Wenthur Lab

Publications

Featured Publications

All Publications

  1. Georgieva, J. V., Katt, M., Ye, Z., Umlauf, B. J., Wenthur, C. J., & Shusta, E. V. (2022). The 46.1 Antibody Mediates Neurotensin Uptake into the CNS and the Effects Depend on the Route of Intravenous Administration. Pharmaceutics, 14(8), 1706. https://doi.org/10.3390/pharmaceutics14081706
  2. Worob, A., & Wenthur, C. J. (2022). Development of Cross-Reactive Antibodies for the Identification and Treatment of Synthetic Cannabinoid Receptor Agonist Toxicity. Vaccines, 10(8), 1253. https://doi.org/10.3390/vaccines10081253
  3. Chitwood, C., Haug, K. L., Wenthur, C., Gillis, C., Maloney, J. D., & Johnson, D. (2022). Evaluation of Prescribing Patterns Following Surgical Procedures in Opioid Naïve Patients at a Veterans Affairs Teaching Hospital. Military medicine, usac106. Advance online publication. https://doi.org/10.1093/milmed/usac106
  4. Navarro, G., Rea, W., Quiroz, C., Moreno, E., Gomez, D., Wenthur, C. J., Casadó, V., Leggio, L., Hearing, M. C., & Ferré, S. (2021). Complexes of ghrelin GHS-R1a, GHS-R1b and dopamine D1 receptors localized in the ventral tegmental area as main mediators of the dopaminergic effects of ghrelin. The Journal of neuroscience : the official journal of the Society for Neuroscience, JN-RM-1151-21. Advance online publication. https://doi.org/10.1523/JNEUROSCI.1151-21.2021
  5. Zheng, Z., Kyzer, J. L., Worob, A., & Wenthur, C. J. (2021). Family of Structurally Related Bioconjugates Yields Antibodies with Differential Selectivity against Ketamine and 6-Hydroxynorketamine. ACS chemical neuroscience, 10.1021/acschemneuro.1c00498. Advance online publication. https://doi.org/10.1021/acschemneuro.1c00498
  6. Banks, M. I., Zahid, Z., Jones, N. T., Sultan, Z. W., & Wenthur, C. J. (2021). Catalysts for change: the cellular neurobiology of psychedelics. Molecular biology of the cell, 32(12), 1135–1144. https://doi.org/10.1091/mbc.E20-05-0340
  7. Wu, S., Frey, T., & Wenthur, C. J. (2021). Naloxone acceptance by outpatient veterans: A risk-prioritized telephone outreach event. Research in social & administrative pharmacy : RSAP, 17(5), 1017–1020. https://doi.org/10.1016/j.sapharm.2020.08.010
  8. Wartenweiler, V., Chung, G., Stewart, A., & Wenthur, C. (2021). Pharmacy stakeholder reports on ethical and logistical considerations in anti-opioid vaccine development. BMC medical ethics, 22(1), 30. https://doi.org/10.1186/s12910-021-00599-2
  9. Kyzer, J. L., McGuire, M., Park, H., Belz, T. F., Bonakdar, R., Janda, K. D., & Wenthur, C. J. (2020). Anti-Opioid Antibodies in Individuals Using Chronic Opioid Therapy for Lower Back Pain. ACS pharmacology & translational science, 3(5), 896–906. https://doi.org/10.1021/acsptsci.0c00057
  10. Kyzer, J. L., & Wenthur, C. J. (2020). Classics in Chemical Neuroscience: Buprenorphine. ACS chemical neuroscience, 11(10), 1385–1399. https://doi.org/10.1021/acschemneuro.0c00100
  11. Worob, A., & Wenthur, C. (2019). DARK Classics in Chemical Neuroscience: Synthetic Cannabinoids (Spice/K2). ACS chemical neuroscience, 10.1021/acschemneuro.9b00586. Advance online publication. https://doi.org/10.1021/acschemneuro.9b00586
  12. Wenthur, C. J., Gautam, R., Zhou, B., Vendruscolo, L. F., Leggio, L., & Janda, K. D. (2019). Ghrelin Receptor Influence on Cocaine Reward is Not Directly Dependent on Peripheral Acyl-Ghrelin. Scientific reports, 9(1), 1841. https://doi.org/10.1038/s41598-019-38549-z
  13. Hwang, C. S., Bremer, P. T., Wenthur, C. J., Ho, S. O., Chiang, S., Ellis, B., Zhou, B., Fujii, G., & Janda, K. D. (2018). Enhancing Efficacy and Stability of an Antiheroin Vaccine: Examination of Antinociception, Opioid Binding Profile, and Lethality. Molecular pharmaceutics, 15(3), 1062–1072. https://doi.org/10.1021/acs.molpharmaceut.7b00933
  14. Wenthur, C. J., Zhou, B., & Janda, K. D. (2017). Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity. Nature, 548(7668), 476–479. https://doi.org/10.1038/nature23464
  15. Wenthur, C. J., Cai, X., Ellis, B. A., & Janda, K. D. (2017). Augmenting the efficacy of anti-cocaine catalytic antibodies through chimeric hapten design and combinatorial vaccination. Bioorganic & medicinal chemistry letters, 27(16), 3666–3668. https://doi.org/10.1016/j.bmcl.2017.07.014
