Publications

PEER-REVIEWED PUBLICATIONS SINCE JOINING UW-MADISON:

38. Gordhan, H. M.; Milanes, J. E.;  Qiu, Y.; Golden, J. E.;  Christensen, K.;  Morris, J. C.;  Whitehead, D. C. A targeted delivery strategy for the development of potent trypanocides. Chem. Commun. 2017, DOI: 10.1039/C7CC03378H.

37. Hackler, A.; Patrick, S.L.; Kahney, E.W.; Flaherty, D.P.; Sharlow, E.R.; Morris, J.C.; Golden , J.E. Antiparasitic lethality of sulfonamidebenzamides in kinetoplastids. Bioorg. Med. Chem. Lett. 2017, Feb 15;27(4):755-758. DOI:10.1016/j.bmcl.2017.01.043 PMID:28119024

36. Adcock R.S.; Chu, Y.K.; Golden, J.E.; Chung, D.-H. Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay. Antiviral Res. 2017 Feb;138:47-56. doi: 10.1016/j.antiviral.2016.11.018. PubMed PMID: 27919709.

35.  Gordhan, H.M.; Patrick, S.L.; Swasy, M.I.; Hackler, A.L.; Anayee, M.; Golden, J.E.; Morris, J.C.; Whitehead, D.C. Evaluation of substituted ebselen derivatives as potential trypanocidal agents. Bioorg. Med. Chem. Lett.  201727, 537-541.

34. Lopez-Sambrooks, C.; Shrimal, S.; Khodier, C.; Flaherty, D.P.; Rinis, N.; Charest, J. C.; Gao, N.; Zhao, P.; Wells, L.; Lewis, T. A.; Lehrman, M. A.; Gilmore, R.; Golden, J. E.; Contessa, J. N. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat. Chem. Biol. 2016,  Dec;12(12):1023-1030. doi: 10.1038/nchembio.2194.

33. Davis, M.I.; Patrick, S.; Blanding, W.M.; Dwiveldi, V.; Suryadi, J.; Golden, J.E.; Coussens, N.P.; Lee, O.W.; Shen, M.; Boxer, M.B.; Hall, M.D.; Sharlow, E.R.; Drew, M.E.; Morris, J.C. Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Anti-parasitic Activity. Antimicrob Agents Chemother., 2016, Sep 23;60(10):6023-33. doi:10.1128/AAC.00914-16.

32. Weisshaar, M.; Cox, R.; Morehouse, Z.; Kumar Kyasa, S.; Yan, D.; Oberacker, P.; Mao, S.; Golden J.E.; Lowen, A.C.; Natchus, M.G.; Plemper, R.K. Identification and Characterization of Influenza Virus Entry Inhibitors through Dual Myxovirus High-Throughput Screening. J. Virol., 2016 Jul 27;90(16):7368-87. doi: 10.1128/JVI.00898-16. 

31. Chung, D.H.; Golden, J.E.; Adcock, R.S.’ Schroeder, C.E.; Chu, Y.K.; Sotsky, J.B.; Cramer, D.E.; Chilton, P.M.; Song, C.; Anantpadma, M.; Davey, R.A.; Prodhan, A.I.; Yin, X.; Zhang, X. Discovery of a Broad-Spectrum Antiviral Compound That Inhibits Pyrimidine Biosynthesis and Establishes a Type 1 Interferon-Independent Antiviral State. Antimicrob Agents Chemother. 2016, Jul 22;60(8):4552-62. doi: 10.1128/AAC.00282-16. 

30. Chattopadhyay, D.; Swingle, M.R.; Salter, E.A.; Wood, E.; D’Arcy, B.; Zivanov, C.; Abney, K.; Musiyenko, A.; Rusin, S.F.; Kettenbach, A.; Yet, L.; Schroeder, C.E., Golden, J.E.; Dunham, W.H.; Gingras, A.C.; Banerjee, S.; Forbes, D.; Wierzbicki, A.; Honkanen, R.E. Crystal Structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C. Biochem. Pharmacol. 2016 Mar 23. pii: S0006-2952(16)00178-7. doi: 10.1016/j.bcp.2016.03.011. [Epub ahead of print] 

29. Schroeder, C.E.; Neuenswander, S.A.; Yao, T.; Aubé, J.; Golden, J.E. One-Pot, Regiospecific Assembly of (E)-Benzamidines From Delta- and Gamma-Amino Acids Via an Intramolecular Aminoquinazolinone Rearrangement. Org. Biomol. Chem. 2016, 14, 3950 – 3955.

