Publications

Lingjun Li Lab peer-reviewed publications based on work at the University of Wisconsin-Madison (as of August 2016).

210. Q. Yu, X. Shi, T. Greer, C. B. Lietz, K. C. Kent, and L. Li* (2016). Evaluation and application of dimethylated amino acids as isobaric tags for quantitative proteomics of TGF-beta/Smad3 signaling pathway. Journal of Proteome Research. July 26, 2016. DOI: 10.1021/acs.jproteome.6b00641

209. X. Zhong, C. B. Lietz, X. Shi, A. R. Buchberger, D.C. Frost, K. C. Kent, and L. Li* (2016). Quantitative phosphoproteomics of TGF-beta and SDF-1 treatment in smooth muscle cells overexpressing Smad3. Manuscript in preparation.

208. Q. Yu, X. Shi, Y. Feng, K. C. Kent, and L. Li* (2016). Improving data quality and preserving HCD-generated reporter ions with EThcD for isobaric tag-based quantitative proteomics and proteome-wide PTM studies. Manuscript in preparation.

207. M.S. Glover, Q. Yu, B. Wang, X. Shi, L.-W. Guo, K.C. Kent and L. Li* (2016). Quantitative cardiovascular proteomics of injured arterial tissue by DiLeu isobaric labeling: Toward novel therapeutic targets for restenosis. Manuscript in preparation.

206. Y. Shi, B. Wang, B. Chen, X. Shi, L-W. Guo, K. C. Kent, and L. Li* (2016). MALDI mass spectral imaging (MSI) visualization reveals the involvement of diacylglycerols and lysophosphatidylcholines in the progression of restenosis. Manuscript in preparation.

205. Q. Yu, Z. Chen, B. Wang, K. C. Kent, and L. Li* (2016). Electron-transfer/higher-energy collision dissociation (EThcD)-enabled intact glycopeptide/glycoproteome characterization . Journal of American Society of Mass Spectrometry. July 10 2017. DOI: 10.1007/s13361-017-1701-4.

204. Z. Liang, S. Jiang, and L. Li* (2016). Enzymatic degradation of neuropeptides probed by in vivo microdialysis coupled with MALDI-mass spectrometry. Manuscript in preparation.

203. B. Chen, C. OuYang, Z. Tian, M. Xu, and L. Li* (2016). A high resolution atmospheric pressure matrix assisted laser desorption/ionization quadrupole-orbitrap platform enables in situ analysis of biomolecules by multi-mode ionization and acquisition. Analytica Chimica Acta, To be submitted.

202. C. Ouyang, B. Chen, and L. Li (2016). High throughput in situ DDA analysis of neuropeptides by coupling novel multiplex mass spectrometric imaging (MSI) with gas-phase fractionation. Journal of American Society for Mass Spectrometry. 26, 1992-2001. Invited contribution to Special Issue with focus on Mass Spectrometry-Based Strategies for Neuroproteomics and Peptidomics, Honoring Dr. Lingjun Li, Recipient of the 2014 ASMS Biemann Medal. Featured on the cover.

201. J. Lu, X. Zhong, H. Liu, L. Hao, C. T-L. Huang, M. A. Sherafat, J. Jones, M. Ayala, L. Li, and S-C Zhang (2016). Generation of serotonin neurons from human pluripotent stem cells. Nature Biotechnology. 34, 89-94. doi: 10.1038/nbt.3435. Epub 2015 Dec 14.

200. R. Hullinger, M. Li, J. Wang, Y. Peng, J.A. Dowell, E. Bomba-Warczak, H.A. Mitchell, C. Burger, E.R. Chapman, J.M. Denu, L. Li, and L. Puglielli (2016). Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation. Journal of Experimental Medicine. 213(7):1267-84.

199. E. Gemperline, H. Horn, M. Chevrette, E. Mevers, J. Clardy, L. Li, and C. Currie (2016). Diversity of chemical response to pathogen exposure reveals insight into the co-evolved fungus-growing ants and Pseudonocardia symbiotic system. Manuscript in preparation.

198. E. Gemperline, H. Horn, C. Currie, and L. Li (2016). Novel MALDI-mass spectrometry imaging method for the analysis of bacteria on the exoskeleton of fungus-growing ants. Manuscript in preparation.

197. E. Gemperline, C. Keller, J. Maeda, D. Jayaraman, M. Sussman, J. Ane, and L. Li (2016). Examination of endogenous peptides in Medicago truncatula using mass spectrometry imaging. Journal of Proteome Research, under revision.

196. Y. Zhang, A. Buchberger, G. Muthuvel, and L. Li (2016). Expression and distribution of neuropeptides in the nervous system of the crab Carcinus maenas and their roles in environmental stress. Proteomics Oct 17. doi: 10.1002/pmic.201500256. [Epub ahead of print].

195. L. Hao, T. Greer, D. Page, Y. Shi, C.M. Vezina, J. A. Macoska, W. Bushman, P.C. Marker, D.E. Bjorling, W.A. Ricke, and L. Li (2016). In-depth characterization and validation of human urine metabolomes reveals novel metabolic signatures of lower urinary tract symptoms. Scientific Reports. 09 Aug 2016. 30869. doi:10.1038/srep30869.

194. D. Frost, A. Buchberger, and L. Li (2016). Development of novel dimethyl pyrimidinyl ornithines (DiPyrO) as mass-defect-based tags for quantitative proteomics. Manuscript in preparation.

193. Q. Yu, A. Buchberger, C. Keller, Z. Chen, and L. Li (2015). Recent advances in mass spectrometry analysis of neuropeptides. Invited contribution. Mass Spectrometry Review. Manuscript in preparation.

192. C. Schmerberg, Z. Liang, and L. Li (2016). Mass spectrometric characterization of the neuropeptidome of the crayfish Orconectes rusticus. Journal of Proteome Research. To be submitted.

191. J. Wang, S. Yokoyama, R. Cunningham, X. Sun, and L. Li (2015). Comparative analysis of the proteomics changes of amniotic fluid in different gestational age for lung development. Manuscript in preparation.

190. J. Wang, R. Cunningham, H. Zetterberg, S. Asthana, C. Carlsson, O. Okonkwo, and L. Li (2016). Label-free quantitative comparison of cerebrospinal fluid glycoproteins and endogenous peptides in subjects with Alzheimer’s disease, mild cognitive impairment and healthy individuals. Proteomics –Clinical Applications. Submitted.

189. B. Chen, X. Zhong, S. Snovida, J. Rogers, and L. Li (2016). Relative quantification of glycans using multiplexed carbonyl-reactive tandem mass tags and multi-notch MS3. Manuscript in preparation.

188. Q. Yu, A. Buchberger, Z. Chen, C. Keller, and L. Li (2016). Recent advances in mass spectrometry analysis of neuropeptides. Mass Spectrometry Reviews, Invited contribution, to be submitted.

187. A.R. Chesney, C. J. Booth, C. B. Lietz, L. Li, and J. A. Pedersen (2016). Peroxymonosulfate rapidly inactivates the disease-associated prion protein. Environmental Science and Technology. 2016 DOI: 10.1021/acs.est.5b06294

186. C. Jia, X. Pang, Z. Chen, and L. Li (2016). Probing the D-amino acid-containing peptide oligomers by ion mobility spectrometry and native mass spectrometry. Journal of American Society for Mass Spectrometry, Invited contribution to Special Issue on Native Mass Spectrometry.

185. R. Chen, B. Yang, K. Hei, M. Xiao, C. Hou, H. Gao, Y. Liu, C. Jia, H. Zhang, L. Li, N. Zhang, Y. Li (2016). Mapping the protein interaction landscape of long non-coding RNA MALAT1 using quantitative proteomics. Molecular and Cellular Proteomics, to be submitted.

184. X. Zhong, L. Hao, J. Lu, H. Ye, S-C. Zhang, and L. Li (2016). Quantitative analysis of serotonin secreted by human embryonic stem cells-derived serotonergic neurons via pH-mediated online stacking-CE-ESI-MRM. Electrophoresis Invited contribution for Special Issue of Mass Spectrometric Detection in Liquid Phase Separations. 2016 Apr;37(7-8):1027-30. doi: 10.1002/elps.201500496. Epub 2016 Feb 24.

