60. Pomeroy, J.M.; Khalifa, M.M.; Milanes, J.E.; Palmentiero, C.M.; Morris, J.C.; Golden, J.E. “Synthesis and Evaluation of Benzylamine Inhibitors of Neuropathogenic Naegleria fowleri “Brain-Eating” Amoeba.” 2024, ACS Med. Chem. Lett. 15, 1, 87-92. DOI: 10.1021/acsmedchemlett.3c00440
59. Lish, M.; Milanes, J.; Sanders, K.; Guzei, I.; Morris, J.; Golden, J.E. “Mannich-Type Condensation and Domino Quinazolinone-Amidine Rearrangement Affords Ring-Fused Mackinazolinones with Anti-Amoebic Activity.” 2023, Adv. Synth. & Catal. doi.org/10.1002/adsc.202300994
58. Cao, X.; Yang, D.; Parvathareddy, J.; Chu, Y.-k.; Kim, E. J.; Fitz-Henley, J. N.; Li, X.; Lukka, P. B.; Parmar, K. R.; Temrikar, Z. H.; Dhole, P.; Adcock, R. S.; Gabbard, J.; Bansal, S.; Lee, J.; Zalduondo, L.; Hayes, E.; Stabenow, J.; Meibohm, B.; Fitzpatrick, E. A.; Bailey, K.; Campos, R. K.; Julander, J. G.; Rossi, S. L.; Chung, D.; Jonsson, C. B.; Golden, J. E. Efficacy of a brain-penetrant antiviral in lethal Venezuelan and eastern equine encephalitis mouse models. 2023, Sci. Transl. Med. 15, (691), eabl9344. doi: 10.1126/scitranslmed.abl9344.
57. Ogorek, T.J.; Golden, J.E. Advances in the Development of Small Molecule Antivirals against Equine Encephalitic Viruses. 2023, Viruses,15 (2). doi: 10.3390/v15020413.
56. Fitz-Henley, J.N.; Rozema, S.D.; Golden, J.E. Dihydropyrazinoquinazolinones via SN2 Sulfamidate Ring-Opening and a Sequential Quinazolinone-Amidine Rearrangement Strategy (SQuAReS). 2022, J. Org. Chem. 87 (21), 14889-14898. doi: 10.1021/acs.joc.2c01717.
55. Milanes, J.E.; Suryadi, J.; Monaghan, N.P.; Harding, E.M.; Morris, C.S.; Rozema, S.D.; Khalifa, M.M.; Golden, J.E.; Phan, I.Q.; Zigweid, R.; Abendroth, J.; Rice, C.A.; McCord, H.T.; Wilson, S.; Fenwick, M.K.; Morris, J.C. Characterization of Glucokinases from Pathogenic Free-Living Amoebae. 2022, Antimicrob Agents Chemother. 66 (6), e0237321. doi: 10.1128/aac.02373-21.
54. Ryan, M.C.; Kim, E.; Cao, X.; Reichard, W.; Ogorek, T.J.; Das, P.; Jonsson, C.B.; Baudry, J.; Chung, D.; Golden, J.E. Piperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones. 2022, ACS Med Chem Lett. 13 (4), 546-553. doi: 10.1021/acsmedchemlett.1c00539.
53. Jonsson, C.B.; Golden, J.E.; Meibohm, B. Time to ‘Mind the Gap’ in novel small molecule drug discovery for direct-acting antivirals for SARS-CoV-2. 2021, Curr. Opin. Virol. 50, 1-7. doi: 10.1016/j.coviro.2021.06.008.
52. Jaffett V.A.; Fitz-Henley, J.N.; Khalifa, M.M.; Guzei, I.A.; Golden, J.E. Diastereoselective, Multicomponent Synthesis of Pyrrolopyrazinoquinazolinones via a Tandem Quinazolinone Rearrangement/Intramolecular Ring Closure of Tautomeric (Z)-Benzamidines. 2021, Org Lett. 23 (15), 5799-5803. doi: 10.1021/acs.orglett.1c01955.
