CancelRx: A Health IT Tool to Reduce Medication Discrepancies in the Outpatient Setting

April 9, 2021

Abstract

Objective

Medication list discrepancies between outpatient clinics and pharmacies can lead to medication errors. Within the last decade, a new health information technology (IT), CancelRx, emerged to send a medication cancellation message from the clinic’s electronic health record (EHR) to the outpatient pharmacy’s software. The objective of this study was to measure the impact of CancelRx on reducing medication discrepancies between the EHR and pharmacy dispensing software.

Materials and Methods

CancelRx was implemented in October 2017 at an academic health system. For 12 months prior, and 12 months after CancelRx implementation, data were collected on discontinued medications in the health system’s EHR and whether those prescriptions were successfully discontinued in the pharmacy’s dispensing software. An interrupted time series analysis was conducted to model the occurrence of prescriptions successfully discontinued over time.

Results

There was an immediate (lag = 0), significant (P < 0.001), and sustained (post-implementation slope 0.02) increase in the proportion of successful medication discontinuations after CancelRx implementation (from 34% to 93%). CancelRx had variable impact based on whether the clinic was primary care (71.4% change prepost) or specialty care (53.9% change prepost). CancelRx reduced the time between when a medication was discontinued in the clinic EHR and pharmacy dispensing software.

Conclusion

CancelRx automated a manual process and illustrated the role for health IT in communicating medication discontinuations between clinics and pharmacies. Overall, CancelRx had a marked benefit on medication list discrepancies and illustrated how health IT can be used across different settings to improve patient care.

Published

Cover page of JAMIA Volume 28 Issue 4

Cited by

This article is cited by 6 publications

  1. Kashyap, N., Jeffery, S., & Agresta, T. (2024). From MedWreck to MedRec: A Call to Action to Improve Medication Reconciliation. Applied clinical informatics, 15(2), 230–233. https://doi.org/10.1055/a-2181-1847
  2. Pitts, S. I., Olson, S., Yanek, L. R., Wang, N. Y., Woodroof, T., & Chen, A. R. (2023). Pharmacy e-Prescription Dispensing Before and After CancelRx Implementation. JAMA internal medicine, 183(10), 1120–1126. https://doi.org/10.1001/jamainternmed.2023.4192
  3. Watterson, T. L., Stone, J. A., Kleinschmidt, P., & Chui, M. A. (2023). CancelRx Case Study: Implications for Clinic and Community Pharmacy Work Systems. Research square, rs.3.rs-2859918. https://doi.org/10.21203/rs.3.rs-2859918/v1
  4. Pitts, S. I., Yang, Y., Thomas, B., & Chen, A. R. (2022). Discontinuation of outpatient medications: implications for electronic messaging to pharmacies using CancelRx. Journal of the American Medical Informatics Association : JAMIA, 29(12), 2101–2104. https://doi.org/10.1093/jamia/ocac181
  5. Watterson, T. L., Stone, J. A., Gilson, A., Brown, R., Xiong, K. Z., Schiefelbein, A., Ramly, E., Kleinschmidt, P., Semanik, M., Craddock, L., Pitts, S. I., Woodroof, T., & Chui, M. A. (2022). Impact of CancelRx on discontinuation of controlled substance prescriptions: an interrupted time series analysis. BMC medical informatics and decision making, 22(1), 50. https://doi.org/10.1186/s12911-022-01779-9