Openings

Publications

Recent Publications from the Tang Lab: 2018 – present

Chemists and Biologists work collaboratively on most current projects in the Tang group.

  1. “Rh(II) and Chiral Phosphoric Acid Co-catalyzed Selective O–H Insertions for Stereodivergent O-Alkylation of Glycosides” Wu, J.;‡ Jia, P.;‡ Tang, H.; Cai, D. and Tang, W.* J. Am. Chem. Soc. 2025, ASAP. Link. (‡Equal Contribution)
  2. “Development of Prostate Cancer-Targeting BRD4 Intramolecular Bivalent Molecular Glue Degraders” Cai, D.;‡ Li, C.;‡ Bio Idrissou, M.; Hawkins, N. J.; Mudududdla, R.; Chen, X.; Nguyen, T. T.; Li, X.; Hernandez, R.; Tang, W.* ChemRxiv 2024. Link. (‡Equal Contribution)
  3. “Development of Potent and Selective RIPK1 Degraders with In Vivo Efficacy for Cancer Treatment” Zhang, Z.;‡ Li, C.;‡ Hawkins, N. J.;‡ Mudududdla, R.; Nie, Y.; Liu, P.-K.; Huang, P.; Del Rio, N. M.; Chang, H.; Brown, M. E.; Li, L.; Tang, W.* ChemRxiv 2024. Link. (‡Equal Contribution)
  4. “Development of Folate Receptor Targeting Chimeras for Cancer Selective Degradation of Extracellular Proteins” Zhou, Y.; Li, C.; Chen, X.; Zhao, Y.; Liao, Y.; Huang, P.; Wu, W.; Nieto, N. S.; Li, L.; and Tang, W.* Nat. Commun. 2024, 15, 8695. Link. Link to PDF file.
  5. “AI is a viable alternative to high throughput screening: a 318-target study” The Atomwise AIMS Program (>100 authors) Sci. Rep. 2024, 14, 7526. Link.
  6. “Development of Integrin Targeting Chimeras (ITACs) for the Lysosomal Degradation of Extracellular Proteins” Zhou, Y.; Liao, Y.; Zhao, Y.; Tang, W.* ChemMedChem 2024, 19, e202300643. Link.
    Schematic illustration of degraders that recruit various lysosome-targeting receptors (LTRs)
  7. “BCR::ABL1 Proteolysis-targeting chimeras (PROTACs): The new frontier in the treatment of Ph+ leukemias?” Cruz-Rodriguez, N.; Tang, H.; Benjamin Bateman, B.; Tang, W.; Deininger, M.* Leukemia 2024, 38, 1885–1893. Link.
  8. “Non-Markovian Dynamic Models Identify Non-Canonical KRAS-VHL Encounter Complex Conformations for Novel PROTAC Design” Qiu, Y.; Wiewiora, R. P.; Izaguirre, J. A.; Xu, H.; Sherman, W.; Tang, W.*; Huang, X.* JACS Au 2024, 4, 3857-3868. Link.
  9. “Development of Phenyl-substituted Isoindolinone- and Benzimidazole-Type Cereblon Ligands for Targeted Protein Degradation” Nie, X.;‡ Zhao, Y.;‡ Tang, H.;‡ Zhang, Z.; Liao, J.; Almodóvar-Rivera, C. M.; Sundaresan, R.; Xie, H.; Guo, L.; Wang, B.; Guan, H.; Xing, Y.; and Tang, W.* ChemBioChem 2024, 25, e202300685. Link. (‡Equal Contribution)
  10. “Stereo- and Site-selective Acylation in Carbohydrate Synthesis” Blaszczyk, S. A.; Li, X.; Wen, P.; and Tang, W.* Synlett 2024, 35, 1745-1762. (an account for our work in the past 10 years or so) Link.
  11. “Targeted Degradation of Extracellular Secreted and Membrane Proteins” Chen, X.; Zhou, Y. ; Zhao, Y.; and Tang, W.* Trends. Pharmacol. Sci. 2023, 44, 762-775. Link.