28. Hong, L.; Guo, Y.; BasuRay, S.; Agola, J.O.; Romero, E.; Simpson, D.S.; Schroeder, C.E.; Simons, P.; Waller, A.; Garcia, M.; Carter, M.; Ursu, O.; Gouveia K.; Golden J.E.; Aubé, J.; Wandinger-Ness, A.; Sklar, L.A. “A Pan-GTPase Inhibitor as a Molecular Probe.” PLoS One 2015 Aug 6;10(8):e0134317. eCollection 2015. 

SELECTED PEER-REVIEWED PUBLICATIONS PRIOR TO UW-MADISON:

27. Schreiber, S.L.; Kotz, J.D.; Li, M.; Aubé, J.; Austin, C.P.; Reed, J.C.; Rosen, H.; White, E.L.; Sklar, L.A.; Lindsley, C.W.; Alexander, B.A.; Bittker, J.A.; Clemons, P.A.; de Souza, A.; Foley, M.A.; Palmer, M.; Shamji, A.F.; Wawer, M.J.; McManus, O.; Wu, M.; Zou, B.; Yu, H.; Golden, J.E.; Schoenen, F.J.; Simeonov, A.; Jadhav, A.; Jackson, M.R.; Pinkerton, A.B.; Chung, T.D.Y.; Griffin, P.R.; Cravatt, B.F.; Hodder, P.S.; Roush, W.R.; Roberts, E.; Chung, D.-H.; Jonsson, C.B.; Noah, J.W.; Severson, W.E.; Ananthan, S.; Edwards, B.; Oprea, T.I.; Conn, P.J.; Hopkins, C.R.; Wood, M.R.; Stauffer, S.R.; Emmitte, K.A.; NIH Molecular Libraries Project Team. “Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.” Cell 2015, 161, 1252-1265.

26. Matharu, D.S.; Flaherty, D.; Simpson, D.; Chung, D.; Yan, D.; Noah, J.W.; Jonsson, C.B.; White, E.L.; Aubé, J.; Plemper, R.K.; Severson, W.E.; Golden, J.E. “Optimization of Potent and Selective Quinazolinediones: Inhibitors of Respiratory Syncytial Virus That Block RNA-dependent RNA-polymerase Complex Activity.” J. Med. Chem. 2014, 57, 10314-10328.

25. Flaherty, D.P.; Miller, J.R.; Garshott, D. M.; Hedrick, M.; Gosalia, P.; Li, Y.; Milewski, M.; Sugarman, E.; Vasile, S.; Salaniwal, S.; Su, Y.; Smith, L. H.; Chung, T. D. Y.; Pinkerton, A. B.; Aubé, J.; Callaghan, M. U.; Golden, J.E.; Fribley, A.M.; Kaufman, R.J. “Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response.” ACS Med. Chem. Lett. 2014, 5 (12), pp 1278–1283.

24. Wender, P.A.; Axtman, A.D.; Golden, J.E.; Kee, J.-M.; Sirois, L.E.; Quiroz, R.V.; Stevens, M.C. “Function Through Bio-Inspired, Synthesis-Informed Design: Step-Economical Syntheses of Designed Kinase Inhibitors.” Org. Chem. Front. 2014, 1, 1166-1171.

23. Schroeder, C.E.; Yao, T.; Sotsky, J.B.; Smith, R.A.; Roy, S.; Chu, Y.K.; Guo, H.; Tower, N.A.; Noah, J.W.; McKellip, S.; Sosa, M.; Rasmussen, L.; Smith, L.H.; White, E.L.; Aubé, J.; Jonsson, C.B.; Chung, D.-H.; Golden, J.E. Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: novel 2-amidinophenylbenzamides as potent inhibitors of Venezuelan equine encephalitis virus. J. Med. Chem. 2014, 57(20), 8608-8621. PMID: 25244572.

22. Flaherty, D.P.; Simpson, D.S.; Miller, M.; Maki, B.E.; Zou, B.; Shi, J.; Wu, M.; McManus, O.B.; Aubé, J.; Li, M.; Golden, J.E. “Potent and Selective Inhibitors of the TASK-1 Potassium Channel Through Chemical Optimization of a Bis-amide Scaffold.” Bioorg. Med. Chem. Lett. 2014, 24, 3968-3973. PMID: 25017033.