183. S. Jiang, Z. Liang, L. Hao, and L. Li (2016). Investigation of neurotransmitters, small molecules, and metabolites found in crustacean hemolymph via in vivo microdialysis using multi-faceted micro-separation techniques coupled to mass spectrometric detection. Electrophoresis Invited contribution for Special Issue of Mass Spectrometric Detection in Liquid Phase Separations. In press. Published on-line. Dec 22. doi: 10.1002/elps.201500497. [Epub ahead of print].

182. B. Chen, C. B. Lietz, C. OuYang, X. Zhong, M. Xu, and L. Li (2016). Matrix-assisted ionization vacuum for protein detection, fragmentation and PTM analysis on a high resolution linear ion trap-orbitrap platform. Analytica Chimica Acta, In press. DOI: 10.1016/j.aca.2016.02.018.

181. E. Gemperline, C. Keller, and L. Li (2016). Mass spectrometry in plant-omics. Analytical Chemistry. Invited Feature Article. In press. DOI: 10.1021/acs.analchem.5b02938. Web publication on February 18, 2016, Featured on the journal cover for April 5, 2016 issue and highlighted on ACS Podcast Interview.

180. C. B. Lietz, D. M. Tilley, C. Kelley, R. Vallejo, B. Rasmin, D. Cedeno, and L Li (2015). The dynamic phosphoproteome of peripheral nerve injury and chronic pain. Pain. To be submitted.

179. S. Thomas, L. Hao, W. A. Ricke, and L. Li (2016). Biomarker discovery in mass spectrometry-based urinary proteomics. Invited contribution to Special Issue on “the topic Reviews 2016”. Proteomics Clinical Application. In press, published on-line Dec 25. doi: 10.1002/prca.201500102. Featured on the inside back cover of the Special Issue of the journal.

178. C. B. Lietz, Z. Chen, C.-Y. Son, X. Pang, Q. Cui, and L. Li (2016). Multiple gas-phase conformations of proline-containing peptides: Is it always cis/trans isomerization? Analyst. 2016, 141, 4863-4869. DOI: 10.1039/c5an00835b

177. A. Buchberger, Q. Yu, and L. Li (2015). Advances in mass spectrometric tools for probing neuropeptides. Invited contribution. Annual Review of Analytical Chemistry, 8, 485-509. doi: 10.1146/annurev-anchem-071114-040210. Epub 2015 Jun 11.

176. H.C. Cohen, D.C. Frost, T.J. Lieberthal, L. Li, and W.J. Kao (2015). Biomaterials differentially regulate Src fkinases and phosphoinositide 3-kinase-gamma in polymorphonuclear leukocyte primary and tertiary granule release. Biomaterials. 50, 47-55.

175. X. Zhong, Z. Chen, S. Snovida, Y. Liu, J.C. Rogers and L. Li (2015). Capillary electrophoresis-electrospray ionization-mass spectrometry for quantitative analysis of glycans labeled with multiplex carbonyl-reactive tandem mass tags. Analytical Chemistry. 87, 6527-6534. doi: 10.1021/acs.analchem.5b01835. Epub 2015 Jun 11.

174. T. Greer, L. Hao, A. Nechyporenko, S. Lee, C. Vezina, W. Ricke, P. Marker, D. Bjorling, W Bushman, and L. Li (2015). Custom 4-plex DiLeu isobaric labels enable relative quantification of urinary proteins in men with lower urinary tract symptoms (LUTS). PLOS ONE. Publication date (web): Aug 12;10(8):e0135415. doi: 10.1371/journal.pone.0135415. eCollection 2015.

173. D.C. Frost, T. Greer, F. Xiang, Z. Liang, and L. Li (2015). Development and characterization of novel 8-plex DiLeu isobaric labels for quantitative proteomics and peptidomics. Rapid Communication in Mass Spectrometry. 29, 1115-24. doi: 10.1002/rcm.7201.

172. E. Gemperline, D. Jayaraman, J. Maeda, J-M. Ane, and L. Li (2015). Multifaceted investigation of metabolites during nitrogen fixation in Medicago via high resolution MALDI-MS imaging and ESI-MS. Journal of American Society for Mass Spectrometry. 26, 149-158.

171. E. Pedroso-Silva, D. Frost, L. Li, N. Bovin, and D. Miller (2015). Identification of lactadherin as a Lewis X trisaccharide binding protein in porcine sperm. IDEALS, http://hdl.handle.net/2142/46796.

170. Z. Liang, C. Schmerberg, and L. Li (2015). Mass spectrometric measurement of neuropeptide secretion in the crab, Cancer borealis, by in vivo microdialysis. Analyst. 140, 3803-3813. Invited contribution to a Themed Issue on In Vivo Analysis.

169. T. Greer, C. B. Lietz, F. Xiang, and L. Li (2015). Novel isotopic N, N-dimethyl leucine (iDiLeu) reagents enable absolute quantification of peptides and proteins using a standard curve approach. Journal of American Society for Mass Spectrometry. 26, 107-119

168. L. Hao, X. Zhong, T. Greer, H. Ye, and L. Li (2015). Relative quantification of amine-containing metabolites using isobaric N, N-dimethyl-leucine (DiLeu) reagents via LC-ESI-MS/MS and CE-ESI-MS/MS. Analyst. 140, 467-475, DOI: 10.1039/c4an01582g. Selected as HOT Article and featured on Analyst blog.

167. C. Ouyang, Z. Liang, and L. Li (2014). Mass spectrometric analysis of spatio-temporal dynamics of crustacean neuropeptides. Biochim Biophys Acta (BBA)-Proteins and Proteomics. Invited contribution to Special Issue on Neuroproteomics. 2014. 1854(7) 798-811.

166. R. Chen, M. Xiao, A. Buchberger, and L. Li (2014). Quantitative neuropeptidomics study of the effects of temperature change in the crab Cancer borealis. Journal of Proteome Research. 13, 5767-5776.

165. K. P. Keil, L. L. Abler, H. M. Altmann, W. Bushman, P. C. Marker, L. Li, W. A. Ricke, D. E. Bjorling, and C. M. Vezina (2014). Influence of animal husbandry practices on void spot assay outcomes in C57BL/6J male mice. Neurourology and Urodynamics. 35(2):192-8.

164. S. Jiang, Z. Zhang, and L. Li (2015) A one-step preparation method of monolithic enzyme reactor for highly efficient sample preparation coupled to mass spectrometry-based proteomics studies. Journal of Chromatography A. 1412,75-81.

163. C. Yang, X. Zhong, and L. Li (2014). Recent advances in enrichment and separation strategies for mass spectrometry-based phosphoproteomics. Electrophoresis Invited review for Special Issue of Phosphoproteomics. 35, 3418-3429.

162. E. Gemperline and L. Li (2014). MALDI-mass spectrometric imaging of endogenous metabolites in biological systems. Invited contribution to eLS (Encyclopedia of Life Sciences), John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0023207]

161. R. Chen, C. Ouyang, M. Xiao, and L. Li (2014). In situ identification and mapping of neuropeptides from the stomatogastric nervous system of Cancer borealis. Rapid Communication in Mass Spectrometry, 28, 2437-2444, DOI: 10.1002/rcm.7037.

160. E. Gemperline, K. Laha, C. O. Scarlett, R.A. Pearce, and L. Li (2014). Measurement of NMDA receptor antagonist, CPP, in mouse plasma and brain tissue following systematic administration using ion-pair LC-MS/MS. Analytical Methods, 6, 6389-6396.

159. B. Chen, C. B. Lietz, and L. Li (2014). In situ characterization of proteins using laserspray ionization on a high-performance MALDI-LTQ-Orbitrap mass spectrometer. Journal of American Society for Mass Spectrometry. 25, 2177-2180

158. D. Frost, T. Greer, and L. Li (2014). High resolution enabled 12-plex isobaric tags for quantitative proteomics. Analytical Chemistry. In press. DOI: 10.1021/ac503276z, Web publication on November 18. http://pubs.acs.org/doi/abs/10.1021/ac503276z. Featured on the journal cover for February 3 issue and highlighted on ACS Podcast.

