Sin Yin (Sean) Lim

Sin Yin’s research utilizes quantitative pharmacokinetics and pharmacodynamics (PK/PD) modeling approach to improve pharmacotherapy. His research has emphasized on understanding and quantifying the impact of physiological changes and pathological factors on drug disposition in special populations, including pediatrics and older adults. He has utilized mechanistically- and physiologically-based PK, and population PK/PD modeling and simulation approaches to describe drug disposition and to evaluate and individualize dosing strategies in these populations. Additionally, his research aims to optimize pain and sedation management in critically ill children, by studying biomarkers and developing a PK/PD model that can help identify tolerance to opioid and sedative therapy, reduce exposure of children to opioids, and avoid iatrogenic withdrawal syndrome.