{"id":273,"date":"2007-01-01T18:56:10","date_gmt":"2007-01-01T18:56:10","guid":{"rendered":"https:\/\/wwwtest.pharmacy.wisc.edu\/faculty\/hong-research-group\/?p=273"},"modified":"2025-06-20T19:06:16","modified_gmt":"2025-06-20T19:06:16","slug":"the-binding-avidity-of-a-nanoparticle-based-multivalent-targeted-drug-delivery-platform","status":"publish","type":"post","link":"https:\/\/pharmacy.wisc.edu\/faculty\/hong-research-group\/2007\/01\/01\/the-binding-avidity-of-a-nanoparticle-based-multivalent-targeted-drug-delivery-platform\/","title":{"rendered":"The Binding Avidity of a Nanoparticle-Based Multivalent Targeted Drug Delivery Platform"},"content":{"rendered":"
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Summary<\/span><\/h2>\r\n
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Dendrimer-based anticancer nanotherapeutics containing \u223c5 folate molecules have shown in\u00a0vitro and in vivo efficacy in cancer cell targeting. Multivalent interactions have been inferred from observed targeting efficacy, but have not been experimentally proven. This study provides quantitative and systematic evidence for multivalent interactions between these nanodevices and folate-binding protein (FBP). A series of the\u00a0nanodevices were synthesized by conjugation with different amounts of folate. Dissociation constants (KD<\/sub>) between the nanodevices and FBP measured by SPR are dramatically enhanced through multivalency (\u223c2,500- to 170,000-fold). Qualitative evidence is also provided for a multivalent targeting effect to KB cells using flow cytometry. These data support the hypothesis that multivalent enhancement of KD<\/sub>, not an enhanced rate of endocytosis, is the key factor resulting in the improved biological targeting by these drug delivery platforms.<\/div>\r\n<\/div>\r\n<\/div>\r\n
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Cited by<\/span><\/h2>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/section><\/section><\/div>\r\n<\/div>\r\n
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