Dendrimer-mediated Multivalent Binding for Enhanced Capture of Tumor Cells

Cited by

1. Poellmann, M. J., Bu, J., Liu, S., Wang, A. Z., Seyedin, S. N., Chandrasekharan, C., Hong, H., Kim, Y., Caster, J. M., & Hong, S. (2023). Nanotechnology and machine learning enable circulating tumor cells as a reliable biomarker for radiotherapy responses of gastrointestinal cancer patients. Biosensors & bioelectronics, 226, 115117. https://doi.org/10.1016/j.bios.2023.115117
2. Poellmann, M. J., Rawding, P., Kim, D., Bu, J., Kim, Y., & Hong, S. (2022). Branched, dendritic, and hyperbranched polymers in liquid biopsy device design. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 14(3), e1770. https://doi.org/10.1002/wnan.1770
3. Rawding, P. A., Bu, J., Wang, J., Kim, D. W., Drelich, A. J., Kim, Y., & Hong, S. (2022). Dendrimers for cancer immunotherapy: Avidity-based drug delivery vehicles for effective anti-tumor immune response. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 14(2), e1752. https://doi.org/10.1002/wnan.1752
4. Jeong, W. J., Bu, J., Jafari, R., Rehak, P., Kubiatowicz, L. J., Drelich, A. J., Owen, R. H., Nair, A., Rawding, P. A., Poellmann, M. J., Hopkins, C. M., Král, P., & Hong, S. (2022). Hierarchically Multivalent Peptide-Nanoparticle Architectures: A Systematic Approach to Engineer Surface Adhesion. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 9(4), e2103098. https://doi.org/10.1002/advs.202103098
5. Nair, A., Bu, J., Bugno, J., Rawding, P. A., Kubiatowicz, L. J., Jeong, W. J., & Hong, S. (2021). Size-Dependent Drug Loading, Gene Complexation, Cell Uptake, and Transfection of a Novel Dendron-Lipid Nanoparticle for Drug/Gene Co-delivery. Biomacromolecules, 22(9), 3746–3755. https://doi.org/10.1021/acs.biomac.1c00541
6. Wu, J., Long, Y., Li, M., & He, Q. (2021). Emerging nanomedicine-based therapeutics for hematogenous metastatic cascade inhibition: Interfering with the crosstalk between “seed and soil”. Acta pharmaceutica Sinica. B, 11(8), 2286–2305. https://doi.org/10.1016/j.apsb.2020.11.024
7. Qin, W., Chen, L., Wang, Z., Li, Q., Fan, C., Wu, M., & Zhang, Y. (2020). Bioinspired DNA Nanointerface with Anisotropic Aptamers for Accurate Capture of Circulating Tumor Cells. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 7(19), 2000647. https://doi.org/10.1002/advs.202000647
8. Bu, J., Nair, A., Iida, M., Jeong, W. J., Poellmann, M. J., Mudd, K., Kubiatowicz, L. J., Liu, E. W., Wheeler, D. L., & Hong, S. (2020). An Avidity-Based PD-L1 Antagonist Using Nanoparticle-Antibody Conjugates for Enhanced Immunotherapy. Nano letters, 20(7), 4901–4909. https://doi.org/10.1021/acs.nanolett.0c00953
9. Dong, J., Chen, J. F., Smalley, M., Zhao, M., Ke, Z., Zhu, Y., & Tseng, H. R. (2020). Nanostructured Substrates for Detection and Characterization of Circulating Rare Cells: From Materials Research to Clinical Applications. Advanced materials (Deerfield Beach, Fla.), 32(1), e1903663. https://doi.org/10.1002/adma.201903663
10. Iliescu, F. S., Poenar, D. P., Yu, F., Ni, M., Chan, K. H., Cima, I., Taylor, H. K., Cima, I., & Iliescu, C. (2019). Recent advances in microfluidic methods in cancer liquid biopsy. Biomicrofluidics, 13(4), 041503. https://doi.org/10.1063/1.5087690