  16. Gooyit, M., Miranda, P. O., Wenthur, C. J., Ducime, A., & Janda, K. D. (2017). Influencing Antibody-Mediated Attenuation of Methamphetamine CNS Distribution through Vaccine Linker Design. ACS chemical neuroscience, 8(3), 468–472. https://doi.org/10.1021/acschemneuro.6b0038
  17. Hwang, C. S., Smith, L. C., Wenthur, C. J., Ellis, B., Zhou, B., & Janda, K. D. (2019). Heroin vaccine: Using titer, affinity, and antinociception as metrics when examining sex and strain differences. Vaccine, 37(30), 4155–4163. https://doi.org/10.1016/j.vaccine.2019.05.061
  18. Kimishima, A., Wenthur, C. J., Zhou, B., & Janda, K. D. (2017). An Advance in Prescription Opioid Vaccines: Overdose Mortality Reduction and Extraordinary Alteration of Drug Half-Life. ACS chemical biology, 12(1), 36–40. https://doi.org/10.1021/acschembio.6b00977
  19. Kimishima, A., Wenthur, C. J., Eubanks, L. M., Sato, S., & Janda, K. D. (2016). Cocaine Vaccine Development: Evaluation of Carrier and Adjuvant Combinations That Activate Multiple Toll-Like Receptors. Molecular pharmaceutics, 13(11), 3884–3890. https://doi.org/10.1021/acs.molpharmaceut.6b00682
  20. Wenthur C. J. (2016). Classics in Chemical Neuroscience: Methylphenidate. ACS chemical neuroscience, 7(8), 1030–1040. https://doi.org/10.1021/acschemneuro.6b00199
  21. Walker, A. G., Wenthur, C. J., Xiang, Z., Rook, J. M., Emmitte, K. A., Niswender, C. M., Lindsley, C. W., & Conn, P. J. (2015). Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction. Proceedings of the National Academy of Sciences of the United States of America, 112(4), 1196–1201. https://doi.org/10.1073/pnas.1416196112
  22. Wenthur, C. J., Morrison, R. D., Daniels, J. S., Conn, P. J., & Lindsley, C. W. (2014). Synthesis and SAR of substituted pyrazolo[1,5-a]quinazolines as dual mGlu(2)/mGlu(3) NAMs. Bioorganic & medicinal chemistry letters, 24(12), 2693–2698. https://doi.org/10.1016/j.bmcl.2014.04.051
  23. Wenthur, C. J., Gentry, P. R., Mathews, T. P., & Lindsley, C. W. (2014). Drugs for allosteric sites on receptors. Annual review of pharmacology and toxicology, 54, 165–184. https://doi.org/10.1146/annurev-pharmtox-010611-134525
  24. Wenthur, C. J., & Lindsley, C. W. (2013). Classics in chemical neuroscience: clozapine. ACS chemical neuroscience, 4(7), 1018–1025. https://doi.org/10.1021/cn400121z
  25. Wenthur, C. J., Morrison, R., Felts, A. S., Smith, K. A., Engers, J. L., Byers, F. W., Daniels, J. S., Emmitte, K. A., Conn, P. J., & Lindsley, C. W. (2013). Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM). Journal of medicinal chemistry, 56(12), 5208–5212. https://doi.org/10.1021/jm400439t
  26. Wenthur, C. J., Cross, B. S., Vernon, V. P., Shelly, J. L., Harth, B. N., Lienhoop, A. D., Madison, N. R., & Murawski, M. M. (2013). Opinions and experiences of Indiana pharmacists and student pharmacists: the need for addiction and substance abuse education in the United States. Research in social & administrative pharmacy : RSAP, 9(1), 90–100. https://doi.org/10.1016/j.sapharm.2012.03.003
  27. Sheffler, D. J., Wenthur, C. J., Bruner, J. A., Carrington, S. J., Vinson, P. N., Gogi, K. K., Blobaum, A. L., Morrison, R. D., Vamos, M., Cosford, N. D., Stauffer, S. R., Daniels, J. S., Niswender, C. M., Conn, P. J., & Lindsley, C. W. (2012). Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorganic & medicinal chemistry letters, 22(12), 3921–3925. https://doi.org/10.1016/j.bmcl.2012.04.112
  28. Wenthur, C. J., Rodríguez, G. J., Kuntz, C. P., & Barker, E. L. (2010). Conformational flexibility of transmembrane helix VII of the human serotonin transporter impacts ion dependence and transport. Biochemical pharmacology, 80(9), 1418–1426. https://doi.org/10.1016/j.bcp.2010.07.005
  29. Sheffler, D. J., Wenthur, C. J., Brunner, J. A., Daniels, J. S., Morrison, R. D., Blobaum, A. L., Dawson, E. S., Engers, J. L., Niswender, C. M., Conn, P. J., & Lindsley, C. W. (2012). Development of the First Selective mGlu3 NAM from an mGlu5 PAM Hit. In Probe Reports from the NIH Molecular Libraries Program. National Center for Biotechnology Information (US).
  30. Wenthur, C., Daniels, J. S., Morrison, R., Engers, J. L., Niswender, C. M., Conn, P. J., & Lindsley, C. W. (2012). Development of a Second Generation mGlu3 NAM Probe. In Probe Reports from the NIH Molecular Libraries Program. National Center for Biotechnology Information (US).

 

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