Evaluation of Dosing Strategies in Pediatrics:

Dosing of mediations in children are often extrapolated from adults. Developmental changes in pediatrics make the drug absorption, distribution, metabolism and excretion (ADME) difficult to predict. Therefore, the dosing extrapolation may result in inadequate outcomes such as overtreatment or undertreatment. This area of research evaluates dosing strategies in neonates and children in various disease states. Specifically, our research currently focuses on the impact of growth and maturation of organ functions on 1) caffeine therapy for the prevention of chronic lung disease in premature neonates, and 2) levetiracetam use in neonatal seizures.