157. C. Lietz, Q. Yu, and L. Li (2014). Global peptide collision cross-section profiling on a travelling wave ion mobility mass spectrometer. Invited contribution to a special focus issue of JASMS honoring Dr. Richard D. Smith, recipient of the 2013 Distinguished Contribution in Mass Spectrometry Award. Journal of American Society for Mass Spectrometry. 25, 2009-2019.

156. Katsumura, C. Yang, M. Boyer, L. Li, and E. Bresnick (2014). Leukemogenic GATA factor mutant reveals a hierarchical phosphorylation mechanism to control hematopoiesis. EMBO Reports. 15, 938-47. doi: 10.15252/embr.201438808. Featured as Hot Off the Press article in the journal.

155. C. Jia, Q. Yu, J. Wang, and L. Li (2014). Qualitative and quantitative top-down mass spectral analysis of crustacean hyperglycemic hormones in response to feeding. Invited Contribution to “Top Down Proteomics” Special Issue. Proteomics. 14, 1185-1194. doi: 10.1002/pmic.201300331.

154. Z. Zhang, J. Kuang, and L. Li (2013). Liquid chromatography-matrix-assisted laser desorption/ionization mass spectrometric imaging with sprayed matrix for improved sensitivity, reproducibility and quantitation. Analyst. 138, 6600-6606, DOI:10.1039/C3AN01225E

153. D. Frost and L. Li (2014). Recent advances in glycoproteomics and its application in biomedicine and pharmacology. Invited contribution, Advances in Protein Chemistry and Structural Biology. 95, 71-123. doi: 10.1016/B978-0-12-800453-1.00003-8.

152.. E. Gemperline, B. Chen, and L. Li (2014). Mass spectrometric imaging of neurotransmitters: challenges and recent advances. Invited contribution, Bioanalysis.6, 525-540. doi: 10.4155/bio.13.341.

151. C. Jia, C. B. Lietz, Q. Yu, and L. Li (2014). Site-specific characterization of D-amino acid-containing peptide epimers by ion mobility spectrometry. Analytical Chemistry. 86, 2972-2981, DOI: 10.1021/ac4033824. Featured as an ACS Editor’s Choice article and on the journal cover.

150. Zhong, Z. Zhang, S. Jiang, and L. Li (2014). Recent advances in microseparations coupled to mass spectrometry detection. Invited review. Electrophoresis. 35, 1214-1225. doi: 10.1002/elps.201300451

149. Q. Yu, C. Ouyang, Z. Liang, and L. Li (2014). Mass spectrometric characterization of crustacean neuropeptidome.  Invited mini-review. Special Issue on “Peptidomics (state-of-the-art 2014). EuPA Open Proteomics. 3, 152-170.

148. C. Jia, Q. Yu, C. Ouyang, F. Ma, C. M. Schmerberg, and L. Li (2015). Rapid and sensitive characterization of neuropeptidome in Dungeness crabs using a Q-Exactive high-resolution mass spectrometer and peptide alterations in response to feeding. EuPA Open Proteomics. 

147. C. Ouyang, A. Kim, and L. Li (2015). Evaluation of neurotoxicity of nanoparticles in decapod crustacean using MS-based peptidomics. Invited contribution. Special Issue on “Peptidomics (state-of-the-art 2014). Journal of Proteome Research. To be submitted.

146. E. Gemperline and L. Li (2014). Investigation of metabolites in Medicago truncatula root nodules with MALDI- mass spectrometric imaging. Invited contribution. Journal of Visualized Experiments (JoVE). Mar 5;(85). doi: 10.3791/51434

145. H. Ye, J. Wang, Z. Zhang, C. Jia, C. Schmerberg, A.D. Catherman, P.M. Thomas, N.L. Kelleher, and L. Li (2015). Defining the neuropeptidome of the spiny lobster Panulirus interruptus brain using a multi-dimensional mass spectrometry-based platform. Journal of Proteome Research. 14, 4776-91. doi: 10.1021/acs.jproteome.5b00627. Epub 2015 Oct 5.

144. E. Gemperline, S. Rawson, and L. Li (2014). Optimization and comparison of multiple MALDI matrix application methods for small molecule mass spectrometric imaging. Analytical Chemistry. 86, 10030-10035. doi: 10.1021/ac5028534. Epub 2014 Oct 10.

143. C. Schmerberg, Z. Liang, and L. Li (2015). Data-independent MS/MS quantification of neuropeptides for determination of putative feeding-related neurohormones in microdialysate.

142. C. Jia, Z. Wu, C. B. Lietz, Z. Liang, Q. Cui, and L. Li* (2013). Gas-phase ion isomer analysis reveals the mechanism of peptide sequence scrambling. Analytical Chemistry86, 2917-2924, doi: 10.1021/ac401578p, featured as a cover article.

141. Z. Zhang, S. Jiang, and L. Li* (2013). Semi-automated liquid chromatography-mass spectrometric imaging platform for enhanced detection and improved data analysis of complex peptide mixtures. Journal of Chromatography A. Invited Contribution to MSB 2012 Shanghai Special Issue, 1293, 44-50.

140. E.W. Rodgers, W.D. Krenz, X. Jiang, L. Li, and D.J. Baro* (2013). Dopaminergic tone regulates transient potassium current maximal conductance through a translational mechanism requiring D1Rs, cAMP/PKA, Erk and mTOR. BMC Neuroscience14, 143. doi:10.1186/1471-2202-14-143.

139. R. Sturm, C. Lietz, and L. Li* (2013). Improved Isobaric Mass Tag Quantification by Ion Mobility Mass Spectrometry. Rapid Communication in Mass Spectrometry. 28, 1051-1060.

138. X. Jiang, F. Xiang, C. Jia, A. Metzler, M. Tlusty, and L. Li* (2013) Relative quantitation of neuropeptides at multiple developmental stages of the American lobster using novel N,N-dimethyl leucine isobaric tandem mass tags. Journal of Proteome Research.

137. H. Ye, J. Wang, T. Greer, K. Strupat, and L. Li* (2013).  Visualizing neurotransmitters and metabolites in the central nervous system by high resolution and high accuracy mass spectrometric imaging. ACS Chemical Neuroscience. 4, 1049-1056.

136. R. Chen, C. Schmerberg, and L. Li* (2013). Discovery and functional assessment of neuropeptides in the decapod crustacean. Progress in Neurobiology. Invited review article.

135. D. Ma, W. Cao, A. Kapur, C. O. Scarlett, M. S. Patankar, and L. Li* (2013). Differential expression of proteins in naïve and IL-2 stimulated primary human NK cells identified by global proteomic analysis. Journal of Proteomics. In press. On-line published Jun 25, 2013. pii: S1874-3919(13)00350-3. doi: 10.1016/j.jprot.2013.06.024.

134. H. Ye, E. Gemperline, M. Venkateshwaran, R. Chen, P-M Delaux, M. Howes-Podoll, J-M. Ane, and L. Li* (2013). MALDI mass spectrometry-assisted molecular imaging of metabolites during nitrogen fixation in the Medicago truncatulaSinorhizobium meliloti symbiosis. The Plant Journal. 75, 130-145. doi: 10.1111/tpj.12191. Epub 2013 May 6.

133. H. Ye, L. Hui, K. Kellersberger, and L. Li* (2013). Mapping of neuropeptides in the crustacean stomatogastric nervous system by imaging mass spectrometry. Journal of American Society for Mass Spectrometry. 24, 134-147. DOI: 10.1007/s13361-012-0502-z

132. C. Jia, C. B. Lietz, L. Hui, H. Ye, S. Yoo, and L. Li* (2013). A multi-scale strategy for discovery of novel endogenous neuropeptides in crustacean nervous system. Journal of Proteomics. 91, 1-12. doi: 10.1016/j.jprot.2013.06.021. Epub 2013 Jun 24.