11. Myung, J. H., Cha, A., Tam, K. A., Poellmann, M., Borgeat, A., Sharifi, R., Molokie, R. E., Votta-Velis, G., & Hong, S. (2019). Dendrimer-Based Platform for Effective Capture of Tumor Cells after TGFβ1-Induced Epithelial-Mesenchymal Transition. Analytical chemistry, 91(13), 8374–8382. https://doi.org/10.1021/acs.analchem.9b01181
12. Gribko, A., Künzel, J., Wünsch, D., Lu, Q., Nagel, S. M., Knauer, S. K., Stauber, R. H., & Ding, G. B. (2019). Is small smarter? Nanomaterial-based detection and elimination of circulating tumor cells: current knowledge and perspectives. International journal of nanomedicine, 14, 4187–4209. https://doi.org/10.2147/IJN.S198319
13. Xu, J., Wang, X., Yan, C., & Chen, W. (2019). A Polyamidoamine Dendrimer-Based Electrochemical Immunosensor for Label-Free Determination of Epithelial Cell Adhesion Molecule- Expressing Cancer Cells. Sensors (Basel, Switzerland), 19(8), 1879. https://doi.org/10.3390/s19081879
14. Myung, J. H., Eblan, M. J., Caster, J. M., Park, S. J., Poellmann, M. J., Wang, K., Tam, K. A., Miller, S. M., Shen, C., Chen, R. C., Zhang, T., Tepper, J. E., Chera, B. S., Wang, A. Z., & Hong, S. (2018). Multivalent Binding and Biomimetic Cell Rolling Improves the Sensitivity and Specificity of Circulating Tumor Cell Capture. Clinical cancer research : an official journal of the American Association for Cancer Research, 24(11), 2539–2547. https://doi.org/10.1158/1078-0432.CCR-17-3078
15. Myung, J. H., Park, S. J., Wang, A. Z., & Hong, S. (2018). Integration of biomimicry and nanotechnology for significantly improved detection of circulating tumor cells (CTCs). Advanced drug delivery reviews, 125, 36–47. https://doi.org/10.1016/j.addr.2017.12.005
16. Jan, Y. J., Chen, J. F., Zhu, Y., Lu, Y. T., Chen, S. H., Chung, H., Smalley, M., Huang, Y. W., Dong, J., Chen, L. C., Yu, H. H., Tomlinson, J. S., Hou, S., Agopian, V. G., Posadas, E. M., & Tseng, H. R. (2018). NanoVelcro rare-cell assays for detection and characterization of circulating tumor cells. Advanced drug delivery reviews, 125, 78–93. https://doi.org/10.1016/j.addr.2018.03.006
17. Shen, M. Y., Chen, J. F., Luo, C. H., Lee, S., Li, C. H., Yang, Y. L., Tsai, Y. H., Ho, B. C., Bao, L. R., Lee, T. J., Jan, Y. J., Zhu, Y. Z., Cheng, S., Feng, F. Y., Chen, P., Hou, S., Agopian, V., Hsiao, Y. S., Tseng, H. R., Posadas, E. M., … Yu, H. H. (2018). Glycan Stimulation Enables Purification of Prostate Cancer Circulating Tumor Cells on PEDOT NanoVelcro Chips for RNA Biomarker Detection. Advanced healthcare materials, 7(3), 10.1002/adhm.201700701. https://doi.org/10.1002/adhm.201700701
18. Zhang, W., Wang, J., Li, P., Wu, C., Zhang, H., Zhang, W., Wang, H., & Tang, B. (2017). Transferrin-navigation Nano Artificial Antibody Fluorescence Recognition of Circulating Tumor Cells. Scientific reports, 7(1), 10142. https://doi.org/10.1038/s41598-017-10486-9
19. Song, Y., Tian, T., Shi, Y., Liu, W., Zou, Y., Khajvand, T., Wang, S., Zhu, Z., & Yang, C. (2017). Enrichment and single-cell analysis of circulating tumor cells. Chemical science, 8(3), 1736–1751. https://doi.org/10.1039/c6sc04671a