  12. “Development of Potent and Selective Coactivator-Associated Arginine Methyltransferase 1 (CARM1) Degraders” Xie, H.;‡ Bacbac, M. S.;‡ Ma, M.; Kim, E.-J.; Wang, Y.; Wu, W.; Li, L.; Xu, W.* and Tang, W.* J. Med. Chem. 2023, 66, 13028–13042. Link. (‡Equal Contribution).Abstract image for Tang publication on "Development of Potent and Selective Coactivator-Associated Arginine Methyltransferase 1(CARM1) Degraders. Key points: (1) Quickly identified E3 libase and linker length by Rapid-TAC platform; (2) Rigid linkers yielded potent PROTACs 3b and 3e; (3) 3b is at least 100-fold more potent than TP-604 for downstream effects; (4) 3b is more potent than TP-064 for inhibiting breast cancer cell mibration
  13. “Dynamic Kinetic Stereoselective Glycosylation via Rh(II) and Chiral Phosphoric Acid-Cocatalyzed Carbenoid Insertion to Anomeric OH Bond for the Synthesis of Glycoconjugates” Wu, J.;‡ Jia, P.;‡ Kuniyil, R.;‡ Liu, P.* and Tang, W.* Angew. Chem. In. Ed. 2023, 62, e202307144. Link. (‡Equal Contribution) Highlighted as “hot paper”An efficient approach for the stereoselective synthesis of α-linked glycoconjugates was reported via a RhII/chiral phosphoric acid (CPA)-cocatalyzed dynamic kinetic anomeric O-alkylation of sugar-derived lactols via carbenoid insertion, achieving excellent anomeric/diastereo-selectivity, broad substrate scope, and high efficiency.
  14. “A Modular Chemistry Platform for the Development of a Cereblon E3 Ligase-based Partial PROTAC Library” Almodóvar-Rivera, C. M.; Zhang, Z.; Li, J.; Xie, H.; Zhao, Y.; Guo, L.; Mannhardt, M. G. and Tang, W.* ChemBioChem 2023, 24, e202300482. Link.
  15. “A platform for the rapid synthesis of molecular glues (Rapid-Glue) under miniaturized conditions for direct biological screening” Li, J.;‡ Li, C.;‡ Zhang, Z.;‡ Zhang, Z.;‡ Wu, Z.; Liao, J.; Wang, Z.; McReynolds, M.; Xie, H.; Guo, L.; Fan, Q.; Peng, J. and Tang, W.* Eur. J. Med. Chem. 2023, 258, 115567. Link. (‡Equal Contribution) Abstract image showing that when 380 commercially available aldehydes are combined with 4 building blocks in DMSO, 1520 compounds are generated under miniaturized conditions.
  16. “Development of Oligomeric Mannose-6-phosphonate Conjugates for Targeted Protein Degradation” Stevens, C. M.‡; Zhou, Y.‡; Teng, P.‡; Rault, L. N.; Liao, Y.; Tang, W.* ACS Med. Chem. Lett. 2023, 14, 719-726. Link. (‡Equal Contribution)Graphical abstract: the development of a series of structurally well-defined mannose-6-phosphonate (M6Pn)-peptide conjugates that are capable of linking to a variety of targeting ligands for proteins of interest and successfully internalizing and degrading those proteins through M6PR.
  17. “Development of Substituted Phenyl Dihydrouracil as the Novel Achiral Cereblon Ligands for Targeted Protein Degradation” Xie, H.‡; Li, C.‡; Tang, H.; Tandon, I.; Liao, J.; Roberts, B. L.; Zhao, Y.; Tang, W.* J. Med. Chem. 2023, 66, 2904-2917. Link. (‡Equal Contribution)Abstract image of findings: substituted achiral phenyl dihydrouracil (PDHU) can be used as a novel class of CRBN ligands for the development of PROTACs. Although the parent PDHU has a minimal binding affinity to CRBN, we found that some substituted PDHUs had a comparable binding affinity to lenalidomide. Structural modeling provided a further understanding of the molecular interactions between PDHU ligands and CRBN. PDHUs also have greater stability than lenalidomide. Finally, potent BRD4 degraders were developed by employing trisubstituted PDHUs.