131. R. Sturm, T. Greer, R. Chen, B. Hensen, and L. Li* (2013). Comparison of NIMS and MALDI platforms for neuropeptide mass spectrometric imaging. Analytical Methods. 5, 1623-1628.

130. C. Lietz, E. Gemperline, and L. Li* (2013). Qualitative and quantitative mass spectrometry imaging of drugs, metabolites, and endogenous molecules. Advanced Drug Delivery Reviews. Invited review for Special Issue on“Delivery of biopharmaceuticals: Advanced analytical and biophysical methods”. 65, 1074-1085. doi: 10.1016/j.addr.2013.04.009.

129. H. Ye, E. Gemperline, and L. Li* (2013). A vision for better health: Mass spectrometry imaging for clinical diagnostics. Clinica Chimica Acta. Invited review for Special Issue on “Clinical Diagnosis in the World Chinese Mass Spectrometry Conference”. 420, 11-22. doi:10.1016/j.cca.2012.10.018.

128. R. Cunningham, P. Jany, A. Messing, and L. Li* (2013). Protein changes in immunodepleted cerebrospinal fluid from transgenic mouse models of Alexander disease detected using mass spectrometry. Journal of Proteome Research, 12, 719-728.

127. C. Schmerberg and L. Li* (2013). Mass spectrometric detection of neuropeptides using affinity-enhanced microdialysis with antibody-coated magnetic nanoparticles. Analytical Chemistry,85, 915-922. http://dx.doi.org/10.1021/ac302403e.

126. R. Sturm, T. Greer, N. Woodards, E. Gemperline, and L. Li* (2013).Mass spectrometric evaluation of neuropeptidomic profiles upon heat stabilization treatment of neuroendocrine tissues in crustaceans. Journal of Proteome Research, 12, 743-752, http://dx.doi.org/10.1021/pr300805f.

125. H. Ye, R. Mandal, A. Catherman, P. M. Thomas, N. Kellerher, C. Ikonomidou,and L. Li* (2013). Top-down proteomics with imaging mass spectrometry: a novel approach towards discovery of early biomarkers for dizocilpine-induced excitatory/inhibition imbalance in infant rats. PLOS ONE. Under revision.

124. L. Hui, B. T. D’Andrea, C. Jia, Z. Liang, A. E. Christie*, and L. Li* (2013).  Mass spectrometric characterization of the neuropeptidome of the ghost crab Ocypode ceratophthalma (Brachyura, Ocypodidae). General and Comparative Endocrinology. 184, 22-34.

123. J. Zhang, K.A. Lanham, W. Heideman, R.E. Peterson, and L. Li* (2013). Statistically enhanced spectral counting approach to TCDD cardiac toxicity in the adult zebrafish heart. Journal of Proteome Research, 12, 3093-3103. doi: 10.1021/pr400312u. Epub 2013 Jun 12.

122. C. Jia, L. Hui, W. Cao, C. Lietz, X. Jiang, R. Chen, A.D. Catherman, P. M. Thomas, Y. Ge, N. L. Kelleher, and L. Li* (2012). High-definition de novo sequencing of crustacean hyperglycemic hormone (CHH)-family neuropeptides. Molecular and Cellular Proteomics, 12, 1951-1964, doi: 10.1074/mcp.M112.020537.

121. R. Cunningham, D. Ma, and L. Li* (2012). Mass spectrometry-based proteomics and peptidomics for systems biology and biomarker discovery. Frontiers in Biology, 7, 313-335.

120. R. Cunningham, J. Wang, D. Wellner, and L. Li* (2012). Investigation and reduction of sub-microgram peptide loss using molecular weight cut-off fractionation prior to mass spectrometric analysis. Journal of Mass Spectrometry, 47, 1327-1332. doi: 10.1002/jms.3069.

119. L. Hui, F. Xiang, Y. Zhang, and L. Li* (2012). Mass spectrometric elucidation of the neuropeptidome of a crustacean neuroendocrine organ. Peptides, 36, 230-239.

118. Z. Zhang, H. Ye, J. Wang, L. Hui, and L. Li* (2012). Pressure-assisted capillary electrophoresis coupling with matrix-assisted laser desorption/ionization-mass spectrometric imaging for quantitative analysis of complex peptide mixtures. Analytical Chemistry, 84, 7684-91.

117. R. Sturm, G. Kreitinger, C. Booth, L. Smith, J. Pedersen, and L. Li* (2012). Absolute quantification of prion protein (90-231) using stable isotope-labeled chymotryptic peptide standards in a LC-MRM AQUA workflow. Journal of American Society for Mass Spectrometry, 9, 1522-33.

116. H. Ye, T. Greer, and L. Li* (2012). Probing neuropeptide signaling at the organ and cellular domains via imaging mass spectrometry. Journal of ProteomicsInvited contribution to Special Issue on “Imaging Mass Spectrometry”, 75, 5014-26. doi: 10.1016/j.jprot.2012.03.015

115. X. Jiang, R. Chen, J. Wang, A. Metzler, M. Tlusty, and L. Li* (2012). Mass spectral charting of neuropeptidomic expression in the stomatogastric ganglion at multiple developmental stages of the lobster Homarus americanus. ACS Chemical Neuroscience, 3, 439-450.

114. D. Ma and L. Li* (2012). Searching for reliable premortem protein biomarkers for prion diseases – challenges and progress to date. Expert Review of Proteomics, Invited contribution. 9, 267-280.

113. Z. Zhang, C. Jia, and L. Li* (2012). Neuropeptide analysis with liquid chromatography-capillary electrophoresis-mass spectrometric imaging. Journal of Separation Science Invited contribution to Special Issue on “Multidimensional Liquid Chromatography”, 35(14), 1779-84.

112. T. Greer and L. Li* (2012). Mass spectrometry based methods for detection, quantitation and localization of pharmaceutical and metabolites in biological samples. European Pharmaceutical Review. Invited article contribution. 17, 39-42.

111. C. Schmerberg and L. Li* (2013). Function-driven discovery of neuropeptides with mass spectrometry-based tools. Protein and Peptide Letters, Invited Review for Special Issue on Peptide Signaling Molecules. 20, 681-694.

110. L. Hui, R. Cunningham, Z. Zhang, W. Cao, C. Jia, and L. Li* (2011) Discovery and characterization of the crustacean hyperglycemic hormone precursor related peptides (CPRP) and orcokinin neuropeptides in the sinus glands of the blue crab Callinectes sapidus using multiple tandem mass spectrometry techniques. Journal of Proteome Research. 10, 4219-29.

109. J. Wang, H. Ye, Z. Zhang, F. Xiang, G. Girdaukas, and L. Li* (2011). MALDI imaging for capillary electrophoresis separation of neuropeptides. Analytical Chemistry 83, 3462-3469.

108. W. Cao, D. Ma, A. Kapur, M. S. Patankar, Y. Ma, and L. Li* (2011). Post-Mascot analysis using retention time deviation to improve peptide and protein identifications. Journal of Proteomics. 75, 480-90

107. Z. Zhang, J. Wang, L. Hui, and L. Li* (2011). Membrane-assisted capillary isoelectric focusing coupling with MALDI-FTMS for neuropeptide analysis. Journal of Chromatography A 1218, 5336-43.

106. Z. Zhang, J. Wang, L. Hui, and L. Li* (2011). Poly (glycidyl methacrylate-divinylbenzene) based immobilized pH gradient capillary isoelectric focusing coupling with matrix-assisted laser desorption/ionization mass spectrometry for enhanced neuropeptide analysis. Electrophoresis Invited contribution to Special Issue on “Mass Spectrometric Detection in Liquid Phase Separations”, 33, 661-665.

105. T. Greer, R. Sturm, and L. Li* (2011). Mass spectrometry imaging for drugs and metabolites, Journal of Proteomics. Invited Review. 74, 2617-31.

104. X. Wei, A. Herbst, D. Ma, J. Aiken, and L. Li* (2011). A quantitative proteomic approach to prion disease biomarker research: delving into the glycoproteome. Journal of Proteome Research, 10, 2687-2702.

