The Golden research group uses synthetic medicinal chemistry to address issues in chemical biology. We develop synthetic methods to generate new chemical architecture and explore its associated pharmacology. Currently, projects in my laboratory focus on chemical methodology development and the optimization of anti-infective and anticancer agents in cell and animal models. We work closely with expert collaborators who assess our compounds against various biological targets, and through structural manipulation of our chemical scaffolds, we refine properties to achieve a desired activity profile. As such, synthetic and medicinal chemistry go hand-in-hand, as we develop novel synthetic transformations that afford distinct, drug-like architecture that permit exploration of underrepresented scaffolds.
Synthetic Methodology
Medicinal Chemistry