21. Chung, D.-H.; Jonsson, C. B.; Tower, N. A.; Chu, Y.-K.; Sahin, E.; Golden, J. E.; Noah, J. W.; Schroeder, C. E.; Sotsky, J. B.; Sosa, M. I.; Cramer, D. E.; McKellip, S. N.; Rasmussen, L.; White, E. L.; Schmaljohn, C. S.; Julander, J. G.; Smith, J. M.; Filone, C. M.; Connor, J. H.; Sakurai, Y.; Davey, R. A. “Discovery of a Novel Compound with Anti-Venezuelan Equine Encephalitis Virus Activity That Targets the Nonstructural Protein 2.” PLoS Pathog. 2014, 10, e1004213. PMID: 24967809.

20. Harris, M.; Walker, D.; Drew, M.; Mitchell, W.; Dao, K.; Schroeder, C.; Flaherty, D.; Weiner, W.; Golden, J.; Morris, J. “Interrogating a Hexokinase-Selected Small Molecule Library for Inhibitors of Plasmodium falciparum Hexokinase.” Antimicrob. Agents Chemother. 2013, 57, 3731-3737. PMID 23716053.

19. Hong, L.; Kenney, S.R.; Philip, G.K.; Simpson, D.; Schroeder, C.E.; Nöth, J.; Romero, E.; Swanson, S.; Waller, A.; Strouse, J.J.; Carter, M.; Chigaev, A.; Ursu, O.; Oprea, T.; Hjelle, B.; Golden, J.E.; Aubé, J.; Hudson, L.G.; Buranda, T.; Sklar, L.A.; Wandinger-Ness, A.“Characterization of a Cdc42 Protein Inhibitor and its Use as a Molecular Probe.” J. Biol. Chem. 2013, 288, 8531-8543. PMID 23382385.

18. Chung, D-H; Moore, B.P.; Matharu, D.S.; Golden, J.E.; Maddox, C.; Rasmussen, L.; Sosa, M.I.; White, E.L.; Ananthan, S.; Jia, F.; Aubé, J.; Jonsson, C.B.; Severson, W.E. “A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus.” Virology J. 2013, 10(19) [Epub ahead of print]. PMID 23302182.

17. Strouse, J.J.; Ivnitski-Steele, I.; Khawaja, H.M.; Perez, D.; Ricci, J.; Yao, T.; Weiner, W.S.; Schroeder, C.E.; Simpson, D.S.; Maki, B.E.; Li, K.; Golden, J.E.; Foutz, T.D.; Waller, A.; Evangelisti, A.M.; Young, S.M.; Chavez, S.E.; Garcia, M.J.; Ursu, O.; Bologa, C.G.; Carter, M.B.; Salas, V.M.; Gouveia, K.; Tegos, G.P.; Oprea, T.I.; Edwards, B.S.; Aubé, J.; Larson, R.S.; Sklar, L.A. “A Selective ATP-binding Cassette Sub-family G Member 2 Efflux Inhibitor Revealed Via High-Throughput Flow Cytometry.”J. Biomol. Screening 2013, 18(1),26-38 – issue cover.PMID: 22923785.

16. Moore, B.P.; Chung, D-H; Matharu, D.S.; Golden, J.E.; Maddox, C.; Rasmussen, L.; Noah, J.W.; Sosa, M.I.; Ananthan, S.; Tower, N.A.; White, E.L.; Jia, F.; Prisinzano, T.E.; Aubé, J.; Jonsson, C.B.; Severson, W.E. “(S)-N-(2,5-Dimethylphenyl)-1-(Quinoline-8-ylsulfonyl) Pyrrolidine-2-Carboxamide as a Small Molecule Inhibitor Probe for the Study of Respiratory Syncytial Virus Infection.” J. Med. Chem. 2012, 55(20), 8582–8587. PMID 23043370.

15. Agola, J.O.; Hong, L.; Surviladze, Z.; Ursu, O.; Waller, A.; Strouse, J.J.; Simpson, D.S.; Schroeder, C.E.; Oprea, T.I.; Golden, J.E.; Aubé, J.; Buranda, T.; Sklar, L.A.; Wandinger-Ness, A. “A Competitive Nucleotide Binding Inhibitor: In vitro Characterization of Rab7 GTPase Inhibition.” ACS Chem. Biol. 2012, 7 (6), p 1095–1108.

14. Chen, J.; Young, S.M.; Allen, C.; Seeber, A.; Péli-Gulli, M-P.; Pauchaund, N.; Waller, A.; Ursu, O.; Tao, T.; Golden, J.E.; Strouse, J.J.; Carter, M.B.; Kang, H.; Bologa, C.G.; Foutz, T.D.; Edwards, B.; Peterson, B.R.; Aubé, J.; Werner-Washburne, M.; Loewith, R.J.; Dew Virgilio, C.; Sklar, L. “Identification of a small molecule yeast TORC1 inhibitor with a flow cytometry based multiplex screen.” ACS Chem. Biol. 2012, 7(4), p 715-722.