  18. “LPA81: Discovery of an Exceptionally Potent Protac Degrading Native and Mutant BCR-ABL1 Oncoprotein in CML” Milad Rouhimoghadam, M.; Tang, H.; Liao, J.; Bates, B.; Uribe-Cano, D.; Zhao, H.; Tang, W.; Deininger, M. W. Blood 2022, 140 (Supplement 1), 485–486. Link.
  19. “Diptoindonesin G is a middle domain HSP90 modulator for cancer treatment” Donahue, K.‡; Xie, H.‡; Li, M.; Gao, A.; Ma, M.; Wang, Y.; Tipton, R.; Semanik, N.; Primeau, T.; Li, S.; Li, L.; Tang, W.*; Xu, W.* J. Biol. Chem. 2022, 298 , 102700. Link. (‡Equal Contribution) (Editor’s pick)
  20. “Development of Selective FGFR1 Degraders using a Rapid Synthesis of Proteolysis Targeting Chimera (Rapid-TAC) Platform” Guo, L.‡; Liu, J.‡; Nie, X.‡; Wang, T.; Ma, Z.- X., Yin, D. Tang, W.* Bioorg. Med. Chem. Lett. 2022, 75, 128982. Link. (‡Equal Contribution)Abstract image for Tang Lab study "Development of selective FGFR1 degraders using a Rapid synthesis of proteolysis targeting Chimera (Rapid-TAC) platform"
  21. “Proteolysis-targeting chimera (PROTAC) delivery system: advancing protein degraders towards clinical translation” Chen, Y.; Tandon, I.; Heelan, W.; Wang, Y.; Tang, W.* and Hu, Q.* Chem. Soc. Rev. 2022, 51, 5330-5350. Link. Graphical abstract: Proteolysis-targeting chimera (PROTAC) delivery system: advancing protein degraders towards clinical translation
  22. “A Platform for the Rapid Synthesis of Proteolysis Targeting Chimeras (Rapid-TAC) under Miniaturized Conditions” Guo, L.‡; Zhou, Y.‡; Nie, X.‡; Zhang, Z.; Zhang, Z.; Li, C.; Wang, T.; and Tang, W.* Eur. J. Med. Chem. 2022, 236, 114317. Link. (‡Equal Contribution)Graphical abstract for Tang Lab study "A platform for the rapid synthesis of proteolysis targeting chimeras (Rapid-TAC) under miniaturized conditions"
  23. “A General Strategy for the Synthesis of Rare Sugars via Ru(II)-catalyzed and Boron-mediated Selective Epimerization of 1,2-trans-diols to 1,2-cis-diols” Li, X.; Wu, J.; and Tang, W.* J. Am. Chem. Soc. 2022, 144, 3727-3736. Link. Highlighted in Organic Chemistry Highlight – Link.
  24. “Streamlined Iterative Assembly of Thio-oligosaccharides by Aqueous S-Glycosylation of Diverse Deoxythio Sugars” Wen, P.‡; Jia, P.‡; Fan, Q.; McCarty, B. J. and Tang, W.* ChemSusChem 2022, 15, e202102483. Link. (‡Equal Contribution)
  25. “In Silico Modeling and Scoring of PROTAC-Mediated Ternary Complex Poses” Liao, J.; Nie, X.; Unarta, I. C.; Ericksen, S. S.*; and Tang, W.* J. Med. Chem. 2022, 65, 6116-6132. Link.
    Illustrated info model that compares poses and whether they are maintained in crystal ref
  26. “Energy Decomposition Analysis Reveals the Nature of Lone Pair−π Interactions with Cationic π Systems in Catalytic Acyl Transfer Reactions” Hao, H.; Qi, X.; Tang, W.* and Liu, P.* Org. Lett. 2021, 23, 4411–4414. Link.
    Graphical abstract for "Energy Decomposition Analysis Reveals the Nature of Lone Pair−π Interactions with Cationic π Systems in Catalytic Acyl Transfer Reactions"
  27. “Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins” Zhou, Y.; Teng, P.; Montgomery, N. T.; Li, X.; and Tang, W.* ACS Cent. Sci, 2021, 7, 499-506. Link.