103. H. Ye, T. Greer, and L. Li* (2011). From pixel to voxel: A deeper view of biological tissue by 3D mass spectral imaging. Bioanalysis. 3, 313-332.

102. T. Szabo, R. Chen, M. Goeritz, R.T. Maloney, L. S. Tang, L. Li, and E. Marder* (2011). Distribution and physiological effects of B-type allatostatins on the stomatogastric nervous system of the crab, Cancer borealis. Journal of Comparative Neurology, 519, 2658-2676.

101. X. Wei, C. Dulberger, and L. Li* (2010). Characterization of murine brain membrane glycoproteins by detergent assisted lectin affinity chromatography (DALAC). Analytical Chemistry, 82, 6329-6333.

100. X. Jiang, C. Jia, Z. Liang, R. Sturm, T. Greer, and L. Li* (2011). Enhanced mass spectrometry imaging of neurotransmitters by pseudo selected reaction monitoring on MALDI-TOF/TOF instrument. Submitted.

99. L. Hui, Y. Zhang, J. Wang, A. Cook, H. Ye, M. Nusbaum, and L. Li* (2011). Discovery and functional study of a novel tachykinin from Callinectes sapidus via a multi-faceted mass spectrometry approach. ACS Chemical Neuroscience. 2, 711-722.

98. J. Wang, Y. Zhang, F. Xiang, Z. Zhang, and L. Li* (2010). Combining capillary electrophoresis-MALDI mass spectrometry and stable isotope labeling techniques for comparative crustacean peptidomics. Journal of Chromatography A, Invited Contribution to MSB 2009 Dalian Special Issue, 1217, 4463-4470.

97. R. Chen and L. Li* (2010).  Mass spectral imaging and profiling of endogenous signaling molecules at the organ and cellular domains. Analytical and Bioanalytical Chemistry.[Invited trend article for Special Issue on Analytical Tools for Cell Research], 397, 3185-3193.

96. F. Xiang, H. Ye, R. Chen, Q. Fu, and L. Li* (2010). N,N-dimethyl leucines as novel isobaric tandem mass tags for quantitative proteomics and peptidomics. Analytical Chemistry, 82, 2817-2825.  http://pubs.acs.org/doi/abs/10.1021/ac902778d

95. R. Chen, L. Hui, S.S. Cape, J. Wang, and L. Li* (2010). Comparative neuropeptidomic analysis of food intake via a multi-faceted mass spectrometric approach. ACS Chemical Neuroscience. 1, 204-214.  http://pubs.acs.org/doi/pdfplus/10.1021/cn900028s One of top 10 most accessed articles in 2010.

94. R. Chen, X. Jiang, I. Mohtashemi, M. P. Conaway, L. Hui, R. Viner, and L. Li* (2010). Mass spectral analysis of neuropeptide expression and distribution in the nervous system of the lobster Homarus americanus. Journal of Proteome Research, 9, 818-832.

93. J. Zhang, K.A. Lanham, R. E. Peterson, W. Heideman, and L. Li* (2010).  Characterization of the adult zebrafish cardiac proteome using online pH gradient SCX-RP 2DLC coupled with ESI tandem mass spectrometry. Journal of Separation Science. [Invited contribution to Special Issue on Two-dimensional Liquid Chromatography] 33, 1462-1471.

92. J. Wang, W. Huang, L. Li*, and J. Cheng (2010). Microchip electrochromatography: Latest developments and applications. Invited review, Chinese Journal of Chromatography, 28, 264-272.

91.  M. Ma, A. L. Gard, F. Xiang, J. Wang, N. Davoodian, P. H. Lenz, S. R. Malecha, A.E. Christie, and L. Li* (2010). Combining in silico transcriptome mining and biological mass spectrometry for peptide paracrine/hormone discovery in the penaeid shrimp Litopenaeus vannameiPeptides, 31, 27-43.

90.  M. Ma, R. M. Sturm, K. K. Kutz-Naber, Q. Fu, and L. Li* (2009). Immunoaffinity-based mass spectrometric characterization of the FMRFamide-related peptide family in the pericardial organ of Cancer borealisBiochemical Biophysical Research Communication, 390, 325-330.

89. J.A. Dowell, J.A. Johnson, and L. Li* (2009). Identification of astrocyte secreted proteins with a combination of shotgun proteomics and bioinformatics. Journal of Proteome Research, 8, 4135-4143.

88. M. Ma, E. K. Bors, E. S. Dickinson, M. A. Kwiatkowski, G. L. Sousa, R. P. Henry, C. M. Smith, D. W. Towle, A.E. Christieand L. Li* (2009).  Characterization of the Carcinus maenas neuropeptidome by mass spectrometry and functional genomics. General and Comparative Endocrinology 161, 320-334.

87. M. Ma, T. Szabo, C. Jia, E. Marder, and L. Li* (2009). Mass spectrometric characterization and physiological actions of first crustacean C-type allatostatins.  Peptides,30, 1660-1668.

86. R. Chen, L. Hui, R. Sturm, and L. Li* (2009). Three dimensional mapping of neuropeptides and lipids in crustacean brain by mass spectral imaging. Journal of American Society for Mass Spectrometry, 20, 1068-77. Featured in the News Section of journal Bioanalysis.

85.  M. Ma, R. Chen, Y. Ge, H. He, A.G. Marshall, and L. Li* (2009). Combining bottom-up and top-down mass spectrometric strategies for de novo sequencing of the crustacean hyperglycemic hormone (CHH) from Cancer borealis. Analytical Chemistry, 81, 240-247 (doi/full/10.1021/ac801910g).

84.  X. Wei, A. Herbst, J. Schmidt, J. Aiken, and L. Li* (2009). Facilitating discovery of prion disease biomarkers by quantitative glycoproteomics. LCGC [Invited technical article, February 2009 issue].

83.  J. Wang, X. Jiang, R. Sturm, and L. Li* (2009). Combining tissue extraction and off-line capillary electrophoresis – MALDI FTMS for neuropeptide analysis using 2,5-dihydroxybenzoic acid as a multifunctional agent. Journal of Chromatography A, Invited contribution, 1216, 8283-8288.

82.  X. Wei, A. Herbst, J. Aiken, and L. Li* (2009).  Comparative glycoproteomics: approaches and applications.  Briefings in Functional Genomics and Proteomics Special Issue on Targeted and Quantitative Proteomics. 8, 104-113[Invited Review, doi:10.1093/bfgp/eln053].

81.  A. Herbst, S. McIlwain, J. J. Schmidt, J. M. Aiken, C. D. Page, and L. Li* (2009). Prion disease diagnosis by proteomic profiling. Journal of Proteome Research, 8, 1030-1036. DOI: 10.1021/pr800832s.

80.  R. Chen, M. Ma, L. Hui, J. Zhang, and L. Li* (2009). Measurement of neuropeptides in crustacean hemolymph via MALDI mass spectrometry. Journal of the American Society for Mass Spectrometry, 20, 708-18.

79.  M. Ma, J. Wang, R. Chen, and L. Li* (2009). Expanding the crustacean neuropeptidome using a multi-faceted mass spectrometric approach. Journal of Proteome Research, 8, 2426-2437.  http://pubs.acs.org/doi/abs/10.1021/pr801047v

78.  J. Yew, Y. Wang, N. Barteneva, S. Dikler, K. Kutz-Naber, L. Li* and E. Kravitz* (2009). Analysis of neuropeptide expression and localization in adult Drosophila melanogaster central nervous system by affinity cell-capture mass spectrometry. Journal of Proteome Research 8, 1271-1284.

77.  X. Wei and L. Li* (2009). Mass spectrometry-based proteomics and peptidomics for biomarker discovery in neurodegenerative diseases. Invited review, International Journal of Clinical and Experimental Pathology. 2, 132-148.

76.  Y.K. Cho, I. Chen, X. Wei, L. Li, and E. V. Shusta* (2009). A yeast display immunoprecipitation method for efficient isolation and characterization of antigens. Journal of Immunological Methods. 341, 117-126.

