetic Cannabinoid Receptor Agonist Toxicity. Vaccines, 10(8), 1253. https://doi.org/10.3390/vaccines10081253
- Chitwood, C., Haug, K. L., Wenthur, C., Gillis, C., Maloney, J. D., & Johnson, D. (2022). Evaluation of Prescribing Patterns Following Surgical Procedures in Opioid Naïve Patients at a Veterans Affairs Teaching Hospital. Military medicine, usac106. Advance online publication. https://doi.org/10.1093/milmed/usac106
- Navarro, G., Rea, W., Quiroz, C., Moreno, E., Gomez, D., Wenthur, C. J., Casadó, V., Leggio, L., Hearing, M. C., & Ferré, S. (2021). Complexes of ghrelin GHS-R1a, GHS-R1b and dopamine D1 receptors localized in the ventral tegmental area as main mediators of the dopaminergic effects of ghrelin. The Journal of neuroscience : the official journal of the Society for Neuroscience, JN-RM-1151-21. Advance online publication. https://doi.org/10.1523/JNEUROSCI.1151-21.2021
- Zheng, Z., Kyzer, J. L., Worob, A., & Wenthur, C. J. (2021). Family of Structurally Related Bioconjugates Yields Antibodies with Differential Selectivity against Ketamine and 6-Hydroxynorketamine. ACS chemical neuroscience, 10.1021/acschemneuro.1c00498. Advance online publication. https://doi.org/10.1021/acschemneuro.1c00498
- Banks, M. I., Zahid, Z., Jones, N. T., Sultan, Z. W., & Wenthur, C. J. (2021). Catalysts for change: the cellular neurobiology of psychedelics. Molecular biology of the cell, 32(12), 1135–1144. https://doi.org/10.1091/mbc.E20-05-0340
- Wu, S., Frey, T., & Wenthur, C. J. (2021). Naloxone acceptance by outpatient veterans: A risk-prioritized telephone outreach event. Research in social & administrative pharmacy : RSAP, 17(5), 1017–1020. https://doi.org/10.1016/j.sapharm.2020.08.010
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Wartenweiler, V., Chung, G., Stewart, A., & Wenthur, C. (2021). Pharmacy stakeholder reports on ethical and logistical considerations in anti-opioid vaccine development. BMC medical ethics, 22(1), 30. https://doi.org/10.1186/s12910-021-00599-2
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Kyzer, J. L., McGuire, M., Park, H., Belz, T. F., Bonakdar, R., Janda, K. D., & Wenthur, C. J. (2020). Anti-Opioid Antibodies in Individuals Using Chronic Opioid Therapy for Lower Back Pain. ACS pharmacology & translational science, 3(5), 896–906. https://doi.org/10.1021/acsptsci.0c00057
- Kyzer, J. L., & Wenthur, C. J. (2020). Classics in Chemical Neuroscience: Buprenorphine. ACS chemical neuroscience, 11(10), 1385–1399. https://doi.org/10.1021/acschemneuro.0c00100
- Worob, A., & Wenthur, C. (2019). DARK Classics in Chemical Neuroscience: Synthetic Cannabinoids (Spice/K2). ACS chemical neuroscience, 10.1021/acschemneuro.9b00586. Advance online publication. https://doi.org/10.1021/acschemneuro.9b00586
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Wenthur, C. J., Gautam, R., Zhou, B., Vendruscolo, L. F., Leggio, L., & Janda, K. D. (2019). Ghrelin Receptor Influence on Cocaine Reward is Not Directly Dependent on Peripheral Acyl-Ghrelin. Scientific reports, 9(1), 1841. https://doi.org/10.1038/s41598-019-38549-z
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Hwang, C. S., Bremer, P. T., Wenthur, C. J., Ho, S. O., Chiang, S., Ellis, B., Zhou, B., Fujii, G., & Janda, K. D. (2018). Enhancing Efficacy and Stability of an Antiheroin Vaccine: Examination of Antinociception, Opioid Binding Profile, and Lethality. Molecular pharmaceutics, 15(3), 1062–1072. https://doi.org/10.1021/acs.molpharmaceut.7b00933
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Wenthur, C. J., Zhou, B., & Janda, K. D. (2017). Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity. Nature, 548(7668), 476–479. https://doi.org/10.1038/nature23464
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Wenthur, C. J., Cai, X., Ellis, B. A., & Janda, K. D. (2017). Augmenting the efficacy of anti-cocaine catalytic antibodies through chimeric hapten design and combinatorial vaccination. Bioorganic & medicinal chemistry letters, 27(16), 3666–3668. https://doi.org/10.1016/j.bmcl.2017.07.014
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Gooyit, M., Miranda, P. O., Wenthur, C. J., Ducime, A., & Janda, K. D. (2017). Influencing Antibody-Mediated Attenuation of Methamphetamine CNS Distribution through Vaccine Linker Design. ACS chemical neuroscience, 8(3), 468–472. https://doi.org/10.1021/acschemneuro.6b0038
- Hwang, C. S., Smith, L. C., Wenthur, C. J., Ellis, B., Zhou, B., & Janda, K. D. (2019). Heroin vaccine: Using titer, affinity, and antinociception as metrics when examining sex and strain differences. Vaccine, 37(30), 4155–4163. https://doi.org/10.1016/j.vaccine.2019.05.061