    Graphical abstract: The attachment of trimeric GalNAc to small molecules or antibodies yields bifunctional molecules that can selectively direct extracellular proteins into the lysosome of liver cells for degradation.
  28. “Evaluation of the binding affinity of E3 ubiquitin ligase ligands by cellular target engagement and in-cell ELISA assay” Yang, K.;  Zhou, Y.; Roberts, R. L.; Nie, X.; Tang, W.* Star Protocols 2021, 2, 100288. Link.
  29. “A neuroanatomical mechanism linking perinatal TCDD exposure to lower urinary tract dysfunction in adulthood” Turco, A. E.; Oakes, S. R.; Stietz, K. P. K. Dunham, C. L.; Joseph, D. B.; Chathurvedula, T. S.; Girardi, N. M.; Schneider, A. J.; Gawdzik, J.; Sheftel, C. M.; Wang, P.; Wang, Z.; Bjorling, D. E.; Ricke, W. A.; Tang, W.; Hernandez, L. L.; Keast, J. R.; Bonev, A. D.; Grimes, M. D.; Strand, D. W.; Tykocki, N. R.; Tanguay, R. L.; Peterson, R. E.; Vezina, C. M. Dis. Models Mech. 2021, 14, dmm049068. Link.
  30. “Development of MDM2 Degraders Based on Ligands Derived from Ugi Reactions:
    Lessons and Discoveries” Wang, B.‡; Liu, J.‡; Tandon, I.; Wu, S.; Teng, P.; Liao, J.; and Tang, W.* Eur. J. Med. Chem. 2021, 219, 113425. Link. (‡Equal Contribution)
    Chemical structure and graph involving MDM2 degraders
  31. “A dancing nickel in asymmetric catalysis: Enantioselective synthesis of boronic esters by 1,1-addition to terminal alkenes” McCarty, B. J. and Tang, W.* Green Syn. Cat. 2021, 2, 1-3. Link.
  32. “Transition Metal-Catalyzed Selective Carbon−Carbon Bond Cleavage of Vinylcyclopropanes in Cycloaddition Reactions” Wang, J.; Blaszczyk, S. A.; Li, X.;* and Tang, W.* Chem. Rev. 2021, 121, 110-139. Link.
  33. “A marine microbiome antifungal targets urgent-threat drug-resistant fungi” Zhang, F.; Zhao, M.; Braun, D. R.; Ericksen, S. S.; Piotrowski, J. S.; Nelson, J.; Peng, J.; Ananiev, G. E. Chanana, S.; Barns, K.; Fossen, J.; Sanchez, H.; Chevrette, M. G.; Guzei, I. A.; Zhao, C.; Guo, L.; Tang, W.; Currie, C. R.; Rajski, S. R.; Audhya, A.; Andes, D. R.; Bugni, T. S. Science, 2020, 370 (issue 6519), 974-978. Link.
  34. “From Methylene Bridged Diindole to Carbonyl Linked Benzimidazoleindole: Development of Potent and Metabolically Stable PCSK9 Modulators” Xie, H.;‡ Yang, K.;‡ Winston-McPherson, G. N.; Stapleton, D. S.; Keller, M. P.; Attie, A. D.; Smith, K. A.; and Tang, W.* Eur. J. Med. Chem. 2020, 206, 112678-112692. Link. (‡Equal Contribution)
    Graphical abstract for Tang research article "From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators"
  35. “Mild Cu(OTf)2-mediated C-glycosylation with Chelation-Assisted Picolinate as a Leaving Group” Ye, W.;‡ Stevens, C. M.;‡ Wen, P.;‡ Simmons, C. J.; and Tang, W.* J. Org. Chem. 2020, 85, 16218–16225. Link. (‡Equal Contribution) (Special Issue on A New Era of Discovery in Carbohydrate Chemistry)
  36. “A Cell-based Target Engagement Assay for the Identification of Cereblon E3 Ubiquitin Ligase Ligands and Their Application in HDAC6 Degraders” Yang, K.;‡  Zhao, Y.;‡ Nie, X.; Wu, H.; Wang, B.; Almodovar-Rivera, C. M.; Xie, H.;* Tang, W.* Cell Chem. Biol. 2020, 27, 866-876. Link. (‡Equal ContributionGraphical abstract for Tang research article "A Cell-Based Target Engagement Assay for the Identification of Cereblon E3 Ubiquitin Ligase Ligands and Their Application in HDAC6 Degraders"
  37. “Two-stage Strategy for Development of Proteolysis Targeting Chimeras and its Application for Estrogen Receptor Degraders” Roberts, B. L.;‡ Ma, Z.-X.;‡ Gao, A.; Leisten, E. D.; Yin, D.; Xu, W.; and Tang, W.* ACS Chem. Biol. 2020, 15, 1487–1496. Link. (‡Equal Contribution)
    Graphical abstract showing Tang lab study stages. Stage 1: Simultaneously examine multiple parameters of a library of unstable PROTACs by in-cell ELISA, and Stage 2: Form stable PROTACs by bioisoteric replacement.