75. C. L. Thomas-Virnig, J. M. Centanni, C. E. Johnston, L. K. He, S. J. Schlosser, K. F. Van Winkle, R. Chen, A. L. Gibson, A. Szilagyi, L. Li, R. Shankar, B. L. Allen-Hoffmann (2009). Inhibition of multidrug-resistant Acinetobacter baumannii by non-viral expression of hCAP-18 in a bioengineered human skin tissue. Molecular Therapy, 17, 562-569.

74.  J. A. Dowell, D. C. Frost, J. Zhang, and L. Li* (2008). Comparison of two-dimensional fractionation techniques for shotgun proteomics. Analytical Chemistry, 80, 6715-6723. [Featured in Journal of Proteome Research on-line news, September 23, 2008]

73. H. Behrens, R. Chen, and L. Li* (2008). Combining microdialysis, nanoLC-MS, and MALDI-TOF/TOF to monitor neuropeptide secretion in the crab, Cancer borealis. Analytical Chemistry, 80, 6949-6958.

72, J. Wang, M. Ma, R. Chen, and L. Li* (2008). Enhanced neuropeptide profiling via capillary electrophoresis off-line coupled with MALDI FTMS. Analytical Chemistry, 80, 6168-6177.

71. S.S. Cape, K. J. Rehm, M. Ma, E. Marder, and L. Li* (2008). Mass spectral comparison of the neuropeptide complement of the stomatogastric ganglion and brain in the adult and embryonic lobster, Homarus americanus. Journal of Neurochemistry 105, 690-702.

70. M. Ma, R. Chen, G.L. Sousa, E.K. Bors, M. Kwiatkowski, C.C. Goiney, M. Goy, A.E. Christieand L. Li* (2008).  Mass spectral characterization of peptide transmitters/hormones in the nervous system and neuroendocrine organs of the American lobster Homarus americanus. General and Comparative Endocrinology 156, 395-409.

69. A. E. Christie*, C. R. Cashman, H. R. Brennan, M. Ma, L. Li, E. A. Stemmler, and P. S. Dickinson (2008). Identification of putative crustacean neuropeptides using in silico analysis of publicly accessible expressed sequence tags. General and Comparative Endocrinology 156, 246-264.

68. L. Li* and J.V. Sweedler* (2008). Peptides in the brain: measurement approaches and challenges.  Inaugural volume of Annual Review of Analytical Chemistry. [Invited review article]. 1, 451-483.

67.  J.J. Schmidt, S. S. McIlwain, D. Page, A. E. Christie, and L. Li* (2008). Combining MALDI-FTMS and bioinformatics for rapid peptidomic comparisons. Journal of Proteome Research. 7, 887-896.

66.  J. Wang, R. Chen, M. Ma, and L. Li* (2008). MALDI MS sample preparation by using paraffin wax film: systematic study and application for peptide analysis.  Analytical Chemistry 80, 491-500.

65.  S.S. DeKeyser, K. K. Kutz-Naber, J. J. Schmidt, G.A. Barrett-Wilt, and L. Li* (2007) Mass spectral imaging of neuropeptides in crustacean nervous tissue by MALDI TOF/TOF. Journal of Proteome Research 6, 1782-1791.  [Cited by Faculty of 1000 Biology Evaluation]

64.  M. Ma, K, K. Kutz-Naber, and L. Li* (2007). Methyl esterification assisted MALDI FTMS characterization of orcokinin neuropeptide family. Analytical Chemistry 79, 673-681.

63.  Q. Fu, L. Tang, E. Marder, and L. Li* (2007).  Mass spectrometric characterization and physiological actions of VPNDWAHFRGSWamide, a novel B-type allatostatin in Cancer crabs. Journal of Neurochemistry 101, 1099-1107.

62.  S. S. DeKeyserand L. Li* (2007). Mass spectrometric charting of neuropeptides in arthropod neurons. Analytical and Bioanalytical Chemistry 387, 29-35.[Invited trend article, peer reviewed]

61.  C. Zhang, Q. Fu, C. Albermann, L. Li, and J. S. Thorson* (2007). The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification. ChemBioChem. 8, 385-390.

60.  S.R. Saideman, M. Ma, K. K. Kutz-Naber, A. Cook, P. Torfs, L. Schoofs, L. Li, and M. P. Nusbaum* (2007). Modulation of rhythmic motor activity by pyrokinin peptides.  Journal of Neurophysiology 97, 579-595.

59.  A. E. Christie*, K. K. Kutz-Naber, E. A. Stemmler, A. Klein, D. I. Messinger, C. C. Goiney, Y.-W. A. Hsu, C. R. Easton, L. Li, and P.S. Dickinson (2007). Midgut epithelial endocrine cells are a rich source of the neuropeptides APSGFLGMRamide (Cancer borealis tachykinin-related peptide Ia) and GYRKPPFNGSIFamide (Gly1-SIFamide) in the crabs Cancer borealis, Cancer magister and Cancer productus. Journal of Experimental Biology 210, 699-714.

58.  P.S. Dickinson, J. Stevens, S. Rus, H. R. Brennan, C. C. Coiney, C. M. Smith, L. Li, D. W. Towle, and A. E. Christie* (2007). Identification and cardiotropic actions of sulfakinin peptides in the American lobster Homarus americanus. Journal of Experimental Biology 210, 2278-2289.

57.  L. Zhao, X. Shi, L. Li, and D. J. Miller* (2007) Dynamin 2 associates with complexins and is found in the acrosomal region of mammalian sperm. Molecular Reproduction and Development 74, 750-757.

56.  L. Zhao, H.R. Burkin, X. Shi, L. Li, K. Reim, and D. J. Miller* (2007).  Complexin I is required for mammalian sperm acrosomal exocytosis. Developmental Biology 309, 236-244.

55.  J. A. Dowell, W. Vander Heyden, and L. Li* (2006). Rat neuropeptidomics by LC/MS/MS and MALDI-FTMS: enhanced dissection and extraction techniques coupled with 2D RP-RP HPLC separation. Journal of Proteome Research 5,3368-3375. [Featured in the Research Profile Section of Journal of Proteome Research and Bio Sphere News Section in Analytical Chemistry.]

54.  S. DeKeyser and L. Li* (2006).  Matrix-assisted laser desorption/ionization Fourier transform mass spectrometry (MALDI FTMS) quantitation via in-cell combination (QUICC). Analyst 131, 281-290. [Invited contribution to the special issue of Emerging Investigators, peer reviewed.  This paper was featured on the cover of the journal.]

53.  C. Zhang, B.R. Griffth, Q. Fu, X. Fu, C. Albermann, I.K. Lee, L. Li, and J.S. Thorson* (2006). Exploiting the indiscriminate and reversible nature of the Calicheamicin Rhamnosyltransferase CalG1 for enediyne glycorandomization. Science 313, 1291-1294.

52.  Q. Fu and L. Li* (2006).  Investigation of several unique MS/MS fragmentation patterns of NFDEIDR, an orcokinin analog, and its N-terminal dimethylated form. Rapid Communications in Mass Spectrometry 20, 553-562.

51.  Q. Fu and L. Li* (2006). The neutral loss of water from the b ions with histidine at the C-terminus. Journal of Mass Spectrometry 41, 1600-1607.

50.  N. Cruz-Bermudez, Q. Fu, K. Kutz, A. Christie, L. Li*, and E. Marder (2006), Mass spectrometric characterization and physiological actions of GAHKNYLRFamide, a novel FMRFamide-like peptide from crabs of the genus Cancer. Journal of Neurochemistry 97, 784-799.

49.  D.J. Schulz*, R.A. Baines, C.M. Hempel, L. Li, B. Liss, H. Misonou (2006). The role of gene expression and cellular excitability in the regulation of functional neuronal identity. Journal of Neuroscience 26, 10362-10367. [Invited Mini-Symposium Review.]

48.  Q. Fu and L. Li* (2006). Fragmentation of peptides with N-terminal dimethylation and imine/methylol adduction at tryptophan side chain. Journal of the American Society for Mass Spectrometry 17, 859-866.