20. Zhang, Z., & King, M. R. (2017). Nanomaterials for the Capture and Therapeutic Targeting of Circulating Tumor Cells. Cellular and molecular bioengineering, 10(4), 275–294. https://doi.org/10.1007/s12195-017-0497-4
21. Jiang, X., Bugno, J., Hu, C., Yang, Y., Herold, T., Qi, J., Chen, P., Gurbuxani, S., Arnovitz, S., Strong, J., Ferchen, K., Ulrich, B., Weng, H., Wang, Y., Huang, H., Li, S., Neilly, M. B., Larson, R. A., Le Beau, M. M., Bohlander, S. K., … Chen, J. (2016). Eradication of Acute Myeloid Leukemia with FLT3 Ligand-Targeted miR-150 Nanoparticles. Cancer research, 76(15), 4470–4480. https://doi.org/10.1158/0008-5472.CAN-15-2949
22. Pearson, R. M., Sen, S., Hsu, H. J., Pasko, M., Gaske, M., Král, P., & Hong, S. (2016). Tuning the Selectivity of Dendron Micelles Through Variations of the Poly(ethylene glycol) Corona. ACS nano, 10(7), 6905–6914. https://doi.org/10.1021/acsnano.6b02708
23. Chen, J. F., Zhu, Y., Lu, Y. T., Hodara, E., Hou, S., Agopian, V. G., Tomlinson, J. S., Posadas, E. M., & Tseng, H. R. (2016). Clinical Applications of NanoVelcro Rare-Cell Assays for Detection and Characterization of Circulating Tumor Cells. Theranostics, 6(9), 1425–1439. https://doi.org/10.7150/thno.15359
24. Myung, J. H., Tam, K. A., Park, S. J., Cha, A., & Hong, S. (2016). Recent advances in nanotechnology-based detection and separation of circulating tumor cells. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 8(2), 223–239. https://doi.org/10.1002/wnan.1360
25. Myung, J. H., & Hong, S. (2015). Microfluidic devices to enrich and isolate circulating tumor cells. Lab on a chip, 15(24), 4500–4511. https://doi.org/10.1039/c5lc00947b
26. Myung, J. H., Roengvoraphoj, M., Tam, K. A., Ma, T., Memoli, V. A., Dmitrovsky, E., Freemantle, S. J., & Hong, S. (2015). Effective capture of circulating tumor cells from a transgenic mouse lung cancer model using dendrimer surfaces immobilized with anti-EGFR. Analytical chemistry, 87(19), 10096–10102. https://doi.org/10.1021/acs.analchem.5b02766
27. Mitchell, M. J., Castellanos, C. A., & King, M. R. (2015). Immobilized surfactant-nanotube complexes support selectin-mediated capture of viable circulating tumor cells in the absence of capture antibodies. Journal of biomedical materials research. Part A, 103(10), 3407–3418. https://doi.org/10.1002/jbm.a.35445
28. Li, S., Chen, N., Gaddes, E. R., Zhang, X., Dong, C., & Wang, Y. (2015). A Drosera-bioinspired hydrogel for catching and killing cancer cells. Scientific reports, 5, 14297. https://doi.org/10.1038/srep14297
29. Sharma, A., & Kakkar, A. (2015). Designing Dendrimer and Miktoarm Polymer Based Multi-Tasking Nanocarriers for Efficient Medical Therapy. Molecules (Basel, Switzerland), 20(9), 16987–17015. https://doi.org/10.3390/molecules200916987
30. Bugno, J., Hsu, H. J., & Hong, S. (2015). Recent advances in targeted drug delivery approaches using dendritic polymers. Biomaterials science, 3(7), 1025–1034. https://doi.org/10.1039/c4bm00351a
31. Tang, L., Yin, Q., Xu, Y., Zhou, Q., Cai, K., Yen, J., Dobrucki, L. W., & Cheng, J. (2015). Bioorthogonal Oxime Ligation Mediated In Vivo Cancer Targeting. Chemical science, 6(4), 2182–2186. https://doi.org/10.1039/C5SC00063G