  38. “Chemical Synthesis and Biological Application of Modified Oligonucleotides” Glazier, D. A.;‡ Liao, J.;‡ Roberts, B. L.;‡ Li, X.; Yang, K.; Stevens, C. M.; and Tang, W.* Bioconjugate Chem. 2020, 31, 1213-1233. Link. (‡Equal Contribution)
    Graphical abstract for Tang article "Chemical Synthesis and Biological Application of Modified Oligonucleotides"
  39. “Development of Selective Histone Deacetylase 6 (HDAC6) Degraders Recruiting Von Hippel–Lindau (VHL) E3 Ubiquitin Ligase” Yang, K.;‡ Wu, H.;‡ Zhang, Z.; Leisten, E. D.; Nie, X.; Liu, B.; Wen, Z.; Zhang, J.; Cunningham, M. D. and Tang, W.* ACS Med. Chem. Lett. 2020, 11, 575-581. Link. (‡Equal Contribution)
    Graphical abstract for Tang article "Development of Selective Histone Deacetylase 6 (HDAC6) Degraders Recruiting Von Hippel–Lindau (VHL) E3 Ubiquitin Ligase"
  40. “Synthesis of Glycosyl Chlorides and Bromides by Chelation Assisted Activation of Picolinic Esters under Mild Neutral Conditions” Wen, P.;‡ Simmons, C. J.;‡ Ma, Z.-X.; Blaszczyk, S. A.; Balzer, P. G.; Ye, W.; Duan, X.; Wang, H.-Y.; Yin, D.; Stevens, C. M.; and Tang, W.* Org. Lett. 2020, 22, 1495-1498. Link. (‡Equal Contribution)
  41. “Synthesis and Biological Evaluation of FICZ Analogues as Agonists of Aryl Hydrocarbon Receptor” Wu, H.;‡ Liu, B.;‡ Yang, K.;‡ Winston-McPherson, G. N.; Leisten, E. D.; Vezina, C. M.; Ricke, W. A.; Peterson, R. E.; and Tang, W.* Bioorg. Med. Chem. Lett. 2020, 30, 126959. Link. (‡Equal Contribution)
  42. “Rhodium-Catalyzed (5 + 2) and (5 + 1) Cycloadditions Using 1,4-Enynes as Five-Carbon Building Blocks” Blaszczyk, S. A.; Glazier, D. A.; and Tang, W.* Acc. Chem. Res. 2020, 53, 231-243. Link.
    Graphical abstract image for Tang article "Rhodium-Catalyzed (5 + 2) and (5 + 1) Cycloadditions Using 1,4-Enynes as Five-Carbon Building Blocks"
  43. “Mechanism of Activation for the Sirtuin 6 Protein Deacylase” Klein, M. A., Liu, C.; Kuznetsov, V. I.; Feltenberger, J. B.; Tang, W.; Denu, J. M.* J. Biol. Chem. 2020, 295, 1385-1399. Link.
  44. “In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure exacerbates urinary dysfunction in hormone-treated C57BL/6J mice through a non-malignant mechanism involving proteomic changes in the prostate that differ from those elicited by testosterone and estradiol” Turco, A. E.; Thomas, S;  Crawford, L. K.; Tang, W.; Peterson, R. E.; Li, L.; Ricke, W. A.; Vezina, C. M.* Am. J. Clin. Exp. Urol. 2020, 8, 59. Link.