47.  Q. Fu and L. Li* (2005).  De novo sequencing of neuropeptides using reductive isotopic methylation and investigation of ESI QTOF MS/MS fragmentation pattern of neuropeptides with N-terminal dimethylation. Analytical Chemistry 77, 7783-7795.

46.  Q. Fu, M. Goy, and L. Li* (2005).  Identification of neuropeptides from the sinus gland of the Jonah crab, Cancer borealis and the Maine lobster, Homarus americanus using nanoscale liquid chromatography tandem mass spectrometry. Biochemical Biophysical Research Communication 337, 765-778.

45.  Q. Fu, A. E. Christie, and L. Li* (2005).  Mass spectrometric characterization of the crustacean hyperglycemic hormone precursor related peptides (CPRPs) from the sinus gland of the crab, Cancer productusPeptides 26, 2137-2150.

44.  Q. Fu, K. K. Kutz, J. J. Schmidt, Y-W.A. Hsu, S. D. Cain, J. M. Edwards, L. V. Ambroggio, T. G. Halatchev, A. E. Christie, and L. Li* (2005).  Hormone complement of the Cancer productus sinus gland and pericardial organ: an anatomical and mass spectrometric investigation.  Journal of Comparative Neurology 493, 606-625.

43.  C. Billimoria, L. Li*, and E. Marder (2005).  Probing neuropeptide release from the crustacean stomatogastric nervous system using MALDI mass spectrometry.  Journal of Neurochemistry 95, 191-199.

42.  D. I. Messinger, K. K. Kutz, J. T. Birmingham, Y-W.A. Hsu, C. T. Ngo, L. Li,  and A. E. Christie* (2005).  Identification and characterization of a tachykinin-containing neuroendocrine organ in the commissural ganglion of the crab Cancer productusJournal of Experimental Biology 208, 3303-3319.

41.  J. Y. Yew*, K. Kutz, S. Dikler, L. Messinger, L. Li, and A. O. Stretton (2005).  A mass spectrometric map of neuropeptide expression in Ascaris suumJournal of Comparative Neurology 488, 396-413.

40.  K. K. Kutz, J. J. Schmidt, and L. Li* (2004).  In situ tissue analysis of neuropeptides by MALDI FTMS in-cell accumulation.  Analytical Chemistry 76, 5630-5640. [Cited by Faculty of 1000 Biology Evaluation].

39.  L. Li*, W.P. Kelley, C. Billimoria, A. Christie, S. R. Pulver, J. V. Sweedler, and E. Marder (2003).  Mass spectrometric investigation of the neuropeptide complement and release in the pericardial organs of the crab, Cancer borealisJournal of Neurochemistry 87, 642-656.

Publications as postdoctoral, graduate and undergraduate researcher:

38.  Proekt, F.S. Vilim, V. Alexeeva, V. Brezina, A. Friedman, J. Jing, L. Li, Y. Zhurov, J.V. Sweedler, and K. R. Weiss (2005).  Identification of new neuropeptide precursor reveals a novel source of extrinsic modulation in the feeding system of Aplysia. Journal of Neuroscience 25, 9637-9648.

37.  B. Hummon, N. P. Hummon, R. W. Corbin, L. Li, F. S. Vilim, K. R. Weiss, and J. V. Sweedler (2003).  From prohormone to final peptides: predicting processing using consensus sequence trends of common basic sites.  Journal of Proteome Research 2, 650-656.

36.  C. Masselon, L. Pasa-Tolic, S.-W. Lee, L. Li, G. A. Anderson, R. Harkewicz, and R. D. Smith (2003). Identification of tryptic peptides from large databases using multiplexed MS/MS: simulations and experimental results.  Proteomics 3, 1279-1286.

35.  Y. Furukawa, K. Nakamaru, K. Sasaki, Y. Fujisawa, H. Minakata, S. Ohta, F. Morishita, O. Matsushima, L. Li, V. Alexeeva, T. A. Ellis, N. C. Dembrow, J. Jing, J. V. Sweedler, K. R. Weiss, and F. S. Vilim (2003).  PRQFVamide, a novel pentapeptide identified from the CNS and gut of AplysiaJournal of Neurophysiology 89, 3114-3127.

34.  J. V. Sweedler, L. Li, S. S. Rubakhin, V. Alexeeva, N. C. Dembrow, O. Dowling, J. Jing, K. R. Weiss, and F. S. Vilim (2002). Identification and characterization of the feeding circuit activating peptides (FCAPs), a novel neuropeptide family of Aplysia. Journal of Neuroscience 22, 7797-7808.

33.  L. Li, S. R. Pulver, W. P. Kelley, V. Thirumalai, J. V. Sweedler, and E. Marder (2002). Orcokinin peptides in developing and adult crustacean stomatogastric nervous systems and pericardial organs.  J. Comp. Neurol. 444, 227-244.

32.  S. Vilim, V.Y. Alexeeva, L.L. Moroz, L. Li, T.P. Moroz, J.V. Sweedler, and K.R. Weiss (2001) Cloning, expression and processing of the CP2 neuropeptide precursor of Aplysia. Peptides 22, 2027-2038.

31.  Y. Furukawa, K. Nakamaru, H. Wakayama, Y. Fujisawa, H. Minakata, S. Ohta, F. Morishita, O. Matsushima, L. Li, E. V. Romanova, J. V. Sweedler, J.H. Park, A. Romero, E.C. Cropper, N.C. Dembrow, K.R. Weiss, and F.S. Vilim (2001) The enterins: a novel family of neuropeptides isolated from the enteric and central nervous system of Aplysia. Journal of Neuroscience 21, 8247-8261.

30.  Y. Shen, N. Tolic, R. Zhao, L. Pasa-Tolic, L. Li, S. J. Berger, R. Harkewicz, G. A. Anderson, M. E. Belov, and R. D. Smith (2001). High-throughput proteomics using high efficiency multiple-capillary liquid chromatography with on-line high performance ESI FTICR mass spectrometry. Analytical Chemistry 73, 3011-3021.

29.  L. Li, C. D. Masselon, G. A. Anderson, L. Pasa-Tolic, S-W. Lee, Y. Shen, R. Zhao, M. S. Lipton, and R. D. Smith (2001). High-throughput peptide identification from protein digests using data-dependent multiplexed tandem FTICR mass spectrometry coupled with capillary liquid chromatography. Analytical Chemistry 73, 3312-3322.

28.  L. Li, P. D. Floyd, S. S. Rubakhin, E. V. Romanova, J. Jing, V. Y. Alexeeva, N. C.  Dembrow, K. R. Weiss, F. S. Vilim, and J. V. Sweedler (2001) Cerebrin prohormone processing, distribution and action in Aplysia californica. Journal of Neurochemistry 77, 1569-1580.

27.  J.V. Sweedler, L. Li, P.D. Floyd, and W. Gilly (2000) Mass spectrometric survey of peptides in cephalopods with an emphasis on the FMRFamide-related peptides. Journal of Experimental Biology 203, 3565-3573.

26.  L. Li, E.V. Romanova, S.S. Rubakhin, V. Alexeeva, K.R. Weiss, F.S. Vilim, and J.V. Sweedler (2000) Peptide profiling of cells with multiple gene products: combining immunochemistry and MALDI-mass spectrometry with on-plate microextraction. Analytical Chemistry72, 3867-3874.

25.  L. Li, R.W. Garden, and J.V. Sweedler (2000) Single-cell MALDI: a new tool for direct peptide profiling. Trends in Biotechnology 18, 151-160. [Invited review, peer reviewed.  This paper was featured on the cover of the journal.]

24.  L. Li, R.W. Garden, E.V. Romanova, and J.V. Sweedler (1999) In Situ sequencing of peptides from biological tissues and single cells using MALDI-PSD/CID analysis. Analytical Chemistry 71, 5451-5458. [This paper was featured as an accelerated article in the journal.]

23.  L. Li, R.W. Garden, P.D. Floyd, T.P. Moroz, J.M. Gleeson, J.V. Sweedler, L. Pasa-Tolic, and R.D. Smith (1999) Egg-laying hormone peptides in the aplysiidae family. J. Exp. Biol. 202, 2961-2973.