32. Xie, J., Wang, J., Chen, H., Shen, W., Sinko, P. J., Dong, H., Zhao, R., Lu, Y., Zhu, Y., & Jia, L. (2015). Multivalent conjugation of antibody to dendrimers for the enhanced capture and regulation on colon cancer cells. Scientific reports, 5, 9445. https://doi.org/10.1038/srep09445
33. Xie, J., Dong, H., Chen, H., Zhao, R., Sinko, P. J., Shen, W., Wang, J., Lu, Y., Yang, X., Xie, F., & Jia, L. (2015). Exploring cancer metastasis prevention strategy: interrupting adhesion of cancer cells to vascular endothelia of potential metastatic tissues by antibody-coated nanomaterial. Journal of nanobiotechnology, 13, 9. https://doi.org/10.1186/s12951-015-0072-x
34. Bugno, J., Hsu, H. J., & Hong, S. (2015). Tweaking dendrimers and dendritic nanoparticles for controlled nano-bio interactions: potential nanocarriers for improved cancer targeting. Journal of drug targeting, 23(7-8), 642–650. https://doi.org/10.3109/1061186X.2015.1052077
35. Wang, S., Wan, Y., & Liu, Y. (2014). Effects of nanopillar array diameter and spacing on cancer cell capture and cell behaviors. Nanoscale, 6(21), 12482–12489. https://doi.org/10.1039/c4nr02854f
36. Xie, J., Zhao, R., Gu, S., Dong, H., Wang, J., Lu, Y., Sinko, P. J., Yu, T., Xie, F., Wang, L., Shao, J., & Jia, L. (2014). The architecture and biological function of dual antibody-coated dendrimers: enhanced control of circulating tumor cells and their hetero-adhesion to endothelial cells for metastasis prevention. Theranostics, 4(12), 1250–1263. https://doi.org/10.7150/thno.8775
37. Tang, Y., Shi, J., Li, S., Wang, L., Cayre, Y. E., & Chen, Y. (2014). Microfluidic device with integrated microfilter of conical-shaped holes for high efficiency and high purity capture of circulating tumor cells. Scientific reports, 4, 6052. https://doi.org/10.1038/srep06052
38. Zhang, J., Sheng, W., & Fan, Z. H. (2014). An ensemble of aptamers and antibodies for multivalent capture of cancer cells. Chemical communications (Cambridge, England), 50(51), 6722–6725. https://doi.org/10.1039/c4cc02002b
39. Myung, J. H., Gajjar, K. A., Chen, J., Molokie, R. E., & Hong, S. (2014). Differential detection of tumor cells using a combination of cell rolling, multivalent binding, and multiple antibodies. Analytical chemistry, 86(12), 6088–6094. https://doi.org/10.1021/ac501243a
40. Zhu, S., & Segura, T. (2014). HYDROGEL-BASED NANOCOMPOSITES OF THERAPEUTIC PROTEINS FOR TISSUE REPAIR. Current opinion in chemical engineering, 4, 128–136. https://doi.org/10.1016/j.coche.2013.12.009
41. Fierer, J. O., Veggiani, G., & Howarth, M. (2014). SpyLigase peptide-peptide ligation polymerizes affibodies to enhance magnetic cancer cell capture. Proceedings of the National Academy of Sciences of the United States of America, 111(13), E1176–E1181. https://doi.org/10.1073/pnas.1315776111
42. Song, Y., Huang, Y. Y., Liu, X., Zhang, X., Ferrari, M., & Qin, L. (2014). Point-of-care technologies for molecular diagnostics using a drop of blood. Trends in biotechnology, 32(3), 132–139. https://doi.org/10.1016/j.tibtech.2014.01.003
43. Wang, E. C., & Wang, A. Z. (2014). Nanoparticles and their applications in cell and molecular biology. Integrative biology : quantitative biosciences from nano to macro, 6(1), 9–26. https://doi.org/10.1039/c3ib40165k