13. Seguin, S.P.; Evans, C.E.; Nebane-Akah, M.; Mckellip, S.; Ananthan, S.; Tower, N.A.; Sosa, M.; Rasmussen, L.; White, E.L.; Maki, B.E.; Matharu, D.S.; Golden, J.E.; Aubé, J.; Brodsky, J.L.; Noah, J.W. “High-Throughput Screening Identifies a Bisphenol Inhibitor of SV40 Large T-Antigen ATPase Activity.” J. Biomol. Screening 2012, 17(2), p.194-203.

12. Frohn, M.; Cee, V.J.; Lanman, B.A.; Pickrell, A. J.; Golden, J.; Rivenzon-Segal,D.; Middleton, S.; Fiorino, M.; Xu, H.; Schrag, M.; Xu, Y.; McElvain, M.; Muller, K.; Siu, J.; Bürli, R. “Novel 5- and 6-Subtituted Benzothiazoles with Improved Physicochemical Properties: Potent S1P1 Agonists With In Vivo Lymphocyte-Depleting Activity.”Bioorg. Med. Chem. Lett. 2011, 22(1), 628-633.

11. Lanman, B.A.; Cee, V.J.; Cheruku, S.R.; Frohn, M.; Golden, J.; Lin, J.; Lobera, M.; Marantz, Y.; Muller, K.M.; Neira, S.C.; Pickrell, A.J.; Rivenzon-Segal, D.; Schutz, N.; Sharadendu, A.; Yu, X.; Zhang, Z.; Buys, J.; Fiorino, M.; Gore, A.; Horner, M.; Itano, A.; McElvain, M.; Middleton, S.; Schrag, M.; Vargas, H.M.; Xu, H.; Xu, Y.; Zhang, X.; Siu, J.; Burli, R.. “Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1(SIP1).”ACS Med. Chem. Lett. 2011, 2(2), p 102-106.

10. Cee, V.; Frohn, M.; Lanman, B.; Golden, J.E.; Muller, K.M.; Neira, S.; Pickrell, A.; Arnett, H.; Gore, A.; Fiorino, M.; Itano, A.; Horner, M.; Lee, M.; McElvain, M.; Middleton, S.; Schrag, M.; Segal, D.; Xu, H.; Xu, Y.; Zhang, X.; Siu, J.; Wong, M.; Bürli, R.W. “Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5.” ACS Med. Chem. Lett. 2011, 2(2), p 107-112.

9. Frohn, M.; Viswanadhan, V.; Pickrell, A.J.; Biddlecome, G.; Yoder, S.; Rogers, N.; Golden, J.E.; Muller, K.M.; Bürli, R.W.; Hungate, R.; Allen, J.R. “Structure-Guided Design of Substituted Aza-Benzimidazoles as Potent Hypoxia Inducible Factor 1α-Prolyl Hydroxylase-2 Inhibitors.” Bioorg. Med. Chem. Lett. 2008, 18, 5023-5026.

8. Frankowski, K.J.; Golden, J.E.; Zeng, Y.; Lei, Y.; Aubé, J. “Syntheses of the Stemona Alkaloids (±)-Stenine, (±)-Neostenine, and (±)-13-Epineostenine Using a Stereodivergent Diels–Alder/Azido-Schmidt Reaction.” J. Am. Chem. Soc. 2008, 130, 6018-6024.

7. Golden, J.E.; Sanders, S.D.; Muller, K.M.; Burli, R.W. “Modulating N- versus O-Arylation in Pyrazolone-Aryl Halide Couplings.” Tetrahedron Lett. 2008, 49, 794-798.

6. Burli, R.W.; Xu, H.; Zou, X.; Muller, K.; Golden, J.E.; Frohn, M.; Adlam, M.; Plant, M. H.; Wong, M.; McElvain, M.; Regal, K.; Viswanadhan, V. N.; Tagari, P.; Hungate, R. “Potent hFPRL1 (ALXR) Agonists as Potential Anti-Inflammatory Agents.” Bioorg. Med. Chem. Lett. 2006, 16, 3713-3718.

5. Lei, Y.; Wrobleski, A.D.; Golden, J.E.; Powell, D.R.; Aubé, J. “Facile C-N Cleavage in a Series of Bridged Lactams.” J. Am.Chem. Soc. 2005, 127, 4552- 4553.

4. Golden, J.E.; Aubé, J. “A Combined Intramolecular Diels-Alder/Intramolecular Schmidt Reaction Process: A Formal Synthesis of (±)-Stenine.” Angew. Chem. Int. Ed. Eng., 2002, 41, 4316-4318.

