Drug Discovery & Development

Drug Discovery Research
Arash Bashirullah
Arash Bashirullah, Associate Professor (Drug Action)| Lab Website

Research Interests: Regulation of tissue growth and destruction during post-embryonic development.

Tim Bugni
Tim Bugni, Associate Professor (Drug Discovery)| Bugni Lab Website

Research Interests: Marine natural products chemistry; antibiotic drug discovery; structure determination of novel natural products using NMR and mass spectrometry; and metabolomics studies of marine invertebrate associated microorganisms.

Ron Burnette
Ron Burnette, Professor and Chair (Drug Delivery)

Research Interests: Developing a molecular level mechanistic understanding of the delivery and stability of drugs by physical chemical characterization of guest-host interactions using computational chemistry and NMR as well as studies in pharmacokinetics and pharmacodynamics.

Margaret Clagett-Dame
Margaret Clagett-Dame, Professor (Drug Action)

Research Interests: Therapeutic applications of vitamin A and vitamin D analogs; retinoids in embryonic and nervous system development.

Lara Collier
Lara Collier, Associate Professor (Drug Action)

Research Interests: The Collier laboratory uses genetic and pharmacologic approaches to study cancer initiation, progression, and treatment. 

Melgardt de Villiers
Melgardt de Villiers, Professor (CHS) (Drug Delivery)

Research Interests: Teaching pharmaceutics and developing novel nanometer and micrometer sized drug delivery systems.

Jennifer Golden
Jennifer Golden, Assistant Professor (Drug Discovery)| Golden Lab Website

Research Interests: Synthetic methodology, medicinal chemistry and drug discovery.  Optimization of structure-activity and structure-property relationships.  Exploratory pharmacological mining of novel chemical scaffolds.  Emphasis on development of anticancer and anti-infective agents.

Warren Heideman
Warren Heideman, Professor (Drug Action)

Research Interests: Understanding the molecular mechanisms that regulate the cellular transition from quiescence to growth; identifying critical mechanisms regulating vertebrate development that are disrupted by environmental contaminants; evaluating the impact of nanomaterials on early development; creating strategies for the fermentative production of biofuels.

Seungpyo Hong
Seungpyo Hong, Professor (Drug Delivery)| Hong Lab website

Research Interests: Biomimetic nanotechnology; Nanomaterial-cell interactions; Targeted drug delivery; Novel designs and engineering of nanocarriers; Cancer diagnostics/prognostics; Surface engineering.

Richard Hsung
Richard Hsung, Professor (Drug Discovery)| Lab Group Page

Research Interests: Developing novel and practical synthetic methods for drug discovery; total syntheses of complex natural products with biological relevance; syntheses of de novo protease inhibitors for drug designs and asymmetric catalysis.

Jiaoyang Jiang
Jiaoyang Jiang, Assistant Professor (Drug Discovery)| Jiang Lab website

Research Interests: Study the mechanism and function of protein post-translational modifications using a variety of interdisciplinary approaches, such as chemical biology, enzymology, biochemistry, mass spectrometry, X-ray crystallography, cell biology, and genetics.

Jeffrey Johnson
Jeffrey Johnson, Professor (Drug Action)| Lab Webpage

Research Interests: Signal transduction, transcriptional control of neuroprotective genes and neurotoxicity in Parkinson’s, Alzheimer’s, Huntington’s and Neuromuscular disease.

Jason Kwan
Jason Kwan, Assistant Professor (Drug Discovery)| Lab Website

Research Interests: The role of uncultured symbionts in natural product biosynthesis within marine invertebrates; marine natural product chemistry; drug discovery; next-generation sequencing; metagenomics; bioinformatics; biosynthesis.

Glen Kwon
Glen Kwon, Professor (Drug Delivery)| Kwon Lab Website

Research Interests: Drug delivery; drug targeting; pharmaceutical nanotechnology; polymeric micelles; polymeric drug conjugates; PEGylation.

 

Charles Lauhon
Charles Lauhon, Associate Professor and Vice Chair (Drug Discovery)

Research Interests: Bioorganic chemistry of RNA modifying enzymes; bioorganic chemistry of RNA; nucleotide based drug design.

Lingjun Li
Lingjun Li, Professor (Drug Action)(Drug Discovery)| Li Lab Website

Research Interests: Analytical neurochemistry; neuropeptides; proteomics and peptidomics; biomarker discovery in neurodegenerative diseases; quantitative system biology; metabolomics; microseparations; imaging mass spectrometry and its application to drug delivery and biodistribution; biological mass spectrometry.

Paul Marker
Paul Marker, Professor (Drug Action)| Marker Lab Website

Research Interests: Molecular basis of prostate development; prostate cancer progression; benign prostatic hyperplasia; roles of cell-cell signaling pathways and the use of mouse genetics to discover novel pathways that underlie prostatic diseases.

Sandro Mecozzi
Sandro Mecozzi, Associate Professor (Drug Delivery)(Drug Discovery)

Research Interests: Fluorous polymers in drug delivery and imaging; micelles and nanoemulsions; nanomedicine; reactions in micellar systems; molecular recognition of RNA.

Richard Peterson
Richard Peterson, Professor (Drug Action)

Research Interests: Reproductive and developmental toxicity of dioxin and nanomaterials in zebrafish and mouse models.

Jeanette Roberts
Jeanette Roberts, Professor
Steven Swanson
Steven Swanson, Professor and Dean (Drug Action)(Drug Discovery)

Research Interests: Molecular and cellular based screens for the discovery of novel anticancer agents from natural substances; elucidation of molecular mechanisms of active compounds; mouse-based studies of preclinical efficiency.

Weiping Tang
Weiping Tang, Professor (Drug Discovery)| Tang Lab Website

Research Interests: Various aspects of drug discovery including synthetic organic chemistry, medicinal chemistry, assay development, and chemical biology.  Current focus is the development of new therapeutics for metabolic disorders and cancers. 

Michael Taylor
Michael Taylor, Assistant Professor (Drug Delivery)

Research Interests: Modeling blood-CNS barriers in zebrafish; developing new strategies for drug delivery to the brain; understanding the regulation of multidrug resistance transporters.

Robert Thorne
Robert Thorne, Assistant Professor (Drug Delivery)| Thorne Lab Website

Research Interests: Mechanisms and strategies for the central nervous system delivery and distribution of biologics (peptides, proteins, siRNA, nanoparticles, and viral gene therapy vectors).  Focus on:  antibody-based drugs and adeno-associated virus vectors for gene therapy; intraparenchymal, intrathecal and intranasal routes of administration.

Haoyuan Wang
Haoyuan Wang, Project Assistant
Ka Yang
Ka Yang, Research Assistant
Lian Yu
Lian Yu, Professor (Drug Delivery)| Yu Lab Website

Research Interests: Solid-state chemistry; Crystallization; Polymorphism; Amorphous solids and glasses; Surface mobility; Polymeric crystallization inhibitors.

 

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