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Kimishima, A., Wenthur, C. J., Zhou, B., & Janda, K. D. (2017). An Advance in Prescription Opioid Vaccines: Overdose Mortality Reduction and Extraordinary Alteration of Drug Half-Life. ACS chemical biology, 12(1), 36–40. https://doi.org/10.1021/acschembio.6b00977
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Kimishima, A., Wenthur, C. J., Eubanks, L. M., Sato, S., & Janda, K. D. (2016). Cocaine Vaccine Development: Evaluation of Carrier and Adjuvant Combinations That Activate Multiple Toll-Like Receptors. Molecular pharmaceutics, 13(11), 3884–3890. https://doi.org/10.1021/acs.molpharmaceut.6b00682
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Wenthur C. J. (2016). Classics in Chemical Neuroscience: Methylphenidate. ACS chemical neuroscience, 7(8), 1030–1040. https://doi.org/10.1021/acschemneuro.6b00199
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Walker, A. G., Wenthur, C. J., Xiang, Z., Rook, J. M., Emmitte, K. A., Niswender, C. M., Lindsley, C. W., & Conn, P. J. (2015). Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction. Proceedings of the National Academy of Sciences of the United States of America, 112(4), 1196–1201. https://doi.org/10.1073/pnas.1416196112
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Wenthur, C. J., Morrison, R. D., Daniels, J. S., Conn, P. J., & Lindsley, C. W. (2014). Synthesis and SAR of substituted pyrazolo[1,5-a]quinazolines as dual mGlu(2)/mGlu(3) NAMs. Bioorganic & medicinal chemistry letters, 24(12), 2693–2698. https://doi.org/10.1016/j.bmcl.2014.04.051
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Wenthur, C. J., Gentry, P. R., Mathews, T. P., & Lindsley, C. W. (2014). Drugs for allosteric sites on receptors. Annual review of pharmacology and toxicology, 54, 165–184. https://doi.org/10.1146/annurev-pharmtox-010611-134525
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Wenthur, C. J., & Lindsley, C. W. (2013). Classics in chemical neuroscience: clozapine. ACS chemical neuroscience, 4(7), 1018–1025. https://doi.org/10.1021/cn400121z
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Wenthur, C. J., Morrison, R., Felts, A. S., Smith, K. A., Engers, J. L., Byers, F. W., Daniels, J. S., Emmitte, K. A., Conn, P. J., & Lindsley, C. W. (2013). Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM). Journal of medicinal chemistry, 56(12), 5208–5212. https://doi.org/10.1021/jm400439t
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Wenthur, C. J., Cross, B. S., Vernon, V. P., Shelly, J. L., Harth, B. N., Lienhoop, A. D., Madison, N. R., & Murawski, M. M. (2013). Opinions and experiences of Indiana pharmacists and student pharmacists: the need for addiction and substance abuse education in the United States. Research in social & administrative pharmacy : RSAP, 9(1), 90–100. https://doi.org/10.1016/j.sapharm.2012.03.003
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Sheffler, D. J., Wenthur, C. J., Bruner, J. A., Carrington, S. J., Vinson, P. N., Gogi, K. K., Blobaum, A. L., Morrison, R. D., Vamos, M., Cosford, N. D., Stauffer, S. R., Daniels, J. S., Niswender, C. M., Conn, P. J., & Lindsley, C. W. (2012). Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorganic & medicinal chemistry letters, 22(12), 3921–3925. https://doi.org/10.1016/j.bmcl.2012.04.112
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Wenthur, C. J., Rodríguez, G. J., Kuntz, C. P., & Barker, E. L. (2010). Conformational flexibility of transmembrane helix VII of the human serotonin transporter impacts ion dependence and transport. Biochemical pharmacology, 80(9), 1418–1426. https://doi.org/10.1016/j.bcp.2010.07.005
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Sheffler, D. J., Wenthur, C. J., Brunner, J. A., Daniels, J. S., Morrison, R. D., Blobaum, A. L., Dawson, E. S., Engers, J. L., Niswender, C. M., Conn, P. J., & Lindsley, C. W. (2012). Development of the First Selective mGlu3 NAM from an mGlu5 PAM Hit. In Probe Reports from the NIH Molecular Libraries Program. National Center for Biotechnology Information (US).
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Wenthur, C., Daniels, J. S., Morrison, R., Engers, J. L., Niswender, C. M., Conn, P. J., & Lindsley, C. W. (2012). Development of a Second Generation mGlu3 NAM Probe. In Probe Reports from the NIH Molecular Libraries Program. National Center for Biotechnology Information (US).