  45. “Tissue-specific quantification and localization of androgen and estrogen receptors in prostate cancer” Sehgal, P. D.; Bauman, T. M.; Nicholson, T. M.; Vellky, J. E.; Ricke, E. A.; Tang, W.; Xu, W.; Huang, W.; Ricke, W. A.* Hum. Pathol. 2019, 89, 99-108. Link.
  46. “Site- and Stereoselective O-Alkylation of Glycosides by Rh(II)-Catalyzed Carbenoid Insertion” Wu, J.;‡ Li, X.;‡ Qi, X.; Duan, X.; Cracraft, W. L.; Guizei, I. A.; Liu, P.;* and Tang, W.* J. Am. Chem. Soc. 2019, 141, 19902-19910. Link. (‡Equal Contribution)
    Graphical abstract image for Tang article "Site-Selective and Stereoselective O-Alkylation of Glycosides by Rh(II)-Catalyzed Carbenoid Insertion"
  47. “A general strategy for diversifying complex natural products to polycyclic scaffolds with medium-sized rings” Zhao, C.; Ye, Z.; Ma, Z.-X.; Wildman, S. A.; Blaszczyk, S. A.; Hu, L.; Guizei, I. A.; Tang, W.* Nat. Commun. 2019, 10, 4015. Link.Graphical abstract: Two Phases of Diversification. Starting from a polycyclic scaffold, we are able to oxidize then functionalize various natural products to produce modified scaffolds
  48. “Discovery of 2,3′-diindolylmethanes as a novel class of PCSK9 modulators” Winston-McPherson, G. N.;‡ Xie, H.;‡ Yang, K.;‡ Li, X.; Shu, D.; Tang, W.* Bioorg. Med. Chem. Lett. 2019, 29, 2345-2348. Link. (‡Equal Contribution)
  49. “Development of Multi-Functional Histone Deacetylase 6 Degraders with Potent Anti-Myeloma Activity” Wu, H.; ‡ Yang, K.; ‡ Zhang, Z.; Leisten, E. D.; Li, Z.; Xie, H.; Liu, J.; Smith, K. A.; Novakova, Z.; Barinka, C.; and Tang, W.* J. Med. Chem. 2019, 62, 7042-7057. Link. (‡Equal Contribution)
    Graphical abstract image for Tang article "Development of Multi-Functional Histone Deacetylase 6 Degraders with Potent Anti-Myeloma Activity"
  50. “Site‐ and Stereoselective Phosphoramidation of Carbohydrates Using a Chiral Catalyst and a Chiral Electrophile” Glazier, D. A.; Schroeder, J. M.; Blaszczyk, S. A.; Tang, W.* Adv. Syn. Cat. 2019, 361, 3729-3732. Link.
    Graphical abstract image for Tang article "Site- and Stereoselective Phosphoramidation of Carbohydrates Using a Chiral Catalyst and a Chiral Electrophile"
  51. “Development of selective small molecule MDM2 degraders based on nutlin” Wang, B.;# Wu, S.;# Liu, J.; Yang, K.; Xie, H.; and Tang, W.* Eur. J. Med. Chem. 2019, 176, 476-491. Link.(#Equal Contribution)
    3-D and chemical diagram showing structure of Degrader 32 within the Ternary Complex
  52. “S‐Adamantyl Group Directed Site‐Selective Acylation and Its Applications in the Streamlined Assembly of Oligosaccharides” Blaszczyk. S. A.;#  Xiao, G.;# Wen, P.;# Hao, H.; Wu, J.; Wang, B.; Carattino, F.; Li, Z.; Glazier, D. A.; McCarty, B. J.; Liu, P.* and Tang, W.* Angew. Chem. Int. Ed. 2019, 58, 9542-9546. Link. (#Equal Contribution)Graphical abstract: The sterically encumbered adamantyl group (Adm) directs site-selective acylation at the C2 position of S-glycosides through dispersion interactions between the adamantyl C−H bonds and the π system of the cationic acylated catalyst. Because of their stability, chemical orthogonality, and ease of activation for glycosylation, the site-selective acylation of S-glycosides can streamline oligosaccharide synthesis.