22.  Y. Fujisawa, Y. Furukawa, S. Ohta, T. A. Ellis, N. C. Dembrow, L. Li, P. D. Floyd, J. V. Sweedler, H. Minakata, K. Nakamaru, F. Morishita, O. Matsushima, K. R. Weiss, and F. S. Vilim (1999) The Aplysia MIP-related peptides (AMRPs): identification, cloning, processing, distribution, and action. J. Neurosci. 19, 9618-9634.

21.  P.D. Floyd, L. Li, S.S. Rubakhin,J.V. Sweedler, C.C. Horn, I. Kupfermann, V. Y. Alexeeva,T.A. Ellis, N.C. Dembrow, K.R. Weiss, and F.S. Vilim (1999) Aplysia californica insulin prohormone processing, distribution, and relation to metabolism. J. Neurosci. 19, 7732-7741.

20.  P.D. Floyd, L. Li, T.P. Moroz, and J.V. Sweedler (1999) Characterization of peptides from Aplysia using microbore liquid chromatography with MALDI-TOF mass spectrometry guided purification. Journal of Chromatography A 830, 105-113.

19.  S.S. Rubakhin, L. Li, T.P. Moroz, and J. V. Sweedler (1999) Characterization of the Aplysia californica cerebral ganglion F-cluster. Journal of Neurophysiology 81, 1251-1260.

18.  R.W. Garden, T.P. Moroz, J.M. Gleeson, P.D. Floyd, L. Li, S.S. Rubakhin, and J.V. Sweedler (1999) Formation of pyroglutamyl peptides from N-Glu and N-Gln precursors in Aplysia neurons. Journal of Neurochemistry 72, 676-681.

17.  L. Li, T.P. Moroz, R.W. Garden, P.D. Floyd, K.R. Weiss, and J.V. Sweedler (1998) Mass spectrometric survey of interganglionically transported peptides in Aplysia. Peptides 19, 1425-1433.

16.  R.W. Garden, S.A. Shippy, L. Li, T.P. Moroz, and J.V. Sweedler (1998) Proteolytic processing of the Aplysia egg-laying hormone prohormone. Proceedings of the National Academy of Science, USA 95, 3972-3977. [This paper was featured in an accompanying commentary (pp 3338-3340).]

15.  K. Jiang, L. Li, Y. Chen, and J. Jin (1997) Determination of PCDD/Fs and dioxin-like PCBs in Chinese commercial PCBs and emissions from a testing PCB incinerator. Chemosphere 34, 941-950.

14.  A. Schecter, and L. Li (1997) Dioxins, dibenzofurans, dioxin-like PCBs, and DDE in US fast food. Chemosphere 34, 1449-1457.

13.  A. Schecter, L. Li, K. Jiang, P. Furst, C. Furst, and O. Papke (1996) Pesticide application and increased dioxin body burden in male and female agricultural workers in China. J. Occup. Environ. Med. 38, 906-911.

12.  A. Schecter, O. Papke, A. Lis, M. Ball, J.J. Ryan, J.R. Olson, L. Li, H. Kessler (1996)Decrease in milk and blood dioxin levels over two years in a mother nursing twins: estimates of decreased maternal and increased infant dioxin body burden from nursing.  Chemosphere 32, 543-549.

11.  A. Schecter, L. Li, and J. R. Olson (1995) Dioxins in U.S. fast food.  Organohalogen Compound26135-139.

10.  K. Jiang, L. Li, Y. Chen, S. Li, and Y. Gong (1995) Residual dioxins in Chinese schistosomiasis region and its eco-environmental risk. Chin. Sci. Bull.(English version) 40, 1740-1747.

9.  K. Jiang, L. Li, Y. Chen, J. Jin, and D. Zhang (1999) Emissions of dioxins and PCBs from PCB-containing waste incinerator. Progress in Environ. Sci. (Chinese) 7, 45-49.

8.  K. Jiang, L. Li, and Y. Chen (1996) Dioxins in stack ash from PCB waste incinerator.  Chin. J. Environ. Sci.17, 68-71.

7.  L. Li and K. Jiang (1995) Determination of dioxin-like PCBs congeners of Chinese PCBs chemicals. Chinese Journal of Environmental Sciences 16, 55-58.

6.  L. Li and K. Jiang (1995) Determination of toxic equivalents of PCDD/Fs in two Chinese commercial PCBs by 13C isotope dilution method.  Acta Environ. Sci.15, 433-439.

5.  L. Li, Y. Chen, Y. Zhou, J. Wu, and K. Jiang (1995) Use of acid-base silica/alumina column and gas chromatography-mass spectrometry (GC/MS) methods for determination of residual PCBs in the solid wastes of an incinerator.  Chin. J. Environ. Chem.14, 322-328.

4.  K. Jiang, Y. Chen, and L. Li (1995) PCDD/Fs in sodium pentachlorophenate (Na-PCP) and human blood, milk, and sediment samples from Chinese schistosomiasis areas. J. Environ. Sci. 7, 52-59.

3.  J. Jin, L. Li, K. Jiang (1995) Toxicity of dioxin-like compounds.  Shanghai Environ. Sci. 14, 29-32.

2.  L. Li, Y. Chen, C. Chiu, G. Poole, W. Miles, and K. Jiang (1994) PCDD/Fs in sediment samples from Chinese schistosomiasis areas and potential human health effects.  Organohalogen Compound 20 (Dioxin ’94), 155-158.

1.  L. Li, J. Wu, Y. Chen, and K. Jiang (1993) Determination of polychlorinated biphenyls in transformer oils. Chin. J. Environ. Sci. 14, 69-72.

 

Non peer-reviewed book chapter and book review:

1.   L. Li* (2005), Invited book review for Drug Discovery for Nervous System Diseases, Am. J. Pharmaceutical Education. 69, 4, 561-562.

2.  S.S. Cape, J.A. Dowell, and L. Li* (2009) Mass spectrometric characterization of neuropeptides. Invited book chapter in Methods in Molecular Biology. 492, 381-393.

3.  H.L. Behrens and L. Li* (2010) Monitoring neuropeptides in vivo via microdialysis and mass spectrometry. Invited book chapter in a new volume Peptidomics Protocols and Methods Handbook as part of series for Methods in Molecular Biology. 615, 57-73.

4.   R.M. Sturm, J.A. Dowell, and L. Li* (2010) Rat brain neuropeptidomics: Tissue collection, protease inhibition, neuropeptide extraction, and mass spectrometric analysis.  Invited book chapter in a new volume Peptidomics Protocols and Methods Handbook as part of series for Methods in Molecular Biology. 615, 217-226.

5.   R. Chen, S.S. Cape, R.M. Sturm, and L. Li* (2010) Imaging mass spectrometry of neuropeptides in decapod crustacean neuronal tissues.  Invited book chapter in Mass Spectrometric Imaging: Principles and Protocols as part of Methods in Molecular Biology Series656, 451-463.

6.   J. Wang, Z. Zhang, and L. Li* (2010) Microchip-based liquid chromatography. Invited book chapter in Contemporary Microscale Separation Technologies. C. Yan. Ed.; New York, USA, In press.

7.   L. Li* and J.V. Sweedler* (2002) Measuring neuropeptides with single-cell mass spectrometry. In Mass Spectrometry and Hyphenated Techniques in Neuropeptide Research. pp495-517.

8.   E. Gemperline and L. Li* (2013) Mass spectrometric imaging of metabolites in legume root nodules. Invited book chapter in the Springer Science Series on MS Imaging of Small Molecules. In preparation.

9.   J. Zhang, K.A. Lanham, W. Heideman, R.E. Peterson, and L. Li* (2013) Characterization of zebrafish cardiac proteome using online pH gradient SCX-RP HPLC-MS/MS platform. Invited book chapter in Heart Proteomics as part of Methods in Molecular Biology Series1005, 119-127.

10. L. Li* (2014) Neurologically Active Peptides in Invertebrates. Invited Neuropeptide Book Series.