3. Black, T.H.; Forsee, J.E.; Probst, D.A. “A Rapid, Nearly Quantitative Conversion of Codeine to Hydrocodone.” Synth. Comm. 2000, 30, 3195-3201.

2. Forsee, J.E.; Aubé, J. “Hydrolysis of Iminium Ethers Derived from the Reaction of Ketones with Hydroxy Azides: Synthesis of Macrocyclic Lactams and Lactones.” J. Org. Chem. 1999, 64, 4381-4385.

1. Forsee, J.E.; Smith, B.T.; Frank, K.E.; Aubé, J. “Reactions of Oxazolinium and Dihydrooxazinium Salts Prepared by an Azide Insertion Sequence: pH Control of Product Distribution.” Synlett 1998, 11, 1258-1260.

SELECTED PATENTS:

11. Selective efflux inhibitors and related pharmaceutical compositions and methods of treatment. Larson, R. S.; Sklar, L. A.; Edwards, B. S.; Strouse, J. J.; Ivnitski-Steele, I.; Khawaja, H. M.; Ricci, J. W.; Aube, J.; Golden, J. E.; Yao, T.; Weiner, W. S.; Schroeder, C.E. US 9056111 B1 20150616. 2015.

10. Preparation of quinazolinone derivatives for treatment of alphavirus. Golden, J.E.; Aube, J.; Chung, D-H.; Schroeder, C.; Yao, T.; White, E.L.; Tower, N.A. WO2014093869 A1 and US20150329499. 2014.

9. Rab7 GTPase Inhibitors and Related Methods of Treatment. Wandinger-ness, A.; Sklar, L.; Agola, J.; Surviladze, Z.; Aube, J.; Golden, J.E.; Schroeder, C.E.; Simpson, D.S. United States US20140248268 A1. 2014.

8. Modulators of GTPase and Use In Relevant Treatment. Wandinger-Ness, A.; Sklar, L.; Surviladze, Z.; Oprea, T.; Hudson, L.; Aube, J.; Golden, J.E.; Schroeder, C.E.; Simpson, D.S.; Noth, J.J. United States US20130345277 A1. 2013.

7. Inhibitors of respiratory syncytial virus. Golden, J.E.; Aube, J.; Simpson, D.S.; Flaherty, D.P.; Matharu, D.S.; Severson, W.E.; Rasmussen, L. United States WO2013184806 A1. 2013.

6. Compounds and methods for activating the apoptotic arm of the unfolded protein response. Golden, J.E.; Aube, J.; Flaherty, D.P.; Fribley, A.M.; Kaufman, R.J.; Chung, T.; Pinkerton, A.B.; Hendrick, M.P. United States WO2013192165 A2. 2013.

5. Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof. Allen, J.R.; Biswas, K.; Cao, G.; Golden, J.E.; Mercede, S.J.; Peterkin, T.; Reed, A.; Tegley, C.M. United States CA2672652 C. 2012.

4. Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof. Allen, J.R.; Biswas, K.; Bryan, M.C.; Burli, R.; Cao, G.; Frohn, M.J.; Golden, J.E.; Mercede, S.; Neira, S.; Peterkin, T. United States WO2008076427 A3. 2009.

3. Diazaquinolones that inhibit prolyl hydroxylase activity. Allen, J.R.; Biswas, K.; Burli, R.; Golden, J.E.; Mercede, S.; Tegley, C.M. United States WO2008137084 A3. 2009.

2. Indanone derivatives that inhibit prolyl hydroxylase. Allen, J.R.; Burli, R,; Golden, J.E.; Muller, K.M.; Reed, A.B. United States WO2008130508 A1. 2008.

1. Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof. Allen, J.R.; Biswas, K.; Burli, R.; Dao, J.; Frohn, M.; Golden, J.E.; Hungate, R.W.; Kurzeja, R.; Mercede, S.J.; Muller, K.M. United States WO2007070359 A3. 2008.

BOOK CHAPTERS:

Mitscher, L.; Aubé, J.; Dutta, A.; Golden, J.E. Combinatorial chemistry and multiple parallel synthesis. In: Abraham, D.J.; Rotella, D.P.; eds. Burger’s Medicinal Chemistry and Drug Discovery, Vol 1: Methods in Drug Discovery. New York, NY: Wiley; 2010: p 275-368.

For a full list of peer-reviewed published works, see:

http://www.ncbi.nlm.nih.gov/sites/myncbi/1ZkmT8l88ekQ8/bibliography/47727841/public/?sort=date&direction=ascending