  53. “Finding the Sweet Spot in SAX-ERLIC Mobile Phase for Simultaneous Enrichment of N-glyco and Phospho- peptides” Cui, Y.; Yang, K.; Tabang D. N.; Huang, J.; Tang, W., Li, L.* J. Am. Soc. Mass Spectrom. 2019, 30, 2491–2501. Link.
    Graphical abstract for Tang article "Finding the Sweet Spot in ERLIC Mobile Phase for Simultaneous Enrichment of N-Glyco and Phosphopeptides"
  54. “Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models” Zhou, T.; Wang, Q.; Phan, N.; Ren, J.; Yang, H.; Feldman, C. C.; Feltenberger, J. B.; Ye, Z.; Wildman, S. A.; Tang, W., Liu, B.* Cell Death & Disease 2019, 10, 226. Link.
    Graphical abstract from Tang article "Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models"
  55. “Intermolecular Regio- and Stereoselective Hetero-[5+2] Cycloaddition of Oxidopyrylium Ylides and Cyclic Imines” Zhao, C.; Glazier, D. A.; Yang, D.; Yin, D.; Guzei, I. A.; Aristov, M. M.; Liu, P.* and Tang, W.* Angew. Chem. Int. Ed.  2019, 58, 887-891. Link.
    Graphical abstract from Tang study "Intermolecular Regio- and Stereoselective Hetero-[5+2] Cycloaddition of Oxidopyrylium Ylides and Cyclic Imines"
  56. “Recent advances in site-selective functionalization of carbohydrates mediated by organocatalysts” Blaszczyk, S. A.; Homan, T. C.; Tang, W.* Carbohydr. Res. 2019, 471, 64-77. Link.
  57. “Organocatalyst-Mediated Dynamic Kinetic Enantioselective Acylation of 2-Chromanols” Glazier, D. A.; Schroeder, J. M.; Liu, J.; Tang, W.* Adv. Syn. Cat. 2018, 360, 4646-4649. Link.
  58. “Development of the first small molecule histone deacetylase 6 (HDAC6) degraders.” Yang, K.; Song, Y.; Xie, H.; Wu, H.; Wu, Y.-T.; Leisten, E. D.;  Tang W.* Bioorg. Med. Chem. Lett. 2018, 28, 2493-2497. Link.
    Graphical abstract for Tang publication "Development of the first small molecule histone deacetylase 6 (HDAC6) degraders"
  59. “Catalytic Asymmetric Synthesis of All Possible Stereoisomers of 2,3,4,6‐Tetradeoxy‐4‐Aminohexopyranosides” Zhu Z.; Glazier, D. A.; Yang D.; Tang, W.* Adv. Syn. Cat. 2018, 360, 2211-2215. Link.
  60. “Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR)” Seok, S.-H.; Ma, Z.-X.; Feltenberger, J. B.; Chen, H.; Chen, H.; Scarlett, C.; Lin, Z.; Satyshur, K. A.; Cortopassi, M.; Jefcoate, C. R.; Ge, Y.; Tang, W.; Bradfield, C. A.; and Xing, Y.* J. Biol. Chem. 2018, 293, 1994-2005. Link.
  61. “Iridium-Catalyzed Dynamic Kinetic Stereoselective Allylic Etherification of Achmatowicz Rearrangement Products.” Zhu, Z.‡; Wang, H.-Y.‡; Simmons, C. J.; Tseng, P.-S.; Qiu, X.; Zhang, Y.; Duan, X.; Yang, J.-K.; and Tang W.* Adv. Syn. Cat. 2018, 360, 595-599. (‡Equal Contribution) Link.
    Graphical abstract image for Tang research article "ridium-Catalyzed Dynamic Kinetic Stereoselective Allylic Etherification of Achmatowicz Rearrangement Products"
  62. “Chiral Reagents in Glycosylation and Modification of Carbohydrates.” Wang, H.-Y.; Blaszczyk, S. A.; Xiao, G.; and Tang W.* Chem. Soc. Rev. 2018, 47, 681-701. Link.