44. Tassa, C., Liong, M., Hilderbrand, S., Sandler, J. E., Reiner, T., Keliher, E. J., Weissleder, R., & Shaw, S. Y. (2013). Microfluidic on-chip capture-cycloaddition reaction to reversibly immobilize small molecules or multi-component structures for biosensor applications. Journal of visualized experiments : JoVE, (79), e50772. https://doi.org/10.3791/50772
45. Sheng, W., Chen, T., Tan, W., & Fan, Z. H. (2013). Multivalent DNA nanospheres for enhanced capture of cancer cells in microfluidic devices. ACS nano, 7(8), 7067–7076. https://doi.org/10.1021/nn4023747
46. Lee, S., Yang, Y., Fishman, D., Banaszak Holl, M. M., & Hong, S. (2013). Epithelial-mesenchymal transition enhances nanoscale actin filament dynamics of ovarian cancer cells. The journal of physical chemistry. B, 117(31), 9233–9240. https://doi.org/10.1021/jp4055186
47. Cho, E. J., Holback, H., Liu, K. C., Abouelmagd, S. A., Park, J., & Yeo, Y. (2013). Nanoparticle characterization: state of the art, challenges, and emerging technologies. Molecular pharmaceutics, 10(6), 2093–2110. https://doi.org/10.1021/mp300697h
48. Jain, J., Veggiani, G., & Howarth, M. (2013). Cholesterol loading and ultrastable protein interactions determine the level of tumor marker required for optimal isolation of cancer cells. Cancer research, 73(7), 2310–2321. https://doi.org/10.1158/0008-5472.CAN-12-2956
49. Xiao, S., Turkyilmaz, S., & Smith, B. D. (2013). Convenient Synthesis of Multivalent Zinc(II)-Dipicolylamine Complexes for Molecular Recognition. Tetrahedron letters, 54(8), 861–864. https://doi.org/10.1016/j.tetlet.2012.11.103
50. Pearson, R. M., Patra, N., Hsu, H. J., Uddin, S., Král, P., & Hong, S. (2013). Positively Charged Dendron Micelles Display Negligible Cellular Interactions. ACS macro letters, 2(1), 77–81. https://doi.org/10.1021/mz300533w
51. Huang, W. Y., Davies, G. L., & Davis, J. J. (2013). High signal contrast gating with biomodified Gd doped mesoporous nanoparticles. Chemical communications (Cambridge, England), 49(1), 60–62. https://doi.org/10.1039/c2cc37545a
52. Tassa, C., Liong, M., Hilderbrand, S., Sandler, J. E., Reiner, T., Keliher, E. J., Weissleder, R., & Shaw, S. Y. (2012). On-chip bioorthogonal chemistry enables immobilization of in situ modified nanoparticles and small molecules for label-free monitoring of protein binding and reaction kinetics. Lab on a chip, 12(17), 3103–3110. https://doi.org/10.1039/c2lc40337d
53. Yang, Y., Sunoqrot, S., Stowell, C., Ji, J., Lee, C. W., Kim, J. W., Khan, S. A., & Hong, S. (2012). Effect of size, surface charge, and hydrophobicity of poly(amidoamine) dendrimers on their skin penetration. Biomacromolecules, 13(7), 2154–2162. https://doi.org/10.1021/bm300545b
54. Liu, J., Gray, W. D., Davis, M. E., & Luo, Y. (2012). Peptide- and saccharide-conjugated dendrimers for targeted drug delivery: a concise review. Interface focus, 2(3), 307–324. https://doi.org/10.1098/rsfs.2012.0009
55. Sunoqrot, S., Bae, J. W., Pearson, R. M., Shyu, K., Liu, Y., Kim, D. H., & Hong, S. (2012). Temporal control over cellular targeting through hybridization of folate-targeted dendrimers and PEG-PLA nanoparticles. Biomacromolecules, 13(4), 1223–1230. https://doi.org/10.1021/bm300316n