Pharmaceutical Sciences Seminar Series
Polycomb Complexes in Control of Epidermal Stem Cells
- Elena Ezhkova, PhD
- Icahn School of Medicine at Mount Sinai
- Hosted by Assistant Professor Jun Dai
Polycomb group proteins are essential epigenetic transcriptional regulators. Traditionally, PcG proteins function as two multi-subunit complexes, Polycomb repressive complex 1 (PRC1) and PRC2, which largely overlap in their genomic binding and cooperate to establish repressive chromatin domains demarcated by H2AK119ub and H3K27me3.
We study the roles of PRC1 and PRC2 in the developing skin epidermis, a tissue that provides essential barrier functions. During development and homeostasis, epidermal stem cells (SCs) located in the basal layer move upward to the suprabasal layer, where they undergo terminal differentiation. Here, we will discuss previously unknown functions of PRC1 and PRC2 in regulation of stem cells during development and adulthood.
This seminar will be held via Webex.