51. Li, X.; Golden, J.E. Construction of N-Boc-2-Alkylaminoquinazolin-4(3H)-ones via a Three-Component, One-Pot Protocol Mediated by Copper(II) Chloride that Spares Enantiomeric Purity. 2021, Adv. Synth. Catal. 363 (6), 1638-1645. DOI: 10.1002/adsc.202001279
50. Wlodarchak, N.; Feltenberger, J.; Ye, Z.; Beczkiewicz, J.; Procknow, R.; King, T.; Yan, G.; Golden, J.E.; Striker, R. Engineering selectivity for reduced toxicity of bacterial kinase inhibitors using structure-guided medicinal chemistry. 2021, ACS Med. Chem. Lett. 12 (2), 228-235. DOI: 10.1021/acsmedchemlett.0c00580
49. Lee, J.; Parvathareddy, J.; Yang, D.; Bansal, S.; O’Connell, K.; Golden, J.E.; Jonsson, C.B. Emergence and magnitude of ML336 resistance in Venezuelan equine encephalitis virus depends on the microenvironment. J. Virology, 2020, 94 (22), e00317-320. DOI: 10.1128/JVI.00317-20
48. Khalifa, M.M.; Martorelli di Genova, B.; McAlpine, S.G.; Gallego-Lopez, G.M.; Stevenson, D.M.; Rozema, S.D.; Monaghan, N.P.; Morris, J.C.; Knoll, L.J.; Golden, J.E. Dual Stage Picolinic Acid Derived Inhibitors of Toxoplasma gondii. 2020, ACS Med. Chem. Lett. 11,12, 2382-2388.
47. Yan, G.; Zekarias, B.L.; Li, X.; Jaffett, V.A.; Guzai, I.; Golden, J.E. Divergent 2-Chloroquinazolin-4(3H)-one Rearrangement: Twisted-Cyclic Guanidines or Ring-Fused N-Acylguanidines via a Domino Process. Chem. Euro. J. 2020, 26 (11), 2486-2492. DOI: 10.1002/chem.201905219
46. Khalifa, M.M.; Philkhana, S.C.; Golden, J.E. Synthesis of Ring-Fused, N-Substituted 4-Quinolinones Using pKa-Guided, Base-Promoted Annulations with Isatoic Anhydrides: Total Synthesis of Penicinotam. J. Org. Chem. 2020, 85, 2, 464- 481. DOI: 10.1021/acs.joc.9b02541.
45. Skidmore, A.; Adcock, R.; Jonsson, C.; Golden, J.E.; Chung, D.-H. Benzamidine ML336 inhibits plus and minus strand RNA synthesis of Venezuelan equine encephalitis virus without affecting host RNA production. Antiviral Res. 2019, Dec 6, 174:104674. DOI: 10.1016/j.antiviral.2019.104674.
44. Jaffett, V.; Nerurkar, A.; Cao, X.; Guzei, I.; Golden, J.E. Telescoped Synthesis of C3-Functionalized (E)-Arylamidines Using Ugi-Mumm and Regiospecific Quinazolinone Rearrangements. Org. Biomol. Chem. 2019, 17, 3118-3128. DOI: 10.1039/C9OB00073A , Featured cover art.
43. Jonsson, C.B.; Cao, X.; Lee, J.; Gabbard, J.D.; Chu, Y.-K.; Fitzpatrick, E.; Julander, J.; Chung, D.-H.; Stabenow, J.; Golden, J.E.; Efficacy of a ML336 Derivative against Venezuelan and Eastern Equine Encephalitis Viruses. 2019, Antiviral Res. July, 167, 25-34. DOI: 10.1016/j.antiviral.2019.04.004
42. Milanes, J.; Suryadi, J.; Abendroth, J.; van Voorhis, W.C.; Barrett, K.; Dranow, D.; Phan, I.; Patrick, S. Rozema, S.; Khalifa, M.; Golden, J.E.; Morris, J. Enzymatic and structural characterization of the Naegleria fowleri glucokinase. Antimicrob Agents Chemother., 2019, April 25, 65 (5), e02410-18. DOI: 10.1128/AAC.02410-18
41. Yan, G.; Golden, J.E. Palladium-catalyzed cyclocarbonylation of pyridinylated vinylogous amides and ureas to generate ring fused pyridopyrimidinones. Org. Lett. 2018, 20 (15) 4393-4396. DOI: 10.1021/acs.orglett.8b01275.
40. Rinis, N.; Golden, J.E.; Van Zandt, M.C.; Gilmore, R.; Contessa, J.N. Editing N-glycan site occupancy with small molecule oligosaccharyltransferase (OST) inhibitors. Cell Chem. Biol., 2018. DOI.org/10.1016/j.chembiol.2018.07.005.
39. Flaherty, D.P.; Harris, M.T.; Schroeder, C.E.; Khan, H.; Kahney, E.; Hackler, A.; Patrick, S.; Weiner, W.S.; Aube, J.; Morris, J.C.; Golden, J.E. Optimization and evaluation of antiparasitic benzamidobenzoic acids as inhibitors of kinetoplastid hexokinase 1. ChemMedChem. 2017, 12 (23),1994-2005.
38. Gordhan, H. M.; Milanes, J. E.; Qiu, Y.; Golden, J. E.; Christensen, K.; Morris, J. C.; Whitehead, D. C. A targeted delivery strategy for the development of potent trypanocides. Chem. Comm. 2017, DOI: 10.1039/C7CC03378H.
37. Hackler, A.; Patrick, S.L.; Kahney, E.W.; Flaherty, D.P.; Sharlow, E.R.; Morris, J.C.; Golden , J.E. Antiparasitic lethality of sulfonamidebenzamides in kinetoplastids. Bioorg. Med. Chem. Lett. 2017, Feb 15;27(4):755-758. DOI:10.1016/j.bmcl.2017.01.043 PMID:28119024
36. Adcock R.S.; Chu, Y.K.; Golden, J.E.; Chung, D.-H. Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay. Antiviral Res. 2017 Feb;138:47-56. DOI: 10.1016/j.antiviral.2016.11.018. PubMed PMID: 27919709.
35. Gordhan, H.M.; Patrick, S.L.; Swasy, M.I.; Hackler, A.L.; Anayee, M.; Golden, J.E.; Morris, J.C.; Whitehead, D.C. Evaluation of substituted ebselen derivatives as potential trypanocidal agents. Bioorg. Med. Chem. Lett. 2017, 27, 537-541.
34. Lopez-Sambrooks, C.; Shrimal, S.; Khodier, C.; Flaherty, D.P.; Rinis, N.; Charest, J. C.; Gao, N.; Zhao, P.; Wells, L.; Lewis, T. A.; Lehrman, M. A.; Gilmore, R.; Golden, J. E.; Contessa, J. N. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat. Chem. Biol. 2016, Dec;12(12):1023-1030. DOI: 10.1038/nchembio.2194.
33. Davis, M.I.; Patrick, S.; Blanding, W.M.; Dwiveldi, V.; Suryadi, J.; Golden, J.E.; Coussens, N.P.; Lee, O.W.; Shen, M.; Boxer, M.B.; Hall, M.D.; Sharlow, E.R.; Drew, M.E.; Morris, J.C. Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Anti-parasitic Activity. Antimicrob Agents Chemother., 2016, Sep 23;60(10):6023-33. DOI: 10.1128/AAC.00914-16.
32. Weisshaar, M.; Cox, R.; Morehouse, Z.; Kumar Kyasa, S.; Yan, D.; Oberacker, P.; Mao, S.; Golden J.E.; Lowen, A.C.; Natchus, M.G.; Plemper, R.K. Identification and Characterization of Influenza Virus Entry Inhibitors through Dual Myxovirus High-Throughput Screening. J. Virol., 2016 Jul 27;90(16):7368-87. DOI: 10.1128/JVI.00898-16.
31. Chung, D.H.; Golden, J.E.; Adcock, R.S.’ Schroeder, C.E.; Chu, Y.K.; Sotsky, J.B.; Cramer, D.E.; Chilton, P.M.; Song, C.; Anantpadma, M.; Davey, R.A.; Prodhan, A.I.; Yin, X.; Zhang, X. Discovery of a Broad-Spectrum Antiviral Compound That Inhibits Pyrimidine Biosynthesis and Establishes a Type 1 Interferon-Independent Antiviral State. Antimicrob Agents Chemother. 2016, Jul 22;60(8):4552-62. DOI: 10.1128/AAC.00282-16.
30. Chattopadhyay, D.; Swingle, M.R.; Salter, E.A.; Wood, E.; D’Arcy, B.; Zivanov, C.; Abney, K.; Musiyenko, A.; Rusin, S.F.; Kettenbach, A.; Yet, L.; Schroeder, C.E., Golden, J.E.; Dunham, W.H.; Gingras, A.C.; Banerjee, S.; Forbes, D.; Wierzbicki, A.; Honkanen, R.E. Crystal Structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C. Biochem. Pharmacol. 2016 Mar 23. pii: S0006-2952(16)00178-7. DOI: 10.1016/j.bcp.2016.03.011. [Epub ahead of print]
29. Schroeder, C.E.; Neuenswander, S.A.; Yao, T.; Aubé, J.; Golden, J.E. One-Pot, Regiospecific Assembly of (E)-Benzamidines From Delta- and Gamma-Amino Acids Via an Intramolecular Aminoquinazolinone Rearrangement. Org. Biomol. Chem. 2016, 14, 3950 – 3955.
28. Hong, L.; Guo, Y.; BasuRay, S.; Agola, J.O.; Romero, E.; Simpson, D.S.; Schroeder, C.E.; Simons, P.; Waller, A.; Garcia, M.; Carter, M.; Ursu, O.; Gouveia K.; Golden J.E.; Aubé, J.; Wandinger-Ness, A.; Sklar, L.A. “A Pan-GTPase Inhibitor as a Molecular Probe.” PLoS One 2015 Aug 6;10(8):e0134317. eCollection 2015.